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*  TYSABRI (concentrate for solution for infusion)
SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright ... The impact of plasma exchange on the restitution of lymphocyte migration and ultimately its clinical usefulness is unknown. ... Specifically, natalizumab binds to the alpha4beta1 integrin, blocking the interaction with its cognate receptor, vascular cell ... In MS, lesions are believed to occur when activated T-lymphocytes cross the blood-brain barrier (BBB). Leukocyte migration ...
http://home.intekom.com/pharm/litha/tysabri.html
*  Takeda Pharmaceuticals North America, Inc.
MAdCAM-1 is mainly expressed on gut endothelial cells and plays a critical role in the homing of T-lymphocytes to gut lymph ... Entyvio, an integrin receptor antagonist, is a humanized monoclonal antibody that specifically binds to the alpha4beta7 ... and death has occurred in patients treated with another integrin receptor antagonist. A risk of PML cannot be ruled out. ... The alpha4beta7 integrin is expressed on the surface of a discrete subset of memory T-lymphocytes that preferentially migrate ...
http://www.takeda.us/newsroom/press_release_detail.aspx?year=2014&id=303
*  Subcellular localization of L-selectin ligand in the endometrium implies a novel function for pinopodes in endometrial...
Kawashima H: Roles of sulfated glycans in lymphocyte homing. Biol Pharm Bull. 2006, 29: 2343-2349. 10.1248/bpb.29.2343.View ... Damsky CH, Fisher SJ: Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors. Curr Opin Cell Biol. ... lymphocyte homing [19], and tumor metastasis [20, 21] indicating the existence of similar pathways between these processes. ... To this end, MECA-79, a monoclonal antibody that blocks L-selectin-dependent lymphocyte attachment and recognizes 6-sulfo sLex ...
https://rbej.biomedcentral.com/articles/10.1186/1477-7827-10-46
*  Lymphocyte homing receptor - Wikipedia
Lymphocyte homing receptors are cell adhesion molecules which target addressins. Lymphocyte homing refers to adhesion of the ... Two well known examples are CD34 and GLYCAM-1. B lymphocyte T lymphocyte Lymphocyte homing receptors at the US National Library ... homing receptors) and on endothelial cells (vascular addressins). Free lymphocytes constantly recirculate in blood after their ... Homing happens in tissue-specific manner-e.g. B lymphocytes migrate better to mucosa-associated lymphoid tissue (Peyer's ...
https://en.wikipedia.org/wiki/Lymphocyte_homing_receptor
*  A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. - Semantic...
... a novel class of integral membrane protein involved in lymphocyte-endothelial cell interactions and lymphocyte homing. ... during extravasation into lymphoid tissues involve an 85-95 kd class of lymphocyte surface glycoprotein(s), gp90Hermes (CD44). ... A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins.. @article{ ... Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. *David M. ...
https://www.semanticscholar.org/paper/A-human-lymphocyte-homing-receptor%2C-the-hermes-is-Goldstein-Zhou/8d71c47e91a55abb6c7910e83d01a98003facb07
*  Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. -...
These high molecular mass proteoglycan-like variants, previously identified in lymphocytes, melanomas, and keratinocytes have ... Receptors, Cell Surface, Receptors, Lymphocyte Homing, Recombinant Proteins ... Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. ... Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. ...
https://www.rdm.ox.ac.uk/publications/102470
*  T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a...
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a ... T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a ... T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a ... T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a ...
https://www.ncbi.nlm.nih.gov/pubmed/19377047
*  MicroRNA-7 suppresses the homing and migration potential of human endothelial cells to highly metastatic human breast cancer...
Receptors, Lymphocyte Homing. Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to ... Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface ... Home » Topics » MicroRNAs (miRNAs) » Research » MicroRNA-7 suppresses the homing and migration potential of human endothelial ... Homing of peripheral stem cells is regulated by one of the most representative homing factors, stromal cell-derived factor 1 ...
https://www.bioportfolio.com/resources/pmarticle/1763423/MicroRNA-7-suppresses-the-homing-and-migration-potential-of-human-endothelial-cells.html
*  Patent US7718400 - Methods of increasing lean tissue mass using OB protein compositions - Google Patents
Lymphocyte homing receptor/immunoglobulin fusion proteins. US5284656. Sep 29, 1992. Feb 8, 1994. Amgen Inc.. Pulmonary ... DNA sequence encoding a functional domain of a lymphocyte homing receptor. US5116964. Nov 22, 1989. May 26, 1992. Genentech, ... Attachment at residues important for receptor binding should be avoided if receptor binding is desired. ... Google Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send Feedback ...
http://www.google.com/patents/US7718400?dq=3657699
*  Patent US7601814 - Reducing the immunogenicity of fusion proteins - Google Patents
... region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. ... thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one ... Lymphocyte homing receptor/immunoglobulin fusion proteins. US5225539. 25 Oct 1991. 6 Jul 1993. Medical Research Council. ... This immune response is mediated by T-lymphocytes (T-cells) which then trigger B-lymphocytes (B-cells) to make antibodies. ...
http://www.google.ca/patents/US7601814
*  Patent US6242570 - Production and use of recombinant protein multimers with increased ... - Google Patents
Lymphocyte homing receptor/immunoglobulin fusion proteins. US5349053. Jun 10, 1993. Sep 20, 1994. Protein Design Labs, Inc.. ... Google Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send Feedback ... Feldman, L., et al., "Four Unique Monoclonal Antibodies to the Putative Receptor Binding Domain of Erythropoietin Inhibit the ... For example, new unpredictable activities can result, such as increased affinity for receptors or binding ligands, which can ...
http://www.google.com/patents/US6242570
*  Patente US7169904 - Immunocytokine sequences and uses thereof - Google Patentes
Lymphocyte homing receptor/immunoglobulin fusion proteins. US5225539. 25 Oct 1991. 6 Jul 1993. Medical Research Council. ... Gillies et al., (1991), "Targeting Human Cytotoxic T Lymphocytes to Kill Heterologous Epidermal Growth Factor Receptor-Bearing ... Lymphocyte cell surface phenotype showed an expansion of CD16+ and CD56+ lymphocytes (natural killer (NK) cell markers) ... IgG molecules can interact with multiple classes of cellular receptors including three classes of Fcγ receptors (FcγR) specific ...
http://www.google.es/patents/US7169904?dq=flatulence
*  Blood group antigens of different types for diagnostic and therapeutic applications - AbSorber AB
Lymphocyte homing receptor/immunoglobulin fusion proteins. 1993-07-06. Capon et al.. 530/387.3. ... In one embodiment the second polypeptide has low or no affinity for the Fc receptor. In an alternative embodiment, the second ... The binding of several receptors on one biological entity to several carbohydrate ligands on another, can result in a 10-10000 ... Fc effector function includes for example, Fc receptor binding, complement fixation and T cell depleting activity. (see for ...
http://www.freepatentsonline.com/7897328.html
*  Frontiers | Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory...
Sackstein, R. (2005). The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr. Opin. Hematol. 12, 444-450. ... Sackstein, R. (2004). The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J. Invest. ... Chase, S. D., Magnani, J. L., and Simon, S. I. (2012). E-selectin ligands as mechanosensitive receptors on neutrophils in ... Springer, T. A. (1994). Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76 ...
https://www.frontiersin.org/articles/10.3389/fonc.2012.00103/full
*  JCI - mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors
Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005;12(6):444-450. ... First, we assessed expression of the SDF-1 receptor CXCR4 and the hyaluronan receptor CD44 (8) and observed that hiPS-HSPCs ... Although BM homing is a critical aspect of HSPC biology, studies assessing the homing properties of HSPCs from human ... To establish the absolute homing efficiency of FUT6 modified mRNA-transfected hiPS-HSPCs, we performed short-term BM homing ...
https://www.jci.org/articles/view/92030
*  Immunohistochemical analysis of c-kit receptor express | Open-i
Immunohistochemical analysis of c-kit receptor expression on freshly prepared human peripheral blood buffy coats. Peripheral ... Receptors, Lymphocyte Homing/physiology*. *Stem Cell Factor/pharmacology*. *Vascular Cell Adhesion Molecule-1/physiology* ... Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 ... We evaluated mature peripheral blood eosinophils for their expression of the surface tyrosine kinase, c-kit, the receptor for ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198988_JEM.970564f2&req=4
*  Patent US5846763 - DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6) - Google Patents
Based on homology with CD44/Hermes, an important lymphocyte homing receptor, TSG-6 is expected to play a role in leukocyte ... of the human lymphocyte homing receptor CD44/gp90 Hermes (32.6% identity). In addition, the C-terminal portion of the TSG-6 ... and regions with homology to cartilage link protein/proteoglycan core/lymphocyte homing receptor CD44, and to C1r A chain are ... 2 with the published sequences of human lymphocyte homing receptor CD44/Hermes, (SEQ ID NO:3) rat cartilage link protein (SEQ ...
http://www.google.com/patents/US5846763?dq=7,603,356
*  Arq. Neuro-Psiquiatr. - vol.61 issue1
Stress regulates the lymphocyte homing receptor CD62L (L-selectin). Manfro, Gisele Gus; Alexandre Netto, Carlos; Pollack, Mark ...
http://www.scielo.br/scielo.php?script=sci_issuetoc&pid=0004-282X20030001&lng=en&nrm=iso
*  Distribution of α4 on multiple K562-α4wt and K562 | Open-i
Receptors, Lymphocyte Homing/chemistry/genetics*/metabolism*. Minor. *Animals. *CHO Cells. *Cell Adhesion/genetics ... Our demonstration of integrin adhesive activity regulated through receptor diffusion/clustering (rather than through altered ... Our demonstration of integrin adhesive activity regulated through receptor diffusion/clustering (rather than through altered ... determined by a single particle tracking technique.Our demonstration of integrin adhesive activity regulated through receptor ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199079_JEM.962074f5&req=4
*  Robert Sackstein | Harvard Catalyst Profiles | Harvard Catalyst
Lymphocyte-homing receptors and preferential migration pathways. Proc Soc Exp Biol Med. 1991 Apr; 196(4):374-80. PMID: 2008438. ... Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005 Nov; 12(6):444-50. ... Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. J Invest ... T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 06; 97(6): ...
https://connects.catalyst.harvard.edu/Profiles/display/Person/77961
*  The Sialomucin CD164 (MGC-24v) Is an Adhesive Glycoprotein Expressed by Human Hematopoietic Progenitors and Bone Marrow Stromal...
Direct demonstration of the lectin activity of gp90mel, a lymphocyte homing receptor. J Cell Biol 1990;11:1225. ... Identification of a carbohydrate based endothelial ligand for a lymphocyte homing receptor. J Cell Biol 1991;113:1213. ... Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among ... The recent cloning of four counter-receptors for the selectin family (GlyCAM-1, CD34, MAdCAM-1, and PSGL-1) has led to the ...
http://www.bloodjournal.org/content/92/8/2613?ijkey=6c0fd18119d1c04eba6444a8c3ebe521da801db4&keytype2=tf_ipsecsha&sso-checked=true
*  George D. Demetri, MD - Dana-Farber Cancer Institute | Boston, MA
Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. J Exp Med. 1989 Jul 01; 170(1):123-33. ... This research targets a nuclear receptor known as PPAR-gamma, which plays a role in the normal development of fat cells, and ... CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res. 2008 Sep 01; 14(17):5626- ... Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for ...
https://www.dana-farber.org/find-a-doctor/george-d-demetri/
*  Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue | BMC Cancer | Full Text
Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005;12:444-50.View ... Dimitroff CJ, Bernacki RJ, Sackstein R. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen ... since the binding of E-selectin receptor to E-selectin ligands is calcium-dependent. Therefore, it's necessary to add up to 2 ... expression: implications in modulating lymphocyte migration to skin. Blood. 2003;101:602-10.View ArticlePubMedGoogle Scholar. ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4410-x
*  Cell adhesion molecule - Wikipedia
Lymphocyte homing receptors target addressins. Two well-known examples are CD34 and GLYCAM-1. The cadherins are homophilic Ca2+ ... Integrins, one of the major classes of receptors within the ECM, mediates cell-ECM interactions with collagen, fibrinogen, ... These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts ...
https://en.wikipedia.org/wiki/Cell_adhesion_molecule
*  CD44 Antibody, PE (Monoclonal, MEM-85)
Extracellular matrix receptor III; GP90 lymphocyte homing adhesion receptor; GP90 lymphocyte homing/adhesion receptor; ... CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 ... recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although ... Hyaluronate receptor; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; soluble CD44 ...
https://www.thermofisher.com/antibody/product/CD44-H-CAM-Antibody-MEM-85-Monoclonal/MA1-19634