Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary...
... an agonist of peroxisome proliferator-activated receptor gamma, may stabilize vulnerable plaque with use of ultrasound ... Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.. *Takashi Kadowaki, ... Adiponectin is released from the heart in patients with heart failure.. *H. Takano, Jyun-ei Obata, +10 authors Kiyotaka ... role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists.. *Peter ...https://www.semanticscholar.org/paper/Rapid-improvement-of-carotid-plaque-echogenicity-1-Hirano-Nakamura/5bfe88c8ebe712fecd813ee85e3eab02352810b0
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin...
... along with increased production of adiponectin. Conversely, a reduction in mitoNEET expression enhances mitochondrial ... Receptor - mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. ... Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in ... Adiponectin and AdipoR 1 regulate PGC - 1 α and mitochondria by Ca 2 + and AMPK / SIRT 1. ...https://www.semanticscholar.org/paper/MitoNEET-driven-alterations-in-adipocyte-activity-a-Kusminski-Holland/4d760240eda11daa56ca81843da7b6bcacb9c968
Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing - Semantic Scholar
Receptor - mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. ...https://www.semanticscholar.org/paper/Three-Dimensional-Structures-of-Membrane-Proteins-Hopf-Colwell/ab1fce99854a62c537ad79e64df7862a776376d7
AMP-activated protein kinase in metabolic control and insulin signaling. - Semantic Scholar
... and adiponectin can interact with the system, and it now appears to play a key role in maintaining energy balance at the whole ... Guava leaf extracts alleviate fatty liver via expression of adiponectin receptors in SHRSP.Z-Leprfa/Izm rats. *Hisae Yoshitomi ... δ-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)- ... kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not ...https://www.semanticscholar.org/paper/AMP-activated-protein-kinase-in-metabolic-control-Towler-Hardie/1615ab886826fcddd1b4d0921dd71a9e56f508a5
Elevated serum leptin levels: a risk factor for non-small-cell lung cancer? - Semantic Scholar
Serum leptin and adiponectin levels were determined following a standard protocol. RESULTS In multiple logistic regression ... Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies.. * ... Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk.. *Victoria M. Chia, Polly A Newcomb, +4 ... The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer. *EM Karapanagiotou, EA ...https://www.semanticscholar.org/paper/Elevated-serum-leptin-levels%3A-a-risk-factor-for-Terzidis-Sergentanis/a767b776b2b6fe8d513d8f46b4e87257a9b5f0db
EXOG gene - Semantic Scholar
Adiponectin and adiponectin receptor in relation to colorectal cancer progression.. *Jeong-Sik Byeon, Jin-Yong Jeong, +7 ...https://www.semanticscholar.org/topic/EXOG-gene/1932350
Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid...
Activation of peroxisome proliferator-activated receptor (PPAR)-α which regulates lipid metabolism in peripheral tissues such ... Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes.. * ... Activation of peroxisome proliferator-activated receptor (PPAR)-α which regulates lipid metabolism in peripheral tissues such ... Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid ...https://www.semanticscholar.org/paper/Activation-of-peroxisome-proliferator-activated-in-Kimura-Takahashi/f7d24957ce6d7ba084bbc16ddae1547b01e217cd
Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac...
The NP activity is largely dependent on the ratio between the signaling receptor NPRA and the clearance receptor NPRC. ... We examined the insulin-mediated regulation of NP receptors in differentiated human adipocytes and tested the association of NP ... adipocyte cell line were treated with insulin in the presence of high-glucose or low-glucose media to study NP receptors and ... receptor expression in visceral adipose tissue (VAT) with metabolic profiles of patients undergoing renal surgery. ...https://www.semanticscholar.org/paper/Insulin%2Fglucose-induces-natriuretic-peptide-in-a-Bordicchia-Ceresiani/b72e3000fef3517df7fb81048d469d422a75f5b9
Systemic Fate of the Adipocyte-Derived Factor Adiponectin - Semantic Scholar
... we examine the half-life of adiponectin in circulation by tracking fluorescently labeled recombinant adiponectin in the ... Even though steady-state levels of adiponectin differ between male and female mice, we failed to detect any differences in ... In a metabolically challenged state (high-fat diet exposure or in an ob/ob background), adiponectin levels are reduced in ... RESULTS Despite its abundant presence in plasma, adiponectin is cleared rapidly with a half-life of approximately 75 min. A ...https://www.semanticscholar.org/paper/Systemic-Fate-of-the-Adipocyte-Derived-Factor-Halberg-Schraw/e883d5ac090f018e2daa91c659ac0b90e428036c
Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. - Semantic Scholar
Development of steatohepatitis in Ob/Ob mice is dependent on Toll-like receptor 4.. *Alton G. Sutter, Arun P Palanisamy, Julie ... Leptin and Adiponectin Levels in Idiopathic Pulmonary Fibrosis : Association with Hypoxia. *Foteini Malli, Panagiotis ... Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.. *Varun ... The pattern of IL-24/mda-7 and its cognate receptors expression following activation of human hepatic stellate cells.. *Iman ...https://www.semanticscholar.org/paper/Leptin-induces-increased-alpha2%28I%29-collagen-gene-in-Saxena-Saliba/05c9e98982d86dd3f6e5e24bf19339d0b4b6e4cc
Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism. - Semantic Scholar
Genomic DNA was isolated from a whole blood sample and analyzed for the -759C/T polymorphism of the 5HT2C receptor gene. A chi( ... Several recent reports have linked a -759C/T polymorphism of the 5HT2C receptor gene and obesity as well as chlorpromazine, ... 759C/T polymorphism of the 5HT2C receptor gene. This study included 41 patients with treatment-refractory schizophrenia (DSM-IV ... Association study of the HTR2C, leptin and adiponectin genes and serum marker analyses in clozapine treated long-term patients ...https://www.semanticscholar.org/paper/Clozapine-induced-weight-gain-associated-with-the-Miller-Ellingrod/7f77419cddf141e336cc0765da4f30069b2052d7
Selective Loss of GRK2 Regulation and Its Consequences: Cerebrovascular Complications and Alzheimer disease - Semantic Scholar
The a priori basis for this inquiry stems from the fact that kinases of this family regulate numerous receptor functions in the ... Also, we consider the consequences for this overexpression as a loss of G-protein coupled receptor (GPCR) regulation, as well ... This review focuses on the role of G protein-coupled receptor kinases, particularly GRK2 as they relate to dementia and how the ... Expression of adiponectin and adiponectin receptors in human pituitary gland and brain.. *Aristea Psilopanagioti, Helen ...https://www.semanticscholar.org/paper/Selective-Loss-of-GRK2-Regulation-and-Its-Conseque-Obrenovich-G%C4%85siorowski/1d35daccfb0acbb257735c1ce135b6080162384b
Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose...
... and high molecular weight adiponectin and expression of adiponectin and adiponectin receptors (AdipoR) in adipose tissue (AT) ... adiponectin receptors in AT and in SM but only a pronounced hypocaloric-induced weight-loss increases circulating adiponectin ... All the adiponectin subforms changed in a similar manner as total adiponectin, indicating no specific regulation of any of the ... The molecular subforms of adiponectin in serum were determined by Western blot. RESULTS The mRNA expression of AdipoR1 and -2 ...https://www.semanticscholar.org/paper/Diet-induced-weight-loss-and-exercise-alone-and-in-Christiansen-Paulsen/cda82a7d4fba0b42426ed7ad8d9e15aedceb1495
Local adiponectin treatment reduces atherosclerotic plaque size in rabbits. - Semantic Scholar
... adiponectin had no effect on the expression of types I and III collagen. These results suggest that local adiponectin treatment ... Serum adiponectin concentrations in rabbits after Ad-APN local transfer to abdominal aortas increased about nine times as much ... Adiponectin significantly suppressed the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1) by 18.5% through intima ... we investigated the in vivo role of adiponectin, an adipocytokine, on the development of atherosclerosis in rabbits mainly ...https://www.semanticscholar.org/paper/Local-adiponectin-treatment-reduces-atherosclerotic-Li-Sun/675e05e2f3a306cccf03c72306773f08937e2cc5
Angiotensin II type 1 and type 2 receptors regulate basal skeletal muscle microvascular volume and glucose use. - Semantic...
... and vasodilatation through the type 2 receptor (AT(2)R). Both are expressed in muscle microvasculature, where substrate ... Angiotensin II causes vasoconstriction via the type 1 receptor (AT(1)R) ... Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary ... Angiotensin II causes vasoconstriction via the type 1 receptor (AT(1)R) and vasodilatation through the type 2 receptor (AT(2)R ...https://www.semanticscholar.org/paper/Angiotensin-II-type-1-and-type-2-receptors-regulate-Chai-Wang/ad858bed5c394c209c83771da292360e62f13ba2
Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes. - Semantic Scholar
This study was conducted to determine the effect of insulin on the expression of adiponectin and its receptors. We demonstrated ... a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist) had no effect on the expression of adiponectin and ... in regulating glucose utilization and fatty acid metabolism in mammals are mediated by two subtypes of adiponectin receptors ( ... Adiponectin is an adipocyte-derived hormone that can improve insulin sensitivity. Its functions ...https://www.semanticscholar.org/paper/Insulin-regulates-the-expression-of-adiponectin-and-Liu-Wang/60e470275477b21b0a4a81dc73fb45eea17653e4
Preferential increase in high-molecular weight adiponectin after niacin. - Semantic Scholar
Low- and medium-molecular weight adiponectin increased by 35% and 33%, respectively, but HMW adiponectin by 88% (all p,0.05). ... independently of the increase in HMW adiponectin. CONCLUSION HMW adiponectin is the fraction most affected by treatment with ... In this study we investigated whether all three adiponectin fractions are increased equally, and, secondly, whether the ... The increase in HMW adiponectin was almost two times as large in patients with lower BMI and better insulin sensitivity. ...https://www.semanticscholar.org/paper/Preferential-increase-in-high-molecular-weight-Westphal-Luley/08caee9ac6aa24f56d46f8359ef9a45d76cf8c26
A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure - Semantic Scholar
We show here that brainstem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on ... inactivation of the leptin receptor in serotonergic neurons recapitulates them fully. This study modifies the map of leptin ... ventromedial hypothalamic neurons and appetite via Htr1a and 2b receptors on arcuate neurons. Leptin inhibits these functions ... inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on ...https://www.semanticscholar.org/paper/A-Serotonin-Dependent-Mechanism-Explains-the-Leptin-Yadav-Oury/617fa39a074acb0528476cd0d55b79b91bb139d5
Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through...
Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells.. *Mika Yamauchi, Toru ... Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 ... Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed ...https://www.semanticscholar.org/paper/Activation-of-AMP-kinase-and-inhibition-of-Rho-the-Kanazawa-Yamaguchi/ede3b87f0564fdb76f79b4e87c2196e97d46f15f
Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. - Semantic...
... and adiponectin, while it decreased tumor necrosis factor-alpha (TNF-alpha). The present observations suggest that factors ... Stepwise-multiple regression analysis also showed a significant influence of adiponectin (F=33.27) on the EC-SOD level. ... EC-SOD in 122 patients and found for the first time that the EC-SOD level was strongly and positively related to adiponectin (r ... activated receptor-gamma.. *Mitsuhiro Iwata, Tetsuro Haruta, +8 authors Masashi Kobayashi ...https://www.semanticscholar.org/paper/Relationship-of-plasma-extracellular-superoxide-in-Adachi-Inoue/56737715de525d634599196a56a6f268935f5917
Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. - Semantic Scholar
Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion.. *Stephen Fitter, ... Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation ...https://www.semanticscholar.org/paper/Mechanism-of-divergent-growth-factor-effects-in-Kratchmarova-Blagoev/754d0b51413a269fc3a2e17067e1b5eff2017949
Skeletal muscle accretion and turnover in lean and obese (ob/ob) mice. - Semantic Scholar
Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies. *Aurélie M Delaigle, Maximin ... Muscle hypertrophy and increased expression of leptin receptors in the musculus triceps brachii of the dominant arm in ...https://www.semanticscholar.org/paper/Skeletal-muscle-accretion-and-turnover-in-lean-and-Trostler-Romsos/a21a1a2d4cd9d1a61dd4de069749fd22a9291311
Diabetes due to Mitochondrial Adipopathy - Semantic Scholar
Unfortunately, we did not examine the expression levels of insulin receptor mRNA or other factors that would have influenced ... We considered that the low plasma adiponectin level (hypoadiponectinemia) and skeletal muscle atrophy would have contributed to ... We considered that the low plasma adiponectin level (hypoadiponectinemia) and skeletal muscle atrophy would have contributed to ... Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist.. *Hiroyo Ninomiya. ...https://www.semanticscholar.org/paper/Diabetes-due-to-Mitochondrial-Adipopathy-Ninomiya-Hirata/e753ecd7913b364ef4126db4de47edb556a9ee5e
Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis - Semantic Scholar
1.30%; p,0.05); a finding endorsed by the effect of GLP-1 receptor agonist on primary human hepatocytes (24.6% decrease in ... 4.0IU/L; p,0.01) and serum leptin, adiponectin, and CCL-2 (all p,0.05). Liraglutide increased hepatic insulin sensitivity (- ... Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives ... Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice.. Xiaokun Ding, Neeraj ...https://www.semanticscholar.org/paper/Glucagon-like-peptide-1-decreases-lipotoxicity-in-Armstrong-Hull/2a41babbf46538296f1f896a07a43c598430369c
Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced...
The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Imo J Akpan, Marcus D. Goncalves, +7 ... Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions.. Shana T ...https://www.semanticscholar.org/paper/Loss-of-Function-Mutation-in-Myostatin-Reduces-%CE%B1-Wilkes-Lloyd/d4f2f5627acfd7e84e2a9f6d4c38be6715f28782