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*  Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. - PubMed - NCBI
Serotonin (5-hydroxytryptamine, 5-HT) is a monoaminergic neurotransmitter that is believed to modulate numerous sensory, motor ... These diverse responses are elicited through the activation of a large family of receptor subtypes. The complexity of this ... actions of serotonin. Here we show that 5-HT2C receptor-deficient mice are overweight as a result of abnormal control of ... prominent G-protein-coupled receptors that are widely expressed throughout the brain and spinal cord and which have been ...
https://www.ncbi.nlm.nih.gov/pubmed/7700379
*  Native serotonin 5-HT2C receptors are expressed as homodimers on the apical surface of choroid plexus epithelial cells. | Sigma...
Native serotonin 5-HT2C receptors are expressed as homodimers on the apical surface of choroid plexus epithelial cells.. [ ... A known monomeric receptor (CD-86) served as a control for decoding the oligomer status of native 5-HT2C receptors by molecular ... G protein-coupled receptors (GPCRs) are a prominent class of plasma membrane proteins that regulate physiologic responses to a ... s and were expressed at 32 receptors/μm(2) on the apical surface of choroid plexus epithelial cells. The functional ...
https://www.sigmaaldrich.com/catalog/papers/25609374
*  ChemiScreen™ Human Recombinant 5-HT 2C Serotonin Receptor Calcium-Optimized Stable Cell Line from MilliporeSigma |...
Human Recombinant 5-HT 2C Serotonin Receptor Calcium-Optimized Stable Cell Line from MilliporeSigma on SelectScience ... Chemicon's cloned human 5-HT2C -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant 5-HT ... Chemicon's cloned human 5-HT2C -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant 5- ... HT2C expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the ...
http://www.selectscience.net/products/chemiscreen--human-recombinant-5-ht-2c--serotonin-receptor-calcium-optimized-stable-cell-line/?prodID=106481&u=F498D1B4-7F21-4F88-89D3-5B1D3DA1B088&techBID=50
*  Hyperlocomotive and Discriminative Stimulus Effects of Cocaine are Under the Control of Serotonin 5- HT2C Receptors in Rat...
HT2C Receptors in Rat Prefrontal Cortex Message Subject (Your Name) has forwarded a page to you from Journal of Pharmacology ... HT2C Receptors in Rat Prefrontal Cortex. Malgorzata M. Filip and Kathryn A. Cunningham ... HT2C Receptors in Rat Prefrontal Cortex. Malgorzata M. Filip and Kathryn A. Cunningham ... HT2C Receptors in Rat Prefrontal Cortex. Malgorzata M. Filip and Kathryn A. Cunningham ...
http://jpet.aspetjournals.org/content/early/2003/04/29/jpet.102.045716
*  Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically...
... receptor (5-HT(2C)R) is essential in normal physiology, whereas aberrant 5-HT(2C)R function is thought to contribute to the ... Serotonin (5-hydroxytryptamine; 5-HT) signaling through the 5-HT(2C) ... Serotonin (5-hydroxytryptamine; 5-HT) signaling through the 5-HT(2C) receptor (5-HT(2C)R) is essential in normal physiology, ... Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically ...
https://www.fpwr.org/fpwr-research-publications/peptide-inhibitors-disrupt-the-serotonin-5-ht2c-receptor-interaction-with-phosphatase-and-tensin-homolog-to-allosterically-modulate-cellular-signali
*  Altered expression of the 5-HT2C (serotonin 2C) receptor in schizophrenia - Nuffield Department of Clinical Neurosciences
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings ...
https://www.ndcn.ox.ac.uk/publications/98160
*  Nigrostriatal lesions alter oral ... preview & related info | Mendeley
Receptors, Serotonin. *Receptors, Serotonin: physiology. *Serotonin Receptor Agonists. *Serotonin Receptor Agonists: ... receptors, a serotonergic receptor subtype present in discrete regions of the basal ganglia. Specifically, the effects of ... Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine ... unilateral lesions of nigrostriatal DA neurons on oral dyskinesia and Fos protein expression induced by the non-selective 5-HT(2C ...
https://www.mendeley.com/research-papers/nigrostriatal-lesions-alter-oral-dyskinesia-cfos-expression-induced-serotonin-agonist-1mchlorophenyl/
*  Find a Cell Line | Charles River
Human A1 Adenosine Receptor Cell Line Human Adenosine A1 Receptor-expressing GPCR (G protein-coupled receptor) stable, ... Human Serotonin 5-HT2B Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line. ... G protein-coupled receptor) stable, replicating cell line. ... G protein-coupled receptor) stable, replicating cell line. ... G protein-coupled receptor) stable, replicating cell line. ... Human 5-HT6 Serotonin Receptor Cell Line Human 5-HT6 Serotonin ...
https://www.criver.com/find-cell-line
*  3 - NA, DA, 5-HT and HA Flashcards by | Brainscape
... promotes receptor internalization of the receptor by binding to clathrin 3. Clathrin starts endocytosis of the receptors (the ... What is often a symptom associated with decreased serotonin 5-HT1a receptors? ... 1. G protein-coupled receptor kinase (GPK) phosphorylates the receptor that then becomes a target for arrestins. 2. β-arrestin ... What are the two dopamine receptor subtypes and the receptors within these subtypes? ...
https://www.brainscape.com/flashcards/3-na-da-5-ht-and-ha-1709203/packs/3196278
*  Compound Report Card
Endothelin receptor ET-B Rattus norvegicus 0.953 CHEMBL324 Serotonin 2c (5-HT2c) receptor Rattus norvegicus 0.875 ... Serotonin 2a (5-HT2a) receptor Rattus norvegicus 0.239 Show More. Calculated Compound Parent Properties. Mol. Weight. Mol. ...
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL641
*  Compound Report Card
5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE , HEALTH AID , HEIDADOUPPI , NATURE'S BLEND , NATROL , MELAPURE , S.GARD , QUALITY ... HEALTH , LIFE EXT , ICENIA , GENERAL NUTRIT , NATURES BOUNTY , N-ACETYL-5-METHOXYTRYPTAMINE , MELATONIN ... Cholecystokinin B receptor Mus musculus 1.000 CHEMBL4768 Acetylcholinesterase Bos taurus 1.000 CHEMBL3459 Serotonin 1b (5-HT1b ... VESPRO , VYTALONIN , CIRCADIN , TRAVELAG , N-(2-(5-METHOXY-1H-INDOL-3-YL)ETHYL)ACETAMIDE , HEALTH AID , HEIDADOUPPI , NATURE'S ...
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL45
*  ASPET | Experimental Biology Program 2012
From farm to pharm: A journey with serotonin.. JULIUS AXELROD SYMPOSIUM: Novel insights into the regulation of serotonin ... Toll-like receptors in neuroplasticity and disease. San Diego Convention Center, Room 3. 9:30 am - 12:00 pm. Sponsored by the ... Role of nuclear receptors in lipid dysregulation and obesity-related diseases. San Diego Convention Center, Room 5A. 3:00 pm - ... Allosteric regulation of serotonin 5-HT2C receptor function.. Kathryn A. Cunningham, Univ. of Texas Med. Br., Galveston ...
https://www.aspet.org/aspet/meetings-awards/meetingsannual-meeting/annual-meeting-archives/experimental-biology-2012/experimental-biology-program-2012
*  Psychopharmakotherapie | Metabolische Nebenwirkungen von Psychopharmaka | springermedizin.de
Levine LR, Rosenblatt S, Bosomworth J. Use of a serotonin re-uptake inhibitor, fluoxetine, in the treatment of obesity. Int J ... H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. ... Aggarwal A, Jethani SL, Rohatgi RK, Kalra J. Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose ... Association study of GABAA alpha2 receptor subunit gene variants in antipsychotic-associated weight gain. J Clin ...
https://www.springermedizin.de/psychopharmakotherapie/metabolische-nebenwirkungen-von-psychopharmaka/12126810
*  Levofenfluramine - Wikipedia
Paradoxically, however, it has been shown that levofenfluramine too acts as a relatively potent releaser of serotonin, though ... receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications". Circulation. 102 (23): ... Balcioglu A, Wurtman RJ (November 1998). "Effects of fenfluramine and phentermine (fen-phen) on dopamine and serotonin release ... Levonorfenfluramine, an active metabolite of levofenfluramine, is also a fairly potent serotonin releasing agent (with a ...
https://en.wikipedia.org/wiki/Levofenfluramine
*  YM-348 - Википедија, слободна енциклопедија
Wacker, DA; Miller, KJ (2008). „Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple ... receptor agonists as potential antiobesity agents". Journal of medicinal chemistry. 49 (14): 4023-34. PMID 16821762. doi: ... Inhibitori preuzimanja serotonin-norepinefrin-dopamina (SNDRI): Brasofensin • Diklofensin • DOV-102,677 • DOV-21,947 • DOV- ... 5-HT2C. Agonisti: Fenetilamini: 2C-B • 2C-E • 2C-I • 2C-T-2 • 2C-T-7 • 2C-T-21 • DOB • DOC • DOI • DOM • MDA • MDMA • Meskalin ...
https://sr.wikipedia.org/wiki/YM-348
*  Doxepin - Wikipedia
... and similarly has no effect on other receptors such as adrenergic and serotonin receptors. The H1 receptor antagonism of ... Although doxepin is selective for the H1 receptor at doses lower than 25 mg, blockade of serotonin and adrenergic receptors may ... It is specifically an antagonist of the histamine H1 and H2 receptors, the serotonin 5-HT2A and 5-HT2C receptors, the α1- ... Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993). "Cloning and expression of a novel serotonin receptor with high ...
https://en.wikipedia.org/wiki/Doxepin
*  A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure - Semantic Scholar
We show here that brainstem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on ... Leptin inhibits these functions and increases energy expenditure because it reduces serotonin synthesis and firing of ... inactivation of the leptin receptor in serotonergic neurons recapitulates them fully. This study modifies the map of leptin ... ventromedial hypothalamic neurons and appetite via Htr1a and 2b receptors on arcuate neurons. ...
https://www.semanticscholar.org/paper/A-Serotonin-Dependent-Mechanism-Explains-the-Leptin-Yadav-Oury/617fa39a074acb0528476cd0d55b79b91bb139d5
*  Bodyweight Gain with Atypical Antipsychotic | SpringerLink
... antipsychotics for histamine H1 receptors as well as the ratio of their affinity for serotonin 5-HT2 and dopamine D2 receptors ... The role of serotonin in eating disorders. Drugs 1990; 39Suppl. 3: S33-S48CrossRefGoogle Scholar ... Serotonin and appetite. Neuropharmacology 1984; 23: 1537-51PubMedCrossRefGoogle Scholar ... Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 1996 ...
https://link.springer.com/article/10.2165%2F00002018-200124010-00005
*  Kanes S[au] - PubMed - NCBI
Imaging D2 receptor occupancy by endogenous dopamine in humans.. Laruelle M, D'Souza CD, Baldwin RM, Abi-Dargham A, Kanes SJ, ... Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine ... On the relationship between D2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice. ... Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications.. Maxwell CR, Kanes SJ, Abel ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kanes+S%5Bau%5D&dispmax=50
*  Update on Office-Based Strategies for the Management of Obesity - American Family Physician
Lorcaserin is a serotonin 5-HT2C receptor agonist administered as a 10-mg tablet twice per day. It should not be used in ... Liraglutide is a glucagon-like peptide-1 receptor agonist that is administered subcutaneously and leads to weight loss when ... Table 5.. Summary of Common Bariatric Procedures. Procedure. Percentage of excess weight lost. Indications. Complications. ... Table 5.. Summary of Common Bariatric Procedures. Procedure. Percentage of excess weight lost. Indications. Complications. ...
https://www.aafp.org/afp/2016/0901/p361.html
*  The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine | Springer for Research & Development
Serretti A, Lorenzi C, Lilli R, Smeraldi E. Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood ... Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. ... Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. J ... Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients ...
https://rd.springer.com/article/10.1007%2Fs40291-018-0335-y
*  brolamfetamine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
Activating mutations of the serotonin 5-HT2C receptor. J Neurochem, 69: 1138-1144. [PMID:9282936] ... receptors. Synapse, 35: 144-150. [PMID:10611640] 2. Egan CT, Herrick-Davis K, Teitler M. (1998) Creation of a constitutively ... Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin ... Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn ...
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=refs&ligandId=163
*  Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids | Journal of...
2005) Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. J Neurochem 93 ... G protein-coupled receptor. GLP-1R. glucagon-like peptide-1 receptor. ERK. extracellular signal-regulated kinase. DMEM. ... In addition, for receptors such as the GLP-1R that involve the interplay between multiple endogenous ligands, probe dependence ... 2003) Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling. Regul Pept 111:137-144. ...
http://jpet.aspetjournals.org/content/336/2/540
*  Structure-Function Studies of the Eighth Hydrophobic Domain of a Serotonin Receptor, Journal of Neurochemistry | 10.1046/j.1471...
"Structure-Function Studies of the Eighth Hydrophobic Domain of a Serotonin Receptor, Journal of Neurochemistry" on DeepDyve, ... HT2C receptor is a prominent serotonin receptor in basal ganglia : evidence from functional studies on serotonin‐mediated ... HT2C receptor and comparing its function and topology with those of the wild‐type receptor. Immunofluorescence microscopy was ... HT2C receptor and comparing its function and topology with those of the wild‐type receptor. Immunofluorescence microscopy was ...
https://www.deepdyve.com/lp/wiley/structure-function-studies-of-the-eighth-hydrophobic-domain-of-a-dyKv70Yjm3