JCI - Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and...
Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and ... Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and ... Both platelet-derived growth factor (PDGF) A- and B-chains are expressed in mammalian neurons, but their precise roles still ... The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell ...
Rat PDGFRb(Platelet Derived Growth Factor Receptor Beta) ELISA Kit - iBiomagazine
Rat PDGFRb(Platelet Derived Growth Factor Receptor Beta) ELISA Kit. Human Platelet Derived Growth Factor Receptor Beta (PDGFRB ... Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit. RDR-PDGFRb-Hu-48Tests Reddot Biotech 48 Tests. 577.2 EUR ... Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit. SEC061Hu-1x48wellstestplate Cloud-Clone 1x48-wells test ... Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) ELISA Kit. SEC061Hu-1x96wellstestplate Cloud-Clone 1x96-wells test ...
Receptor, Platelet-Derived Growth Factor beta | Profiles RNS
Platelet-Derived Growth Factor beta*Receptor, Platelet-Derived Growth Factor beta. *Receptor, Platelet Derived Growth Factor ... Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]. *Receptor, Platelet-Derived Growth Factor beta ... Receptors, Platelet-Derived Growth Factor [D12.776.543.750.060.625]. *Receptor, Platelet-Derived Growth Factor beta [D12.776. ... Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]. *Receptor, Platelet-Derived Growth Factor beta [ ...
Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 ...
... and greater preoperative use of beta-blockers (all P=0.0041) than the SR patients. No significant differences were observed in ... Expression of platelet-derived growth factor (PDGF), Rac1 and nuclear factor-kappa B NF-κB in left atrial of rats. (A-C) ... Expression of platelet-derived growth factor (PDGF), Rac1 and nuclear factor-kappa B NF-κB in human RAAs. (A-C) Expression of ... Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 / ...
MedlinePlus: Genes: P
PDGFRA: platelet derived growth factor receptor alpha. *PDGFRB: platelet derived growth factor receptor beta ... PDGFB: platelet derived growth factor subunit B. * ... PLCB4: phospholipase C beta 4. *PLCG2: phospholipase C gamma 2 ... PKD1: polycystin 1, transient receptor potential channel interacting. *PKD2: polycystin 2, transient receptor potential cation ...
Pericyte antigens in angiomyolipoma and PEComa family tumors
Although PEComa family tumors commonly demonstrate a perivascular growth pattern, pericyte antigen expression has not yet been ... Receptor, Platelet-Derived Growth Factor beta / analysis * Receptor, Platelet-Derived Growth Factor beta / metabolism ... Although PEComa family tumors commonly demonstrate a perivascular growth pattern, pericyte antigen expression has not yet been ... 1 Division of Growth and Development, School of Dentistry, University of California, Los Angeles, CA, USA. ...
PLATELET-DERIVED
This assay is designed to evaluate the presence of one of the main factors that contributes to the resistance of a cell ... in particular if there is platelets aggregation as this will protect transformed cells from destruction. It will also ... containing the factor to be destroyed (apoptosis). High PDGF Rβ quantities are associated with an inhibition of the destruction ... Platelet-derived Growth Factor (pdgf) Gene Expression. *Platelet-derived Growth Factor Receptor. Beta (pdgf Rβ) Gene Expression ...
Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts |...
As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF receptor isoforms, and deletion of ... Neutralising antibodies against PDGFRs were shown to block signalling through PDGFRα and PDGFRβ receptors, reduce human PDGF-AA ... either of the receptors in vivo produces an embryonic lethal phenotype, it is not know which ligand and receptor combinations ... In this study, we used PDGFR-specific neutralising antibodies to dissect out receptor-specific signalling events in fibroblasts ...
P79749 | SWISS-MODEL Repository
Human PDGFRL (Platelet Derived Growth Factor Receptor Like Protein) ELISA Kit | G-EC-02321 | Gentaur Elisa Kits
Platelet Derived Growth Factor Receptor Like Protein) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-02321. USA, UK & ... Target Synonym: PRLTS, PDGF-Receptor Beta-Like Tumor Suppressor. Tested Sample Types: Serum, plasma and other biological fluids ... Human PDGFRL (Platelet Derived Growth Factor Receptor Like Protein) ELISA Kit , G-EC-02321. Gentaur Elisa ... Human PDGFRL (Platelet Derived Growth Factor Receptor Like Protein) ELISA Kit , G-EC-02321 ...
Platelet-derived growth factor receptor - Wikipedia
Montmayeur JP, Valius M, Vandenheede J, Kazlauskas A (December 1997). "The platelet-derived growth factor beta receptor ... "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ...
Recombinant Human PDGFR beta protein (ab185609) | Abcam
Recombinant Human PDGFR beta protein is an Escherichia coli Protein fragment 33 to 532 aa range, , 90% purity and validated in ... Beta platelet derived growth factor receptor. *Beta-type platelet-derived growth factor receptor ... Platelet derived growth factor receptor beta. *Platelet derived growth factor receptor beta polypeptide ... Recombinant Human PDGFR beta protein. See all PDGFR beta proteins and peptides. ...
t(1;5)(q21;q32) PDE4DIP/PDGFRB
... involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are ... PDGFRB is the receptor for PDGFB (platelet-derived growth factor-b); Ig like, transmembrane and tyrosine kinase domains; ... constitutive activation of protein tyrosine kinases is a common feature of neoplasms with fusion genes derived from PDGFRB, ... membrane tyrosine kinase; can homodimerize; activated in response to ligand binding and receptor dimerization. ...
Publications | Molecular Virology
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.Wu K, Wu H, Lyu W, Kim Y, ... Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.Yang M, Wu H, Chu J, Gabriel LA, ... Lys-64 of the A chain is involved in the enzymatic activity and neurotoxic effect of beta-bungarotoxin.Chang LS, Chu YP, Cheng ... WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.Booth CJ, Brooks MB, ...
New molecular target for diabetes treatment discovered | ScienceDaily
... the pathway is governed by the expression of a molecule called platelet-derived growth factor receptor. PDGF-receptor ... "When we destroyed the beta cells with this toxin, the expression of PDGF receptor was induced," said Kim, "and the beta cells ... They detected no PDGF receptor in the adult beta cells, but found it readily in the islet beta cells from young donors. ... Adult animals lacking expression of the beta cell PDGF receptor were also less able than their peers to regenerate beta cells ...
JCI - Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism ... Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1α/CXCR4 axis. ... Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by ... Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. ...
TotalSeq™-D0129 anti-human CD140b (PDGFRβ) Antibody, CD140b, 18A2
The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or ... CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. ... Platelet-derived growth factor receptor, beta polypeptide, PDGFR1, PDGFRβ, PDGFRb, PDGF receptor beta Isotype Mouse IgG1, κ ... The 18A2 monclonal antibody recognizes human CD140b also known as the platelet-derived growth factor receptor, beta polypeptide ...
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? | Thorax
Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and ... 46 Increased secretion of other growth factors, that is, VEGF, fibroblast growth factor 2, insulin-like growth factor 1 and HGF ... production and secreted factors including transforming growth factor-β (TGF-β) and hepatocyte growth factor (HGF). Recent data ... transforming growth factor-β; TNF-α, tumour necrosis factor-α; VEGF-A, vascular endothelial growth factor-A. ...
Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates | Scientific Reports
... platelet-derived growth factor Beta, TGFB receptor, and vascular endothelial growth factor 1 and 2. All conditions also ... fibroblast growth factor receptor, Insulin receptor, transforming growth factor Beta (TGFB), and nerve growth factor, and the ... growth-factor receptor electro-polarization37, purinergic receptors38, lipid rafts39, and glycocalyx bending40. ... Several growth-factor-associated pathways were also up-regulated for both cells including Reactome pathways for EGFR, ...
Renal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Treatment, Interleukin-2 and Interferon
... platelet-derived growth factor receptor alpha (PDGFR-alpha), and PDGFR-beta. Approval of sunitinib was based on the high ... a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in ... The receptor tyrosine kinases inhibited by sunitinib include vascular endothelial growth factor receptors 1,2, and 3 (VEGFR 1-3 ... PDGFR-beta, c-KIT, fmslike tyrosine kinase-3 (FLT-3); and the glial cell-line-derived neurotrophic factor receptor (RET). A ...
A Case of Chronic Myelomonocytic Leukemia with Severe Eosinophilia Having t(5;12)(q31;p13) with t(1;7)(q10;p10) | Acta...
Role of the platelet-derived growth factor receptor beta. Acta Haematol 2002;107:113-122. ... Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and ... Chronic myelomonocytic leukemia, Eosinophilia, Platelet-derived growth factor receptor-β, t(1;7), t(5;12) ... Platelet-Derived Growth Factor Receptor-β Expression in Human Peritoneum Nephron Clinical Practice (November,2014) ...
Synergistic Effect between Cisplatin and Sunitinib Malate on Human Urinary Bladder-Cancer Cell Lines
"SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer," ... It is also responsible for inhibition of vascular endothelial growth factors receptors, plateletderived growth factor receptors ... S. Takahashi, "Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy ... and stem cell factor receptor [8, 9]. Its therapeutic effects on urinary bladder cancer have already been assessed in two ...
Brain Metastasis Medication: Corticosteroids, Anticonvulsants, General Anesthetics, Systemic, Antineoplastics, Monoclonal...
... vascular endothelial growth factor receptor [VEGFR]-1, VEGFR-2, VEGFR-3, and platelet-derived growth factor receptor-beta) ... such as platelet-derived growth factor receptors, and vascular endothelial growth factor receptors, which play a role in both ... Park SJ, Kim HT, Lee DH, Kim KP, Kim SW, Suh C. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for ... Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor; may also block angiogenesis and cellular proliferation. ...
Cold seawater induces early sexual developmental stages in the BPG axis of European eel males | BMC Genomics | Full Text
With the aim of obtaining the highest gamete quality, the study of the effects of environmental factors, such as temperature, ... and several growth factor related genes including platelet-derived growth factor receptor beta (pgfrb; FDR = 0.005) or vascular ... also included several growth factor related genes including pgfrb or vegfc (see Additional file 1: Figure S3 and S7). Growth ... Expression of T cell receptor beta locus in central nervous system neurons. Proc Natl Acad Sci U S A. 2003;100(22):13048-53. ...
Nutrients | Free Full-Text | A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model...
... transforming growth factor beta (TGFβ), and platelet derived growth factor receptor beta (PDGFRβ) (data for 50 μM: −93%, −92%, ... and regulation of key transcription factors such as nuclear factor kappa B (NFκB) and peroxisome proliferator-activated ... B) Interleukin 6 (IL-6) and (C) tumor necrosis factor alpha (TNFα) relative mRNA expression in murine macrophages from the ... B) Interleukin 6 (IL-6) and (C) tumor necrosis factor alpha (TNFα) relative mRNA expression in murine macrophages from the ...
William Miller, PhD
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism ... beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. The Journal of ... beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1- ... Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct ...
Drug Discovery Assay Kits | INDIGO Biosciences
Peroxisome Proliferator-Activated Receptor Gamma (PPARg, NR1C3) (4) *. Platelet-Derived Growth Factor Receptors alpha & beta (1 ... Fibroblast Growth Factor Receptor 1c and β-Klotho (FGFR/β-Klotho) (1) ... INDIGOs Nuclear Receptor Assay Kits use transiently transfected cells, less prone to genetic drift and batch-to-batch ... Do INDIGOs Nuclear Receptor Assay Kits use stable cell lines or transiently transfected cells? ...
PDGFRbeta, active - DiscoverX
Inhibition of PDGFRB (PDGFR1, JTK12, CD140B,Beta platelet-derived growth factor) receptor kinase may be useful in the treatment ... Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, ... epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins ... They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular ...
CDK6 | Cancer Genetics Web
... derived growth factor receptor alpha (PDGFRA), calmodulin 3 (CALM3), cyclin‑dependent kinase 6 (CDK6), calcium/calmodulin‑ ... dependent protein kinase type II subunit beta (CAMK2B), retinoblastoma‑associated protein (RB1) and protein kinase C beta type ... Eight genes [(GTPase NRas (NRAS), calcium/calmodulin‑dependent protein kinase type II subunit Gamma (CAMK2G), platelet‑ ... Nerve growth factor receptor (NGFR), a member of kinase protein, is emerging as an important target for Glioblastoma (GBM) ...