Normal mesothelial cells predominantly express PDGF alpha-receptor mRNA and protein, whereas most malignant meso … ... alpha- and beta-receptors differ between normal and malignant mesothelial cell lines. ... In earlier studies we showed that the expression of patterns of platelet-derived growth factor (PDGF) ... Platelet-Derived Growth Factor alpha * Receptor, Platelet-Derived Growth Factor beta * Receptors, Platelet-Derived Growth ...
Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease ... Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease ... Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease ... Myeloid neoplasm associated with eosinophilia and platelet-derived growth factor receptor-alpha rearrangement. Hossain NM, Jain ...
A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients ... A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients ... Olaratumab: A Novel Platelet-Derived Growth Factor Receptor α-Inhibitor for Advanced Soft Tissue Sarcoma. Andrick BJ, Gandhi A. ... Purpose: The platelet-derived growth factor receptor (PDGFR) has an important role in tumorigenesis and tumor progression. ...
... nuclear factor kappa beta; PDGF, platelet derived growth factor; PTEN, phosphatase and tensin homolog; ROS, reactive oxygen ... tumor necrosis factor-alpha; TORC1, target of rapamycin complex 1; VEGF, vascular endothelial growth factor ... insulin-like growth factor-1; IR, insulin resistance; IRS-1, insulin receptor substrate-1; JNKs, c-Jun amino acid-terminal ... A goal of better understanding factors that predict those who are at greatest risk for HCC is laudable. In a disease with 30 to ...
PDGFRA: platelet derived growth factor receptor alpha. *PDGFRB: platelet derived growth factor receptor beta ... PDGFB: platelet derived growth factor subunit B. * ... POGZ: pogo transposable element derived with ZNF domain. *POLG ... PKD1: polycystin 1, transient receptor potential channel interacting. *PKD2: polycystin 2, transient receptor potential cation ... PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. *PIK3CD: phosphatidylinositol-4,5-bisphosphate ...
Receptor, Platelet-Derived Growth Factor alpha / genetics * Receptor, Platelet-Derived Growth Factor alpha / metabolism* ... Platelet-derived growth factor receptor β (PDGFRβ) and platelet-derived growth factor receptor α (PDGFRα) have previously been ... Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive ... Receptor, Platelet-Derived Growth Factor alpha * Receptor, Platelet-Derived Growth Factor beta ...
... diagnosed with severe BPD expressed increased airway miR-219-5p and decreased platelet derived growth factor receptor alpha ( ... MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. *Amelia Freeman1 na1, ... MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha ... we and other researchers found that platelet derived growth factor receptor alpha PDGFR-α was a top predicted target of miR-219 ...
There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, ... "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ...
... platelet-derived growth factor receptor-alpha; POU4F1, POU domain, class 4, transcription factor 1; RGS4, protein expression of ... transcription factor 1)]; PAX3, paired box 3; PDGFRA, platelet-derived growth factor receptor-alpha; PRDM1, PR domain- ... and platelet-derived growth factor receptor-alpha (PDGFRA)] against human OCT4 (Catalog no. C30A3), SRY-box transcription ... ab134057), Kruppel-like factor 5 (KLF5; Catalog no. ab137676), transient receptor potential cation channel subfamily M member 8 ...
... which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health ... The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), ... The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which ... platelet-derived growth factor receptor alpha. *platelet-derived growth factor receptor, alpha polypeptide ...
Clinical features predict responsiveness to imatinib in platelet-derived growth factor receptor-alpha-negative ... 4. Absolute neutrophil count , 1000/mm3 or platelet count ,10,000/mm3 or ,50,000/m3 with clinical evidence of bleeding. 5. ...
Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease. J ... Additionally, we are interested in the influence of immigration and other environmental factors associated with EGID-risk. Our ...
Platelet-Derived Growth Factor/physiology*; Pleura/cytology; Protein Processing, Post-Translational; Rats; Receptors, Platelet- ... Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; MAP Kinase Signaling ... Platelet-derived growth factor (PDGF) is an important mediator of fibrosis and cancer that has been implicated in the ... Title: Nickel nanoparticles enhance platelet-derived growth factor-induced chemokine expression by mesothelial cells via ...
Multiple gastrointestinal stromal and other tumors caused by platelet-derived growth factor receptor alpha gene mutations: a ...
Knockout Tested Rabbit recombinant monoclonal PDGFR alpha antibody [EPR22059-270] - BSA and Azide free. Validated in WB, IP, ... Platelet derived growth factor receptor antibody. *Rearranged in hypereosinophilia platelet derived growth factor receptor ... Platelet derived growth factor receptor alpha antibody. *Platelet derived growth factor receptor alpha polypeptide antibody ... indirect ELISA using ab203491 at varying antibody concentrations (4000~0 ng /ml) and Human PDGF Receptor alpha antigen at 1000 ...
We found that only platelet-derived growth factor receptor alpha (pdgfra) interacted with ethanol during zebrafish craniofacial ... However, tumor necrosis factor alpha (TNF-α) expression was increased only in wildtype mice. This attenuation of TNF-α ... In this paper, the role of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/NRF2) as well as AKT that act as regulators of ... As such, we demonstrate the involvement of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/NRF2) as well as AKT that act as ...
Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment ... Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha.. Tingström A; Reuterdahl C ... 8. [Platelet-derived growth factor. A growth factor of great physiopathological importance].. Westermark B. Lakartidningen; ... Structure and function of the platelet-derived growth factor family and their receptors.. Hart KC; Galvin BD; Donoghue DJ. ...
Name: platelet derived growth factor receptor, alpha polypeptide. Synonyms: CD140a, Pdgfr-2 ...
Alpha platelet-derived growth factor receptor, PGDS_HUMAN Icon Locations in the PathwayBrowser Expand all ... Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens) * Signaling by PDGFR in disease ... STAT binds to the mutant PDGFRA receptor (Homo sapiens) * p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens) * ... GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens) * p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo ...
platelet derived growth factor receptor alpha. involved_in. ISS. IEA. ISO. GO_REF:0000024. GO_REF:0000107. (PMID:8188664). ... platelet derived growth factor subunit A. involved_in. ISO. IEA. ISS. (PMID:2538439). GO_REF:0000107. GO_REF:0000024. RGD. ... platelet derived growth factor subunit B. involved_in. ISO. ISS. IEA. (PMID:2538439). GO_REF:0000024. GO_REF:0000107. RGD. ... fibroblast growth factor 2. involved_in. ISO. (PMID:19577615). RGD. PMID:19577615. NCBI chr 2:120,236,328...120,290,673 Ensembl ...
2003) Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms Molecular and Cellular ... T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA- ... Stimuli favoring oligodendrocyte progenitor production include Epidermal Growth Factor Receptor signaling (EGFR). EGFR ... 2005) Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor The FASEB Journal 19:863-865. ...
... including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet-derived growth factor receptor alpha (PDGFR ... Receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) ... It works by slowing or stopping the growth of cancer cells. HOW TO USE: Read the Patient Information Leaflet if available from ... Normal hair growth should return after treatment has ended.People using this medication may have serious side effects. However ...
Receptor, Platelet-Derived Growth Factor alpha. *Pregnancy. *Polymorphism, Single Nucleotide. *Phenotype. *Ophthalmology & ...
the treatment of adults with unresectable or metastatic GIST harboring a platelet-derived growth factor receptor alpha (PDGFRA ... and that is caused by certain abnormal platelet-derived growth factor receptor alpha (PDGFRA) genes. Your healthcare provider ... for the treatment of adults with unresectable or metastatic GIST harboring a platelet-derived growth factor receptor alpha ( ... Interrupt AYVAKIT until platelet count is ≥ 50 × 109/L, then resume at reduced dose (per Table 1). If platelet counts do not ...