Cell-specific localization of insulin-like growth factor binding protein mRNAs in rat liver | Gastrointestinal and Liver...
IGF-I type 1 receptor probe protects 271 nt of IGF-I receptor mRNA. Lanes are labeled as follows: probe + RNase, IGF-I and IGF ... GH regulation of hepatic IGFBP-3 expression solely to IGF-I given the paucity of type 1 IGF receptors or type 1 IGF receptor ... target tissue for IGF-I actions because hepatocyte cell membranes contain few type 1 IGF receptors and type 1 IGF receptor mRNA ... IGF-I, type 1 IGF receptor, and GH receptor expression. RNase protection assays revealed that adult rat liver, isolated ...http://ajpgi.physiology.org/content/278/3/G447.long
Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor. | DIAL.pr ...
Receptor, IGF Type 2 - metabolism ... of the cation-independent mannose 6-phosphate receptor.. In: ... Document type. :. Article de périodique (Journal article) - Journal Article, Research Support, Non-U.S. Gov't ... Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor. Primary tabs ... Home» Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor. ...https://dial.uclouvain.be/pr/boreal/object/boreal:28770
Domains of the insulin-like growth factor I receptor required...
Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases.: ... The type 1 insulin-like growth factor receptor (IGF-IR) activates the extracellular signal-regulated kinases (ERK1 and -2). The ... Type. Published Article. Journal. Endocrinology Publication Date. Apr 01, 2000 Volume. 141 Issue. 4 Pages. 1289-1300 ... The importance of the C-terminus of the IGF-IR in ERK activation (in the absence of IRS-1) is confirmed by the failure of the ...https://www.mysciencework.com/publication/show/domains-insulin-like-growth-factor-i-receptor-required-activation-extracellular-signal-regulated-kinases-bbd5018c
Factor consider about IGF-1 for bodybuilding - Contraceptive pills side effects, Contraceptive pills names, Contraceptive...
There are two different types of the growth factors are available in human body like mechano growth factor that trigger action ... Insulin like growth factor 1 bodybuilding is mostly interacting with the insulin cell receptors. It is having capability to ... IGF-1 is the sisters of IGF-2 and IGF-3. Most of the people are using IGF-1 for bodybuilding cycle because it acts as growth ... In fact IGF-1 for bodybuilding is also called as insulin like growth factor-1 and it is the peptide hormone and it is most ...http://www.getpillstoday.net/factor-consider-about-igf-1-for-bodybuilding/
Plasma Insulin-Like Growth Factor-I and Serum IGF-Binding Protein 3 Can Be Associated with the Progression of Breast Cancer,...
IGF) is a mitogen for breast cancer cells. However, the associations of plasma IGF-I with tumor histopathology in high-risk ... IGF-I did not correlate with estrogen receptor status, but did increase in progesterone-receptor-positive patients. IGF-I ... Type the blue character in "4R7XA57KHS". To view the fulltext, please log in ... Guvakova M, Surmacz E: Tamoxifen interferes with the insulin-like growth factor-I receptor (IGF-IR) signaling pathway in breast ...https://www.karger.com/Article/Abstract/12052
Urinary growth hormone (GH), insulin-like growth factor I (IGF-I), and IGF-binding protein-3 measurements in the diagnosis of...
Type:. Article. Language:. en. ISSN:. 0021-972X. Appears in Collections:. All Christie Publications Full metadata record. DC ... Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth ... Diagnostic efficiency of serum IGF-I, IGF-binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and urinary GH measurements in ... Urinary IGF and IGF binding protein-3 in children with disordered growth. The North West Paediatric Endocrine Group.Authors: ...http://christie.openrepository.com/christie/handle/10541/91977
ActoFactor™ Recombinant Mouse Insulin-like growth factor 1 | Creative Bioarray
IGF-1 is produced by several cell types and may have autocrine, paracrine and endocrine functions. IGF-1 is a potent mitogen ... Recombinant mouse IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. IGF-1 receptor is a disulfide-linked ... Lyophilized samples are stable for greater than six months at -20°C to -70°C. Upon reconstitution, mouse IGF-1 can be stored ... A DNA sequence encoding the mature IGF-1 protein was expressed in E. coli. ...https://www.creative-bioarray.com/ActoFactor-Recombinant-Mouse-Insulin-like-growth-factor-1-CSC-CTK0032-item-4234.htm
Insulin-like growth factor type-I receptor (IGF-1R) dependent phosphorylation of ERK1/2 but not Akt (PKB) can be induced by...
Insulin-like growth factor type-I receptor (IGF-1R) dependent phosphorylation of ERK1/2 but not Akt (PKB) can be induced by ... Insulin-like growth factor type-I receptor (IGF-1R) dependent phosphorylation of ERK1/2 but not Akt (PKB) can be induced by ... Insulin-like growth factor type-I receptor (IGF-1R) dependent phosphorylation of ERK1/2 but not Akt (PKB) can be induced by ... Insulin-like growth factor type-I receptor (IGF-1R) dependent phosphorylation of ERK1/2 but not Akt (PKB) can be induced by ...http://molpharm.aspetjournals.org/content/early/2007/12/10/mol.107.040014
Adelaide Research & Scholarship: Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in...
Placenta; Humans; Insulin-Like Growth Factor II; Receptor, IGF Type 2; Sequence Analysis, DNA; DNA Methylation; Gene Expression ... Type: Journal article. Title: Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in ...https://digital.library.adelaide.edu.au/dspace/handle/2440/76127
Insulin-Like Growth Factor-I Axis as a Pathway for Cancer Chemoprevention | Clinical Cancer Research
IGFs bind to three receptors with differing affinities. The type 1 IGF receptor binds both IGF-I and IGF-II with high affinity ... and virtually all of the biological activities of the IGFs result from binding to the type 1 receptor. IGF-I receptor (IGF-IR) ... Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II ... IGFBPs seem to inhibit IGF action by competing with IGF receptors for IGF peptides; however, under certain conditions, several ...http://clincancerres.aacrjournals.org/content/12/19/5611?ijkey=8b2d63ccffe2f768fdcee61d0627fcf03cf5f229&keytype2=tf_ipsecsha
Frontiers | The Structure and Biological Function of CREG | Cell and Developmental Biology
Biochemical studies revealed that CREG interacts with mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R) and ... Biochemical studies revealed that CREG interacts with mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R) and ... M6P/IGF2R is a scavenger receptor for IGF-2. It is also involved in the transport of acid hydrolases from the trans-Golgi ... Sun-Wada, G. H., and Wada, Y. (2015). Role of vacuolar-type proton ATPase in signal transduction. Biochim. Biophys. Acta 1847, ...https://www.frontiersin.org/articles/10.3389/fcell.2018.00136/full
Frontiers | Insulin/Insulin-Like Growth Factors in Cancer: New Roles for the Aryl Hydrocarbon Receptor, Tumor Resistance...
... ligands inhibit breast cancer cell responses to IGFs, suggesting that targeting AHR may have benefit in cancers whose ... and the insulin receptor (IR) are receptor tyrosine kinases (RTKs) that are expressed in cancer cells. The results of different ... and the insulin receptor (IR) are receptor tyrosine kinases (RTKs) that are expressed in cancer cells. The results of different ... Our recent reports indicate that pharmacological aryl hydrocarbon receptor (AHR) ligands inhibit breast cancer cell responses ...https://www.frontiersin.org/articles/10.3389/fendo.2015.00012/full
Michel Jadot - Fingerprint - the Research Portal - University of Namur
Fingerprint Fingerprint is based on mining the text of the person's research documents to create an index of weighted terms, which defines the key subjects of each individual researcher. ...https://researchportal.unamur.be/en/persons/michel-jadot/fingerprints/
Characterization of clathrin-coated vesicles isolated | Open-i
Receptor, IGF Type 2/genetics/physiology*. Minor. *Adaptor Protein Complex alpha Subunits ... Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN. ... The transport of the two mannose 6-phosphate receptors (MPRs) from the secretory pathway to the endocytic pathway is mediated ... The transport of the two mannose 6-phosphate receptors (MPRs) from the secretory pathway to the endocytic pathway is mediated ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2139777_JCB.laborgne6&req=4
Loss of Tumorigenicity and Metastatic Potential in Carcinoma Cells Expressing the Extracellular Domain of the Type 1 Insulin...
The receptor for the type 1 insulin-like growth factor (IGF-IR) was identified as a major regulator of the malignant phenotype ... up-regulated expression of IGF-IR, IGF-I, IGF-II, or combinations thereof have been documented. Suppression of IGF-I or IGF-IR ... soluble type II and type III transforming growth factor-β receptors (16 , 17) and soluble fibroblast growth factor receptor-1 ( ... Reduced type I insulin-like growth factor receptor (IGF-IR) functions in H-59 cells expressing His-IGFIR933. A, cell ...http://cancerres.aacrjournals.org/content/64/10/3380?ijkey=db4d2a1c7c6811a0cecebb29aaa92842ce67c22d&keytype2=tf_ipsecsha
IGF and Insulin Receptor Signaling in Breast Cancer | SpringerLink
Major molecular abnormalities in breast cancer include the deregulation of several components of the IGF system. It is well ... Immunological studies of type I IGF receptors and insulin receptors: characterisation of hybrid and atypical receptor subtypes ... Breast cancer Insulin receptor IGF-I receptor IGF-I IGF-II IGF system ... Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal ...https://link.springer.com/article/10.1007%2Fs10911-008-9099-z
The Insulin-like Growth Factor Axis and Prostate Cancer: Lessons from the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP)...
Expression of type-1 IGF receptor (IGF1R) mRNA, encoding the cognate receptor for both IGF-I and IGF-II, as well as type-2 IGF ... 3 The abbreviations used are: IGF, insulin-like growth factor; IGF1R, type-1 IGF receptor; IGF2R, type-2 IGF receptor; IGFBP, ... IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/Insulin hybrid, and IGF-I analogs. Endocrinology, 132: 1337-1344, 1993. ... The biological functions of these ligands are mediated primarily by the type-1 IGF receptor (IGF1R), a tyrosine kinase ...http://cancerres.aacrjournals.org/content/59/9/2203?ijkey=ac9e4e15054ffac0dc6c261a94da8aa75e989b01&keytype2=tf_ipsecsha
Time Course and Mechanisms of Circulating Progenitor Cell Reduction in the Natural History of Type 2 Diabetes | Diabetes Care
Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor dependent signalling. ... Both type 1 and type 2 diabetes are associated with a significant reduction of circulating EPCs (9,10), which parallels the ... Endothelial dysfunction in type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 2006; 16( Suppl. 1): S39- S45. ... Type 2 diabetes is characterized by a two- to fourfold increased risk of cardiovascular disease (CVD) (1). This is generally ...http://care.diabetesjournals.org/content/33/5/1097
Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats | SpringerLink
Type 2 diabetes (T2D) is a modern socioeconomic burden, mostly due to its long-term complications affecting nearly all tissues ... Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, O'Neill C (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/ ... Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats. ... glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. doi: 10.1016/S0140- ...https://link.springer.com/article/10.1007/s12035-017-0622-3
Jonathan Eggenschwiler | Department of Genetics
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. ... Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel ... Biol. Jul 15;391(2). Eggenschwiler, J.T. and Liu, A. (2014) Identifying essential genes in mouse development via an ENU-based ...http://genetics.uga.edu/directory/jonathan-eggenschwiler
Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird |...
2003). IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N. Engl. J. Med. 349, 2211-2222. ... receptor type C was higher in control males than control females in the liver, but higher in control females than control males ... Serotonin 1B receptor has a range of effects on both behavior and physiology (Donaldson et al., 2013), though its role in ... Serotonin 1B receptor expression is upregulated by mineralcorticoids in the aorta of rats (Banes and Watts, 2002); thus, ...http://jeb.biologists.org/content/217/4/507
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism |...
... angiotensin type 1 receptor; AT2R, angiotensin type 2 receptor; FoxO, forkhead box O; GAPDH, glyceraldehyde-3-phosphate ... dehydrogenase; IGF-1, insulin-like growth factor-I; MHC, myosin heavy chain; RAS, renin-angiotensin system; UPS, ubiquitin- ... Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism. ... Angiotensin-(1-7) [Ang-(1-7)], through its receptor Mas, produces the opposite effects than AngII. We assessed the effects of ...http://www.clinsci.org/content/128/5/307
Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air | The EMBO Journal
... type Air promoter. Heterozygous 13.5 d.p.c. embryonic DNA from Thp/Igf2r‐del and from Thp/wild‐type reciprocal crosses was cut ... phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev, 8, 2953-2963. ... type situation. RNase protection analysis using probe MlMs1 on 11.5 d.p.c. embryo RNA from Thp/Igf2r‐del and from Thp/wild‐type ... type situation. RNA blot of 11.5 d.p.c. placenta RNA from Thp/Igf2r‐del and Thp/wild‐type reciprocal crosses hybridized with ...http://emboj.embopress.org/content/22/14/3696
ADA: New Inhaled Insulin Matches Injections for Type 2 Diabetes | Medpage Today
... "until concerns about the effects of high concentrations of insulin on local IGF-I receptors are resolved," they wrote in the ... The international, open-label study included 677 adults with type 2 diabetes uncontrolled (mean hemoglobin A1c 8.7%) on insulin ... for glucose control in type 2 diabetes, a randomized trial showed.. Glycosylated hemoglobin fell by an absolute 0.68% with the ... may make initiation of insulin therapy more palatable to patients with type 2 diabetes and improve compliance as well, noted ...https://www.medpagetoday.com/meetingcoverage/ada/20890
Intravenous Insulin-like Growth Factor-I Receptor Antisense Treatment Reduces Angiotensin Receptor Expression and Function in...
IGF-IR, insulin-like growth factor-I receptor; AT1R, angiotensin II type 1 receptor; AT2R, angiotensin II type 2 receptor; AS, ... Changes in the level of radioligand binding to both the IGF-I receptor and AT receptors could reflect altered affinity rather ... Insulin-like growth factor-I receptor (IGF-IR) antisense, but not full mismatch treatment, decreased IGF-IR expression in both ... Nguyen TT and White PJ (2005) Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses ...http://jpet.aspetjournals.org/content/318/3/1171