"Differential roles of insulin-like growth factor receptor- and insulin" by Ya-Wen Chen, Victor L. Boyartchuk et al.
Although previous studies indicate that IGF ligands can signal through IGF1R/insulin receptor (IR) heterodimers, and IR-A ... Yet, the role of IGF-induced signaling in the dissemination of HCC remains unclear. We have previously observed elevated IGF2 ... Here, we demonstrate that inhibition of IGF2, or its receptor IGF1R, impairs the migration and invasion activities of murine ... Receptor, IGF Type 1; Receptor, Insulin; Reverse Transcriptase Polymerase Chain Reaction; *Signal Transduction ...https://escholarship.umassmed.edu/oapubs/2185/
Cell-specific localization of insulin-like growth factor binding protein mRNAs in rat liver | Gastrointestinal and Liver...
The IGF-I receptor probe protected a 271-nt fragment of the IGF-I receptor (40). The protected fragment contained 15 nt of the ... Stellate cells can be cultured, however, and cultured cells have been shown to be IGF-I responsive and express IGF-I type 1 ... and tissue-specific localization of IGF-I, and to modulate the interaction between IGF-I and its receptor (15). IGF-I- ... we studied the cellular sites of synthesis of IGF-I, IGF receptor, growth hormone (GH) receptor, and IGFBPs in freshly isolated ...http://ajpgi.physiology.org/content/278/3/G447.long
Nuclear Insulin-Like Growth Factor Binding Protein-3 Induces Apoptosis and Is Targeted to Ubiquitin/Proteasome-Dependent...
There is increasing evidence that IGF/IGF-receptor (IGF-R)-independent actions of IGFBP-3 play an important role in its ... High-affinity interactions between IGFs and IGFBP-3 antagonize the binding of IGF to the type 1 IGF receptor or stabilize IGF. ... Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human ... 6 and in intracellular degradation of IGFBP-3 in fibroblasts of IGF-II receptor/IGF-II-deficient mice. Horm Metab Res 1999; 31 ...http://cancerres.aacrjournals.org/content/66/6/3024.full
Domains of the insulin-like growth factor I receptor required...
Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases.: ... Type. Published Article. Journal. Endocrinology Publication Date. Apr 01, 2000 Volume. 141 Issue. 4 Pages. 1289-1300 ... The two major substrates of the IGF-IR, insulin receptor substrate-1 (IRS-1) and the Shc proteins, are known to contribute to ... The importance of the C-terminus of the IGF-IR in ERK activation (in the absence of IRS-1) is confirmed by the failure of the ...https://www.mysciencework.com/publication/show/domains-insulin-like-growth-factor-i-receptor-required-activation-extracellular-signal-regulated-kinases-bbd5018c
IGF-II analogues - Patent # 5736363 - PatentGenius
The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they ... IGF-II) analogues in which at least one of R37 and R38 is replaced with another amino add residue, the most preferred being IGF ... R37Q R38Q, can readily be produced in E. coli, unlike natural IGF-II, which is cleaved on secretion. ... The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they ...http://www.patentgenius.com/patent/5736363.html
Structure and functional analysis of the IGF‐II/IGF2R interaction | The EMBO Journal
IGF‐I and IGF‐II) along with the type I (IGF‐1R) and type II (IGF2R) cell‐surface receptors, the insulin receptor (IR) and ... phosphate receptor has gained an IGF‐II‐binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF‐II; ... IGF‐II) mutants specific for either the IGF‐II/cation‐independent mannose 6‐phosphate receptor or IGF‐I receptor. J Biol Chem ... As well as IGF‐I and IGF‐II, integral components of this system include the signalling IR and IGF‐1R cell‐surface receptors, ...http://emboj.embopress.org/content/27/1/265
ActoFactor™ Recombinant Mouse Insulin-like growth factor 1 | Creative Bioarray
IGF-1 is produced by several cell types and may have autocrine, paracrine and endocrine functions. IGF-1 is a potent mitogen ... Recombinant mouse IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. IGF-1 receptor is a disulfide-linked ... Lyophilized samples are stable for greater than six months at -20°C to -70°C. Upon reconstitution, mouse IGF-1 can be stored ... A DNA sequence encoding the mature IGF-1 protein was expressed in E. coli. ...https://www.creative-bioarray.com/ActoFactor-Recombinant-Mouse-Insulin-like-growth-factor-1-CSC-CTK0032-item-4234.htm
Insulin-like development factor-I receptor (IGF-IR) represents among the main targets where | Resveratrol downregulates PI3K...
The individual T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks ... Introduction Substantial evidence indicates the insulin-like growth element (IGF)-I/IGF-I receptor (IGF-IR) signaling cascade ... cells upregulate IGF-I/IGF-IR signaling by overexpressing IGF-IR and/or acquiring autocrine/paracrine capacity for IGF-I- ... mediated signaling, therefore bypassing the dependency on circulating IGF-I (4). Activation of IGF-IR by IGF-I prospects to the ...http://87paydays.info/insulin-like-development-factor-i-receptor-igf-ir-represents-among-the-main-targets-where/
Structure-function analysis of insuline-like growth factor I interactions
... and a soluble form of the IGF type I receptor (sIGF-I(R)), respectively. Side chains of the substituted residues are all ... the Z-IGF-I fusion protein, with twice the receptor affinity of IGF-I-Z, displays only about 70% of the IGF-I-Z growth ... The IGF-I-Z fusion, with the lowest receptor affinity, shows similar proliferative potential to native IGF-I. However, ... and a soluble form of the human IGF type I receptor extracellular domains (sIGF-IR). The growth promoting effects on SaOS-2 ...http://kth.diva-portal.org/smash/record.jsf?pid=diva2:8080
IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration | CIQUIBIC
During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological ... IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration. Posted by CIQUIBIC Nieto Guil ... Cells lacking the IGF-1 receptor remain arrested as multipolar forming a highly disorganized tissue. The typical orientation of ... In neurons in culture we showed that IGF-1 receptor activation is important for growth cone assembly and axonal formation. ...http://ciquibic.fcq.unc.edu.ar/en/igf-1-receptor-regulates-dynamic-changes-in-neuronal-polarity-during-cerebral-cortical-migration/
Insulin-like growth factor I regulates the expression of isoforms of Wilms' tumor 1 gene in breast cancer | TJ
Conversely, inhibition of IGF-I by IGF-binding protein 3 and of IGF-I receptor (IGF-IR) by anti-IGF-IR antibody (b-IR3) uses ... Article Type: ORIGINAL RESEARCH ARTICLE. DOI:10.1700/1390.15461 Authors. Musaffe Tuna, Hiroaki Itamochi ... Results. In the study, we showed that the treatment of MCF-7 breast cancer cells with insulin-like growth factor I (IGF-I) ... We thus newly identified a mechanism by which IGF-I up-regulates WT1, especially the (+exon 5/-KTS) isoform, at the ...http://www.tumorijournal.com/article/insulin-like-growth-factor-i-regulates-the-expression-of-isoforms-of-wilms--tumor-1-gene-in-breast-cancer
Factor consider about IGF-1 for bodybuilding - Contraceptive pills side effects, Contraceptive pills names, Contraceptive...
There are two different types of the growth factors are available in human body like mechano growth factor that trigger action ... IGF-1 is the sisters of IGF-2 and IGF-3. Most of the people are using IGF-1 for bodybuilding cycle because it acts as growth ... In fact IGF-1 for bodybuilding is also called as insulin like growth factor-1 and it is the peptide hormone and it is most ... IGF-1 plays most important role as the growth hormone and it is secreted by glands of endocrine system and it produced variety ...http://www.getpillstoday.net/factor-consider-about-igf-1-for-bodybuilding/
OriGene - IGFBP1 (NM 000596) cDNA Clone
Human insulin-like growth factor binding protein 1 (IGFBP1) available for purchase from OriGene - Your Gene Company. ... Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided ... Therefore, Refseq is one curated sequence, not to be perceived as the wild type. ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. ...http://www.origene.com/human_cdna/NM_000596/SC119777.aspx
JCI - Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor
IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication. J Mol Endocrinol 2000. 24:303-311. View ... Thus, ablation of the insulin/IGF receptor substrate IRS-2 impairs β cell proliferation (20, 21), whereas ablation of p70s6k1, ... Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory ... Although the roles of IGFs in β cells have not been completely elucidated, these ligands and their cognate receptors are both ...https://www.jci.org/articles/view/15276
IGF Type 1 Receptor - IGF 1 Receptor Summary Report | CureHunter
Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a ... A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. ... IGF-I Receptor; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor I; Receptor, Insulin-Like Growth Factor Type 1 ... Cell Surface Receptors: 753*Peptide Receptors: 579*Growth Factor Receptors: 766*Somatomedin Receptors: 289*IGF Type 1 Receptor ...http://www.curehunter.com/public/keywordSummaryD017526-IGF-Type-1-Receptor-IGF-1-Receptor.do
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks. - Nuffield Department of...
CONCLUSIONS: These data indicate a role for IGF-1R in DSB repair, at least in part via HR, and support use of IGF-1R inhibitors ... In contrast, IGF-1R depletion induced only minor radiosensitization in LNCaP cells, and did not influence repair. Cell cycle ... This study investigated the hypothesis that IGF-1R regulates DNA double strand break (DSB) repair. METHODS: We tested effects ... RESULTS: We confirmed that IGF-1R depletion sensitized DU145 and PC3 prostate cancer cells to ionizing radiation. DU145 control ...https://www.nds.ox.ac.uk/publications/329062
Ciliary neurotrophic factor induces expression of the IGF type I receptor and FGF receptor 1 mRNAs in adult rat brain...
IGF) type I receptor (IGF-IR), fibroblast growth factor (FGF) receptor (FGFR)-1, FGFR3, and platelet-derived growth factor ( ... PDGF) receptor-alpha (PDGFRalpha). We determined that CNTF injection increased expression of IGF-IR and FGFR1 mRNAs in adult ... Here we tested the hypothesis that CNTF can induce expression of receptors on oligodendrocytes for factors that are known to ... Cellular analysis indicated that these receptor mRNAs were induced in interfascicular oligodendrocytes. In contrast, CNTF had ...https://www.semanticscholar.org/paper/Ciliary-neurotrophic-factor-induces-expression-of-I-Jiang-Levison/0f7db30af7e987351f2c9084bd0128544f2dbec3
Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells.
IGF) receptor (IGF1R) is a transmembrane tyrosine kinase involved in breast cancer proliferation, survival, and metastasis. ... Several monoclonal antibodies directed against the receptor are in clinical trials. In ... The type I insulin-like growth factor (IGF) receptor (IGF1R) is a transmembrane tyrosine kinase involved in breast cancer ... 0/Antibodies, Monoclonal; 67763-96-6/Insulin-Like Growth Factor I; EC 184.108.40.206/Receptor, IGF Type 1 ...http://www.biomedsearch.com/nih/Detection-downregulation-type-IGF-receptor/18418709.html
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt...
Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing ... Receptor, IGF Type 1 / genetics, metabolism*. Signal Transduction / drug effects*. Stilbenes / pharmacology*. Time Factors. ... Emerging evidence suggests that members of the insulin-like growth factors (IGFs) family, including IGF-I, IGF-II, IGF-IR, and ... Ohlsson C,Kley N,Werner H,LeRoith D,p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced ...http://www.biomedsearch.com/nih/Resveratrol-suppresses-IGF-1-induced/20504360.html
NIH VideoCast - When natural products meet cellular targets: A potential role of IGF-1 receptor in lycopene and docetaxel ...
A potential role of IGF-1 receptor in lycopene and docetaxel combination for prostate cancer therapy ... Publication Types: Lectures. Webcasts Download: To download this event, select one of the available bitrates:. [256k] [512k] ... When natural products meet cellular targets: A potential role of IGF-1 receptor in lycopene and docetaxel combination for ... When natural products meet cellular targets : a potential role of IGF-1 receptor in lycopene and docetaxel combination for ...https://videocast.nih.gov/summary.asp?Live=9954
Deciphering Growth, Book by J.-C. Carel (Hardcover) | chapters.indigo.ca
Putting IGF-I Biology into a Clinical Perspective.- IGF Resistance: The Role of the Type 1 IGF Receptor.- The Importance of the ... Growth Hormone Receptor Signaling and Differential Actions in Target Tissues Compared To IGF-I.- IGF-I and Brain Growth: ... In mammals, the major factors involved in the regulation of body growth are known: insulin-like growth factors (IGF) are key ... Growth hormone (GH), secreted by the pituitary gland, directly regulates circulating levels of IGF-I, which is the major ...https://www.chapters.indigo.ca/en-ca/books/deciphering-growth/9783540261926-item.html
Expression of CXCR4 and IGF-1R in synovial sarcoma. Imm | Open-i
Expression of CXCR4 and IGF-1R in synovial sarcoma. Immunohistochemical expression of CXCR4 with cytoplasmatic (a) and nuclear ... Receptor, IGF Type 1/biosynthesis/genetics*. *Receptors, CXCR4/biosynthesis/genetics*. *Sarcoma, Synovial/diagnosis/genetics*/ ... Expression of CXCR4, IGF-1R and Ezrin were evaluated by immunohistochemistry.. Results: Tumor samples from 88 SS patients (45 ... Expression of CXCR4, IGF-1R and Ezrin were evaluated by immunohistochemistry.. Results: Tumor samples from 88 SS patients (45 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4320838_13023_2014_222_Fig1_HTML&req=4
The levels of Akt1 and Akt2. Western blot for Akt1 and | Open-i
Western blot for Akt1 and Akt2 in wild type (WT) mammary tissues from four different mice and mammary tumors from four ... kinase that mediates signaling downstream of tyrosine kinase receptors like the type I insulin-like growth factor receptor (IGF ... kinase that mediates signaling downstream of tyrosine kinase receptors like the type I insulin-like growth factor receptor (IGF ... In this manuscript, the impact of disrupting Akt1 or Akt2 in mammary tumors induced by IGF-IR overexpression were examined to ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3750479_1471-2407-13-375-1&req=4
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U ... Type 2 diabetes-who is conducting the orchestra? Nat Genet 1998;20:223-225pmid:9806535. ... Type 2 diabetes (T2D) can be viewed as a failure of homeostatic mechanisms that promote nutrient turnover and storage in ... Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 2000;105:199 ...http://diabetes.diabetesjournals.org/content/60/3/700
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 2002;110:1011-1019pmid:12370279 ... Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 2000;105:199 ... Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest 2013;123:3305-3316pmid:23863625. ... A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest 2007;117:2477-2485pmid: ...http://diabetes.diabetesjournals.org/content/64/8/2868