Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism | JCB
ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer. 5:341-354. doi:10.1038/nrc1609. ... EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 105:233-244. ... β2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 583:1237-1242. doi:10.1016/j.febslet.2009.03.032 ... Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Mol. Cell. Biol. 29:4508-4518. doi:10.1128/ ...http://jcb.rupress.org/content/190/3/461
David F. Stern, PhD > Stern Lab | Pathology | Yale School of...
ERBB family) of tyrosine kinases, so we also study differential signaling by the three related receptors (EGF receptor [HER]), ... The HER-2/Neu/ErbB-2 receptor tyrosine kinase is a major human oncogene and a validated therapeutic target in breast cancer. We ... Amin DN, Perkins AS, Stern DF: Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 ... 1. The receptor tyrosine kinase ErbB2/HER2 drives 25% of breast cancers. This receptor is the target for two drugs in use for ...http://medicine.yale.edu/lab/stern/people/df_stern-2.profile
Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for...
Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin ... Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for ... Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: ... Previous studies have shown that the over-expression of epidermal growth factor receptor (EGFR) predicts poor survival and ...https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-0879-6
Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue...
Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently ... Yamauchi H, Stearns V, Hayes DF (2001) When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive ... Fehm T, Gebauer G, Jäger W (2002) Clinical utility of serial serum c-erbB-2 determinations in the follow-up of breast cancer ... Akiyama T, Sudo C, Ogawara H, Toyoshima K, Yamamoto T (1986) The product of the human c-erbB-2 gene: a 185-kilodalton ...https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-4-089.php?jid=ijccr
Receptor Tyrosine Protein Kinase ERBB 3-Pipeline Review H2 2017
... with 101 pages available at USD 3500 for single User PDF at ... The report reviews Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell ... The report assesses Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell ... Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor ...http://www.reportsweb.com/receptor-tyrosine-protein-kinase-erbb-3-pipeline-review-h2-2017
ERBB3 | Cancer Genetics Web
Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.. Mol Ther. 2013; 21(11):1996- ... The ERBB receptors are a family of heterodimerization partners capable of driving transformation and metastasis. While the ... One of the main challenges in ErbB-targeting therapy is to inactivate signaling mediated by ErbB2-ErbB3 oncogenic receptor ... To examine the functional consequences of HRG-mediated decreases in ErbB receptor levels, we performed cell-cycle analysis. HRG ...http://www.cancerindex.org/geneweb/ERBB3.htm
ERBB3 erb-b2 receptor tyrosine kinase 3 [Ailuropoda melanoleuca (giant panda)] - Gene - NCBI
ErbB signaling pathway, conserved biosystem (from KEGG) ErbB signaling pathway, conserved biosystemThe ErbB family of receptor ... ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of ... receptor tyrosine-protein kinase erbB-3. Names. v-erb-b2 erythroblastic leukemia viral oncogene homolog 3. ... XM_002915974.3 → XP_002916020.1 receptor tyrosine-protein kinase erbB-3. UniProtKB/TrEMBL. G1L9H7 Related. ENSAMEP00000003549.1 ...https://www.ncbi.nlm.nih.gov/gene?amp=&cmd=Retrieve&dopt=Graphics&list_uids=100468735
CC -!- DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like CC domain. CC -!- PTM: Proteolytic cleavage close to ... DR GO; GO:0030971; F:receptor tyrosine kinase binding; IDA:MGI. DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central ... activation of the ERBB receptors. The multiple isoforms perform CC diverse functions such as inducing growth and ... DR GO; GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB- ...https://www.genome.jp/dbget-bin/www_bget?uniprot:P43322
Protein sequence for HAGRID 24 (NRG1)
receptor tyrosine kinase binding. GO:0043125. ErbB-3 class receptor binding. GO:0045499. chemorepellent activity. ... transmembrane receptor protein tyrosine kinase activator activity. GO:0030971. ...http://genomics.senescence.info/genes/seq.php?id=24&type=cds
Expression of ERBB3 in cancer - Summary - The Human Protein Atlas
Receptor tyrosine-protein kinase erbB-3; cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein ... G-protein coupled receptors. Mapped to UniProt SWISS-PROT. Nuclear receptors. Plasma proteins. Potential drug targets. ... This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane- ... Erb-b2 receptor tyrosine kinase 3. Protein classi. Protein class the gene product belongs to according to selected gene lists. ...http://www.proteinatlas.org/ENSG00000065361-ERBB3/pathology
Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface ... downstream of receptor, with protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein ... HER2 a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, ... CST Pathways: ErbB/HER Signaling , Tyrosine Kinases & Substrates Protein-Specific Antibodies or siRNAs from Cell Signaling ...https://www.phosphosite.org/proteinAction.action?id=1580
HRG-β1 induces upregulation of the transcription facto | Open-i
HRG-β1 induces upregulation of the transcription factor Snail and EMT markers in SK-BR-3 cells. (a) The cells were incubated ... One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the ... One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the ... In SK-BR-3 cells, vimentin and fibronectin were expressed in a time-dependent manner after HRG-β1 treatment, while E-cadherin ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3750857_1471-2407-13-383-1&req=4
Publications | Benny Geiger's
Waterman, H; Sabanai, I; Geiger, B; Yarden, Y (1998). Alternative intracellular routing of ErbB receptors may determine ... Morphogenetic activity of neuregulin requires interactions of neuregulin and its receptor ErbB-3 with heparan sulfate ... Revach O-Y, Sandler O, Samuels Y, Geiger B (2019). Cross-talk between the receptor tyrosine kinases AXL and ERBB3 regulates ... Geiger, B; Salomon, D; Takeichi, M; Hynes, RO (1992). A chimeric N-cadherin/beta 1-integrin receptor which localizes to both ...https://www.weizmann.ac.il/mcb/Geiger/publications?qt-view__publications__page=39
The 5y-RFS of patients with different levels of the ind | Open-i
The 5y-RFS of patients with different levels of the indicated receptor tyrosine kinase expression, as detected using IHC, was ... fig04: The 5y-RFS of patients with different levels of the indicated receptor tyrosine kinase expression, as detected using IHC ... fig04: The 5y-RFS of patients with different levels of the indicated receptor tyrosine kinase expression, as detected using IHC ... Receptor, ErbB-3/genetics*/metabolism*. *Stomach Neoplasms/diagnosis*/drug therapy*/pathology. Minor ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317956_cas0105-1591-f4&req=4
UniProtKB/SwissProt variant VAR 049711
Receptor tyrosine-protein kinase erbB-3. Topological domain. 665 - 1342. Cytoplasmic. Alternative sequence. 184 - 1342. Missing ...https://web.expasy.org/variant_pages/VAR_049711.html
Human ERBB2 lentiviral particles - Creative Biogene
... receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and the ... receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane ... ATP binding; ErbB-3 class receptor binding; RNA polymerase I core binding; epidermal growth factor-activated receptor activity ...https://www.creative-biogene.com/Human-ERBB2-lentiviral-particles-LV00275Z-1233596-85.html
Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and...
Receptor, Epidermal Growth Factor/metabolism. MESH. Receptor, erbB-2/metabolism. MESH. Receptor, erbB-3/metabolism. MESH. ... Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and ... BACKGROUND: Receptors belonging to the epidermal growth factor receptor (EGFR) family transfer extracellular signals by ... BACKGROUND: Receptors belonging to the epidermal growth factor receptor (EGFR) family transfer extracellular signals by ...https://epub.uni-regensburg.de/15396/
Recombinant Human V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian) ERBB3-2514H - Creative BioMart
RecombinantHuman V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian)protein, was expressed in Human HEK293 cells ... ErbB receptor signaling network, organism-specific biosystem;. Function:. ATP binding; growth factor binding;growth factor ... This gene encodes amember of the epidermal growth factor receptor (EGFR) family of receptortyrosine kinases. This membrane- ... However, itdoes form heterodimers with other EGF receptor family members which do havekinase activity. Heterodimerization leads ...https://www.creativebiomart.net/description_107501_8.htm
Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel | Springer for Research & Development
Receptor tyrosine-protein kinase erbB-2 (7%,16%), Receptor tyrosine-protein kinase erbB-3 (6%,16%), Stem cell factor (7%,14%), ... Receptor tyrosine-protein kinase erbB-4 (6%,15%), Hepatocyte growth factor (8%,15%), Disintegrin and metalloproteinase domain- ... Fc receptor-like B (8%,14%), Annexin A1 (8%,16%), Folate receptor alpha (8%,15%). One sample for R-spondin-3 and one sample for ... Tumor necrosis factor receptor superfamily member 6B (9%,13%), Syndecan-1 (8%,15%), TGF-beta receptor type-2 (8%,15%), ...https://rd.springer.com/article/10.1186%2Fs13104-019-4237-9
Frontier Pharma: Breast Cancer - First-in-Class Innovation Underlies Immunotherapeutic Potential and Pipeline Diversification...
Pipeline Programs Targeting Receptor Tyrosine Protein Kinase ERBB 3(HER3) *7.7. Pipeline Programs Targeting Neuregulin-1(NRG1) ... 9.4.3. Licensing and Co-development Deals *9.5. Contact Us *9.6. Disclaimer List of Tables. *Table 1: Breast Cancer, Global, ... 8.3.3. Deals by Molecule Type and Molecular Target *8.3.4. List of Deals with Disclosed Deal Values *8.4. Co-development Deals ... 8.4.3. Deals by Molecule Type and Molecular Target *8.4.4. List of Deals with Disclosed Deal Values *8.5. First-In-Class ...https://www.giiresearch.com/report/gbi676509-frontier-pharma-breast-cancer-first-class.html
Receptor tyrosine-protein kinase erbB-3. Potentially involved in: kidney cancer; carcinoma; type 1 diabetes mellitus; alopecia ... SMILES: CC(C)NC(=O)[C@@H](Nc1cnc(Nc2cccc(-c3ccn[nH]3)c2)nc1C(F)(F)F)C(C)C ... SMILES: CC(C)NC(=O)[C@H](Nc1c(Nc2ccc(-c3ccn[nH]3)cc2)ncnc1C(F)(F)F)C(C)C ... SMILES: CN(C)C(C)(C)[C@]1(c2cccc(F)c2)COc2cccc(-c3nnc(-c4cccc(F)c4)[nH]3)c21 ...http://matter.farm/P21860/
2018-2023 Global Microfluidics Device Consumption Market Report - RnR Market Research
Global Receptor Tyrosine Protein Kinase ERBB 3 Market Data Survey Report 2025 Published: 11-Nov-2018 Price: US 1500 Onwards ... Summary The global Receptor Tyrosine Protein Kinase ERBB 3 market will reach Volume Million USD in 2018 with CAGR xx% 2018-2025 ... 11.5.3 UK Market Forecast. 11.5.4 Italy Market Forecast. 11.5.5 Russia Market Forecast. 11.5.6 Spain Market Forecast. 11.6 ... 11.3.3 Mexico Market Forecast. 11.3.4 Brazil Market Forecast. 11.4 APAC Forecast by Countries. 11.4.1 China Market Forecast. ...http://www.rnrmarketresearch.com/2018-2023-global-microfluidics-device-consumption-market-report-market-report.html
2015-2023 World Blood Glucose Lancets Market Research Report by Product Type, End-User (Application) and Regions (Countries) :...
Summary The global Receptor Tyrosine Protein Kinase ERBB 3 market will reach Volume Million USD in 2018 with CAGR xx% 2018-2025 ... Global Receptor Tyrosine Protein Kinase ERBB 3 Market Data Survey Report 2025 ... 5.2.3 Asia-Pacific. 5.2.4 South America. 5.2.5 Middle East & Africa. 6 North America Market. 6.1 by Type. 6.2 by End-Use / ... 3 Global Market by Type. 3.1 Market Share. 3.2 Introduction of End-Use by Different Products. 4 Global Market by End-Use / ...https://www.reportsnreports.com/reports/1547959-2015-2023-world-blood-glucose-lancets-market-research-report-by-product-type-end-user-application-and-regions-countries.html
Global Veterinary Surgical Instruments Market Growth 2018-2023 : ReportsnReports
Summary The global Receptor Tyrosine Protein Kinase ERBB 3 market will reach Volume Million USD in 2018 with CAGR xx% 2018-2025 ... Global Receptor Tyrosine Protein Kinase ERBB 3 Market Data Survey Report 2025 ... 11.5.3 UK Market Forecast. 11.5.4 Italy Market Forecast. 11.5.5 Russia Market Forecast. 11.5.6 Spain Market Forecast. 11.6 ... 11.3.3 Mexico Market Forecast. 11.3.4 Brazil Market Forecast. 11.4 APAC Forecast by Countries. 11.4.1 China Market Forecast. ...https://www.reportsnreports.com/reports/1745445-global-veterinary-surgical-instruments-market-growth-2018-2023.html
2016 Guanethidine (CAS 645-43-2) Industry Market Report - RnR Market Research
Global Receptor Tyrosine Protein Kinase ERBB 3 Market Research Report 2018 Published: 15-Feb-2018 Price: US 2900 Onwards Pages: ... In this report, the global Receptor Tyrosine Protein Kinase ERBB 3 market is valued at USD XX million in 2017 and is expected ... market share and growth rate of Receptor Tyrosine Protein Kinase ERBB 3 in these regions, from 2013 to 2025 (forecast), ... The global optical imaging system market is predicted to reach US$ 3 billion by 2024. It is expected to grow at a stable rate ...http://www.rnrmarketresearch.com/2016-guanethidine-cas-645-43-2-industry-market-report-market-report.html