Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and...
Receptor, Epidermal Growth Factor/metabolism. MESH. Receptor, erbB-2/metabolism. MESH. Receptor, erbB-3/metabolism. MESH. ... Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and ... BACKGROUND: Receptors belonging to the epidermal growth factor receptor (EGFR) family transfer extracellular signals by ... BACKGROUND: Receptors belonging to the epidermal growth factor receptor (EGFR) family transfer extracellular signals by ...https://epub.uni-regensburg.de/15396/
David F. Stern, PhD > Stern Lab | Pathology | Yale School of...
ERBB family) of tyrosine kinases, so we also study differential signaling by the three related receptors (EGF receptor [HER]), ... Amin DN, Perkins AS, Stern DF: Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 ... 1. The receptor tyrosine kinase ErbB2/HER2 drives 25% of breast cancers. This receptor is the target for two drugs in use for ... Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer ...http://medicine.yale.edu/lab/stern/people/df_stern-2.profile
Synergy of Epidermal Growth Factor Receptor Kinase Inhibitor AG1478 and ErbB2 Kinase Inhibitor AG879 in Human Colon Carcinoma...
... there is a hierarchy of ErbB dimer formation dictated by the nature of the ligand and the cell's complement of ErbB receptors. ... The intrinsic tyrosine kinase activities of ErbB receptors are activated on ligand-induced receptor homodimerization or ... The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000; 19: 3159-67. ... ErbB2 is an orphan receptor without a physiologic ligand and is the preferred dimerization partner for other ErbB members ( 2, ...http://cancerres.aacrjournals.org/content/65/13/5848
Receptor tyrosine-protein kinase erbB-2 - DrugBank
Receptor tyrosine-protein kinase erbB-2. P04626. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ... Receptor tyrosine-protein kinase erbB-2. Details. Name. Receptor tyrosine-protein kinase erbB-2. Kind. protein. Organism. Human ...https://www.drugbank.ca/biodb/bio_entities/BE0000511
Receptor tyrosine-protein kinase erbB-2 - Ganfyd
Systematic reviews of Receptor tyrosine-protein kinase erbB-2. Receptor tyrosine-protein kinase erbB-2 in N Eng J Med, Lancet, ... Receptor tyrosine-protein kinase erbB-2. From Ganfyd. (Redirected from Human epidermal growth factor receptor 2 protein) ... NHS Evidence on Receptor tyrosine-protein kinase erbB-2 Centre for Reviews and Dissemination databases -DARE & NHS EED ( ... ChemSpider on Receptor tyrosine-protein kinase erbB-2. CTD (Comparative Toxicogenomics Database) on Receptor tyrosine-protein ...http://www.ganfyd.org/index.php?title=Human_epidermal_growth_factor_receptor_2_protein
erbB-2 Receptor - Semantic Scholar
It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. ... Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member. ... A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. ... Receptor, ErbB-2, Proto-Oncogene Protein HER-2 (More). A cell surface protein-tyrosine kinase receptor that is overexpressed in ...https://www.semanticscholar.org/topic/erbB-2-Receptor/18181
RCSB PDB - Protein Feature View - Receptor tyrosine-protein kinase erbB-2 - P04626 (ERBB2 HUMAN)
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ... Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ... ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the ...http://www.rcsb.org/pdb/protein/B4DHN3
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response | PNAS
Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy ... Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response John Stagg, ... We thus demonstrated that the combination of anti-DR5 and anti-ErbB2 mAbs might be an effective form of treatment for ErbB-2- ... Remarkably, treatment with a combination of anti-DR5 and anti-ErbB-2 mAbs induced complete response in a majority of mice. In ...https://www.pnas.org/content/105/42/16254.abstract
Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer...
Objectives: To measure the expression of epidermal growth factor receptor (EGFR) and erbB-2 in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ...http://cancerres.aacrjournals.org/content/64/7_Supplement/1046.3
The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth...
With the exception of ErbB-3, which acts as a noncatalytic partner to other erbB family members, the type I receptors have ... Inhibition of Receptor Autophosphorylation in Cells. The ability of GW2016 to inhibit the activity of EGFR and ErbB-2 in intact ... Receptors were immunoprecipitated using either EGFR or ErbB-2 antibodies and blotted for phosphotyrosine content. Treatment ... Receptors were immunoprecipitated with antibodies to EGFR or ErbB-2 and blotted for phosphotyrosine. This representative ...http://mct.aacrjournals.org/content/1/2/85.long
Abstract 5345: DMBA promotes erbB-2 mediated carcinogenesis through activation of estrogen receptor and receptor tyrosine...
ErbB-2 is a receptor tyrosine kinase (RTK) that is amplified/overexpressed in 20-30% of all invasive breast malignancies; it ... In this study, female MMTV-erbB-2 transgenic mice at 6-weeks of age were treated weekly by oral gavage with either 1.0 mg DMBA ... In addition to its well known mutational effect, DMBA induced deregulation of ER and erbB-2 pathways plays a critical role in ... DMBA promotes erbB-2 mediated carcinogenesis through activation of estrogen receptor and receptor tyrosine kinase pathways. [ ...http://cancerres.aacrjournals.org/content/74/19_Supplement/5345
erbB-2|Tyrosine kinase (TK) receptor
The human epidermal growth factor receptor (erbB-2) is a transmembrane receptor th ... receptor whose overexpression is associated with adverse prognosis in breast cancer,sup,1,/sup,.,/p, ,p, ... p,erbB-2,strong, ,/strong,is a transmembrane, tyrosine kinase (TK) ... The human epidermal growth factor receptor (erbB-2) is a transmembrane receptor that is overexpressed in 15%-25% of breast ...http://www.apexbt.com/erbb-2.html
Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points | PerkinElmer
ErbB-2, NEU, or HER2) in serum, buffered solution or cell culture medium. ... AlphaLISA no-wash assay kit for detection and quantitation of Human epidermal growth factor receptor 2 ( ... is a type I membrane glycoprotein that is a member of the ERBB family of tyrosine kinase receptors. It serves as a receptor for ... Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points * ...http://www.perkinelmer.de/product/alphalisa-erbb2-her2-kit-5-000-pts-al235f
Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue | Retractions and...
Steroid hormone receptors, estrogen receptors, progesterone receptors, and c-erbB2 expression of breast cancer tissue samples ... Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue. Turk J Surg. 1950;1( ... Estrogen receptors, PRs, and c-erbB2 receptors remain stable in a medium at pH 7.4, but ischemia shifts pH value to acidosis, ... Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue. ...https://www.turkjsurg.com/full-text/1612/eng
Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy.
... the CXC chemokine receptor 4 (CXCR4), estrogen receptor (ER), Proliferating Cell Nuclear Antigen (PCNA), DNA topoisomerase II ( ... Biological molecular markers such as proto-oncogene erbB-2 (HER-2/neu, c-erbB-2), ... 0/Receptors, CXCR4; 0/estrogen receptor alpha, human; EC 18.104.22.168/ERBB2 protein, human; EC 22.214.171.124/Receptor, erbB-2 ... Estrogen Receptor alpha / metabolism. Female. Humans. Immunohistochemistry. Middle Aged. Receptor, erbB-2 / metabolism*. ...http://www.biomedsearch.com/nih/Decreased-expression-C-erbB-2/23046610.html
In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor | Journal of...
... family comprising four receptors (ErbB1-4) . As for other members of these receptors, the ErbB-2 signal output is ... binding to receptors mediating the activation of signalling pathways, e.g. Ptc [6, 7] and ErbB-2 . With regard to the ... including receptor tyrosine kinases (RTK) such as TRK-A  and ErbB-2  of the epidermal growth factor receptor (EGFR) ... the preferred heterodimerization partner of all ErbB receptors is a mediator of lateral signaling. EMBO J. 1997, 16: 1647-1655 ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-58
ERBB3 | Cancer Genetics Web
Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.. Mol Ther. 2013; 21(11):1996- ... HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3 Location:. 12q13. ... The ERBB receptors are a family of heterodimerization partners capable of driving transformation and metastasis. While the ... One of the main challenges in ErbB-targeting therapy is to inactivate signaling mediated by ErbB2-ErbB3 oncogenic receptor ...http://www.cancerindex.org/geneweb/ERBB3.htm
ACSL3 | Cancer Genetics Web
Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.. PLoS One. 2011; 6(8): ... The aim of the present study was to characterize the androgen receptor (AR) response in hormonal therapy-resistant PC346 cells ... Long chain acyl-CoA synthetase-3 is a molecular target for peroxisome proliferator-activated receptor delta in HepG2 hepatoma ... Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer.. Cancer Prev Res ( ...http://www.cancerindex.org/geneweb/ACSL3.htm
FGF3 | Cancer Genetics Web
fibroblast growth factor receptor signaling pathway - Golgi apparatus - growth factor activity - insulin receptor signaling ... Fibroblast growth factor receptor 3 (FGFR3) was shown to play a major role in several types in cancer. Dovitinib, an inhibitor ... The chromosomal region 11q13 is amplified in 15-20% of breast cancers; an event not only associated with estrogen receptor (ER ... Fibroblast growth factor ligands and receptors (FGF and FGFR) play critical roles in tumorigenesis, and several drugs have been ...http://www.cancerindex.org/geneweb/FGF3.htm
RAS Pathway v2.0 - National Cancer Institute
epidermal growth factor receptor. ERBB, ERBB1, HER1, PIG61, mENA. EIF4EBP1. eukaryotic translation initiation factor 4E-binding ... receptor tyrosine-protein kinase erbB-2. CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1. ... fibroblast growth factor receptor 3. CH, CD333, CEK2, HSFGFR3EX, JTK4. FGFR4. fibroblast growth factor receptor 4. CD334, JTK2 ... anaplastic lymphoma receptor tyrosine kinase; ALK tyrosine kinase receptor. CD246, NBLST3 APAF1. apoptotic peptidase activating ...https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
Superior outcome after neoadjuvant chemotherapy with docetaxel, anthracycline, and cyclophosphamide versus docetaxel plus...
Receptor, erbB-2 / metabolism. Taxoids / administration & dosage, adverse effects, therapeutic use. Treatment Outcome. Triple ... 0/Taxoids; 15H5577CQD/docetaxel; 6PLQ3CP4P3/Etoposide; 8N3DW7272P/Cyclophosphamide; EC 126.96.36.199/Receptor, erbB-2 ...http://www.biomedsearch.com/nih/Acknowledgement-reviewers-2013/24292815.html
Her-2 immunohistochemical expression in oral squamous cell carcinomas is associated with polysomy of chromosome 17, not Her-2...
Based on the prognostic role of Her-2 amplification and protein overexpression in breast cancer, various studies have been ... EC 188.8.131.52/Receptor, erbB-2 Comments/Corrections. From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine ... Her-2 immunohistochemical expression in oral squamous cell carcinomas is associated with polysomy of chromosome 17, not Her-2 ... Four cases were negative and 37 cases were positive for Her-2. Staining was faint in 15 cases and moderate in 22 cases. CISH ...http://www.biomedsearch.com/nih/Her-2-Immunohistochemical-Expression-in/20596843.html
Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody...
Receptor, erbB-2 / immunology*. Recombinant Fusion Proteins / chemistry, immunology, metabolism, pharmacokinetics*. Staining ...http://www.biomedsearch.com/nih/Effects-lysine-containing-mercaptoacetyl-based/19035668.html
Severe thrombocytopenia related to trastuzumab infusion.
... monoclonal antibody that interferes with the HER2/neu receptor and binds selectively to the HERB2 protein which causes ... EC 184.108.40.206/Receptor, erbB-2; P188ANX8CK/trastuzumab ... The HER receptors are proteins that are embedded into the cell ... Trastuzumab is a humanized, monoclonal antibody that interferes with the HER2/neu receptor and binds selectively to the HERB2 ... BACKGROUND: Trastuzumab is a humanized, monoclonal antibody that interferes with the HER2/neu receptor and binds selectively to ...http://www.biomedsearch.com/nih/Severe-thrombocytopenia-related-to-trastuzumab/21709639.html
Rationale for a Phase II Trial of Pertuzumab, a HER-2 Dimerization Inhibitor, in Patients with Non-Small Cell Lung Cancer |...
receptor, erbB-2. There have been extensive efforts to develop agents effective against the HER family of tyrosine kinase ... The HER family of receptors is composed of four related receptors, the epidermal growth factor receptor (EGFR, HER-1, or ErbB1 ... Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab ... EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to ...http://clincancerres.aacrjournals.org/content/12/14/4436s