Receptor tyrosine-protein kinase erbB-2 - DrugBankReceptor tyrosine-protein kinase erbB-2 - DrugBank

Receptor tyrosine-protein kinase erbB-2. P04626. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ... Receptor tyrosine-protein kinase erbB-2. Details. Name. Receptor tyrosine-protein kinase erbB-2. Kind. protein. Organism. Human ...
more infohttps://www.drugbank.ca/biodb/bio_entities/BE0000511

Receptor tyrosine-protein kinase erbB-2 - GanfydReceptor tyrosine-protein kinase erbB-2 - Ganfyd

Systematic reviews of Receptor tyrosine-protein kinase erbB-2. Receptor tyrosine-protein kinase erbB-2 in N Eng J Med, Lancet, ... Receptor tyrosine-protein kinase erbB-2. From Ganfyd. (Redirected from Human epidermal growth factor receptor 2 protein) ... NHS Evidence on Receptor tyrosine-protein kinase erbB-2 Centre for Reviews and Dissemination databases -DARE & NHS EED ( ... ChemSpider on Receptor tyrosine-protein kinase erbB-2. CTD (Comparative Toxicogenomics Database) on Receptor tyrosine-protein ...
more infohttp://www.ganfyd.org/index.php?title=Human_epidermal_growth_factor_receptor_2_protein

erbB-2 Receptor - Semantic ScholarerbB-2 Receptor - Semantic Scholar

It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. ... Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member. ... A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. ... Receptor, ErbB-2, Proto-Oncogene Protein HER-2 (More). A cell surface protein-tyrosine kinase receptor that is overexpressed in ...
more infohttps://www.semanticscholar.org/topic/erbB-2-Receptor/18181

RCSB PDB - Protein Feature View 









 - Receptor tyrosine-protein kinase erbB-2 - P04626 (ERBB2 HUMAN)RCSB PDB - Protein Feature View - Receptor tyrosine-protein kinase erbB-2 - P04626 (ERBB2 HUMAN)

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ... Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ... ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the ...
more infohttp://www.rcsb.org/pdb/protein/B4DHN3

RCSB PDB - Protein Feature View 









 - Receptor tyrosine-protein kinase erbB-2 - P04626 (ERBB2 HUMAN)RCSB PDB - Protein Feature View - Receptor tyrosine-protein kinase erbB-2 - P04626 (ERBB2 HUMAN)

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ... Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ... ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the ...
more infohttp://www.rcsb.org/pdb/protein/P04626

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response | PNASAntibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response | PNAS

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy ... Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response John Stagg, ... We thus demonstrated that the combination of anti-DR5 and anti-ErbB2 mAbs might be an effective form of treatment for ErbB-2- ... Remarkably, treatment with a combination of anti-DR5 and anti-ErbB-2 mAbs induced complete response in a majority of mice. In ...
more infohttps://www.pnas.org/content/105/42/16254.abstract

EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival.  - PubMed -...EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival. - PubMed -...

c-erbB-4 expression was associated with a more favourable outcome. Co-expression of c-erbB-2 and EGFR was associated with a ... c-erbB-4 expression, however, showed an antagonistic effect on the clinical influence of c-erbB-2 expression. In conclusion, c- ... However, c-erbB-4 antagonizes the c-erbB-2 effect on clinical course in breast carcinomas. To achieve best results with ... c-erbB-3, and c-erbB-4. All the immunoreactive tumours were confirmed positive by RT-PCR. Tumour size, histological grade, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11748637?dopt=Abstract

Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points | PerkinElmerReceptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points | PerkinElmer

ErbB-2, NEU, or HER2) in serum, buffered solution or cell culture medium. ... AlphaLISA no-wash assay kit for detection and quantitation of Human epidermal growth factor receptor 2 ( ... is a type I membrane glycoprotein that is a member of the ERBB family of tyrosine kinase receptors. It serves as a receptor for ... Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points ...
more infohttps://www.perkinelmer.com/product/alphalisa-erbb2-her2-kit-5-000-pts-al235f

Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer...Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer...

Objectives: To measure the expression of epidermal growth factor receptor (EGFR) and erbB-2 in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ... Investigation of epidermal growth factor receptor and erbB-2 molecular targeted therapies in undifferentiated thyroid cancer ...
more infohttp://cancerres.aacrjournals.org/content/64/7_Supplement/1046.3

The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth...The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth...

With the exception of ErbB-3, which acts as a noncatalytic partner to other erbB family members, the type I receptors have ... Inhibition of Receptor Autophosphorylation in Cells. The ability of GW2016 to inhibit the activity of EGFR and ErbB-2 in intact ... Receptors were immunoprecipitated using either EGFR or ErbB-2 antibodies and blotted for phosphotyrosine content. Treatment ... Receptors were immunoprecipitated with antibodies to EGFR or ErbB-2 and blotted for phosphotyrosine. This representative ...
more infohttps://mct.aacrjournals.org/content/1/2/85?ijkey=14c6c6e88b51f665f41ac3df63e99f72c503284c&keytype2=tf_ipsecsha

The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth...The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth...

With the exception of ErbB-3, which acts as a noncatalytic partner to other erbB family members, the type I receptors have ... Inhibition of Receptor Autophosphorylation in Cells. The ability of GW2016 to inhibit the activity of EGFR and ErbB-2 in intact ... Receptors were immunoprecipitated using either EGFR or ErbB-2 antibodies and blotted for phosphotyrosine content. Treatment ... Receptors were immunoprecipitated with antibodies to EGFR or ErbB-2 and blotted for phosphotyrosine. This representative ...
more infohttp://mct.aacrjournals.org/content/1/2/85.long

Abstract 5345: DMBA promotes erbB-2 mediated carcinogenesis through activation of estrogen receptor and receptor tyrosine...Abstract 5345: DMBA promotes erbB-2 mediated carcinogenesis through activation of estrogen receptor and receptor tyrosine...

ErbB-2 is a receptor tyrosine kinase (RTK) that is amplified/overexpressed in 20-30% of all invasive breast malignancies; it ... In this study, female MMTV-erbB-2 transgenic mice at 6-weeks of age were treated weekly by oral gavage with either 1.0 mg DMBA ... In addition to its well known mutational effect, DMBA induced deregulation of ER and erbB-2 pathways plays a critical role in ... DMBA promotes erbB-2 mediated carcinogenesis through activation of estrogen receptor and receptor tyrosine kinase pathways. [ ...
more infohttp://cancerres.aacrjournals.org/content/74/19_Supplement/5345

erbB-2|Tyrosine kinase (TK) receptorerbB-2|Tyrosine kinase (TK) receptor

The human epidermal growth factor receptor (erbB-2) is a transmembrane receptor th ... receptor whose overexpression is associated with adverse prognosis in breast cancer,sup,1,/sup,.,/p, ,p, ... p,erbB-2,strong, ,/strong,is a transmembrane, tyrosine kinase (TK) ... The human epidermal growth factor receptor (erbB-2) is a transmembrane receptor that is overexpressed in 15%-25% of breast ...
more infohttp://www.apexbt.com/erbb-2.html

Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points | PerkinElmerReceptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points | PerkinElmer

ErbB-2, NEU, or HER2) in serum, buffered solution or cell culture medium. ... AlphaLISA no-wash assay kit for detection and quantitation of Human epidermal growth factor receptor 2 ( ... is a type I membrane glycoprotein that is a member of the ERBB family of tyrosine kinase receptors. It serves as a receptor for ... Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit, 5,000 Assay Points * ...
more infohttp://www.perkinelmer.de/product/alphalisa-erbb2-her2-kit-5-000-pts-al235f

Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue | Retractions and...Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue | Retractions and...

Steroid hormone receptors, estrogen receptors, progesterone receptors, and c-erbB2 expression of breast cancer tissue samples ... Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue. Turk J Surg. 1950;1( ... Estrogen receptors, PRs, and c-erbB2 receptors remain stable in a medium at pH 7.4, but ischemia shifts pH value to acidosis, ... Effect of postoperative ischemia on steroid hormone receptors and c-erbB-2 levels in breast cancer tissue. ...
more infohttps://www.turkjsurg.com/full-text/1612/eng

In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor | Journal of...In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor | Journal of...

... family comprising four receptors (ErbB1-4) [16]. As for other members of these receptors, the ErbB-2 signal output is ... binding to receptors mediating the activation of signalling pathways, e.g. Ptc [6, 7] and ErbB-2 [15]. With regard to the ... including receptor tyrosine kinases (RTK) such as TRK-A [14] and ErbB-2 [15] of the epidermal growth factor receptor (EGFR) ... the preferred heterodimerization partner of all ErbB receptors is a mediator of lateral signaling. EMBO J. 1997, 16: 1647-1655 ...
more infohttps://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-58

Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy.Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy.

... the CXC chemokine receptor 4 (CXCR4), estrogen receptor (ER), Proliferating Cell Nuclear Antigen (PCNA), DNA topoisomerase II ( ... Biological molecular markers such as proto-oncogene erbB-2 (HER-2/neu, c-erbB-2), ... 0/Receptors, CXCR4; 0/estrogen receptor alpha, human; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2 ... Estrogen Receptor alpha / metabolism. Female. Humans. Immunohistochemistry. Middle Aged. Receptor, erbB-2 / metabolism*. ...
more infohttp://www.biomedsearch.com/nih/Decreased-expression-C-erbB-2/23046610.html

Untangling the ErbB signalling network.  - PubMed - NCBIUntangling the ErbB signalling network. - PubMed - NCBI

2001 Feb;2(2):127-37. Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P.H.S.; Review ... When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling ... Untangling the ErbB signalling network.. Yarden Y1, Sliwkowski MX.. Author information. 1. Department of Biological Regulation ... a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11252954?dopt=Abstract

ERBB3 | Cancer Genetics WebERBB3 | Cancer Genetics Web

Inactive ERBB receptors cooperate with reactive oxygen species to suppress cancer progression.. Mol Ther. 2013; 21(11):1996- ... HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3 Location:. 12q13. ... The ERBB receptors are a family of heterodimerization partners capable of driving transformation and metastasis. While the ... One of the main challenges in ErbB-targeting therapy is to inactivate signaling mediated by ErbB2-ErbB3 oncogenic receptor ...
more infohttp://www.cancerindex.org/geneweb/ERBB3.htm

ACSL3 | Cancer Genetics WebACSL3 | Cancer Genetics Web

Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.. PLoS One. 2011; 6(8): ... The aim of the present study was to characterize the androgen receptor (AR) response in hormonal therapy-resistant PC346 cells ... Long chain acyl-CoA synthetase-3 is a molecular target for peroxisome proliferator-activated receptor delta in HepG2 hepatoma ... Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer.. Cancer Prev Res ( ...
more infohttp://www.cancerindex.org/geneweb/ACSL3.htm

Superior outcome after neoadjuvant chemotherapy with docetaxel, anthracycline, and cyclophosphamide versus docetaxel plus...Superior outcome after neoadjuvant chemotherapy with docetaxel, anthracycline, and cyclophosphamide versus docetaxel plus...

Receptor, erbB-2 / metabolism. Taxoids / administration & dosage, adverse effects, therapeutic use. Treatment Outcome. Triple ... 0/Taxoids; 15H5577CQD/docetaxel; 6PLQ3CP4P3/Etoposide; 8N3DW7272P/Cyclophosphamide; EC 2.7.10.1/Receptor, erbB-2 ...
more infohttp://www.biomedsearch.com/nih/Acknowledgement-reviewers-2013/24292815.html

RAS Pathway v2.0 - National Cancer InstituteRAS Pathway v2.0 - National Cancer Institute

epidermal growth factor receptor. ERBB, ERBB1, HER1, PIG61, mENA. EIF4EBP1. eukaryotic translation initiation factor 4E-binding ... receptor tyrosine-protein kinase erbB-2. CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1. ... fibroblast growth factor receptor 3. CH, CD333, CEK2, HSFGFR3EX, JTK4. FGFR4. fibroblast growth factor receptor 4. CD334, JTK2 ... anaplastic lymphoma receptor tyrosine kinase; ALK tyrosine kinase receptor. CD246, NBLST3 APAF1. apoptotic peptidase activating ...
more infohttps://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2

Rationale for a Phase II Trial of Pertuzumab, a HER-2 Dimerization Inhibitor, in Patients with Non-Small Cell Lung Cancer |...Rationale for a Phase II Trial of Pertuzumab, a HER-2 Dimerization Inhibitor, in Patients with Non-Small Cell Lung Cancer |...

receptor, erbB-2. There have been extensive efforts to develop agents effective against the HER family of tyrosine kinase ... The HER family of receptors is composed of four related receptors, the epidermal growth factor receptor (EGFR, HER-1, or ErbB1 ... Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab ... EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to ...
more infohttp://clincancerres.aacrjournals.org/content/12/14/4436s

CDK5 Gene - GeneCards | CDK5 Protein | CDK5 AntibodyCDK5 Gene - GeneCards | CDK5 Protein | CDK5 Antibody

Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. *Neurophysiological process Receptor- ... 2. ^. 3a. ·. 3b. ^. 4a. ·. 4b. ^. 5. ^. 6a. ·. 6b. ^. 7. ^. 8. ^. 9a. ·. 9b. ·. 9c. ^. 10. ^. 11. ^. 12a. ·. 12b. ^. 13a. ·. ... 2. FANTOM5 Ensembl ENCODE dbSUPER 11.7. +47.4. 47404. 7.7. HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B DMAP1 SLC30A9 NOS3 ... The GeneCards human gene database index: 1 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CDK5&snp=69

MUC4 - Mucin-4 - Homo sapiens (Human) - MUC4 gene & proteinMUC4 - Mucin-4 - Homo sapiens (Human) - MUC4 gene & protein

ErbB-2 class receptor binding Source: InterPro. *extracellular matrix constituent, lubricant activity Source: InterPro ... regulation of signaling receptor activity Source: InterPro. Complete GO annotation on QuickGO ... ... Annotation score:2 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ... Annotation score:2 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ...
more infohttps://www.uniprot.org/uniprot/A0A0G2JRU8