Researchers interested in Receptor, EphB4 | Directory of Faculty Research Interests
EPH receptor B4 - Wikipedia
EPHB4 EPH receptor B4". Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 ... Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrin receptors and their ligands, the ... 1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 ... Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene ...
Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4 |...
... the EphB4/ephrin-B2 balance in many cancer cells is disrupted by over-expression of the EphB4 receptor. EphB4 is reported as ... Three commercially available human EphB4-specific polyclonal antibodies EphB4 (N-19), EphB4 (H-200) and EphB4 (C-16) were ... the single physiologically-relevant ligand of the EphB4 receptor is ephrin-B2 [2]. Both the receptor and the ligand are ... EphB4 (N-19) (N), EphB4 (H-200) (H) and EphB4 (C-16) (C) all from Santa Cruz Biotechnology. The H200 antibody showed a ...
Bile Duct Cancer (Cholangiocarcinoma) Global Clinical Trials Review, H1, 2020
PCalign: a method to quantify physicochemical similarity of protein-protein interfaces | BMC Bioinformatics | Full Text
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol ... Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc Natl Acad Sci U S A. 2005;102(30):10652-7. ... Comparison of the NiV-G-ephrin-B2 complex and the cognate ephrin-B2-ephrin-B4 receptor complex reveals striking similarity in ... Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2. Nat Struct Mol Biol. 2008;15(6 ...
Xu K et al. (2011),
Blood vessel tubulogenesis requires Rasip1 regu... -
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... distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. 1998 ... Genes referenced: arhgap1 arhgap29 cdc42 ephb4 gja5 kdr pard3 rac1 rasip1 rho rho.2 rhoa sacs Article Images: [+] show captions ... M�P) Connexin40 (Cx40 or Gja5) (M and N) or EphB4-lacZ (O and P) in littermate E9.5 Rasip1+/ and Rasip1 / yolk sacs (M and N) ...
Regulation of ephrinB2-dependent angiogenesis by PS1 in normal and AD - JPND Neurodegenerative Disease Research
Binding of the extracellular sequence of EphB4 receptor to its transmembrane ligand ephrinB2 protein on the surface of ... a critical step in EphB4-induced angiogenesis. Here we propose to explore the mechanisms via which the EphB4/ephrinB2 and PS1 ... We found that EphB4 stimulates the metalloproteinase (MP) and PS/?-secretase processing of ephrinB2 producing cytosolic peptide ... Additional literature shows that the EphB4/ephrinB2 system is an important regulator of the development and function of the ...
In vivo uptake and cellular distribution of gold nanoshells in a preclinical model of xenografted human renal cancer | Gold...
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The erythropoietin-producing hepatocellular carcinoma (Eph) receptors are the largest receptor tyrosine kinases family. EphB4 ... EphB4-overexpressed Chinese hamster ovary (CHO)-K1 (CHO/EphB4) cells were immunized into mice, and we established an anti-EphB4 ... The CXC chemokine receptor 4 (CXCR4, CD184) is a member of the G protein-coupled receptor family that is expressed in most ... CC chemokine receptor 6 (CCR6) is one of the members of G protein-coupled receptor (GPCR) family that is upregulated in many ...
Filopodia are dispensable for endothelial tip cell guidance | Development | The Company of Biologists
The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis ... Netrins and Unc5 receptors, Semaphorins, Plexins and Neuropilins, and Ephrins and Eph receptors (Adams and Eichmann, 2010). It ... The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system ... Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in ...
Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions | bioRxiv
EphB4, ErbB2, ErbB3, ErbB4, ErbB6, FGFR1, FGFR2 alpha, FGFR3, FGFR4, Flt-3/Flk, HGF R/c-MET, IGF-I R, Insulin R/CD220, M-CSF R ... The epidermal growth factor receptor (EGFR) is a HER-family receptor tyrosine kinase (RTK) that is involved in cell signaling ... The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer ... The density of the receptors expressed was in the range of 100-2000 receptors/μm2. Lower Deff and higher fc values indicate ...
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Receptor EphB4 (1) * Células Endoteliales (1) * Canal de Sodio Activado por Voltaje NAV1.5 (1) ... Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlapping phenotypes. Martin- ... Correction: Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlapping ...
The Clinical Proteomic Technologies for Cancer | Details for CPTC-EPHB4-1
EPHB4; ephrin type-B receptor 4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; tyrosine-protein ... In conjunction with the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is ... Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene ... Western Blot using CPTC-EPHB4-1 as primary Ab against EPHB4 (rAg 10657) in lane 2. Also included are molecular wt. standards ( ...
坂口光洋記念講座(発生・分化生物学) - 研究成果 -
Function of the receptor tyrosine kin ÄSE, HTK/EPHB4 and its ligand, HTKL/EPHRIN-B2 in erythropoiesis. Inada, T., Sakano, S. & ... Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., ... Receptor tyrosine kinases involved in hematopoietic progenitor cells. Suda, T., Iwama, A., Hashiyama, M., Sakano, S. & Ohno, M. ... Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells. Hamada, K., Oike, Y., Ito, Y., Maekawa, H ...
Positive Tested Species Reactivity: Lizard, altricial-fish-larva
UniProtKB/SwissProt variant VAR 081712
NAKAZAWA, YOZO | Shinshu University Researcher Directory
Chimeric Antigen Receptor T Cells Redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma. MOLECULAR THERAPY,26(5):340- ... Chimeric Antigen Receptor T Cells Redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma. PEDIATRIC BLOOD & CANCER,64: ... Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma ... Keywords:AML; CD116; GM-CSF; GM-CSF receptor; GMR; low affinity;. A lymphodepleted non-human primate model for the assessment ...
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Toll-like receptor signaling pathway 12. NOD-like receptor signaling pathway 13. RIG-I-like receptor signaling pathway 14. T ... Nanoparticle-mediated activation of receptor signaling 6. Signal Transduction of S1P Receptor 7. Parkinsons Disease Pathway 8. ... EGF receptor signaling pathway 4. FGF signaling pathway 5. Interferon-gamma signaling pathway 6. Oxidative stress response 7. ... Toll-like receptor signaling pathway 2. Insulin Signaling 3. MAPK Cascade 4. MAPK Signaling Pathway 5. ...
SZGR2
EPHB4. HTK , MYK1 , TYRO11. EPH receptor B4. 7q22. CV:PGCnp. DMG:Wockner_2014. Expression. GO_Annotation. ... leukemia inhibitory factor receptor alpha. 5p13-p12. PMID:cooccur. 1008. CDH10. -. cadherin 10. 5p14.2. CV:PGCnp. PMID:cooccur ... G protein-coupled receptor kinase 5. 10q26.11. CV:PGCnp. DMG:Jaffe_2016. DMG:Nishioka_2013. DMG:Wockner_2014. PMID:cooccur. ... discoidin domain receptor tyrosine kinase 1. 6p21.3. Association. CV:PGCnp. DMG:Montano_2016. Expression. GO_Annotation. GR_Ng ...
Venous endothelial injury in central nervous system diseases | BMC Medicine | Full Text
TRDRP Grant: Human tryptase gene expression: role in COPD
Fred Weaver | USC Profiles
Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol. 2006 Jul; 169(1):279-93. Kumar SR, Singh J, ... The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. Br ... EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival. Oncogene. 2006 Feb 02; 25 ... Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. Cancer Res. 2009 May 01; 69(9 ...
Than that in 6hhi Quercetin (binding power -103.144 ten.692 kJ/mol) (TableThan that in 6hhi Quercetin (binding | EphB4...
... dopamine receptor Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor Interleukin-10 Interleukin-1 beta Interferon-gamma ... dopamine receptor Mitogen-activated protein kinase 1 Glucocorticoid receptor Tumor necrosis aspect Estrogen receptor ... Ranscription from Zp and Rp contain transforming development aspect (TGF- ), B-cell receptor cross-linking, phorbol ... CHRNA2 COL1A1 CYP2B6 DRD1 GABRA1 GRIA2 HTR3A SLC6A2 Protein name Insulin-like growth factor I 5-hydroxytryptamine receptor 2A ...
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Behzad Toosi). Research title: "Expression and function of the EphB4 receptor in canine and human osteosarcoma." ... Behzad Toosi). Research title: "Evaluation of expression and function of the EphA2 receptor tyrosine kinase in canine and human ... Vikram Misra). Research title: "Towards the identification of the receptor of a new bat alphacoronavirus." ...
Recombinant Human EphB4 Protein (His Tag), Biotinylated | Beta LifeScience
A DNA sequence encoding the EPHB4 (NP_004435.3) (Met1-Ala539) was expressed with a C-terminal His tag. The purified protein was ... Interleukins and Receptors Growth Factors and Receptors Chemokines and Receptors Tumor Necrosis Factors and Receptors (TNFs) ... Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein ... Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 ...
In-silico</i> and structure-based assessment to evaluate pathogenicity of missense mutations associated with non-small cell...
... fibroblast growth factor receptor (FGFR) Ser249Cys mutation dimerizes the receptor and leads to constitutive signaling by ... F) EphB4 kinase domain Val748Ala. Wild type residues are indicated in blue and mutant in pink. ... Eph receptor belongs to the largest family of RTK. Based on sequence homology, Eph and ephrin have been classified into EphA/ ... Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells. Mol Med Rep 2016; ...
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The vascular-specific Ephrin-B2 ligand and EphB4 receptor function in a roughly analogous manner in angiogenesis. To study this ... Æ 766 VII DRUGS AFFECTING THE ENDOCRINE SYSTEM Insulin receptor Cell membrane ATP Initial Events Related to Receptor Kinase ... The existence of the third histamine receptor subtype, inhibiting the synthesis and release of histamine, was suggested by ...
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