Cannabinoid type 1 (CB1) receptor. en_US. dc.subject. Endocannabinoids. en_US. ... Experimental approach: Rats received intra-dlPAG administration of the CB1 receptor antagonist/inverse agonist rimonabant, or ...
The effects of JZL184 were mediated by cannabinoid CB1 receptors. Genetic deletion of mTOR with adeno-associated viral (AAV) ...
Cannabinoid receptor type 1,CB1 receptors]] and [[Cannabinoid receptor type 2,CB2 receptors]] in [[Sensory neuron,sensory]] and ... member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor ... The plant-biosynthesized cannabinoid [[cannabidiol]] also shows "either direct or indirect activation" of TRPV1 receptors.,ref ... NMDA receptor]]s have been proposed to be the receptors through which these SPMs operate to [[down-regulate]] TRPV1 and thereby ...
long-term genetic ablation of CB1 receptors.. A number of studies have shown that CB1 receptors are expressed in the developing ... Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. A. Bilkei-Gorzo, I. Racz, O. Valverde, M. ... Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. A. Bilkei-Gorzo, I. Racz, O. Valverde, M. ... Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. A. Bilkei-Gorzo, I. Racz, O. Valverde, M. ...
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.. Bertini S1, Chicca A2, Gado F1, Arena C1, ... Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor ... Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor ... Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor ...
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Zoltán Járai, Jens ... Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors ... Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors ... Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors ...
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.. Jin K1, Xie L, Kim SH, Parmentier-Batteur S, Sun Y, ... indicating involvement of a non-CB1 receptor. Action at one such non-CB1, SR141716A-sensitive site, the VR1 vanilloid receptor ... Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogenesis in the adult brain. To ... Thus, CB1 and VR1 receptors both seem to have roles in regulating adult neurogenesis. ...
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. ... Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. ... Cannabinoid-1 receptor (CB1R) antagonists reduce body weight and improve cardiometabolic abnormalities in experimental and ...
... Cipriano, Mariateresa Umeå ... Background: In prostate cancer, tumour expression of cannabinoid CB1 receptors is associated with a poor prognosis. One ... CB1 receptor immunoreactivity (CB1IR) was rescored from previously published data using the same scale as pAkt-IR. There was a ... In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well- ...
Cannabinoid Receptor Agonists. Cannabinoid Receptor Modulators. Neurotransmitter Agents. Molecular Mechanisms of ... Cannabinoid Receptor (CB1) Agonist Treatment in Severe Chronic Anorexia Nervosa. The safety and scientific validity of this ...
... a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse ... Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats. ... SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has ... Involvement of the spinal cannabinoid receptor in nociception. Abstracts, 1995 Symposium on Cannabis and the Cannabinoids, p 44 ...
Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid receptors. CB1 ... The regional distribution of CB1 receptor expression in the striatum further suggests that, in sensorimotor sectors, CB1 ... We investigated CB1 receptor expression within specific corticostriatal circuits by mapping CB1 mRNA levels in striatal sectors ... We investigated CB1 receptor expression within specific corticostriatal circuits by mapping CB1 mRNA levels in striatal sectors ...
CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and ... These results demonstrate for the first time the spatial distribution of CB1 receptors in the healthy canine CNS and PNS. These ... Therefore, we assessed the spatial distribution of CB1 receptors in the normal canine CNS and PNS. Immunohistochemistry of ... CB1 labelled neurons and satellite cells of the dorsal root ganglia, and myelinating Schwann cells in the PNS. ...
... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 ... Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 ...
Several evidences suggest that an alteration of cannabinoid CB1 receptor function could be involved in the pathophysiology of ... Several evidences suggest that an alteration of cannabinoid CB1 receptor function could be involved in the pathophysiology of ... Behavioral phenotypes of mice lacking cannabinoid CB1 receptors in different neuronal subpopulations. focus on sex-related ... Behavioral phenotypes of mice lacking cannabinoid CB1 receptors in different neuronal subpopulations. focus on sex-related ...
The CB1 cannabinoid receptor is one of the most abundant receptors in the brain and it helps to regulate movement, as well as ... Scientists find a new pharmacological target to modulate the effect of cannabinoids through their CB1 receptors 05.07.2012 ... the CB2 receptors may be a new pharmacological target for the modulation of the effect of cannabinoids through the CB1 receptor ... the CB2 receptors act as a brake on the CB1 receptors.. The research shows that it is necessary to take these heteromers into ...
... Neuroreport. 2004 Oct 25;15(15):2381-5. doi: ... a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. ... These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and ... temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of ...
The pharmacological actions of THC result from its activity at the cannabinoid CB1 receptor, located mainly in the central ... After the discovery of endogenous ligands of CB1 and CB2 receptors and of nonclassical cannabinoids a multitude of structure- ... A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in ... hCB2 Receptor Binding Results. Table 7 indicates that the order of importance of the variables is , , . Table 8 shows that no ...
2003) Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60: ... 2005) The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc ... 1998a) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75:111-119. ... 1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci U S A 96 ...
Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK ... Mathieu Verdurand, Vu Nguyen, Daniela Stark, et al., "Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult ...
Stop-CB1 mice (n = 4), and conventional CB1 receptor KO mice (CB1-KO, n = 2). CB1 receptor transcript levels in Stop-CB1 was ... Stop-CB1 mice and their Glu-CB1 receptor rescue (Glu-CB1-RS) littermates, and mice from the complete CB1 receptor rescue (CB1- ... Quantification of CB1 receptor protein in hippocampal extracts revealed 28% of CB1 receptor in Glu-CB1-RS relative to CB1-RS ... Stop-CB1, CB1-RS, and Glu-CB1-RS. Black triangles, loxP sites; white box (stop), stop cassette; white box (CB1), CB1 receptor ...
These results also suggest that inhibition of CB(1) receptors may exert beneficial effects in renal (a … ... receptors promotes cisplatin-induced tissue injury by amplifying MAPK activation, cell death and interrelated inflammation and ... CB1 Cannabinoid Receptors Promote oxidative/nitrosative Stress, Inflammation and Cell Death in a Murine Nephropathy Model Br J ... Receptor, Cannabinoid, CB1 / antagonists & inhibitors * Receptor, Cannabinoid, CB1 / genetics * Receptor, Cannabinoid, CB1 / ...
Functional CB1 cannabinoid receptors in human vascular endothelial cells. Jie LIU, Bin GAO, Faridoddin MIRSHAHI, Arun J. SANYAL ... Functional CB1 cannabinoid receptors in human vascular endothelial cells. Jie LIU, Bin GAO, Faridoddin MIRSHAHI, Arun J. SANYAL ... Functional CB1 cannabinoid receptors in human vascular endothelial cells Message Subject (Your Name) has forwarded a page to ... a selective CB1 receptor antagonist. Transfection of ECV304 cells with CB1 receptor antisense, but not sense, oligonucleotides ...
A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded ... soluble cannabinoid CB1 receptor. agonists. Julia M. Adam,*a Jim Cairns,a Wilson Caulfield,a Phillip Cowley,a Iain Cumming,a ... soluble cannabinoid CB1 receptor. agonists. J. M. Adam, J. Cairns, W. Caulfield, P. Cowley, I. Cumming, M. Easson, D. Edwards, ... A novel CB1 receptor agonist. lead series was identified using a high-throughput screening approach. The initial screen ...
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- ... Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- ...