After years of studying the role of the IGF system in tumour biology, novel agents for IGF1R targeting will soon be available ... Design of specific kinase inhibitors is problematic because of homology between the IGF1R and insulin receptor. This obstacle ... including the requirement of established tumours for IGF signalling, and the efficacy and toxicity of IGF1R inhibitors. ... The type 1 insulin-like growth factor receptor (IGF1R) is a promising anticancer treatment target, being frequently ...
IGF-1R) and variant insulin receptors, IGFs promote cancer progression, aggressiveness, and treatment resistance. Of specific ... Indeed, anti-IGF-1R antibodies, IGF-1R tyrosine kinase inhibitors, and anti-IGF-1/2 antibodies have demonstrated antitumor ... suggesting that bone metastases may reflect IGF dependency. Therapeutic targeting of the IGF axis may therefore provide an ... Furthermore, preclinical evidence suggests that tumor cells can be primed to metastasize to bone by a high IGF-1 environment in ...
IGF-1R:EGFR cross-talk contributes to resistance to agents targeting either pathway, supporting trials of dual receptor ... In S1 (n=40) DLTs were G4 ALT/AST and G3 hyperglycemia in 2 pts at OSI-906 600 mg + E 100 mg; G3 ALT/AST in 1 pt at 450+100 mg ... PD effects of OSI-906 were observed after co-administration with E. Four pts had partial response: 1 pt at S2 50+100 mg (spinal ... Three dosing schedules (S) were investigated; S1: intermittent OSI-906 QD 1-3 q7 d at 50-600 mg + E; S2: continuous OSI-906 QD ...
IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ... Type. Conference paper. Publication Date. 05/2019. Volume. 105. Pages. A182 - A182 ... THYMOSIN beta 4-A NOVEL REGULATOR OF LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 1 (LRP1) IN VASCULAR DISEASE ... THYMOSIN beta 4-A NOVEL REGULATOR OF LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 1 (LRP1) IN VASCULAR DISEASE ...
... our experiments show that Tip60 can also enhance transactivation through the estrogen receptor and progesterone receptor in a ... The importance of such proteins in enhancing nuclear hormone receptor-mediated transcriptional activation is widely accepted, ... is a member of the nuclear hormone receptor superfamily. Recent work in this field has been focused upon defining the ... Tip60 enhances transactivation to levels observed with the coactivators steroid receptor coactivator 1, p300, and CREB-binding ...
Human prostate cells (LNCaP, VCaP, C4-2B, normal RWPE-1) and a tissue microarray were used. Cells were treated with anti- ... Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is ... Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is ... IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ...
The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the ... Illustrating the impact of these unmasked AR-driven pathways, dihydroceramide desaturase 1 was identified as an AR-regulated ... The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the ... IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ...
... that bind to epitopes of the CD40 receptor distinct to that of 3/23. Neither mAb revealed endothelial expression of CD40. ... IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ... that bind to epitopes of the CD40 receptor distinct to that of 3/23. Neither mAb revealed endothelial expression of CD40. ... Type. Journal article. Journal. Endothelium. Publication Date. 2003. Volume. 10. Pages. 111 - 117 ...
and 1 000 mg/m2, respectively). The maximum plasma concentration was attained within 5 min of completing the infusion and ... The plasma level declined rapidly in a monophasic manner with an elimination half-life of 2.1 and 2.5 h for dose level 1 and 2 ... Fourteen patients received a total of 37 cycles of OGT 719 at four dose levels ([500 mg/m2 first cycle, 1 000 mg/m2 subsequent ... OGT 719 has the capacity selectively to bind to asialoglycoprotein receptors that are found exclusively on hepatocytes and ...
CD86 receptor saturation was higher in patients who were receiving belatacept every 4 weeks (74%) compared with every 8 weeks ( ... of renal function in kidney transplant recipients demonstrated similar efficacy and significantly higher measured GFR at 1 year ... Type. Journal article. Journal. J Am Soc Nephrol. Publication Date. 09/2010 ... IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ...
... human epidermal growth factor receptor-2 measurement is mandatory for predicting response to trastuzumab, and urokinase ... For breast cancer, estrogen and progesterone receptors are mandatory for predicting response to hormone therapy, ... plasminogen activator/plasminogen activator inhibitor 1 may be used for determining prognosis in lymph node-negative patients. ... IGF Group * The RESPOND Programme * Problem and Approach * Theoretical Background * For RESPOND Leaders ...