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*  Effects of Human Renin in the Vasculature of Rats Transgenic for Human Angiotensinogen | Hypertension
Sizes are indicated in nucleotides (nt). AO indicates aorta of a transgenic rat; rLI, rat liver of a nontransgenic control rat ... The transgenic line was developed as outlined elsewhere.19 The rats were kept in rooms at 24±2°C and fed a standard rat diet ( ... The presence of human angiotensinogen in the vascular tissue of our transgenic rats makes these rats a highly suitable model ... Total RNA was isolated from a transgenic rat aorta and a nontransgenic rat liver by the lithium chloride precipitation ...
http://hyper.ahajournals.org/content/26/2/272
*  Increased cytosolic sodium and reduced Na,K-ATPase activity in transgenic rats. | Hypertension
Na,K-ATPase activity was significantly reduced in transgenic rats compared with Sprague-Dawley rats (4.0 +/- 0.3 versus 8.1 ... Resting cytosolic sodium was significantly higher in transgenic rats compared with Sprague-Dawley rats (31.7 +/- 2.2 versus ... Increased cytosolic sodium and reduced Na,K-ATPase activity in transgenic rats.. M Tepel, G Theilmeier, J Bachmann, M ... The transgenic rat TGR(mRen2)27 is a new monogenetic model in hypertension research that develops fulminant hypertension after ...
http://hyper.ahajournals.org/content/23/1_Suppl/I198
*  FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
Establishment of this FUS transgenic rat model will allow not only for mechanistic study of FUS-related diseases, but also for ... Here, we describe a novel rat model that expresses a mutated form of the human fus gene and manifests the phenotypes and ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002011
*  Involvement of Neuropeptide Y in Hyperphagia in Human Growth Hormone Transgenic Rats
... rats that show low circulating levels of both hGH and endogenous rat GH. Although body length of the TG rats is normal, they ... of the TG rats was always lower than those of the WT rats, suggesting increased transport of NPY from the ARC to PVN in the TG ... adipose tissue weight and plasma triglyceride concentrations in the TG rats. These results suggest that, in the TG rats, ... In both wild-type (WT) and TG rats, the highest value of plasma ghrelin levels was observed just before the dark phase, and ...
https://www.jstage.jst.go.jp/article/jvms/68/9/68_9_959/_article
*  Changes in Vsmc Phenotypes in Ang Ii-Dependent Hypertension of TGR (mREN2) 27 (Tgr) Transgenic Rats | Hypertension
Changes in Vsmc Phenotypes in Ang Ii-Dependent Hypertension of TGR (mREN2) 27 (Tgr) Transgenic Rats. Gian Paolo P Rossi, ... Changes in Vsmc Phenotypes in Ang Ii-Dependent Hypertension of TGR (mREN2) 27 (Tgr) Transgenic Rats ... Changes in Vsmc Phenotypes in Ang Ii-Dependent Hypertension of TGR (mREN2) 27 (Tgr) Transgenic Rats ... Changes in Vsmc Phenotypes in Ang Ii-Dependent Hypertension of TGR (mREN2) 27 (Tgr) Transgenic Rats ...
http://hyper.ahajournals.org/content/36/Suppl_1/688.2
*  Immunodeficient Parameters in the HIV-1 Transgenic Rat Model | Science Publications
... to 5 mo old HIV-1Tg rats, age-matched transgenic control (Tg) rats, and F344/NHsd (F344) control background strain rats. LPS ... and F344 control rats. Our data show that, in the HIV-1Tg rat, there is a negative correlation between the LEA response and the ... However, in the HIV-1Tg rats, there was no LEA response to LPS. Following LPS administration, there was significantly greater ... rat model was created that carries a gag-pol-deleted HIV-1 genome under the control of the HIV-1 viral promoter. However, other ...
https://thescipub.com/abstract/10.3844/ajidsp.2007.202.207
*  Molecular Imaging of Human ACE-1 Expression in Transgenic Rats | JACC: Cardiovascular Imaging
A) Radiotracer uptake is demonstrated in a control rat (left), transgenic rats (middle), and a transgenic rat after unlabeled ... Each rat was injected with approximately 3 mCi Tc-Lis. Nine of 21 Tg rats and 8 of 18 control rats received 0.6 mg/kg cold ... Twenty-one ACE-1 over-expressing Tg rats and 18 wild-type Sprague-Dawley control rats were studied. The Tg rats were obtained ... Molecular Imaging of Human ACE-1 Expression in Transgenic Rats. Vasken Dilsizian, Todd K. Zynda, Artiom Petrov, Satoru Ohshima ...
http://imaging.onlinejacc.org/content/5/4/409
*  TRIP - Transgenic Rats and Immunophenomics Platform | Biogenouest
Transgenic rats by microinjection of short DNA fragments or lentiviral vectors. *Knockout rats by microinjection of Zinc-Finger ... Fundamental/Health Research: Transgenic and Knockout rat models for studies on human diseases or specific genetic/biological ... Exploration fonctionnelle Transgenesis and animal models TRIP - Transgenic Rats and Immunophenomics Platform ... The Rat transgenesis core facility is the only academic structure in France offering comprehensive expertise and 15 years ...
https://www.biogenouest.org/en/contenu/core-facilities/functional-exploration/transgenesis-and-animal-models/rat-transgenesis
*  P23H Rhodopsin Transgenic Rat: Correlation of Retinal Function with Histopathology | IOVS | ARVO Journals
... and this led to the development of the rhodopsin transgenic rat, which has larger eyes. The P23H transgenic rat carries a ... The log S values for transgenic rats was higher across the entire stimulus intensity range compared with SD control rats ... and control rats (dashed line) elicited by 2.1 log cd-s/m2. The peak a-wave amplitude of the transgenic rats is shown ... and control rats (dashed line) elicited by 2.1 log cd-s/m2. The peak a-wave amplitude of the transgenic rats is shown ...
https://iovs.arvojournals.org/article.aspx?articleid=2123095
*  Relationship of Retinal Vasculature Development and Photoreceptor Degeneration in Mutant Rhodopsin Transgenic Rats | IOVS |...
... transgenic rats were counted and compared to age matched Sprague-Dawley rats. All of the profiles in a single section along the ... Relationship of Retinal Vasculature Development and Photoreceptor Degeneration in Mutant Rhodopsin Transgenic Rats ... Relationship of Retinal Vasculature Development and Photoreceptor Degeneration in Mutant Rhodopsin Transgenic Rats ... we have examined the formation of the DCP in 8 lines of transgenic rats with different ages of onset and rates of PR cell loss. ...
http://iovs.arvojournals.org/article.aspx?articleid=2395568
*  Transgenic Rat Model of Huntington's Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the...
Rats transgenic for Huntington's disease (tgHD51 CAG rats), surviving up to two years, represent an animal model of HD similar ... Transgenic Rat Model of Huntington's Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the ... To the best of our knowledge, our findings are the first to document that tgHD51 CAG rats can be used as a valid animal model ... A basic difference between HD pathology in human and tgHD51 rats is in the rate of NDP progression that originates primarily ...
https://www.hindawi.com/journals/bmri/2014/291531/abs/
*  Behavioral and In Vivo Electrophysiological Evidence for Presymptomatic Alteration of Prefrontostriatal Processing in the...
Transgenic rats presented more variability in their individual bisection curves than did wt rats (Fig. 4A). Fitting the curves ... The transgenic HD rat carries a truncated huntingtin cDNA fragment with 51 CAG repeats under the control of the rat huntingtin ... We used a transgenic rat model of HD with 51 CAG repeats (tgHD) (von Hörsten et al., 2003) that closely resembles the human ... Animals were run at the same time each day in six cohorts with approximately the same number of transgenic and wt rats. Each ...
http://www.jneurosci.org/content/31/24/8986
*  "Developing tTA transgenic rats for inducible and reversible gene expre" by Hongxia Zhou, Cao Huang et al.
The tTA transgenic rat allows for inducible and reversible gene expression in the rat; this important tool will be valuable in ... We examined the dynamics of Doxycycline (Dox)-regulated gene expression in transgenic rats. In the two transmittable lines, tTA ... we generated several lines of the transgenic rats carrying the tetracycline-controlled transactivator (tTA) gene. Using a ... Administration of Dox to pregnant or nursing rats can provide a continual suppression of tTA-dependent gene expression during ...
https://jdc.jefferson.edu/pacbfp/119/
*  Supplemental Antioxidants Do Not Ameliorate Colitis Development in HLA-B27 Transgenic Rats Despite Extremely Low Glutathione...
Dietary calcium inhibited colitis development in HLA-B27 transgenic rats, an animal model mimicking IBD. As antioxidants might ... Supplemental Antioxidants Do Not Ameliorate Colitis Development in HLA-B27 Transgenic Rats Despite Extremely Low Glutathione ... and interleukin-1 beta levels were significantly lower in rats fed both antioxidants and calcium compared to rats supplemented ... Methods: HLA-B27 rats were fed a control diet or the same diet supplemented with the antioxidants glutathione, vitamin C, and ...
http://library.wur.nl/WebQuery/wurpubs/428497
*  Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of...
A: Typical islets from wild-type (WT) rats, HIP rats, HIP rats treated with sitagliptin (HIP+SIT), and HIP rats treated with ... rats (n = 7), HIP rats (n = 8), HIP rats treated with sitagliptin (HIP+SIT; n = 8), HIP rats treated with metformin (HIP+MET; n ... rats (n = 7), HIP rats (n = 8), HIP rats treated with sitagliptin (HIP+SIT; n = 8), HIP rats treated with metformin (HIP+MET; n ... rats (n = 5), HIP rats (n = 6), HIP rats treated with sitagliptin (HIP+SIT; n = 7), HIP rats treated with metformin (HIP+MET; n ...
http://diabetes.diabetesjournals.org/content/58/7/1604.full
*  Regulation of Aldosterone Biosynthesis by Adrenal Renin Is Mediated Through AT1 Receptors in Renin Transgenic Rats |...
Effects of Low-Salt Diet and DuP 753 on Mouse and Rat Renin in TG Rats and in SD Rats. Hormonal Assays. In TG rats, the ... Hypertension in the transgenic rat TGR(mRen-2)27 may be due to enhanced kinetics of the reaction between mouse renin and rat ... Differential expression of mouse and rat renin in the transgenic rat: alteration by an ACE inhibitor. J Hypertens. 1994;12( ... Our results also show that the low rat renal renin levels of TG rats can be modified by inhibition of AT1 receptors, since rat ...
http://circres.ahajournals.org/content/77/1/73
*  Abstract 2474: Increased PKC expression in diacylglycerol-induced mammary carcinogenesis in the human c-Ha-ras proto-oncogene...
... ras proto-oncogene transgenic rat. Masumi Suzui, Ichiro Yoshida, Masashi Ishihara, Makoto Nakashima, Toshiyuki Matsunaga, Akira ... Hras128 rats (6-week-old) were randomly assigned into four experimental groups. DAG oil was administered to the rat as oral ... ras proto-oncogene transgenic rat. Masumi Suzui, Ichiro Yoshida, Masashi Ishihara, Makoto Nakashima, Toshiyuki Matsunaga, Akira ... ras proto-oncogene transgenic rat. Masumi Suzui, Ichiro Yoshida, Masashi Ishihara, Makoto Nakashima, Toshiyuki Matsunaga, Akira ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/2474
*  Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones - UCL...
Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones. J PHYSIOL ... This transgenic rat model enables us to study physiological regulation of hypothalamic transgene protein production, transport ... Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones ... Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones. ...
http://discovery.ucl.ac.uk/31480/
*  Protection of Cone Photoreceptors by Oncostatin M (OSM) in the Transgenic Rats Carrying the S334ter Rhodopsin Mutation | IOVS |...
Protection of Cone Photoreceptors by Oncostatin M (OSM) in the Transgenic Rats Carrying the S334ter Rhodopsin Mutation ... Protection of Cone Photoreceptors by Oncostatin M (OSM) in the Transgenic Rats Carrying the S334ter Rhodopsin Mutation ... in the Transgenic Rats Carrying the S334ter Rhodopsin Mutation. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3705. ... on the secondary cone degeneration in the transgenic rats carrying the murine rhodopsin mutation S334ter. ...
https://iovs.arvojournals.org/article.aspx?articleid=2372340
*  Notable Paper: Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats - Webvision
This paper in IOVS, "Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats" by Laura ... Notable Paper: Tauroursodeoxycholic Acid (TUDCA) Prevents Retinal Degeneration in Transgenic P23H Rats. ...
https://webvision.med.utah.edu/2011/05/tauroursodeoxycholic-acid-tudca-prevents-retinal-degeneration-in-transgenic-p23h-rats/
*  Developing tTA Transgenic Rats for Inducible and Reversible Gene Expression [Abstract]
The tTA transgenic rat allows for inducible and reversible gene expression in the rat; this important tool will be valuable in ... To develop transgenic lines for conditional expression of desired genes in rats, we generated several lines of the transgenic ... Developing tTA Transgenic Rats for Inducible and Reversible Gene Expression. Int J Biol Sci 2009; 5(2):171-181. doi:10.7150/ ... Developing tTA Transgenic Rats for Inducible and Reversible Gene Expression Hongxia Zhou1, Cao Huang1, Min Yang1, Carlisle P ...
http://www.ijbs.com/v05p0171
*  Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for...
Here, we investigated the neuroanatomical changes in a transgenic rat model for a subset of sporadic chronic mental illness ( ... Here, we investigated the neuroanatomical changes in a transgenic rat model for a subset of sporadic chronic mental illness ( ... Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for ... Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for ...
http://www.zora.uzh.ch/id/eprint/136439/
*  The Adult DCX-dsRed Transgenic Rat Retina: Characterization of DsRed Positive Cells | IOVS | ARVO Journals
Results: In adult DCX-dsRed transgenic rats, dsRed-positive cells were detected in the inner nuclear layer (INL), the ganglion ... Purpose: The doublecortin-dsRed transgenic reporter rat was designed to analyze neurogenesis in the aged brain. Doublecortin ( ... The Adult DCX-dsRed Transgenic Rat Retina: Characterization of DsRed Positive Cells ... The Adult DCX-dsRed Transgenic Rat Retina: Characterization of DsRed Positive Cells ...
https://iovs.arvojournals.org/article.aspx?articleid=2147806