Rats, Mutant Strains - MeSH - NCBI
Mutant StrainsRats, BrattleboroRats, GunnRats, HairlessRats, NudeRats, Zucker ... Rats, Mutant Strains. Rats bearing mutant genes which are phenotypically expressed in the animals. ... All MeSH CategoriesOrganisms CategoryEukaryotaAnimalsChordataVertebratesMammalsEutheriaRodentiaMuridaeMurinaeRatsRats, ... Mutant Strains Rat. *Mutant Strains Rats. *Rat, Mutant Strains. *Strains Rat, Mutant ...https://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term=%22Rats,+Mutant+Strains%22%5BMeSH+Terms%5D
Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport - Jansen - 1985 -...
A mutant rat strain is described with autosomal recessive conjugated hyperbilirubinemia. Transport of conjugated bilirubin and ... 10 ± 6 μmoles per liter in normal rats. The bile flow in mutant rats is reduced to about 50%. This might be caused by a ... However, unlike Dubin-Johnson syndrome, the mutant rats do not have the characteristic black hepatic pigment. These rats ... In young rats, serum bile acid levels are normal. In adult rats, bile acid levels are elevated to 49 ± 11 μmoles per liter vs. ...http://onlinelibrary.wiley.com/doi/10.1002/hep.1840050408/abstract?globalMessage=0
Electrophysiological studies of the feasibility of suprachoroidal-transretinal stimulation for artificial vision in normal and...
Rats. Rats, Long-Evans. Rats, Mutant Strains. Retina / physiology*. Retinal Degeneration / physiopathology*. Superior Colliculi ... METHODS: In 17 normal hooded rats and 12 Royal College of Surgeons (RCS) rats, a small area of the retina was focally ... The responses to minimal STS were localized in an area on the SC surface measuring 0.12 +/- 0.07 mm(2) in normal rats and 0.24 ... RESULTS: In both normal and RCS rats, STS elicited triphasic EPs that were vastly diminished by changing polarity of ...http://www.biomedsearch.com/nih/Electrophysiological-studies-feasibility-suprachoroidal-transretinal/14744899.html
Comparative analysis of anxiety-like behaviors and sensorimotor functions in two rat mutants, ci2 and ci3, with lateralized...
Rats. Rats, Inbred Lew. Rats, Mutant Strains. Rotarod Performance Test. Rotation. Species Specificity. Startle Reaction / ... The abnormal motor response to external stimuli raised the possibility that the circling rat mutants may be more likely to ... The reduced emotionality of the mutant rats indicated by the present experiments may not be specifically linked to anxiety per ... Based on previous findings of dysfunctions of the central dopamine system in ci2 and ci3 mutant rats, we assume that ...http://www.biomedsearch.com/nih/Comparative-analysis-anxiety-like-behaviors/18320635.html
A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats | SpringerLink
The onset of diabetes mellitus was observed only in male LEA/Tohm rats; however, urinary... ... rat has recently been established as a new rat model of type 2 diabetes. ... Konno R, Okamura T, Kasai N, Summer KH, Niwa A (2009) Mutant rat strain lacking D-amino-acid oxidase. Amino Acids 37:367-375 ... The LEA rats were established from an outbred colony of Long-Evans rats, and were sometimes used as a control strain for the ...https://link.springer.com/article/10.1007%2Fs00335-018-9790-3
Identification of a Rat Model for Usher Syndrome Type 1B by N-Ethyl-N-nitrosourea Mutagenesis-Driven Forward Genetics | Genetics
Mutant phenotype:. Rat models for human disease traditionally result from breeding of inbred strains that were specifically ... 1990 Catalog of inbred strains of rats, pp. 411-480 in Genetic Monitoring of Inbred Strains of Rats: A Manual on Colony ... In this study, we describe the identification and characterization of the first autosomal recessive mutant rat strain from an ... Deafness in the mutants was observed by a negative Preyer's reflex. Moreover, the mutant rats show locomotory hyperactivity, ...http://www.genetics.org/content/170/4/1887
Disturbed GABAergic transmission in mutant Han-Wistar rats: further evidence for basal ganglia dysfunction. [Muscimol.xyz]
A mutant strain of Wistar rats which carries an autosomal gene defect is characterized by a progressively developing ... Disturbed GABAergic transmission in mutant Han-Wistar rats: further evidence for basal ganglia dysfunction. Article date: 1985/ ... Rats; Rats, Inbred Strains/genetics; Rats, Mutant Strains; Receptors, GABA-A/drug effects; Substantia Nigra/physiopathology; ... and pons of mutant rats. Mutant rats exhibit a lower activity of GAD in synaptosomal fractions of olfactory bulbs and ...https://muscimol.xyz/2998553
Optimization of condition(s) towards establishment of primary islet cell cultures from WNIN/Ob mutant rat | Springer for...
... a mutant rat strain, developed at the National Center for Laboratory Animal Sciences (NCLAS) facility of National Institute of ... WNIN/Ob, a mutant rat strain, developed at the National Center for Laboratory Animal Sciences (NCLAS) facility of National ... Inbred Wistar rat strain established at NIN. WNIN/Ob. Wistar rats raised in the National Institute of Nutrition, with obesity ... Optimization of condition(s) towards establishment of primary islet cell cultures from WNIN/Ob mutant rat. ...https://rd.springer.com/article/10.1007/s10616-011-9409-y
... chronic PhIP administration resulted in the induction of tumors in these organs in Nagase analbuminemic mutant strain rats ... studies conducted with PhIP in vitro with rat serum albumin and in vivo in rats after high-dose exposures have indicated that ... Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2 ... Sesardic D., Boobis A. R., Edwards R. J., Davies D. S. A form of cytochrome P450 in man, orthologous to form d in the rat, ...http://cebp.aacrjournals.org/content/8/6/507
Phoenix MICRON CNV System used to test a novel treatment for age-related macular degeneration | Phoenix Research Labs
Characterizing a mutant rat strain with the Phoenix Micron OCT and Ganzfeld ERG. ... Characterizing a mutant rat strain with the Phoenix Micron OCT and Ganzfeld ERG. ... Characterizing a mutant rat strain with the Phoenix Micron OCT and Ganzfeld ERG. ... Characterizing a mutant rat strain with the Phoenix Micron OCT and Ganzfeld ERG ...http://www.phoenixreslabs.com/phoenix-micron-cnv-system-used-to-test-a-novel-treatment-for-age-related-macular-degeneration/
Most recent papers with the keyword A2BAR | Read by QxMD
Sprague-Dawley (SD) rats, Dahl salt sensitive (SS) rats and SS mutant rat strains containing a mutation in the A2B adenosine ... Effects of electroacupuncture on the expression of adenosine receptors in the heart tissue of myocardial ischemia rats]. ... Thirty healthy male SD rats were divided randomly into a control group ( n =6), a model group ( n =12) and an EA group ( n =12 ... on the protein expression of adenosine receptors in the heart of the rats with myocardial ischemia (MI). METHODS: ...https://www.readbyqxmd.com/keyword/57718
Metabolic Studies Using Rat as Model Organism sub-cluster 22
A mutant strain of Wistar rats with L-gulono-gamma-lactone oxidase deficiency has recently been established. To investigate ... Three groups of killer rats were used: spontaneous killer rats (K rats) and nonkillers which became killers following para- ... Expression of the mutant gene for L-gulono-gamma-lactone oxidase in scurvy-prone rats. ... in rat liver tissues were investigated after pretreatment with total hepatic ischemia. When the gel filtration of these rats ...http://www.biomedsearch.com/cluster/0/Metabolic-Studies-Using-Rat-as-Model-Organism/sub-22-p7.html
Rat Models for Sex Steroid Action - Michael Soares
The rat is a valuable model for studying physiological processes and i... ... Our characterization of the mutant rat strains will focus on phenotypes associated with the female reproductive tract. Rats ... genome editing to produce rat knock out strains. In this application, we propose to generate and characterize rat models for ... Rat Models for Sex Steroid Action Soares, Michael J. University of Kansas, Kansas City, KS, United States ...http://grantome.com/grant/NIH/R21-OD010478-02
JCI - Welcome
We generated a panel of mutant rat strains in which specific modifications of Shc1. were introduced into the Dahl SS rats. In ... Conversely, deletion of p66Shc from these rats restored the myogenic responsiveness of renal preglomerular arterioles ex vivo ... SS rats, overexpression of p66Shc was linked to increased renal damage. ...https://tgnanke.com.www.mobile.jci.org/tags/31?content=articles&page=2
JCI - Welcome
We generated a panel of mutant rat strains in which specific modifications of Shc1. were introduced into the Dahl SS rats. In ... in rats, but these effects were absent in rats treated with imatinib, another BCR-ABL tyrosine kinase inhibitor. Furthermore, ... In addition, βCys93 mutant mice exhibited adaptive collateralization of cardiac vasculature that mitigated ischemic injury and ... In the monocrotaline rat model of PH, pharmacologic modulation of pulmonary vascular stiffness and YAP-dependent ...https://j8k9.com.www.mobile.jci.org/tags/42?content=articles&page=3
Lessons from the Eker Rat Model: From Cage to Bedside | Bentham Science
Keywords: eker rat, wistar strain, carcinogenesis, cancer genetics, homozygote mutant, tumor suppressor genes ... Keywords:eker rat, wistar strain, carcinogenesis, cancer genetics, homozygote mutant, tumor suppressor genes ... Reidar Eker described one of the earliest examples of an autosomal dominant model of renal tumors in a unique strain of rats. ... Reidar Eker described one of the earliest examples of an autosomal dominant model of renal tumors in a unique strain of rats. ...http://www.eurekaselect.com/62202
KAKEN - Research Projects | The role of reduced expression of glutathione peroxidase gene on the development and progression of...
The Long-Evans Cinnamon (LEC) rat is a mutant strain in which hepatitis and liver cancer spontaneously develop at extremely ... Activation of GSH-Px promoter was found in both cell llines expressing wild-type p53 and mutant p53, indicating that GSH-Px ... We observed marked reduction in the activity of cellular glutathione peroxidase (GSH-Px) in the liver of LEC rats and p53 ... LEC rat / p53 / glutathione peroxidase / hepatitis / グルタチオン・ベルオキシダーゼ. Research Abstract. ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457065/
Acne Models | SpringerLink
Paracortical hyperplasia of superficial lymph nodes in a new mutant strain of hairless rats (ISh): a lesion similar to ... Mann SH (1971) Hair loss and cysts formation in hairless and rhino mutant mice. Anat Rec 170:485-500PubMedGoogle Scholar ... Karasek J (1968) The ultrastructure of the sebaceous gland of the rat. Folia Morphol (Praha) 16:272-276Google Scholar ... Morphometric evaluation by light microscopy in the rat has shown that castration causes a large reduction in the volume of the ...https://link.springer.com/referenceworkentry/10.1007/978-3-642-27728-3_104-1
OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. - Nuffield...
Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting ... Lung, T-Lymphocyte Subsets, T-Lymphocytes, Animals, Rats, Rats, Mutant Strains, Rats, Nude, Graft vs Host Disease, Antigens, ... Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting ...https://www.ndorms.ox.ac.uk/publications/28027
Melinda R. Dwinell, PhD | Associate Professor | Medical College of Wisconsin
... and the development of the Rat Genome Database (RGD). ... Generation of knockout and mutant rat models for physiological ... blood and vasculature and achieved this goal by developing two panels of consomic rat strains and ENU-induced mutant strains ... Rat Genome and Model Resources.. (Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M.) ILAR J. 2017 07 01;58(1):42- ... A Primer for the Rat Genome Database (RGD).. (Laulederkind SJF, Hayman GT, Wang SJ, Smith JR, Petri V, Hoffman MJ, De Pons J, ...https://www.mcw.edu/academic-profiles/melinda-dwinell-phd
Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion...
From our stock of SDRs (Sprague-Dawley rats), we established a mutant strain having small opaque eyes and named it HiSER ( ... Brown Norway rat; GCL, ganglion cell layer; GFAP, glial fibrillary acidic protein; HHR, Hirosaki hairless rat; HiSER, Hirosaki ... Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion ... Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion ...http://www.biochemj.org/content/471/2/293
Strain Report - Rat Genome Database
Strain reports include a comprehensive description of function and biological process as well as disease, expression, ... mutant. Source:. Laboratory Animal Center of Zhengzhou University, Henan Province, China. Origin:. Several rats curled arose ... spontaneously in a closed colony of SD rats maintained at Laboratory Animal Center of Zhengzhou University. a 3 bp deletion at ...https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=10002787
Strain Report - Rat Genome Database
Strain reports include a comprehensive description of function and biological process as well as disease, expression, ... mutant. Source:. PhysGen Knockouts. Origin:. This strain was produced by injecting ZFNs targeting the sequence ... ATCCTGGCCCTGGGTgtgtggGCTGTGGCCCAGCGG into SS/JrHsdMcwi rat embryos. The resulting mutation is a 100-bp mutation deleting part ...https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=5143996
Strain Report - Rat Genome Database
Strain reports include a comprehensive description of function and biological process as well as disease, expression, ... mutant. Source:. MCW Gene Editing Rat Resource Center. Origin:. CRISPR/Cas9 system was used to introduce a mutation in the Spp1 ... gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in Exon 3 of the Spp1 gene.. ...http://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207529
Strain Report - Rat Genome Database
Strain reports include a comprehensive description of function and biological process as well as disease, expression, ... mutant. Source:. PhysGen, Rat Resource and Research Center. Origin:. Male founders are injected with ENU (N-ethyl-N-nitrosourea ...https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1579687