Using rat strains that are resistant or susceptible to Toxoplasma we found that macrophages from resistant rats rapidly die ... We determined the transcriptomes and functional responses of macrophages from recombinant inbred mouse strains that differ in ... We are investigating this co-evolution of ROP5 with these GTPases from different mouse and rat strains with the goal of linking ... Many strains share haploblocks and these strains appear to have formed through recent recombination events. We found that the ...

... and sensitivity in inbred mouse strains ... Although rat models have shown striking adolescent-specific ... Ethanol-dependent rats exhibited heightened sensitivity to CRF and CRF1 antagonists on CeA GABA release. Intra-CeA CRF1 ... Ethanol augments CeA GABA release in ethanol-naive rats and mice. CRF and ethanol augmented CeA GABAergic transmission in naive ... Polymerase chain reaction studies indicate increased expression of CRF and CRF1 in CeA of dependent rats. Chronic CRF1 ...

Thus, for rats that had been alcohol-dependent, Tang et al. (1982) reported "a history of ethanol overindulgence was not a ... Those with inbred metabolic defects could conceivably account for only a small percentage of those who become addicted over ... Moreover, this type of theorizing is badly strained-as are all metabolic theories of addiction-by the commonplace observations ... Rats habituated to morphine in a diverse, social environment refused the drug in the same environment when offered a choice, ...

Belknap, J.K.; Crabbe, J.C.; Young, E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology 1993, ... D rats increased, their alcohol consumption. Opposingly, male 12:12 L:D rats increased, while male 6:6 L:D rats decreased, ... Yoneyama, N.; Crabbe, J.C.; Ford, M.M.; Murillo, A.; Finn, D.A. Voluntary ethanol consumption in 22 inbred mouse strains. ... Comparing voluntary alcohol drinking via the two-bottle choice paradigm across 10-20 inbred mouse strains repeatedly ...

... and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality. Author(s): Dubey JP, Ferreira LR, Martins J, ... Diabetes causes marked changes in function and metabolism of rat neutrophils. Author(s): Alba-Loureiro TC, Hirabara SM, ... Cytotoxicity of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and ... Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 ...

Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains. Pharmacol Biochem Behav (2002) 73(4): ... The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain ... The initiating stimulus depends on context (environmental or learned), location (eye strain, neck strain, and GI), type ( ... neurons display more extensive dendritic arborization in female rats vs. male rats (203). Clinically, hormone fluctuations are ...

Rats[2] Sprague-Dawley and cotton rats are given a single-bolus dose of 10 mg/kg TMC353121 intravenously (i.v.). Blood samples ... Inbred 8- to 12-week-old female BALB/c mice are used. TMC353121 is administered intravenously in saline at doses of 0.25-10 mg/ ... TMC353121 is active against wild-type RSV (strain LO), with a 50% effective concentration (EC50) of 0.07 ng/mL in HeLaM cells[2 ... at room temperature at a volume of 5 mL per Sprague-Dawley rat or 2.5 mL per cotton rat. After gentle injection of the lavage ...

Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice. ... Sex differences in a rat model of risky decision making. Behavioral neuroscience. 130(1):50-61 [DOI] 10.1037/bne0000111. [PMID ... Acute vagus nerve stimulation enhances reversal learning in rats. Neurobiology of learning and memory. 184 [DOI] 10.1016/j.nlm. ... Distinct manifestations of executive dysfunction in aged rats. Neurobiology of aging. 34(9):2164-74 [DOI] 10.1016/j. ...

In inbred mice, genetic strain effects can have significant effects on phenotype. Because of this the following controls for ... Mice and rats. *Gene symbols should be in italics with only the first letter capitalised, e.g. Sox2. ... Please use symbols approved by the International Committee on Standardized Genetic Nomenclature for Mice and the Rat Genome and ... State the breed or strain and source of animals, and give details of age, weight, sex and housing. ...

Mice in genetic researchIn 1909, Clarence C. Little developed the first inbred strain, the DBA (Dilute, brown non-Agouti) mouse ... but to be honest, I do not think he will ever lose that "jump" Also do not let your mouse go near your rat. Rats eat mice, its ... I recommend the larger rat size because it creates a larger platform for the mouse to step on. Step 4 Rat poison is the last ... So I was stuck with 2 rats and a small mouse. I was able to save the mouse but, had I not noticed it would be dead.------Mouse ...

Social deficits, stereotypy and early emergence of repetitive behaviour in the C58/J inbred mouse strain. Behav Brain Res. 2010 ... Acceleration of AMPA receptor kinetics underlies temperature-dependent changes in synaptic strength at the rat calyx of Held. J ... Social approach and repetitive behaviour in eleven inbred mouse strains. Behav Brain Res. 2008;191:118-29. ... Behavioural characterization of the C58 strain at baseline. The natural mutant C58 mouse was chosen as a suitable strain in ...

In the first series of studies, six groups of isolated working rat hearts (n = 6-8 per group) were perfused for 40 minutes with ... In the first series of studies, six groups of isolated working rat hearts (n = 6-8 per group) were perfused for 40 minutes with ... Effects of propionate on mechanical and metabolic performance in aerobic rat hearts.. ... Effects of propionate on mechanical and metabolic performance in aerobic rat hearts. Cardiovascular drugs and therapy, 5 Suppl ...

... diabetes only through interaction with heretofore undefined modifiers in the genetic background of certain inbred strains. Here ... In contrast, treatment with IL-1ra had no effect on the bone density and the bone turnover of sham-operated rats, indicating ... Therefore, we studied the chronic effect of CysA on rat mesenteric artery resistance vessels (ex vivo). CysA (25 mg/kg per d ... The role of cytosolic free Ca2+ ([Ca2+]i) in hypoxic injury was investigated in rat proximal tubules. [Ca2+]i was measured ...

Rats, Inbred F344. Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, ... Mice, Mutant Strains. Orner GA, Dashwood W-M, Blum CA, G Díaz D, Li Q, Dashwood RH. 2003. Suppression of tumorigenesis in the ... Rats. Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, Williams DE et al ... Mice, Inbred C57BL. Orner GA, Dashwood W-M, Blum CA, G Díaz D, Li Q, Dashwood RH. 2003. Suppression of tumorigenesis in the Apc ...

Homozygous inactivation of this gene causes embryonic lethality and extensive developmental defects in inbred strains. In an ... 1 human;1 mouse;1 rat;1 zebrafish. * HCOP. vertebrate homology predictions: POLE4 ... Strain. Gene Model ID. Feature Type. Coordinates. Select Strains. C57BL/6J MGI_C57BL6J_1914229. protein coding gene. Chr6: ...

... line of argument which we took was that we had some strains of mice which we used in cancer research which were highly inbred ... In the course of his presentation on some work with the rat diaphragm in the metabolism of adrenaline, somebody in the back of ...

... - laboratory and animal investigations David Shoseyov ... Highly inbred BN rats (n = 24) were obtained from Harlan. The animals were housed in metal cages in a room with controlled ... The influence of antigen dose on IgE production in different rat strains. Immunology 1979; 36:151-157 ... Late airway responses to antigen challenge in sensitized inbred rats. Am Rev Respir Dis 1988; 137:1033-1037 ...

... inbred) strains of mice and in subsequent studies from other labs C57BL/6 and FVB/N (inbred) strains have been used. We dont ... Unlike rat models, in mice doses lower than 400 mg/100 g were not found effective for induction of acute pancreatitis (Fig 3). ... Rats become slow after the 2nd injection but gradually recover. Animals can be sacrificed from 6 h onward to evaluate changes ... In the rat model of L-arginine- induced pancreatitis, partial inhibition of L-arginase activity, the enzyme which converts L- ...

... infection undetected by dirty-bedding sentinel monitoring and revealed after embryo transfer of an inbred strain derived from ... Efficacy of soiled bedding transfer for transmission of mouse and rat infections to sentinels: a systematic review. PloS one, ... Besselsen, D. G., Wagner, A. M., & Loganbill, J. K. (2000). Effect of mouse strain and age on detection of mouse parvovirus 1 ...

Differences in exercise capacity and responses to training in 24 inbred mouse strains. . Frontiers in Physiology,. 8,. 974. . ... Koch, L.G., Pollott, G.E., & Britton, S.L. (2013). Selectively bred rat model system for low and high response to exercise ... Differences in exercise capacity and responses to training in 24 inbred mouse strains. Frontiers in Physiology, 8, 974. https ... Selectively bred rat model system for low and high response to exercise training. . Physiological Genomics,. 45. (. 14. ), 606 ...

The nomenclature used for Strain Description (0010,0212). See Section C.7.1.1.1.4. ... which includes a snapshot of strains from the International Mouse Strain Resource (IMSR), as children of (C14421, NCIt, "Inbred ... The MGI-Guidelines for Nomenclature of Mouse and Rat Strains recommends the use of the laboratory codes assigned by the ... The strain of an animal (group of animals that is genetically uniform), if known, may be encoded in Strain Description (0010, ...

C57BL/6J is an inbred strain, commonly used as a genetic background when genetically modified mice are utilised as models for ... rats, hamsters, guinea pigs and rabbits to name a few examples. ... It was the first mouse strain to have its genome sequenced, ... This important part of their business includes research animal models such as inbred, outbred, disease and immunodeficiency ...

Animals, Inbred Strains [B01.050.050.199.520] * Rats, Inbred Strains [B01.050.050.199.520.760] * Rats, Inbred ACI [B01.050. ... Rats [B01.050.150.900.649.313.992.635.505.700] * Rats, Inbred Strains [B01.050.150.900.649.313.992.635.505.700.400] * Rats, ... Long-Evans Cinnamon Rats Rats, Inbred Long-Evans Cinnamon Previous Indexing. Rats (1989-1998). See Also. Rats, Long-Evans. ... Rats, Inbred LEC Preferred Concept UI. M0029974. Scope Note. A cinnamon-colored strain of Long-Evans rats which carries a ...

The present study was performed on F2 hybrid mice obtained from breeding 129 germ line chimeras to the inbred strain C57BL/6 as ... Generation of β1 (-/-) mice. SCN1B was cloned from a mouse 129 library (Stratagene, La Jolla, CA) using the full-length rat β1 ... SCN1B was cloned from a mouse 129 library (Stratagene) using the full-length rat β1 cDNA as a probe (Isom et al., 1992). The ... The time course of inward currents at -30 mV or outward currents at +20 mV were similar in the two mouse strains. Finally, the ...

Inbred mice have shown to benefit significantly less from CR interventions than non-inbred mice, with some inbred mice strains ... 14.0 14.1 Swindell, W. (2012). Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype- ... Strains belonging to the lower end of percentage of lifespan extension are often recombinant inbred strains.[14] Other studies ... 2016). Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism, 23(6), 1093-1112. doi: 10.1016 ...

Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions ... Wistar rats (14-week-old, male, 20 rats/group) were fed a powder diet containing 0 or 5 ppm 24R, 25(OH)2D3 for 57 weeks. Final ... Female Wistar rats were exposed orally to 200 and 400 ppm propineb (Zn-containing dithiocarbamate) and 250 ppm maneb (Mn- ... PLN cellularity indices were determined on day 7. In the three strains tested, the penicillin G and D-penicillamine injections ...

Highly susceptible mouse strains such as SJL/N, A.SW, B10.S (H-2s) develop multiple autoimmune manifestations after exposure to ... I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin Immunol ... The antigen proteins were obtained from rat liver nuclei [20], and the proteins were separated by 15% SDS-PAGE. Preparations ... mercury toxicokinetics differ among inbred mouse strains. As Nielson and Hultman [52] demonstrated, there is a correlation ...

In mice, for example, classic genetic studies of inbred strains have estimated that the development of neuropathic pain is ... Using rats with an experimentally induced nerve injury, they have shown that drugs that do not normally reinforce behavior can ... 2. Genetic determinants of pain; inbred strain studies; haplotype maps*. 08:33 ... Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image ...

Inbred strain Mouse. C57BL/6NJcl. Origin. In 1921, Littel obtained mice from Lathrop and named a strain of mice that was ... For Mice,Rats,And Hamsters. *Diet For Mice And Rats Used In Diabetes And Obesity Studies ... The sixth subline of C57BL, i.e., C57BL/6, was introduced to the Jackson Laboratory to form the C57BL/6J strain. C57BL/6J mice ... "This substrain is at least (a number>20 by definition) generations removed from the originating JAXR Mice strain and has NOT ...