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*  Typ 2-diabetes | Svensk MeSH
Rats, Inbred OLETF. *Metabolic Syndrome. Svenska synonymer. Diabetes mellitus, icke-insulinberoende - Diabetes, icke- ...
https://mesh.kib.ki.se/term/D003924
*  List of MeSH codes (B01) - Wikipedia
... rats, inbred lec MeSH B01.050.157.760.280 --- rats, inbred lew MeSH B01.050.157.760.290 --- rats, inbred oletf MeSH B01.050. ... rats, inbred lec MeSH B01.050.199.520.760.280 --- rats, inbred lew MeSH B01.050.199.520.760.290 --- rats, inbred oletf MeSH ... rats, inbred aci MeSH B01.050.157.760.090 --- rats, inbred bb MeSH B01.050.157.760.110 --- rats, inbred bn MeSH B01.050.157.760 ... rats, inbred aci MeSH B01.050.199.520.760.090 --- rats, inbred bb MeSH B01.050.199.520.760.110 --- rats, inbred bn MeSH B01.050 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)
*  Combinations of Nondiabetic Parental Genomes Elicit Impaired Glucose Tolerance in Mouse SMXA Recombinant Inbred Strains |...
These studies have used the GK rat (7), the OLETF rat (7), the NSY mouse (8), the NZO mouse (9), the TSOD mouse (10), the KK-Ay ... Recombinant inbred (RI) strains are derived by inbreeding different sets of F2 progeny from a cross between two inbred strains ... Recombinant inbred (RI) strains are a powerful tool for analyzing not only single genetic traits but also multifactorial ... Inbred strains are genetically homogeneous, and the genetic and environmental components can be strictly controlled in the ...
http://diabetes.diabetesjournals.org/content/52/1/180
*  Biology of Obesity: Lessons from Animal Models of Obesity
K. Kawano, T. Hirashima, S. Mori, and T. Natori, "OLETF (Otsuka Long-Evans Tokushima fatty) rat: a new NIDDM rat strain," ... D. B. West, C. N. Boozer, D. L. Moody, and R. L. Atkinson, "Dietary obesity in nine inbred mouse strains," American Journal of ... L. M. Zucker and T. F. Zucker, "Fatty, a new mutation in the rat," Journal of Heredity, vol. 52, no. 6, pp. 275-278, 1961. View ... G. A. Bray, "The Zucker fatty rat: a review," Federation Proceedings, vol. 36, no. 2, pp. 148-153, 1977. View at Google Scholar ...
https://www.hindawi.com/journals/bmri/2011/197636/ref/
*  A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat
OLETF) rat [2], Spontaneously Diabetic Torii (SDT) rat [3], SDT fatty rat [4], Wistar fatty rat [5], Zucker diabetic fatty (ZDF ... The ZDF strain is an inbred rat model of early-onset diabetes in which all of the fa/fa male rats develop diabetes at 10 to 12 ... rats at 6 weeks of age (fa/fa ng/mL versus +/+ ng/mL, ) and that in fa/fa rats was increased until 20 weeks of age (fa/fa ng/mL ... these include the SDT fatty rat, WBN/Kob fatty rat [13], Wistar fatty rat, ZDF rat, and the Zucker fatty (ZF) rat [14], all of ...
https://www.hindawi.com/journals/jdr/2013/103731/
*  Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review |...
Neuronal nitric oxide synthase and cyclooxygenase-2 in diabetic nephropathy of type 2 diabetic OLETF rats. Exp Anim Tokyo. 2006 ... Chen SM, Mukoyama T, Sato N, Yamagata SI, Arai Y, Satoh N, Ueda S: Induction of nephrotoxic serum nephritis in inbred mice and ... Macpherson BR, Pfeiffer CJ: Experimental Production of Diffuse Colitis in Rats. Digestion. 1978, 17 (2): 135-150.PubMedGoogle ... Ahmadi-Yazdi C, Williams B, Oakes S, Moore FD: Attenuation of the Effects of Rat Hemorrhagic Shock with a Reperfusion Injury- ...
https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-9-123
*  Role of endothelium in the response to endothelin in hypertension. - Semantic Scholar
... in WKY rat aortic rings. The reduced endothelium-dependent relaxation in response to ACh in the WKY rat probably reflects the ... The release of EDRF by endothelin is less in SHRSP than it is in WKY rats. Because of this failure of endothelin to release ... In aortas from WKY rats but not in those from SHRSP, the contraction produced by endothelin was augmented when the intact ... Treatment with indomethacin (5 x 10(-6) M) had no effect on endothelin-induced contraction in either WKY rat or SHRSP aortic ...
https://www.semanticscholar.org/paper/Role-of-endothelium-in-the-response-to-endothelin-Wu-Bohr/ed0c4fe89d428ec6d81294c3dd000384c94a6fab
*  Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice |...
OLETF) rats, which were fed a non-physiological choline-deficient L-amino acid-defined diet [16, 18]. In our representative HF- ... in contrast with the inbred C57BL/6 J mouse strain we used for our experiments) on treatment outcome. Very little is known ... attenuates the liver fibrosis development of non-alcoholic steatohepatitis in the rat. BMC Res Notes. 2009;2:70.View Article ... Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis. J Gastroenterol Hepatol ...
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-017-0432-7
*  成果報告
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.. Exp Anim. 2015 Feb 5;64(1):25-9. ... Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat.. Exp Diabetes Res. 2012;2012:582546. Epub 2012 Oct ... NBRP-Rat: The worldwide rat resource center. The XVIIIth International Workshop on Genetic Systems in the Rat(京都市)2010.11.30- ... Stress-reactive rats (high-avoidance female rats) have a shorter lifespan than stress-nonreactive rats (low-avoidance female ...
http://www.anim.med.kyoto-u.ac.jp/nbr/publications_jp.aspx
*  Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats, Mammalian...
"Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats, Mammalian ... Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus ... G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat ... Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse ...
https://www.deepdyve.com/lp/springer_journal/mapping-diabetes-qtl-in-an-intercross-derived-from-a-congenic-strain-iZZAC8mVik
*  Plus it
Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun ... Each subsequent generation was stratified and bred in a similar fashion with precaution being taken to minimize inbreeding (,1 ... LCR rats were already 100 grams heavier than HCR rats (P , 0.001; Fig. 2A). At 6 mo, LCR rats were still heavier than HCR rats ... 1 showed HCR rats from generation 13 had a ninefold greater run distance to exhaustion than LCR rats (P , 0.001). LCR rats were ...
http://ajpendo.physiology.org/content/293/1/E31
*  Takatoshi Murase
OLETF) rats. Yutaka Mori. Department of Internal Medicine, National Hospital Organization, Utsumomiya National Hospital, ... inbred balb c mice*plant extracts*tea*oxygen consumption*running*swimming*fatty liver*nonesterified fatty acids*obesity*body ... Digestion and assimilation features of dietary DAG in the rat small intestine. Hidehiko Kondo. Biological Science Laboratories ... Dietary phospholipids ameliorate fructose-induced hepatic lipid and metabolic abnormalities in rats. Takuya Mori. Biological ...
https://www.labome.org/expert/japan/kao/murase/takatoshi-murase-204751.html
*  Plus it
Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. ... At the N15 generation, line N3 was backcrossed to the inbred WF/NHsd strain and refixed at the N16 generation for the Mcs1bCOP ... We have mapped rat Mcs1b to a 1.8 Mb region of rat chromosome 2 using multiple congenic lines. We found that rat Mcs1b is ... Rat Mcs1b-resistant genotype is associated with higher body weight and rat/human MIER3/MIER3 levels are higher in rat mammary ...
http://cancerres.aacrjournals.org/content/72/22/6002
*  2018-6-5 Koterov rus
I. The effects in inbreeding on the growth and variability in the body weight of the albino rat // J. Exp. Zool. 1918. Vol. 26 ... High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats // Amer. J ... Donaldson H.H. The rat. Reference tables and data for the albino rat (Mus norwegicus albinos) and the Norway rat (Mus ... Rat Genome Database // Site Medical College of Wisconsin 'Bioinformatics Research Center'. 'Gene Editing Rat Research Centre'. ...
http://medradiol.ru/ru/vypuski?id=834
*  Experimental Diabetes Mellitus in Different Animal Models
This type 2 diabetes (T2D) model originates from Wistar (W) rat established by repeated inbreeding with Wistar (W) rats at the ... "Examination of the pathogenesis of diabetic nephropathy in OLETF rats," Journal of Veterinary Medical Science, vol. 61, no. 11 ... rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and ... 3. BB Rats. This type of rat was derived from outbred Wistar rats. Firstly, spontaneous autoimmune diabetes was identified in ...
https://www.hindawi.com/journals/jdr/2016/9051426/
*  Frontiers | Obesity in the Otsuka Long Evans Tokushima Fatty Rat: Mechanisms and Discoveries | Nutrition
Understanding the neural systems underlying the controls of energy balance has been greatly advanced by identifying the deficits and underlying mechanisms in rodent obesity models. The current review focuses on the Otsuka Long Evans Tokushima Fatty (OLETF) rat obesity model. Since its recognition in the 1990's significant progress has been made in identifying the causes and consequences of obesity in this model. Fundamental is a deficit in the cholecystokinin (CCK) 1 receptor gene resulting in the absence of CCK 1 receptors in both the gastrointestinal track and the brain. OLETF rats have a deficit in their ability to limit the size of meals and in contrast to CCK1 receptor knock-out mice, do not compensate for this increase in the size of their spontaneous meals, resulting in hyperphagia. Prior to becoming obese and in response to pair feeding, OLETF rats have increased expression of neuropeptide Y (NPY) in the compact ...
https://www.frontiersin.org/articles/10.3389/fnut.2016.00021/full
*  Most recent papers with the keyword Cholesterol consumption | Read by QxMD
BACKGROUND: Obesity and type 2 diabetes (T2D) increase fracture risk; however, the association between obesity/T2D may be confounded by consumption of a diet high in fat, sucrose, and cholesterol (HFSC). OBJECTIVE: The study objective was to determine the main and interactive effects of obesity/T2D and a HFSC diet on bone outcomes using hyperphagic Otuska Long Evans Tokushima Fatty (OLETF) rats and normophagic Long Evans Tokushima Otsuka (LETO) controls. METHODS: At 8weeks of age, male OLETF and LETO rats were randomized to either a control (CON, 10 en% from fat as soybean oil) or HFSC (45 en% from fat as soybean oil/lard, 17 en% sucrose, and 1wt%) diet, resulting in four treatment groups ...
https://www.readbyqxmd.com/keyword/63862
*  Most recent papers with the keyword Loading on long bones | Read by QxMD
BACKGROUND: Obesity and type 2 diabetes (T2D) increase fracture risk; however, the association between obesity/T2D may be confounded by consumption of a diet high in fat, sucrose, and cholesterol (HFSC). OBJECTIVE: The study objective was to determine the main and interactive effects of obesity/T2D and a HFSC diet on bone outcomes using hyperphagic Otuska Long Evans Tokushima Fatty (OLETF) rats and normophagic Long Evans Tokushima Otsuka (LETO) controls. METHODS: At 8weeks of age, male OLETF and LETO rats were randomized to either a control (CON, 10 en% from fat as soybean oil) or HFSC (45 en% from fat as soybean oil/lard, 17 en% sucrose, and 1wt%) diet, resulting in four treatment groups ...
https://www.readbyqxmd.com/keyword/32793
*  Oral administration of green algae, Euglena gracilis, inhibits hyperglycemia in OLETF rats, a model of spontaneous type 2...
In the present study, the effects of Euglena and paramylon on hyperglycemia were examined in Otsuka Long-Evans Tokushima fatty (OLETF; type 2 diabetes mellitus model) rats. OLETF rats were fed an AIN-93 M diet containing cellulose, Euglena, or paramylon for 10 weeks. Long-Evans Tokushima Otsuka (LETO) rats w
http://pubs.rsc.org/en/Content/ArticleLanding/FO/2016/C6FO00606J
*  An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Masanori Nozako, Takashi Koyama, Chifumi Nagano, Makoto Sato, Satoshi Matsumoto, Kiminobu Mitani, Reiko Yasufuku, Masayuki Kohashi, Tomohiro Yoshikawa].
http://www.sigmaaldrich.com/catalog/papers/26606054
*  Role of cholecystokinin (CCK)-A receptor for pancreatic growth after weaning: a study in a new rat model without gene...
This work extends a recent observation that Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of non-insulin-dependent diabetes mellitus, show no expression of the cholecystokinin (CCK)-A receptor gene in the pancreas. The CCK-A receptor is known to be in...
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART00001743
*  Pharma Marketing Blog: Male Otsuka UK Marketing Executive's Behavior Worse Than Bill Cosby's: Has Women Subordinates Provide...
The complainant stated that he/she went from the private function area at a hotel where dinner had been held to the public hotel bar and noticed three Otsuka employees. Descriptions were provided. A female health professional, who the complainant remembered as being very drunk at the dinner, subsequently entered the bar and started talking to the Otsuka employees. Although she was obviously intoxicated a male Otsuka employee continued to ply her with drinks; his two female colleagues seemed unhappy with this" (see "AUTH/2752/3/15 - Anonymous v Otsuka ...
http://pharmamkting.blogspot.com/2015/06/male-otsuka-uk-marketing-executives.html
*  Plus it
These results show that in short-access, two-bottle preference tests prediabetic OLETF rats exhibit a markedly enhanced preference for sucrose compared with nonmutant LETO rats. We also show that OLETF rats consumed more sucrose than LETO rats in the absence of gastric or intestinal feedback stimulation. Finally, OLETF rats were less responsive to the inhibitory effects of intraduodenal infusion of sucrose compared with LETO rats. To our knowledge, these are the first studies to demonstrate an altered preference for sucrose in the CCK-A receptor-deficient rat using two different paradigms: the short-access, two bottle test and sham feeding preparation.. Intake and preference for sucrose in rats have been shown to depend on solution concentration (17). In our short-access tests, OLETF as well as LETO rats ...
http://ajpregu.physiology.org/content/288/1/R292
*  α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase | Arteriosclerosis,...
Defective endothelium-dependent vascular relaxation is an early event in the development of atherosclerosis.19 We confirmed that endothelium-dependent vascular relaxation is impaired in obese OLETF rats20,21 and found that this impairment is associated with increased lipid accumulation and apoptosis and decreased NO synthesis and AMPK activities in endothelial cells. All of these alterations in endothelial cells and vascular dysfunction were substantially improved by ALA treatment.. Our previous study demonstrated strong anorexic effects of ALA in normal and obese rodents.7 In the present study, ALA reduced food intake (data not shown) and normalized body weight in OLETF rats. In addition, all of the metabolic changes (FFA, triglycerides, insulin, etc) observed in OLETF rats were normalized by ALA. The normalization of metabolic parameters seemed to be attributable to the reduction in food intake because it ...
http://atvb.ahajournals.org/content/25/12/2488
*  Dr. Norman Otsuka, MD - Bronx, NY - Orthopedic Surgery | Healthgrades.com
Visit Healthgrades for information on Dr. Norman Otsuka, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
https://www.healthgrades.com/physician/dr-norman-otsuka-yf3pt