Development of Heart Failure in Chronic Hypertensive Dahl Rats | Hypertension
Characterization of new inbred strains of Dahl-Iwai salt-sensitive and salt-resistant rats. Lab Anim Sci. 1994; 44: 462-467. ... Eighty Dahl salt-sensitive rats were fed either a high-salt (HS) or low-salt (LS, controls) diet starting at age 7 weeks. ... Tsunooka K, Morita H. Effect of a chronic high-salt diet on whole-body and organ sodium contents of Dahl rats. J Hypertens. ... Development of Heart Failure in Chronic Hypertensive Dahl Rats. Stefan Klotz, Ilan Hay, Geping Zhang, Mathew Maurer, Jie Wang ...http://hyper.ahajournals.org/content/47/5/901
Find Research Projects - Augusta University
Inbred Dahl Rats Salts Hypertension Kidney Role of NF-kB in Fas-mediated Apoptosis and Tumor Suppression. Liu, K. ...https://augusta.pure.elsevier.com/en/projects/
Chlamydia pneumoniae Accelerates Coronary Artery Disease Progression in Transgenic Hyperlipidemia-Genetic Hypertension Rat Model
... transgenic-CAD Dahl salt-sensitive (S) hypertensive (Tg53) rats and control inbred, non-transgenic Dahl S (nonTg) rats to ... high triglyceride on regular rat chow (17). All test and control rats are inbred Dahl S strain, thus eliminating genetic ... Transgenic Rat Model of Coronary Atherosclerosis We used an inbred transgenic rat model of coronary atherosclerosis with ... we infected Tg53 rats (n = 4) and control nontransgenic Dahl S rats (n = 3) with 1 × 107 ifu of purified infectious Cpn. No ...http://pubmedcentralcanada.ca/pmcc/articles/PMC1430827/
A mutation in the start codon of γ-crystallin D leads to nuclear cataracts in the Dahl SS/Jr-Ctr strain, Mammalian Genome | 10...
"A mutation in the start codon of γ-crystallin D leads to nuclear cataracts in the Dahl SS/Jr-Ctr strain, Mammalian Genome" on ... Strain designations for inbred Dahl salt sensitive and inbred salt resistant rats ... Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats ... Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat ...https://www.deepdyve.com/lp/springer_journal/a-mutation-in-the-start-codon-of-crystallin-d-leads-to-nuclear-7lEROMly04
Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction |...
Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension ... to Dahl salt-sensitive rats results in the progressive development of hypertrophy and diastolic dysfunction. When Dahl salt- ... A progressive increase in GLUT1 expression was seen in Dahl salt-sensitive rat hearts during the HSD (Fig. 3a and b). Since ... This was examined using the Dahl salt-sensitive rat, a well characterized model of HFpEF (Horgan et al. 2014; Rapp and Dene ...https://link.springer.com/article/10.1186/s10020-018-0005-x
Neither the New Zealand Genetically Hypertensive Strain nor Dahl Salt-Sensitive Strain Has an A1079T Transversion in the α1...
A putative 1079A→T mutation in the α1 isoform of the Na+, K+-ATPase (Atp1a1) gene of the Dahl salt-sensitive rat inbred by John ... 23 Genomic DNA from 11 SS/Jr rats, 7 SR/Jr rats, 2 GH rats, 1 BN rat, 1 WKY rat, 1 SHR, 1 DRY rat, and 1 Lewis rat was assayed ... 61644, SS/Jr; (6) RAT No. 62869, SS/Jr; (7) RAT No. 35315, SR/Jr; (8) RAT No. 34581, SR/Jr; (9) RAT No. 63335, SS/Jr; (10) RAT ... 61644, SS/Jr; (3) RAT No. 62869, SS/Jr; (4) RAT No. 35315, SR/Jr; (5) RAT No. 34581, SR/Jr; (6) RAT No. 63335, SS/Jr; (7) RAT ...http://hyper.ahajournals.org/content/38/4/786
A genetic locus (Hyp-2) controlling vascular smooth muscle response in spontaneously hypertensive rats. | Hypertension
The SHR were crossed with Dahl salt-resistant rats that had been inbred for 21 generations (R/JR strain) to produce F1, F2, and ... In F2 rats there was a bimodal distribution segregating three intermediate type: one R/JR type. In F2 rats there was a ... A genetic locus (Hyp-2) controlling vascular smooth muscle response in spontaneously hypertensive rats.. J P Rapp ... Aortic vascular smooth muscle from spontaneously hypertensive rats (SHR) is known to respond in vitro to nonphysiologic cations ...http://hyper.ahajournals.org/content/4/4/459
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats | Protocol
This manuscript describes in vitro video microscopy protocols for evaluating vascular function in rat cerebral resistance... ... including the Dahl salt-sensitive (SS) rat-an inbred rat strain that is the most widely used experimental model to study the ... In the consomic rat panels, every chromosome from the Brown Norway rat has been introgressed individually into the Dahl SS24,25 ... from male Dahl SS rats and SS.5BN consomic rats carrying chromosome 5 (containing Brown Norway genes for various isoforms of ...https://www.jove.com/video/56133/evaluation-vascular-control-mechanisms-utilizing-video-microscopy
Progression of Glomerular Filtration Rate Reduction Determined in Conscious Dahl Salt-Sensitive Hypertensive RatsNovelty and...
Pressure natriuresis and cortical and papillary blood flow in inbred Dahl rats. Am J Physiol. 1991;261(3 pt 2):R595-R602. ... Prevention with thiazide of NaCl-induced hypertension in Dahl S rats. Evidence for a Na-retaining humoral agent in S rats. ... Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension. 2001;37(2 pt 2):456-461. ... Male Dahl SS rats (SS/JrHsdMcwi) were obtained as weanlings from colonies maintained at the Medical College of Wisconsin since ...http://hyper.ahajournals.org/content/62/1/85
Candidate Genes in the Regulation of Na+ Transport by Inner Medullary Collecting Duct Cells From Dahl Rats | Hypertension
Inbred strains of Dahl salt-sensitive (Dahl SS/Jr), salt-resistant (Dahl SR/Jr), and congenic rats were bred at the University ... IMCD cells cultured from Dahl S rats absorb more Na+ than Dahl R rats. Am J Physiol. 1996;271:F1029-F1036. ... Roman RJ, Kaldunski M. Pressure natriuresis and cortical and papillary blood flow in inbred Dahl rats. Am J Physiol. 1991;261: ... S and R rats were crossed, and the resulting F1 rats were backcrossed to S. Rats heterozygous for genetic markers at the 11β- ...http://hyper.ahajournals.org/content/31/2/608
Find a Model | Charles River
Dahl/Salt Sensitive Rat Ideal For. Hypertension, diastolic heart failure, nephropathy Specie Types ...https://www.criver.com/products-services/find-model?f%5B0%5D=therapeutic_area%3A3516
Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension
... and calcium channel receptors in inbred Dahl hypertension-sensitive (S/JR) and hypertension-resitant (R/JR) rats," American ... "Differential sensitivity of Dahl salt-sensitive and Dahl salt-resistant rats the hypotensive action of acute nifedipine ... S. Kazda, B. Garthoff, J. Dycka, and J. Iwai, "Prevention of malignant hypertension in salt loaded "S" Dahl rats with the ... J. Nedvidek and J. Zicha, "Age-dependent changes of baroreflex efficiency in Dahl rats: effects of high salt intake," ...https://www.hindawi.com/journals/bmri/2017/8029728/ref/
Renal arteriolar Na+/Ca2+ exchange in salt-sensitive hypertension.
Rats, Rats, Inbred Dahl, Renal Circulation, Sodium Chloride, Sodium-Calcium Exchanger, Tetradecanoylphorbol Acetate ... PMA increased Delta[Ca2+]i in afferent arterioles from R rats but not from S rats. These results suggest that Na+/Ca2+ exchange ... rats. Renal arterioles were obtained by microdissection from S and R rats on either a low-salt (0.3% NaCl) or high-salt (8.0% ... in afferent arterioles from R rats fed the low- and high-salt diet, respectively. In afferent arterioles from S rats on a high- ...http://scholars.uab.edu/display/pub23574
Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an...
For the studies described here, the Dahl Salt-Sensitive (SS/JrHsdMcwi) hypertensive rat strain was used. The SS rat is a ... naturally occurring inbred genetic model of salt-sensitive hypertension that recapitulates many aspects of progressive human ... Mattson, D. L., et al. Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension ... 1. Isolation of the Rat Aorta. *Anesthetize rats with isoflurane (5% induction, 1.5 to 2.5% maintenance) or another IACUC ...https://www.jove.com/video/52734/two-photon-imaging-intracellular-ca2-handling-nitric-oxide-production
List of MeSH codes (B01) - Wikipedia
... rats, inbred bn MeSH B01.050.157.760.130 --- rats, inbred buf MeSH B01.050.157.760.165 --- rats, inbred dahl MeSH B01.050. ... rats, inbred bn MeSH B01.050.199.520.760.130 --- rats, inbred buf MeSH B01.050.199.520.760.165 --- rats, inbred dahl MeSH ... rats, inbred strains MeSH B01.050.157.760.080 --- rats, inbred aci MeSH B01.050.157.760.090 --- rats, inbred bb MeSH B01.050. ... rats, inbred lec MeSH B01.050.157.760.280 --- rats, inbred lew MeSH B01.050.157.760.290 --- rats, inbred oletf MeSH B01.050. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)
MGI - Inbred Strains: OXYS
Inbred Strains of Rats: OXYS. OXYS Inbr.F>75. Colour: Albino. Genet. c. Origin: Developed in 1972 at the Institute of Cytology ... However, since this S symbol has previously been used to designate the Dahl Salt Sensitive strain the symbol assigned to the ... INBRED STRAINS OF RATS. Updated 9 Apr. 1998. Michael FW Festing. MRC Toxicology Unit, Hodgkin Building,. University of ... Solovyova N. A., Morozkova T. S., and Salganik R. I. (1975) Development of the inherited galactosemia symptoms in rats. ...http://www.informatics.jax.org/inbred_strains/rat/docs/OXYS.shtml
Sex differences in primary hypertension | Biology of Sex Differences | Full Text
This is a robust and highly conserved sex difference that it is also observed across species including dogs, rats, mice and ... When these rats were backcrossed onto the Lewis inbred strain creating the congenic mRen2.Lewis rat, the hypertension was less ... Dahl LK, Knudsen KD, Ohanian EV, Muirhead M, Tuthill R: Role of the gonads in hypertension-prone rats. J Exp Med 1975, 142: 748 ... rats (SD+Aldo) a and L-NAME-treated Wistar rats (W+L-NAME) c. Salt-sensitive models include SD rats maintained on a 1% ...https://bsd.biomedcentral.com/articles/10.1186/2042-6410-3-7
Trophoblast Differentiation - Michael Soares
The BN inbred rat has restricted trophoblast cell invasion and has been used to generate consomic rat strains with the Dahl SS ... inbred rat and BN consomic rat strains. Maternal hypoxia during critical phases of placentation can activate the invasive ... Dhakal, Pramod; Soares, Michael J (2017) Single-step PCR-based genetic sex determination of rat tissues and cells. ... 2 is on investigating mechanisms underlying BN rat trophoblast cell invasion defects. We assert that intrauterine trophoblast ...http://grantome.com/grant/NIH/R01-HD020676-22
High dietary salt does not significantly affect plasma 25-hydroxyvitamin D concentrations of Sprague Dawley rats | BMC Research...
... but not the Dahl salt-resistant rat, develops hypertension and hypovitaminosis D when fed a high salt diet. Since the salt- ... sensitive rat and salt-resistant rat were bred from the Sprague Dawley rat, the aim of this research was to test the hypothesis ... The salt-sensitive rat, thus, appears to be a more appropriate model than the Sprague Dawley rat for assessing possible effects ... These data indicate that the effect of high salt intake on the vitamin D endocrine system of Sprague Dawley rats at week 3 was ...https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-3-332
Renal Physiology | Research Areas | Physiology | Medical College of Wisconsin
Experimental models include various strains of inbred and genetically manipulated rats and mice.. Another research focus is the ... hypertension resulting from the introgression of chromosome 13 from a normal Brown Norway rat into a Dahl salt-sensitive rat. ... and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. ...https://www.mcw.edu/departments/physiology/research/content/research-areas/renal-physiology
Hypertension Suppression, Not a Cumulative Thrust of Quantitative Trait Loci, Predisposes Blood Pressure Homeostasis to...
MAP of Dahl salt sensitive rats (DSS) minus Lewis is ≈80 mm Hg as underlined and in bold on the y axis. The actual MAPs for ... Inbred Lewis rats sustain normotension despite a genetic push in altering BP. It was unknown whether this rigid resistance to ... Indeed, BP of BC3 rats turned sharply higher than that of BC2 rats (Figure III in the Data Supplement). Because each rat in BC2 ... α-Kinase 2 is a novel candidate gene for inherited hypertension in Dahl rats. J Hypertens. 2011;29:1320-1326. doi: 10.1097/HJH. ...http://circgenetics.ahajournals.org/content/8/4/610
Genetic Isolation of a Chromosome 1 Region Affecting Blood Pressure in the Spontaneously Hypertensive Rat | Hypertension
Wistar-Kyoto rats,6 and in a series of recombinant inbred strains derived from SHR×BN-Lx rats.7 ... Genetic contamination of Dahl SS/Jr rats: impact on studies of salt-sensitive hypertension. Hypertension.. 1994;23:786-790. ... Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J ... SA gene and blood pressure cosegregation using Dahl salt-sensitive rats. Am J Hypertens.. 1996;6:330-334. ...http://hyper.ahajournals.org/content/30/4/854
Evidence for protein 4.1B acting as a metastasis suppressor | Journal of Cell Science
The use of inbred rats further helped to reduce heterogeneity. Thus, we were able to focus on the genetic differences ... Gutmann, D. H., Hirbe, A. C., Huang, Z. Y. and Haipek, C. A. (2001). The protein 4.1 tumor suppressor, DAL-1, impairs cell ... Second, the use of inbred rats for the model provides both a uniform genetic background, reducing the `noise' in the microarray ... Sarcoma model of metastasis developed in inbred LEWIS rats and the characterisation of four cell populations. We developed a ...http://jcs.biologists.org/content/120/4/606
... from the inbred BN rat was substituted one at a time into the homogeneous background of the inbred SS rat. In this case, BN and ... The parental strains of rats used in this study, Dahl salt-sensitive (SS/JrHsdMcwi) and Brown Norway (BN/NHsdMcwi) rats, ... A widely used approach to addressing these issues is the use of inbred rat strains, since the rat is a well-recognized model ... rat onto the homogeneous genetic background of the Dahl salt-sensitive rat (SS/JrHsdMcwi). For 3 wk before the experiment, the ...http://physiolgenomics.physiology.org/content/26/3/218
Interferon gamma attenuates hypertensive renal injury in salt-sensitive Dahl rats. | Hypertension
Evidence has been provided that the immunological mechanism is involved in the genesis or maintenance of hypertension. In the present study, we investigated the effects of interferon gamma, a potent immunomodulator derived from lymphocytes, on hypertension and organ damage in Dahl salt-sensitive rats and in spontaneously hypertensive rats. Subcutaneous injection of interferon gamma (5 x 10(4) units/kg body wt once a week for 10 weeks) reduced blood pressure in Dahl salt-sensitive rats fed a 4% high salt diet (174 versus 194 mm Hg, p less than 0.025). This blood pressure reduction was associated with an improvement of renal functions, an increase in glomerular filtration rate (690 versus 569 ml/day/100 g body wt, p less than 0.05), and decreases in urinary protein excretion (48 versus 78 mg/day/100 g body wt, p less than 0.025) and urinary N-acetyl-beta-D-glucosaminidase excretion (143 versus 183 milliunits/day/100 g body wt, ...http://hyper.ahajournals.org/content/19/6_Pt_2/804