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*  Assessment of PCR Multiplex Tests as a Tool to Obtain a Quicker Diagnosis of Bacteria Responsible for Foot Osteomyelitis Than...
Rats, Inbred Bb. A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES ... Different bone sites-specific response to diabetes rat models: Bone density, histology and microarchitecture. ...
https://www.bioportfolio.com/resources/trial/200003/Assessment-of-PCR-Multiplex-Tests-as-a-Tool-to-Obtain-a-Quicker.html
*  Effect of NN5401 in Japanese Subjects With Type 1 Diabetes
Rats, Inbred Bb. A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES ...
https://www.bioportfolio.com/resources/trial/68851/Effect-of-NN5401-in-Japanese-Subjects-With-Type-1-Diabetes.html
*  "A regulatory CD4+ T cell subset in the BB rat model of autoimmune diab" by Jan-Luuk Hillebrands, Barbara J. Whalen et al.
... rats model type 1 autoimmune diabetes (T1D). BB diabetes-prone (BBDP) rats develop T1D spontaneously. BB diabetes-resistant ( ... In BBDR and control Wistar Furth rats, CD25+ T cells comprised 5-8% of CD4+ T cells. In vitro, rat CD4+CD25+ T cells were ... We conclude that CD4+CD25+ cells in the BBDR rat act in vitro and in vivo as natural Tregs. In addition, another population ... Adoptive transfer of purified CD4+CD25+ BBDR T cells to prediabetic BBDP rats prevented diabetes in 80% of recipients. ...
https://escholarship.umassmed.edu/oapubs/1080/
*  "BB rat thymocytes cultured in the presence of islets lose their abilit" by Barbara J. Whalen, Jan Marounek et al.
We conclude that islet antigens involved in the initiation of autoimmune diabetes in BB rats may be absent or deficient in BB ... It is also known that the development of BB rat T-cells is recapitulated in adult thymus organ cultures (ATOCs). Based on these ... We observed that cells recovered from adult diabetes-resistant BB (BBDR) rat thymi cultured for up to 14 days can adoptively ... rat thymi. Exposure of ATOCs to exogenous islets may lead to deletion or anergy of diabetogenic T-cells or to the positive ...
https://escholarship.umassmed.edu/oapubs/484/
*  "Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the" by Karen E. Ellerman and Arthur A. Like
BB rat T-cell lines activated in vitro with antigen-presenting cells (APC) and BB islet cell crude membranes (CM), but not ... to naive syngeneic or MHC class II-compatible rats with islet cell-activated T-cell lines derived from diabetic BB/Wor rats. ... rat, type 1 diabetes develops spontaneously with an incidence of ,90%. BB diabetes can be adoptively transferred ... We conclude that a major CD4+ T-cell target autoantigen in BB diabetes is a membrane-associated beta-cell molecule with the ...
https://escholarship.umassmed.edu/oapubs/485/
*  List of MeSH codes (B01) - Wikipedia
... rats, inbred aci MeSH B01.050.157.760.090 --- rats, inbred bb MeSH B01.050.157.760.110 --- rats, inbred bn MeSH B01.050.157.760 ... rats, inbred aci MeSH B01.050.199.520.760.090 --- rats, inbred bb MeSH B01.050.199.520.760.110 --- rats, inbred bn MeSH B01.050 ... rats, inbred buf MeSH B01.050.157.760.165 --- rats, inbred dahl MeSH B01.050.157.760.200 --- rats, inbred f344 MeSH B01.050. ... rats, inbred lew MeSH B01.050.157.760.290 --- rats, inbred oletf MeSH B01.050.157.760.300 --- rats, inbred shr MeSH B01.050. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)
*  "Adoptive transfer of autoimmune diabetes and thyroiditis to athymic ra" by Una McKeever, John P. Mordes et al.
... and diabetes-resistant BB strains, and in diabetes-prone BB rats. Adoptive transfer was facilitated by prior in vivo depletion ... Lymphocytes with these capabilities were found in normal rats of the YOS, WAG, PVG, ... that organ-specific autoreactive cells may be present to various degrees but suppressed to a variable extent in many rat ... and thyroiditis in athymic rats following injections of major histocompatibility complex compatible spleen cells. ...
https://escholarship.umassmed.edu/oapubs/1828/
*  "Role of the Intestinal Immune System in the Pathogenesis of Autoimmune" by Derrick James Todd
The cause of autoimmune diabetes in BB rats and humans is still unknown, but both genetic and environmental factors appear to ... BBDP rats spontaneously develop autoimmune diabetes mellitus and are severely deficient in peripheral T cells. BBDR rats do not ... The yield of rat IELs using this method is 5-10 fold greater than that reported for other methods. Morphological and phenotypic ... In this dissertation, I report a new method for the isolation of rat IELs that is based on the selective removal of intestinal ...
https://escholarship.umassmed.edu/gsbs_diss/138/
*  Biobreeding rat - Wikipedia
Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmune Type ... 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat. BB rats are the most extensively studied rat model of ... Subsequent BB rat colonies were established. One in Worcester, Massachusetts, has been inbred and known as BBDP/Wor and another ... Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of ...
https://en.wikipedia.org/wiki/Biobreeding_rat
*  Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene. - Nuffield Department of Orthopaedics,...
Most involve a T-helper cell (Th)1-type disease, including the diabetic BioBreeding (BB) rat. To investigate the roles of ... The rats developed high serum IgE and made IgG autoantibodies that detected a nonleukocytic cell present in the intestinal wall ... All rats developed disease, and the median age at humane killing was approximately 36 weeks. This panintestinal disease showed ... METHODS: Genetically lymphopenic rats and congenic wild-type partners were compared for gross pathologic, histologic, and ...
https://www.ndorms.ox.ac.uk/publications/7922
*  RePub, Erasmus University Repository: New rat model that phenotypically resembles autosomal recessive polycystic kidney...
Rats, Rats, Inbred BB/genetics, Rats, Wistar/*genetics, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., ... Han:SPRD-CY: rats have been proposed as a model for human autosomal dominant PKD. A new spontaneous rat mutation, designated ... Although homology mapping indicates that rat wpk and human ARPKD involve distinct genes, this new rat mutation provides an ... New rat model that phenotypically resembles autosomal recessive polycystic kidney disease. Publication. Publication. American ...
https://repub.eur.nl/pub/9545
*  Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats | Diabetes
Markholst H, Andreasen B, Eastman S, Lernmark Å: Diabetes segregates as a single locus in crosses between inbred BB rats prone ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats ... Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats ...
http://diabetes.diabetesjournals.org/content/55/12/3351
*  NAVER Academic | Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the...
In the present study, we examined, in the diabetic bio-breeding Worcester rat, the short- and long-term effects of acetyl-L- ... which was increased two-fold compared to nontreated diabetic rats. These results demonstrate that acetyl-L-carnitine has a ... recovery of the conduction defect and corrected neuropathologic changes characteristic of 4-mo diabetic rats. Acetyl-L- ... Rats, Rats, Inbred BB, Sciatic Nerve, physiology, Sodium-Potassium-Exchanging ATPase, Sorbitol, Time Factors. ...
https://academic.naver.com/article.naver?doc_id=329855562
*  Alterations in intestinal permeability | Gut
Probably the best example is that of type 1 diabetes in the BB rat. In this model of autoimmune diabetes an inbred line of rat ... Given that the BB rat model of type 1 diabetes provides strong support for increased permeability playing a key role in disease ... Recent work has demonstrated that in the BB rat, coincident with the increase in permeability, there is increased zonulin ... Food-induced type 1 diabetes in the BB rat. Diabetes Metab Rev1996;12:341-59. ...
https://gut.bmj.com/content/55/10/1512?ijkey=428aee4abb5564a2e4003e484591c41c8444eba9&keytype2=tf_ipsecsha