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*  RASGRP4 antibody | acris-antibodies.com
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine ... family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two ... The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) ... Rabbit Polyclonal antibody to RASGRP4 (RAS guanyl releasing protein 4). Rabbit. IgG. Aff - Purified. Hu. ICC/IF, P, WB. 0.1 ml ...
https://www.acris-antibodies.com/target/rasgrp4-antibody.htm
*  The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF. - University of...
The Ras guanine-nucleotide exchange factor Ras-GRF/Cdc25(Mn) harbors a complex array of structural motifs that include a Dbl- ... The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF. ... The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF. Journal of Biological ... Here, we present evidence that Ras-GRF requires its DH domain to translocate to the membrane, to stimulate exchange on Ras, and ...
http://eprints.hud.ac.uk/id/eprint/23414/
*  The role of the guanine nucleotide exchange factor Rab3GEP in the regulation of Rab27a - Nottingham ePrints
Rabs are GTPases and belong to the Ras superfamily proteins. Rab27a is one of the main actors of this process, it promotes the ... Sanzà, Paolo (2017) The role of the guanine nucleotide exchange factor Rab3GEP in the regulation of Rab27a. PhD thesis, ... The role of the guanine nucleotide exchange factor Rab3GEP in the regulation of Rab27a ... in general DENN domains are considered as domains with a guanine exchange factor activity. Down-regulation of this Rab3GEP in ...
http://eprints.nottingham.ac.uk/47834/
*  Rho Guanine Nucleotide Exchange Factor 7 CBCRY28 - Creative BioMart
ARHGEF7(ARHGEF7, Rho guanine nucleotide exchange factor (GEF) 7) can be used for N/A. ... Purified Rho Guanine Nucleotide Exchange Factor 7 from Creative Biomart. ... The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging ... guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding. ...
https://www.creativebiomart.net/description_559_23.htm
*  GRB2 (Growth factor receptor-bound protein 2)
Growth factor receptor-bound protein 2), Authors: Gagani Athauda, Donald P Bottaro. Published in: Atlas Genet Cytogenet Oncol ... SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange ... In these cells the SH3 domains of GRB2 bind Vav-family proteins, guanine nucleotide exchange factors for Rho-family GTPases. ... tyrosine kinase activity SH3/SH2 adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor ...
http://atlasgeneticsoncology.org/Genes/GC_GRB2.html
*  EspM2 is a RhoA guanine nucleotide exchange factor.
EspM2 induced nucleotide exchange in RhoA but not in Rac1 or H-Ras, while SifA induced nucleotide exchange in none of them. ... Magnetic Resonance Spectroscopy revealed that EspM2 has a similar fold to SifA and the guanine nucleotide exchange factor (GEF ... These results suggest that binding of SifA to RhoA does not trigger nucleotide exchange while EspM2 is a unique Rho GTPase GEF. ... We identified a direct interaction between EspM2 or SifA and nucleotide-free RhoA. Nuclear ...
https://qmro.qmul.ac.uk/xmlui/handle/123456789/13847
*  OriGene - ARHGEF7 (NM 001113513) Human ORF cDNA Clone
Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5 available for purchase from OriGene - Your ... ARHGEF7 (GFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5. pCMV6-AC-GFP. ... Gene Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of ... Arhgef7 (Myc-DDK-tagged) - Mouse Rho guanine nucleotide exchange factor (GEF7) (Arhgef7), transcript variant 2. $880. 4 weeks. ...
http://www.origene.com/orf_clone/trueclone/NM_001113513/RC226057/ARHGEF7.aspx
*  A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. - PubMed - NCBI
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.. Quilliam LA1, ... Guanine nucleotide exchange factors (GEFs) are primarily responsible for linking cell-surface receptors to Ras protein ... ras GTPase-Activating Proteins/metabolism. *ras Guanine Nucleotide Exchange Factors/chemistry. *ras Guanine Nucleotide Exchange ... GTPases of the Ras subfamily regulate a diverse array of cellular-signaling pathways, coupling extracellular signals to the ...
https://www.ncbi.nlm.nih.gov/pubmed/12102558?dopt=Abstract
*  The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis...
Recently, expression and post-translational modification of Ras guanine nucleotide releasing factor 1 (RasGRF1) was found to ... Production of MMP-1 and MMP-3 in RA but not non-RA synovial tissue positively correlated with expression of RasGRF1 and co- ... and abrogation of Ras family signaling is therapeutic in animal models of RA. ... Expression of RasGRF1 was significantly enhanced in RA synovial tissue, and detected in FLS and synovial macrophages in situ. ...
https://arthritis-research.biomedcentral.com/articles/10.1186/ar2785
*  SOS1 Gene - GeneCards | SOS1 Protein | SOS1 Antibody
SOS Ras/Rac Guanine Nucleotide Exchange Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression ... This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine ... SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with SOS1 include Noonan ... that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor ( ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=SOS1
*  SOS1 gene - Genetics Home Reference
SOS Ras/Rac guanine nucleotide exchange factor 1. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All ... Within the RAS/MAPK signaling pathway, the SOS1 protein regulates a protein, called Ras, that stimulates cells to grow and ... nucleotide). The mutation inserts the nucleotide cytosine into an area of the gene called exon 21 (written 3248_3249insC) and ... The SOS1 gene provides instructions for making a protein that is involved in controlling (regulating) the activation of the RAS ...
https://ghr.nlm.nih.gov/gene/SOS1
*  Rasgrf2 - Ras-specific guanine nucleotide-releasing factor 2 - Mus musculus (Mouse) - Rasgrf2 gene & protein
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for ... "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.". Fam N.P., Fan W.-T., Wang Z., ... "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.". Fam N.P., Fan W.-T., Wang Z., ... "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase ...
http://www.uniprot.org/uniprot/P70392
*  Search: All Pfam signatures | InterPro | EMBL-EBI
Ras guanine-nucleotide exchange factors catalytic domain (IPR001895) Pfam signature: PF00617 Ras-like guanine nucleotide ... Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain (IPR014038) Pfam signature: PF00736 ... Septin-type guanine nucleotide-binding (G) domain (IPR030379) Pfam signature: PF00735 ... CTF transcription factor/nuclear factor 1 (IPR000647) Pfam signature: PF00859 Xanthine/uracil/vitamin C permease (IPR006043) ...
http://www.ebi.ac.uk/interpro/member-database/Pfam
*  CDC25 Protein | SGD
Ras family guanine nucleotide exchange factor CDC25 Feature Type. ORF , Verified Description. Membrane bound guanine nucleotide ... exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p ... and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 ...
https://www.yeastgenome.org/locus/S000004301/protein
*  Rasgrp1 RAS guanyl releasing protein 1 [Mus musculus (house mouse)] - Gene - NCBI
Guanine nucleotide exchange factor for Ras-like small GTPases. smart00229. Location:54 → 176. RasGEFN; Guanine nucleotide ... RAS guanyl-releasing protein 1. Names. calcium and DAG-regulated guanine nucleotide exchange factor II. ... Ras guanyl-nucleotide exchange factor activity ISO Inferred from Sequence Orthology. more info ... guanine nucleotide exchange factor RasGRP1 inhibited Rhes-mediated control of striatal motor activity in mice. RasGRP1 ...
https://www.ncbi.nlm.nih.gov/gene?amp=&cmd=Retrieve&dopt=Graphics&list_uids=19419
*  KEGG BRITE: KEGG Orthology (KO) - Camelus ferus (Wild Bactrian camel)
102507247 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 102517014 SOS2; SOS Ras/Rho guanine nucleotide exchange factor ... 102507247 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 102517014 SOS2; SOS Ras/Rho guanine nucleotide exchange factor ... 102521802 RAPGEF1; Rap guanine nucleotide exchange factor 1 102510699 RHOQ; ras homolog family member Q 102510731 EXOC7; ... Rap guanine nucleotide exchange factor 1 K07194 RHOQ; Ras homolog gene family, member Q K07195 EXOC7; exocyst complex component ...
http://www.genome.jp/kegg-bin/get_htext?cfr00001+102511249
*  KEGG NETWORK: N00278
SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1. 6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2. ... Hutchinson RA, Adams RA, McArt DG, Salto-Tellez M, Jasani B, Hamilton PW ... New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and ... The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. ...
https://www.genome.jp/dbget-bin/www_bget?ne:N00278
*  Patent US20030120640 - Construction method of substance dictionary, extraction of binary ... - Google Patents
Ex.) [Ras] guanine nucleotide exchange [factor Sos]→[Ras guanine nucleotide exchange factor Sos] ... Ex.) the Ras guanine nucleotide exchange factor Sos the Ras guanine nucleotide releasing protein Sos the Ras exchanger Sos the ... GDP-GTP exchange factor Sos Sos (mSos), a GDP/GTP exchange protein for Ras ... Ex.) epidermal growth factor receptor,EGF receptor,EGFR poly(ADP-ribose)polymerase,poly(ADP-Ribose)polymerase,PARP c-Fos,c-fos, ...
http://www.google.com/patents/US20030120640?dq=7069184
*  Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from...
aras guanine nucleotide exchange factor L isoform X8. Md. 12 h Down regulated ... Again, a component of Ras GTPase signaling such as the homolog of Ras guanine exchange factor was identified in genes induced ... Small GTPases of the Ras superfamily are known regulators of cell junctions, cytoskeleton and vesicular traffic in cells [37, ... Carmona D, Rodriguez-Almazan C, Munoz-Garay C, Portugal L, Perez C, de Maagd RA, et al. Dominant negative phenotype of Bacillus ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-2240-7
*  SMART: RasGEFN domain annotation
A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the ... The crystal structure of the guanine nucleotide exchange factor (GEF) region of human Sos1 complexes with Ras has been solved ... It has been suggested that a key event in growth factor-induced p21Ras activation by the guanine nucleotide exchange factor Sos ... the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, which is essential for control of Ras ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=RasGEFN&BLAST=DUMMY
*  Genetics of RAS Signaling in Drosophila | SpringerLink
RAS proteins play a key role in the signaling pathways that regulate cell growth and differentiation in Drosophila. Although ... Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 1993; 260:1338-43.PubMedGoogle Scholar ... Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange [published erratum appears in ... Zheng Y, Hart MJ, Cerione RA. Guanine nucleotide exchange catalyzed by dbl oncogene product. Methods Enzymol 1995; 256:77-84. ...
https://link.springer.com/chapter/10.1007/978-1-4613-1183-6_1
*  Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and...
2002). Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Mol. Cell ... 2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180. doi ... 2014). Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 33, 4021 ... The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1 ...
http://jcs.biologists.org/content/131/14/jcs216580
*  SMART: RasGEF domain annotation
This entry represents the catalytic domain of the Ras guanine-nucleotide exchange factors. ... It has been suggested that a key event in growth factor-induced p21Ras activation by the guanine nucleotide exchange factor Sos ... Binding / catalysis: protein-binding, Ras-binding, guanine nucleotide exchange activity towards Ras ... The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine- ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=RasGEF
*  KIND domain (IPR011019) | InterPro | EMBL-EBI
Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.. Gene Expr. Patterns 6 79-85 ... Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain ( ...
http://www.ebi.ac.uk/interpro/entry/IPR011019
*  Cancers | Free Full-Text | Genetic Interactions of STAT3 and Anticancer Drug Development | HTML
... epidermal growth factor receptor, and reduction-oxidation pathways; and molecular mechanisms that modulate therapeutic ... This review focuses on functional regulation of STAT3 activity; possible interactions of the STAT3, RAS, ... SOS is one of the guanine nucleotide exchange factors that activate RAS [141,142]. RAS activation has resulted in stimulation ... Binding of Ras with GTP is facilitated by guanine nucleotide exchange factors (GEFs) via catalysis of the release of GDP and is ...
http://mdpi.com/2072-6694/6/1/494/htm