RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation | DIAL.pr -...
McCormick Frank, ras GTPase activating protein: Signal transmitter and signal terminator, 10.1016/0092-8674(89)90976-8 ... Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein, 10.1038/377695a0 ... p120 GTPase Activating Protein ; Arteriovenous Malformations ; Capillaries ; DNA Mutational Analysis ; Female ; Gene Order ; ...https://dial.uclouvain.be/pr/boreal/object/boreal:156811
ras Proteins Summary Report | CureHunter
... monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21 ... The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell ... RAS), plays a role in normal cellular growth, differentiation and development. ... we demonstrate that unlike oncogenic Ras proteins, which are primarily activated by mutations that eliminate GTPase activity, ...http://www.curehunter.com/public/keywordSummaryD018631-ras-Proteins.do
OriGene - KRAS (NM 004985) Human ORF cDNA Clone
... a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase ... A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated ... Protein Families:. Druggable Genome. Protein Pathways:. MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathway ... Synonyms: C-K-RAS; c-Ki-ras2; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RALD; RefSeq Size: 5312 ...http://www.origene.com/orf_clone/Search/retrieve_results.mspx?sku=RC400114
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis | PNAS
Here, we identify a missense mutation (G125V) in the scat Rasa3 gene, encoding a Ras GTPase activating protein (RasGAP), and ... Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Lionel Blanc, ... Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis ... leading to increased GTP-bound Ras. Erythropoiesis is severely blocked in scat crisis mice, and ∼94% succumb during the second ...https://www.pnas.org/content/early/2012/07/05/1204948109.abstract?elq=a0eb7d81ea19471d83abd99bc9c8958e
Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae ...
... Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae ... Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae ... Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae ...http://www.genetics.org/content/early/2018/11/16/genetics.118.301490?rss=1
Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3 - Zurich Open Repository and...
All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK ... All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK ... Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3 ... Download PDF 'Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3'. Item ...http://www.zora.uzh.ch/id/eprint/9430/
Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus...
In vitro reconstitution experiments using baculovirus-expressed proteins demonstrate that both v-Src and c-Src associate in ... which are highly conserved structural motifs postulated to mediate interactions among proteins, diminishes GAP phosphorylation ... Ras GTPase-activating protein (GAP) has been implicated in mitogenic signal transduction downstream of oncogenic and receptor ... Ras GTPase-activating protein (GAP) has been implicated in mitogenic signal transduction downstream of oncogenic and receptor ...https://www.semanticscholar.org/paper/Reconstitution-of-interactions-between-the-Src-and-Park-Marshall/129b9b6a7d03404e82d77e28eb9369349a9e68fa
Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein - UCL Discovery
... ras GTPase-Activating Proteins) RN - 0 (DNA, Complementary) RN - 0 (GTPase-Activating Proteins) RN - 0 (Proteins) PT - JOURNAL ... Mammalian Ras GTPase-activating protein (GAP), p120 Ras-GAP, has been implicated as both a downregulator and effector of Ras ... Protein-Tyrosine Kinase, Ras, ras Proteins, Receptor Protein Tyrosine Kinase, Receptor Protein-Tyrosine Kinases, ... Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein. Molecular and ...http://discovery.ucl.ac.uk/22312/
Syngap1 - Ras/Rap GTPase-activating protein SynGAP - Mus musculus (Mouse) - Syngap1 gene & protein
Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long- ... Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role ... View protein in PROSITE. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. ... View protein in PROSITE. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. ...http://www.uniprot.org/uniprot/F6SEU4
Ras GTPase-activating-like protein IQGAP1
The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with ... Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly ... Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008 ... positive regulation of cellular protein localization 4 positive regulation of vascular associated smooth muscle cell migration ...https://pharos.nih.gov/idg/targets/P46940
SYNGAP1 Gene - GeneCards | SYGP1 Protein | SYGP1 Antibody
Protein Coding), Synaptic Ras GTPase Activating Protein 1, including: function, proteins, disorders, pathways, orthologs, and ... Synaptic Ras GTPase activating protein 1 homolog (Rat) (B1AZX6_HUMAN). *Synaptic Ras GTPase-activating protein 1 (SYGP1_HUMAN) ... Protein Symbol:. Q96PV0-SYGP1_HUMAN. Recommended name:. Ras/Rap GTPase-activating protein SynGAP Protein Accession:. Q96PV0. ... SYNGAP1 (Synaptic Ras GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with SYNGAP1 include Autosomal ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=SYNGAP1&rf=/home/genecards/current/website/carddisp.pl&origene_ab_prot=3
oncogenes/tumor suppressor genes Flashcards by Elizabeth DeGroot | Brainscape
Ras GTPase activating protein (neurofibromin) 20 NF2 Tumor suppressor gene. NeuroFibromatosis type 2. Merlin (schwannomin) ...https://www.brainscape.com/flashcards/oncogenes-tumor-suppressor-genes-4990507/packs/7366707
Foundations Flashcards by Rutvi Patel | Brainscape
NF1 on Ch17 - RAS GTPase activating protein 242 What TSG is linked w/ Neurofibromatosis type 2? what chromosome? ... 1. Cyclin D -- activated CDK4 --> phosphorylates Rb protein which releases it from the TF E2F which transcribes and synthesizes ... regulatory proteins that control cell cycle. They are phase specific and activate CDKs ... barrel-shaped protein complex that degrades damaged or unnecessary proteins tagged for destruction w/ ubiqutin ...https://www.brainscape.com/flashcards/foundations-1666593/packs/3141178
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.
Scaffold proteins are key elements in coordinating signalling molecules for their app ... 0/IQ motif containing GTPase activating protein 1; 0/ras GTPase-Activating Proteins; EC 2.7.1.-/Map2k1 protein, mouse; EC 2.7.1 ... Proto-Oncogene Proteins c-raf / metabolism. Signal Transduction*. Time Factors. Ventricular Remodeling*. ras GTPase-Activating ... EC 18.104.22.168/Mapk1 protein, mouse; EC 22.214.171.124/Mitogen-Activated Protein Kinase 1; EC 126.96.36.199/Mitogen-Activated Protein ...http://www.biomedsearch.com/nih/IQGAP1-regulates-AKT-signaling-in/21493702.html
ASK1-interacting protein-1 (AIP1) a recently identified member of the Ras GTPase-activating - Heat Shock Proteins & Heat Shock...
17 18 AIP1 via its Ras GTPase-activating proteins (Ras-GAP) TAK-875 activity inhibits Ras-mediated cell survival signaling ... ASK1-interacting protein-1 (AIP1) a recently identified member of the Ras GTPase-activating protein family is highly expressed ... also called DAB2-interacting proteins (DAB2IP) a lately identified book person in the Ras GTPase-activating proteins family ... ASK1-interacting protein-1 (AIP1) a recently identified member of the Ras GTPase-activating. Published March 12, 2017 ...http://neuroart2006.com/?p=2199
RASA ELISA Kits from antibodies-online | Biocompare.com
Ras Gtpase Activating Protein. *. Detection Range: 0.5-10 ng/mL. *. Reactivity: Rat (Rattus) ...https://www.biocompare.com/pfu/110627/soids/2-59084/Assay_Kit/ELISA_RASA?vids=104431
Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic...
... through inhibition of Ras-GTPase activating protein and methyl-CpG-binding protein 2, which are validated miR-132 targets. ... which activates angiogenic and antifibrotic mechanisms in the recipient heart by inhibiting Ras-GTPase activating protein and ... Ras-GTPase activating protein. Scr. scrambled sequence. SVP. saphenous vein-derived pericyte progenitor. SVP-CM. conditioned ... and antifibrotic activity via inhibition of its targets Ras-GTPase activating protein (RasGAP, also named RASA1) and methyl-CpG ...http://circres.ahajournals.org/content/109/8/894
Plastic Surgery for Capillary Malformations: History of the Procedure, Problem, Epidemiology
The RASA1 gene encodes p120 Ras GTPase-activating protein. When mutated, p120 Ras GTPase-activating protein binds to Krev-1/ ... Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science. 1990 Jul 13. 249( ... rap1a, an integrin β1-mediated cell adhesion and angiogenesis protein. The pathogenesis of capillary malformations is not ...https://emedicine.medscape.com/article/1295898-overview
Rasa2 - PrimePCR Assay and Template | Life Science | Bio-Rad
Ras GTPase-activating protein 2 Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5172134 Info: FAM; Same ... Ras GTPase-activating protein 2 Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5172135 Info: HEX; Same ... Ras GTPase-activating protein 2 Assay Type: Probe Assay Design: intron_spanning Application: Gene Expression Unique Assay ID: ... Ras GTPase-activating protein 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dRnoEG5138078 Info: EG; Same ...http://www.bio-rad.com/en-us/prime-pcr-assays/gene/rasa2-rat
Anti-SAM68 antibody (ab86239) | Abcam
p21 Ras GTPase activating protein associated p62 antibody. *p21 Ras GTPase-activating protein-associated p62 antibody ... functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ...https://www.abcam.com/sam68-antibody-ab86239.html
Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia | Journal of Neuroinflammation | Full Text
... whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the ... Ras GTPase activating protein. SHIP: SH2-containing inositol phosphatase. SHP: Src homology 2 domain containing phosphatase ... Absorbance was read at 450 nm, values were corrected for protein and expressed as pg/ml protein. ... Activated microglia also release inflammatory cytokines and, in parallel with the changes in markers of microglial activation ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-107
CRK CRK proto-oncogene, adaptor protein [Homo sapiens (human)] - Gene - NCBI
2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al..... *Pathways in cancer, organism-specific biosystem ( ... RAS GTPase and MAP kinases, organism-specific biosystem (from REACTOME) PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ... activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich ... MET activates RAP1 and RAC1, organism-specific biosystemThe adapter protein GAB1 is involved in recruitment, through CRK and ...https://www.ncbi.nlm.nih.gov/gene/1398
Iqgap2 MGI Mouse Gene Detail - MGI:2449975 - IQ motif containing GTPase activating protein 2
IPR000593 RasGAP protein, C-terminal. IPR001936 Ras GTPase-activating protein. IPR023152 Ras GTPase-activating protein, ... IQGAP2, IQ motif containing GTPase activating protein 2. Orthology source: HomoloGene, HGNC ...http://www.informatics.jax.org/marker/MGI:2449975
... the Rho-GTPase interacting protein Citron (Zhang et al., 1999), and the synaptic Ras-GTPase activating protein SynGAP (Chen et ... Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ... guanylate kinase domain-associated protein/synapse-associated protein-associated protein) and Shank/ProSAP family proteins, are ... PSD95 family proteins are MAGUKs (membrane-associated guanylate kinases) that contain multiple protein-protein interaction ...http://www.jneurosci.org/content/24/2/378
SynGAP, a Ras GTPase activating protein, is nearly as abundant in the PSD fraction as PSD-95 itself (Chen et al., 1998) and can ... 1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20:895-904. ... In contrast to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three PDZ domains ... 6 A). SynGAP, a Ras GTPase-activating protein, is also highly concentrated at the same postsynaptic sites that contain CaM ...http://www.jneurosci.org/content/19/1/96