... Synonyms - GTPase-activating protein 1, Gap1 Cytological map position - 67D2--3 Function - Ras ... a Ras GTPase-activating protein). No interactions were seen between Sprouty and several other proteins involved in the Ras ... A novel GTPase-activating protein (GAP) for Ras has been purified: it is immunologically distinct from the known Ras GAPs, ... Ras GTPase activating protein 1 : Biological Overview , Regulation , Developmental Biology , Effects of Mutation , Evolutionary ...

Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of ... Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of ... Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of ... Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a potential target of ...

SYNE1: spectrin repeat containing nuclear envelope protein 1. *SYNGAP1: synaptic Ras GTPase activating protein 1 ...

A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions. Previous ... ras GTPase-Activating Proteins / genetics* Substances * DAB2IP protein, human * ras GTPase-Activating Proteins ... A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions. Previous ... We also found intratumoral heterogeneity (ITH) of DAB2IP frameshift mutations in 7 of 16 CRCs (43.8%). Loss of DAB2IP protein ...

Neurofibromin, a GTPase-activating protein, primarily regulates the protein Ras. NF1 is located on the long arm of chromosome ... a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP ... Neurofibromin is a GTPase-activating protein (GAP) that negatively regulates Ras pathway activity by accelerating hydrolysis of ... "Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21". Oncogene. 7 ...

IPR001936 Ras GTPase-activating domain. IPR039360 Ras GTPase-activating protein. IPR023152 Ras GTPase-activating protein, ... protein coding gene. Chr1:156962752-157240170 (-). 129S1/SvImJ MGP_129S1SvImJ_G0016631. protein coding gene. Chr1:162141166- ... protein coding gene. Chr1:173635385-173956428 (-). DBA/2J MGP_DBA2J_G0016478. protein coding gene. Chr1:154558177-154836363 (-) ... protein coding gene. Chr1:160360737-160652455 (-). BALB/cJ MGP_BALBcJ_G0016573. protein coding gene. Chr1:156112395-156391089 ...

The RASA1 gene encodes p120 Ras GTPase-activating protein. When mutated, p120 Ras GTPase-activating protein binds to Krev-1/ ... rap1a, an integrin β1-mediated cell adhesion and angiogenesis protein. The pathogenesis of capillary malformations is not ...

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP ... CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an ... This activates the unfolded protein response (UPR) to re-establish the balance between ER protein folding capacity and protein ... demonstrate that the protein kinase MAP4K3 [mitogen-activated protein kinase kinase kinase kinase-3, a Ste20 family protein ...

Among the top differentially expressed proteins was the synaptic Ras GTPase-activating protein 1 (SYNGAP1). Using Western ... A total of N = 487 differentially expressed proteins were found in WIN-exposed animals compared to controls. Gene ontology ... We also found that one of the most significant differentially expressed proteins was the synaptic Ras GTPase-activating protein ... Among the top differentially expressed proteins was the synaptic Ras GTPase-activating protein 1 (SYNGAP1). Using Western ...

Targeting the MAPK Pathway in RAS Mutant Cancers. Sarah G. Hymowitz and Shiva Malek. Ras-Specific GTPase-Activating Proteins ... MRAS: A Close but Understudied Member of the RAS Family. Lucy C. Young and Pablo Rodriguez-Viciana. The K-Ras, N-Ras, and H-Ras ... Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. ... Posttranslational Modifications of RAS Proteins. Ian Ahearn, Mo Zhou, and Mark R. Philips. Ras and the Plasma Membrane: A ...

CCS1, GLC4, Ras GTPase activating protein IRA2, L000000874, YOL081W. GTPase-activating protein; negatively regulates RAS by ... Ras GTPase activator activity [IDA, IMP]. Gene Ontology Cellular Component. *cytoplasm [IDA]*endoplasmic reticulum membrane [ ... negative regulation of Ras protein signal transduction [IMP]*negative regulation of cAMP biosynthetic process [IMP]*positive ... Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ...

Sperm surface protein Sp17.. *Ras GTPase-activating-like protein IQGAP1. IQGAP1 contains 4 IQ motifs. ... Click on the protein counts, or double click on taxonomic names to display all proteins containing IQ domain in the selected ... A growing family of proteins is regulated by protein kinase C and calmodulin through IQ domains, a regulatory motif originally ... Several other RNA-binding proteins, including TLS/FUS and PSF, co-purify with EWS. PKC phosphorylation of these proteins also ...

In this study, we demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) is responsible for TMZ-resistance in ... Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein ... Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol. Brain Res. 115, 121-129 (2003 ... Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J. Biol. Chem. 277, ...

... and discuss how this molecule infl uences the retention and clustering of diverse synaptic proteins to regulate synaptic ... and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic ... These include synaptic Ras GTPase-activating protein, which regulates the Ras-extracellular signal-regulated kinase pathway ( ... With multiple PDZ domains, in conjunction with additional protein interaction domains, MAGUK proteins are capable of forming a ...

Regulation of the neuron-specific ras GTPase-activating protein, syngap, by Ca2+/calmodulin-dependent protein kinase II. , ... Manzerra, Pasquale, Synaptic Ras GTPase activating protein (SynGAP) regulates N-methyl-D-aspartate receptor (NMDAR)-mediated ...

2. Site-Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function. Baker R, Lewis SM, Wilkerson ... 4.Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Hobbs GA, Gunawardena HP, ... Ras proteins are critical regulators of multiple pathways involved in cellular growth control. Activating mutations in Ras ... K-Ras G12C. We find that this activating mutation introduces a redox active cysteine that renders Ras G12C sensitive to thiol ...

H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM ... both in the presence or absence of its GTPase-activating protein Ras-GAP. This effect is not due to a different stoichiometry ... H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM. *PDB DOI: https ... we show that the acceleration of the GTPase by Mn2+ appears to be a general phenomenon of GTP-binding proteins. ...

... allowing Epac to activate small Ras-like GTPase proteins, such as Rap1. ... The phosphorylated proteins may act directly on the cells ion channels, or may become activated or inhibited enzymes. Protein ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ... Not all protein kinases respond to cAMP. Several classes of protein kinases, including protein kinase C, are not cAMP-dependent ...

... approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that ... Repressor Proteins. , Sequence Analysis, DNA. , Sex Characteristics. , Transcription Factors. , Young Adult. , ras GTPase- ... Myeloid-Lymphoid Leukemia Protein. , Nerve Tissue Proteins. , Parents. , Phenotype. , Prevalence. , Protein Phosphatase 2C. , ... CDC2 Protein Kinase. , Casein Kinase II. , Child. , Chromosomal Proteins, Non-Histone. , Cohort Studies. , DEAD-box RNA ...

Key Words : ras p21, small G proteins, Prenylation, GDP/GTP exchange protein, GTPase activating protein, Tumor markers. Less ... Publications] Hata, Y.: Inhibition of the ras p21 GTPase-activating protein-stimu-lated GTPase activity of c-Ha-ras p21 by smg ... ras p21 / small GTP-binding proteins / prenylation / GDP / GTP exchange protein / GTPase activating protein / Tumor markers / , ... Publications] Hata,Y.: Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg ...

Conidial morphogenesis and septin-mediated plant infection require Smo1, a Ras GTPase-activating protein in Magnaporthe oryzae ...

A Ras GTPase activating protein tumor suppressor, DAB2 interacting protein (DAB2IP), was discovered as an miR431 target. ... Overexpression of DAB2IPs rat homolog DIP, but not its mutant defective in Ras GTPase activating protein activity, reverses ... Herein, we show that miR431 overexpression activates Ras/extracellular signal-regulated kinase (Erk) signaling and promotes ... Taken together, miR431 silences DAB2IP to active Ras/Erk and promote metastasis of PNETs. miR431 may be targeted to manage ...

DAB2 Interacting Protein (DAB2IP)). DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor ... DAB2 interacting protein (DAB2IP) Antikörper. DAB2 interacting protein b (dab2ipb) Antikörper. DAB2 interacting protein (dab2ip ... DAB2 interacting protein (Dab2ip) Antikörper. disabled 2 interacting protein (Dab2ip) Antikörper. 2310011D08Rik Antikörper. ...

TBC1D15 activated three novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs. Thus, this ... TBC1D15-NOTCH1 interaction activated and stabilized NOTCH1 which upregulated transcription of NANOG essential for TIC expansion ... Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. ... the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and ...

Sequence similarity was found to a putative Ras GTPase activating protein and a human interferon-gamma binding protein both in ... GTPase-activating proteins and nucleotide-exchange factors, including such proteins as Vav, Dbl and Bcr, and there are two PH ... GTPase-activating proteins and nucleotide-exchange factors. Its function is not known, but many proteins that contain a PH ... guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like ...

Protein: P46940 IQGAP1, Ras GTPase-activating-like protein IQGAP1, human. Predictions only. Length 1,657 aa. ... Protein. RNA. Prediction (catRAPID). Interaction (ENCODE eCLIP). Gene UniProt Accession Transcript Symbol Ensembl Transcript ID ... Retrieved 100 of 98,524 protein-RNA pairs in 15.4 ms ...

SynGAP is a Ras/Rap GTPase-activating protein (GAP) present in high concentration in postsynaptic densities (PSDs) from ... The Protein Expression Center is supported by the Beckman Institute. Conflict of interest: The authors declare that they have ... We support this hypothesis by showing that three critical postsynaptic signaling proteins that bind to the PDZ domains of PSD- ... We show that phosphorylation of synGAP by Ca^(2+)/calmodulin-dependent protein kinase II (CaMKII) decreases its affinity for ...

We recently discovered that the stress granule protein G3BP1 (Ras GTPase-activating protein-binding protein 1) anchors the TSC ... The tuberous sclerosis protein (TSC) complex acts as a relay for anabolic signaling and as a tumor suppressor. These functions ... This seems to be at odds with the requirement of amino acids for protein biosynthesis in rapidly growing tumor cells; raising ... Alexander Martin Heberle: "A stress granule protein integrates metabolic signals and controls lysosomal TSC recruitment and ...

The intracellular region of plexins is essential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) ... Plexins are Ras/Rap family GTPase activating proteins (GAPs) and we find that the PlexA GAP domain is phosphorylated by the ... The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by ... This phosphorylation occurs in the active site of the plexin GTPase-activating protein (GAP) domain, which in turn inhibits ...

... a gene that encodes the Ras-GTPase activating protein neurofibromin. ... Isolation of Adult Human Astrocyte Populations from Fresh-frozen Cortex using Fluorescence-Activated Nuclei Sorting. , ColeCole ... Protein expression of OLIG2, a novel marker in RMS, was investigated utilizing antibody EP112 (Cell Marque). ... Fluorescence-activated nuclei sorting (FANS) can be utilized to efficiently isolate and research human neuronal nuclei (NeuN+) ...