rho, a Small GTP-Binding Protein, Is Essential for Shigella Invasion of Epithelial Cells | JEM
1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410, pmid:1643658.. ... rho, a Small GTP-Binding Protein, Is Essential for Shigella Invasion of Epithelial Cells. Masahisa Watarai, Yoichi Kamata, ... 1990) The cellular function of small GTP-binding proteins. Science (Wash DC) 249:635-640, pmid:2116664.. ... 1995) Monoglucosylation of lowmolecular-mass GTP-binding Rho proteins by clostridial cytotoxins. Trends Cell Biol 5:441-443, ...http://jem.rupress.org/content/185/2/281
Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier...
The implication of Rac and Cdc42 was analyzed in transient transfection experiments using either constitutively active (V12) or ... These observations suggest that Rho is involved in the maintenance of endothelial barrier function and Rac participates in ... The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.. *Anne J Ridley, Hugh F. Paterson, C. L. ... Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.. *Nicolas Tapon, Alan G Hall ...https://www.semanticscholar.org/paper/Regulation-of-the-actin-cytoskeleton-by-thrombin-in-Vouret-Craviari-Boquet/16d4f2d205346e19ae201cffcb84f8a8a339ee83
Analysis of mesodermal derivatives in mbc mutant embryo | Open-i
Insect Proteins/chemistry/genetics*/physiology*. *Muscle Fibers, Skeletal/cytology*/metabolism. *rac GTP-Binding Proteins* ... MBC bears striking homology to human DOCK180, which interacts with the SH2-SH3 adapter protein Crk and may play a role in ... MBC bears striking homology to human DOCK180, which interacts with the SH2-SH3 adapter protein Crk and may play a role in ... For this purpose we used mbcF12.7, since the protein is truncated at amino acid 492, and analyzed embryos that were genetically ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2141626_JCB.29169f7&req=4
Schematic illustration of substrate contact dynamics in | Open-i
GTP-Binding Proteins/genetics/metabolism. *Goldfish. *Intracellular Signaling Peptides and Proteins. *Myosin-Light-Chain Kinase ... Their formation is associated with the activation of Rac and Cdc42, respectively. Each type of primary contact can develop into ... or green fluorescent protein. For cells allowed to spread in the presence of nocodazole the turnover of contacts was retarded, ... or green fluorescent protein. For cells allowed to spread in the presence of nocodazole the turnover of contacts was retarded, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2169483_JCB9904118.f9&req=4
Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control of plant growth and development...
Role of rop proteins in the control of plant growth and development, Russian Journal of Plant Physiology" on DeepDyve, the ... "Superfamily of monomeric GTP-binding proteins in plants: 1. ... The Small GTP-Binding Protein Rac Is a Regulator of Cell Death ... Rac-Related GTP-Binding Protein in Elicitor-Induced Reactive Oxygen Generation by Suspension-Cultured Soybean Cells ... Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control... Novikova, G.; Moshkov, I. ...https://www.deepdyve.com/lp/springer_journal/superfamily-of-monomeric-gtp-binding-proteins-in-plants-1-role-of-rop-bJUCGEA0QQ
Mice expressing melanocyte lineage NRasQ61K retain pigm | Open-i
Oncogene Protein p21(ras)/genetics*/metabolism. *Skin Neoplasms/metabolism/pathology*. *rac GTP-Binding Proteins/genetics/ ... MAPK/ERK kinase/mitogen-activated protein kinase (MAPK) pathways to enhance proliferation. The Ras oncogene also activates ... MAPK/ERK kinase/mitogen-activated protein kinase (MAPK) pathways to enhance proliferation. The Ras oncogene also activates ... Oncogene Protein p21(ras)/genetics*/metabolism. *Skin Neoplasms/metabolism/pathology*. *rac GTP-Binding Proteins/genetics/ ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3472562_jid2012186f2&req=4
Corneal Re-epithelialization Stimulated by Diadenosine Polyphosphates Recruits RhoA/ROCK and ERK1/2 Pathways | IOVS | ARVO...
Signal transduction through the GTP-binding proteins Rac and Rho. J Cell Sci Suppl. 1994;18:127-131. [PubMed] ... Protein concentration was determined by Bradford protein assay. Protein (45 μg) was subjected to SDS-PAGE (10% for ERK1/2, 7% ... P2Y receptors are seven-transmembrane-domain proteins coupled to G proteins that trigger different signal transduction pathways ... A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000;275(15)10767-10771. [CrossRef] [PubMed] ...https://iovs.arvojournals.org/article.aspx?articleid=2125250
References for PMC Articles for PubMed (Select 8943367) - PubMed - NCBI
Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins. ... Detection and modulation in vivo of helix-loop-helix protein-protein interactions. ...https://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed_refs&from_uid=8943367
NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin...
Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins. Curr. Opin. Cell Biol. 6: 212-218. ... The TIR domain of TLR2 functions in heterodimerization and as the binding site for other cytosolic adaptor proteins containing ... Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 63: 1291-1297. ... purified protein derivative; SAPK, stress-activated protein kinase; siCat, cathelicidin siRNA; siNS, nonspecific control siRNA ...http://www.jimmunol.org/content/182/6/3696
Regulation of Endogenous Reactive Oxygen Species in Platelets Can Reverse Aggregation | Arteriosclerosis, Thrombosis, and...
... and the cytosolic proteins, p47-phox, p67-phox, p40-phox, and a small GTP-binding protein Rac.10 Activation of this highly ... Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins. Curr Opin Cell Biol. 1994; 6: 212-218. ... Alpha-tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide relase. FASEB J. 2000; 14: 2377-2379. ... In platelets, protein kinase C phosphorylation of eNOS is believed to decrease platelet-derived NO.23 Therefore, we evaluated ...http://atvb.ahajournals.org/content/24/1/187
The PI3K-PTEN-AKT-TOR Signaling Pathway in Cancer, Metabolism, and Aging | The New York Academy of Sciences
PIP3 also regulates proteins that control Arf, Rac and Ras family GTP-binding proteins. This lipid is elevated in cancers, ... that acts as a membrane bound second messenger to activate AKT/PKB family protein Ser/Thr kinases as well Tec family protein- ... PTEN is mutated somatically in a small percentage of breast cancer cases; however, reduced PTEN protein occurs approximately ... FOXO transcription factors (FOXO) are directly phosphorylated in response to insulin/growth factor signaling by the protein ...https://www.nyas.org/events/2007/the-pi3k-pten-akt-tor-signaling-pathway-in-cancer-metabolism-and-aging/
OsAGO2 controls ROS production and the initiation of tapetal PCD by epigenetically regulating OsHXK1 expression in rice anthers...
1999) The small GTP-binding protein rac is a regulator of cell death in plants. Proc Natl Acad Sci USA 96:10922-10926. ... 2007) Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension. Plant Cell 19:4022-4034. ... 2014) Rice germline-specific Argonaute MEL1 protein binds to phasiRNAs generated from more than 700 lincRNAs. Plant J 78:385- ... 2006) p53 protein or BID protein select the route to either apoptosis (programmed cell death) or to cell cycle arrest opposing ...https://www.pnas.org/content/116/15/7549
Viruses | Free Full-Text | Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions | HTML
Ridley, A.J.; Paterson, H.F.; Johnston, C.L.; Diekmann, D.; Hall, A. The small GTP-binding protein rac regulates growth factor- ... Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev. 1997, 11, 2239 ... domains bind to dynamin and synaptojanin . Another adaptor protein NUMB, can bind to the α-adaptin subunit of AP-2  and ... binding ligands Gas6 and Protein S, which bridge the virus particle and TAM . PtdSer‑binding members of the TIM family are ...http://mdpi.com/1999-4915/4/12/3647/htm
Frontiers | NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis | Physiology
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254, 1512-1515. doi: 10.1126/ ... protein kinase B and Src), and/or protein phosphatases, including protein tyrosine phosphatase (Damico et al., 2012). ... regulate phosphorylation levels of multiple proteins modulated by redox-sensitive kinases and/or protein phosphatase (Brown and ... activate multiple redox sensitive molecule including mitogen-activated protein, non-receptor tyrosine kinases, protein tyrosine ...https://www.frontiersin.org/articles/10.3389/fphys.2015.00194/full
ancient schwannoma 2005:2010 - BioMedLib™ search engine
Prkar1a protein, mouse; 0 / Rac1 protein, mouse; EC 220.127.116.11 / rac GTP-Binding Proteins; EC 18.104.22.168 / rac1 GTP-Binding Protein ... rac GTP-Binding Proteins / physiology. *[MeSH-minor] Animals. Down-Regulation / genetics. Mice. Mice, Knockout. Schwann Cells ... rac1 GTP-Binding Protein. *PhosphoSitePlus. gene/protein/disease-specific - PhosphoSitePlus® - comprehensive post-translational ... Amino Acid, Peptide, or Protein. A22.214.171.124.1.8. Carbohydrate. A126.96.36.199.1.9. Lipid. A188.8.131.52.1.9.1. Steroid. A184.108.40.206.1.9.2. ...http://bmlsearch.com/?kwr=ancient%20schwannoma%202005:2010
TCR, LFA-1, and CD28 Play Unique and Complementary Roles in Signaling T Cell Cytoskeletal Reorganization | The Journal of...
Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108: 225. ... The actin-binding protein talin has been shown to colocalize with clustered and occupied integrins, in part via direct ... Filamentous actin (17, 18) and the actin-binding protein talin (15) accumulate at the T cell:APC interface, and the T cell ... 1⇓). While very few T cells bound to Ag-pulsed ProPAR or ProAd cells, a large number of T cells bound to Ag-pulsed ProAd-ICAM ...http://www.jimmunol.org/content/162/3/1367.full
Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of...
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254: 1512-1515. ... Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 353: 668-670. ... small GTPase Rac (9, 10), and protein kinases AKT and protein kinase Cδ (11-14). NADPH oxidase reduces molecular oxygen to ... Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and ...http://www.jimmunol.org/content/188/5/2316
Differential Effects of B Cell Receptor and B Cell Receptor-FcγRIIB1 Engagement on Docking of Csk to GTPase-activating Protein ...
... a molecule with GAP activity toward the small GTP-binding proteins Rho and Rac ((46)). Rho and Rac, in turn, participate in the ... 1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410, pmid:1643658.. ... 1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth ... The amount of bound protein was estimated by SDS-PAGE and Commassie staining. To prepare affinity matrices for use in binding ...http://jem.rupress.org/content/186/2/259
Angiotensin II Activates RhoA in Cardiac Myocytes | Circulation Research
Nobes CD, Hawkins P, Stephens L, Hall A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J ... Since Rho is a member of the small GTP-binding proteins, activation of Rho could be shown by its increased binding of GTP. ... Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J Biol Chem. 1994;269:31674-31679 ... Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced ...http://circres.ahajournals.org/content/82/6/666
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination |...
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein rac regulates ... Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress ... Higgs, H. N. and Pollard, T. D. (1999). Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins. J. Biol. ... Miki, H. and Takenawa, T. (2003). Regulation of actin dynamics by WASP family proteins. J. Biochem. (Tokyo) 134,309 -313. ...http://dev.biologists.org/content/136/21/3657.long
Myosin phosphatase releases moesin-mediated inhibition. | Open-i
cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ... cdc42 GTP-Binding Protein/antagonists & inhibitors/metabolism. *rac GTP-Binding Proteins/antagonists & inhibitors/metabolism ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4322047_JEM_20140508_Fig8&req=4
Growth factor signaling to mTORC1 by amino acid-laden macropinosomes | JCB
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410. doi:10.1016/0092-8674(92 ... Rac1 binds to mTOR independently of its GTP-binding status, and sequesters it in a regulatory manner. Our results indicate a ... Fluorescent PIP3-binding proteins localize to circular ruffles in BMMs stimulated with M-CSF (Fig. 8 A; Yoshida et al., 2015). ... Rac-WT and Rac-N17 sequences were PCR amplified and subcloned into the pIRES-mCFP between Nhe1 and EcoR1 sites, resulting in ...http://jcb.rupress.org/content/211/1/159?ijkey=47c072f23b9d9cfe6b2b25304dab3bf39c2e5c1a&keytype2=tf_ipsecsha
Ena drives invasive macrophage migration in Drosophila embryos | Disease Models & Mechanisms
1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410. ... 2005). Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J. Biol. Chem. 280, 28653 ... 2007). Ena/VASP proteins have an anti-capping independent function in filopodia formation. Mol. Biol. Cell 18, 2579-2591. ... 2004). Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 42 ...http://dmm.biologists.org/content/4/1/126
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells | JCB
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410. ... The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth ... These erythrocytes were then bound to a biotinylated protein or antibody for the desired receptor (e.g., Ebab-vitronectin or E ... resulted in particle binding. However, bound particles were not ingested unless PS was present. The PS-dependent uptake of ...http://jcb.rupress.org/content/155/4/649?ijkey=24e722557272d1801cb4d1d2b7668ffcbaa408d0&keytype2=tf_ipsecsha
Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber...
Ridley, A., Paterson, H., Johnston, C., Diekmann, D. and Hall, A. ( 1992). The small GTP-binding protein rac regulates growth ... Ridley, A. and Hall, A. ( 1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress ... and DNA synthesis via the GTP-binding protein rho. Cell Adhes. Commun. 5, 249-255. ... Goretzki, L., Burg, M., Grako, K. and Stallcup, W. ( 1999). High affinity binding of bFGF and PDGF-AA to the core protein of ...http://jcs.biologists.org/content/114/12/2315