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Quinazolines - Halogenated Heterocycles | Sigma-Aldrich  Quinazolines - Halogenated Heterocycles | Sigma-Aldrich
Quinazoline derivatives have found applications as anti-malarial agents and in cancer treatment. The presence of a halogen ... Quinazoline is composed of fused benzene and pyrimidine rings. ... quinazoline AldrichCPR C8H3ClFN3O2 * pricing ... Quinazoline is composed of fused benzene and pyrimidine rings. Quinazoline derivatives have found applications as anti-malarial ... quinazoline AldrichCPR C8H4FN3O3 * pricing ...
more infohttps://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=16271308
Quinazolines, Supplement 1, Volume 55 | Organic Chemistry | Chemistry | Subjects | Wiley  Quinazolines, Supplement 1, Volume 55 | Organic Chemistry | Chemistry | Subjects | Wiley
Quinazoline, Alkylquinazolines, and Arylquinazolines.. Halogenoquinazolines.. Oxyquinazolines.. Thioquinazolines.. Nitro, Amino ... Due to the vast increase in the number and types of individual quinazolines described in recent literature, the author has ... replaced the myriad classified tables of known quinazolines with a single alphabetical table of simple known quinazolines. To ... and Related Quinazolines.. Quinazolinecarboxylic Acids and Related Derivatives.. Appendix.. References.. Index. ...
more infohttps://www.wiley.com/en-us/Quinazolines%2C+Supplement+1%2C+Volume+55-p-9780471145653
Quinazolines as potassium ion channel inhibitors - Patent # 8575184 - PatentGenius  Quinazolines as potassium ion channel inhibitors - Patent # 8575184 - PatentGenius
A compound of formula (I) wherein A, X, Y, Z, R.sub.1 and R.sub.24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, I.sub.Kur-associated disorders, and other disorders mediated by ion channel function. ##STR00001##
more infohttp://www.patentgenius.com/patent/8575184.html
US5411963A - Quinazoline derivatives 
        - Google Patents  US5411963A - Quinazoline derivatives - Google Patents
Substituted quinazolines of the formula (1): ##STR1## wherein: R 1 to R 4 are independently H, halo, (C 1 -C 4 ) alkyl, ... C07D239/72-Quinazolines; Hydrogenated quinazolines * C07D239/74-Quinazolines; Hydrogenated quinazolines with only hydrogen ... C07D239/72-Quinazolines; Hydrogenated quinazolines * C07D239/86-Quinazolines; Hydrogenated quinazolines with hetero atoms ... C07D239/72-Quinazolines; Hydrogenated quinazolines * C07D239/86-Quinazolines; Hydrogenated quinazolines with hetero atoms ...
more infohttps://patents.google.com/patent/US5411963A/en
US5614627A - Quinazoline compounds 
        - Google Patents  US5614627A - Quinazoline compounds - Google Patents
A quinazoline compound represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein ... It relates to a quinazoline compound useful as a medicine exhibiting an inhibitory action on calmodulin-dependent cGMP-PDE. ... C07D239/72-Quinazolines; Hydrogenated quinazolines * C07D239/86-Quinazolines; Hydrogenated quinazolines with hetero atoms ... Process for preparing quinazolines JPS53103484A (en) * 1977-02-21. 1978-09-08. Takeda Chem Ind Ltd. Quinazoline derivatives, ...
more infohttps://patents.google.com/patent/US5614627A/en
Preparation of piperazinyl quinazolines as 5-HT6 modulators.  Preparation of piperazinyl quinazolines as 5-HT6 modulators.
For example, reaction of 2-chloro-4-(4-methylpiperazin-1-yl)quinazoline with N-methyl-4-chlorobenzenesulfonamide gave II in 10 ... quinazoline piperazinyl benzenesulfonamide prepn 5HT6 modulator, Alzheimer schizophrenia obesity Parkinson disease treatment ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:888187
Biotransformation of quinazoline and phthalazine by Aspergillus niger. | Sigma-Aldrich  Biotransformation of quinazoline and phthalazine by Aspergillus niger. | Sigma-Aldrich
Biotransformation of quinazoline and phthalazine by Aspergillus niger.. [John B Sutherland, Thomas M Heinze, Laura K ... Quinazoline was oxidized to 4-quinazolinone and 2,4-quinazolinedione, and phthalazine was oxidized to 1-phthalazinone. ... Cultures of Aspergillus niger NRRL-599 in fluid Sabouraud medium were grown with quinazoline and phthalazine for 7 days. ...
more infohttps://www.sigmaaldrich.com/catalog/papers/21169055
Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives  Chemical Characteristics, Synthetic Methods, and Biological Potential of Quinazoline and Quinazolinone Derivatives
W. L. F. Armarego, A Text Book of Quinazolines, 1963. *R. Rajput and A. P. Mishra, "A review on biological activity of ... I. P. Jung, H. L. So, S. C. Chan, and S. K. Kwan, "Study on the selective reduction of 1H-quinazoline-2,4-diones," Bulletin of ... B. Pati and S. Banerjee, "Quinazolines: an illustrated review," Journal of Advanced Pharmacy. Education & Research, vol. 3, no ... H.-Q. Li, D.-D. Li, X. Lu, Y.-Y. Xu, and H.-L. Zhu, "Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as ...
more infohttps://www.hindawi.com/journals/ijmc/2014/395637/ref/
Quinazolines Made Using Metal-Free Domino Process | Technology Networks  Quinazolines Made Using Metal-Free Domino Process | Technology Networks
Quinazoline is a heterocycle and is, for example, a subunit of many anti-cancer drugs. Up to now, the synthesis of quinazoline ... Like Dominoes: Metal-Free Synthesis of Quinazolines News May 03, 2017 , Original Story from the Friederich-Alexander ... In addition, the novel quinazolines have shown that they are highly effective against herpes viruses, and in contrast to many ... This novel one-pot domino process creates a completely new type of quinazolines, which have intrinsic fluorescence properties. ...
more infohttps://www.technologynetworks.com/drug-discovery/news/quinazolines-made-using-metal-free-domino-process-288312
Structure Cluster 









- 2WZ6: G93A SOD1 mutant complexed with Quinazoline. 3D Similarity Report Page  Structure Cluster - 2WZ6: G93A SOD1 mutant complexed with Quinazoline. 3D Similarity Report Page
2WZ6: Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
more infohttp://www.rcsb.org/pdb/explore/structureCluster.do?structureId=2WZ6
Molecules | Free Full-Text | Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study  Molecules | Free Full-Text | Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study
... quinazolines. The latter were, in turn, subjected to sequential (Sonogashira and Suzuki-Miyaura) and one-pot two-step ( ... quinazolines. The imidazoquinazolines were screened for in vitro cytotoxicity against human breast adenocarcinoma (MCF-7) cells ... quinazolines; cytotoxicity dihalogenated 2H-imidazo[1,2-c]quinazolines; cross-coupling; imidazo[1,2-c]quinazolines; ... Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study. Tebogo Ankie Khoza 1. ...
more infohttp://www.mdpi.com/1420-3049/20/12/19863
US Patent # 9,708,274. Sulfoximine substituted quinazolines for pharmaceutical compositions - Patents.com  US Patent # 9,708,274. Sulfoximine substituted quinazolines for pharmaceutical compositions - Patents.com
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I ##STR00001## wherein Ar, R.sup.1 ... C. for 1.5 h. After cooling to RT the solvent is evaporated giving rise to crude 4,5-dichloro-7-iodo-quinazoline. To a mixture ... STR00065## 4,5,7-substituted quinazolines of the general formula 3-4, wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as ... Sulfoximine substituted quinazolines for pharmaceutical compositions Abstract. This invention relates to novel sulfoximine ...
more infohttp://patents.com/us-9708274.html
Quinazoline | CAS 253-82-7 | SCBT - Santa Cruz Biotechnology  Quinazoline | CAS 253-82-7 | SCBT - Santa Cruz Biotechnology
Buy Quinazoline (CAS 253-82-7), a specialty product for proteomics research, from Santa Cruz. Molecular Formula: C8H6N2, ... Quinazoline (CAS 253-82-7) *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
more infohttps://www.scbt.com/p/quinazoline-253-82-7/
Quinazoline - Wikipedia  Quinazoline - Wikipedia
Quinazolinone Niementowski quinazoline synthesis Armarego, W. L. F. (1963). "Quinazolines". Advances in Heterocyclic Chemistry ... The reduced intermediate condenses with formic acid to yield dihydroquinazoline, which was oxidized to quinazoline. Quinazoline ... quinazoline-2-carboxylic acid). In 1903, Siegmund Gabriel reported the synthesis of the parent quinazoline from o- ... Quinazoline is a organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting ...
more infohttps://en.wikipedia.org/wiki/Quinazoline
Molecules | Free Full-Text | Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II  Molecules | Free Full-Text | Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II
Five of the novel thiazolo[5,4-f]quinazoline derivatives prepared, EHT 5372 (8c), EHT 6840 (8h), EHT 1610 (8i), EHT 9851 (8k) ... quinazolines was realized mainly under microwave irradiation. A novel 6-aminobenzo[d]thiazole-2,7-dicarbonitrile (1) was used ... Five of the novel thiazolo[5,4-f]quinazoline derivatives prepared, EHT 5372 (8c), EHT 6840 (8h), EHT 1610 (8i), EHT 9851 (8k) ... Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II. Alicia Foucourt 1. ...
more infohttp://www.mdpi.com/1420-3049/19/10/15411
US Patent # 3,997,538. 2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines - Patents.com  US Patent # 3,997,538. 2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines - Patents.com
... quinazolines of the formula: ##STR1## wherein R is (1-pyrrolidinyl)propyl; 3-[bis-(2-hydroxyethyl)amino]propyl; 2,3- ... A mixture of 45 g. (0.145 mole) of 4-chloro-2-(3,4-dichlorophenyl)quinazoline and 44 g. (0.3 mole) of 1-amino-3-diethylamino-2- ... A mixture of 46.5 g. (0.15 mole) of 4-chloro-2-(3,4-dichlorophenyl)quinazoline in 500 ml of dimethylformamide and 29 g (0.31 ... 2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines Abstract. A series of 2-(3,4-dichlorophenyl)-4-(substituted amino) ...
more infohttp://patents.com/us-3997538.html
IUCr) 7H-[1,2]Benzo-thia-zolo[3,2-b]quinazoline 5,5-dioxide  IUCr) 7H-[1,2]Benzo-thia-zolo[3,2-b]quinazoline 5,5-dioxide
For the uses and biological importance of benzothia-zole and quinazoline derivatives, see: Schwartz et al. (1992. ); Wolfe et ... In the title compound, C14H10N2O2S, the benzothia-zole and quinazoline ring systems are essentially planar with maximum ... The quinazoline ring system is also essentially planar with the maximum deviation of -0.1588 (15)Å for the N1 atom. The ... For the uses and biological importance of benzothiazole and quinazoline derivatives, see: Schwartz et al. (1992); Wolfe et al. ...
more infohttp://journals.iucr.org/e/issues/2012/11/00/rk2382/index.html
Plus it  Plus it
Design and synthesis of quinazoline derivatives as potential anticancer agents. Ming-Hsieh Chuang, Meng-Ling Chen, Ji-Wang ... Design and synthesis of quinazoline derivatives as potential anticancer agents. Ming-Hsieh Chuang, Meng-Ling Chen, Ji-Wang ... Design and synthesis of quinazoline derivatives as potential anticancer agents. Ming-Hsieh Chuang, Meng-Ling Chen, Ji-Wang ... Design and synthesis of quinazoline derivatives as potential anticancer agents Message Subject (Your Name) has forwarded a page ...
more infohttp://mct.aacrjournals.org/content/6/11_Supplement/A2
Niementowski quinazoline synthesis - Wikipedia  Niementowski quinazoline synthesis - Wikipedia
The Niementowski quinazoline synthesis is the chemical reaction of anthranilic acids with amides to form 4-oxo-3,4- ... Hensbergen et al.[4] have shown a synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a ... Williamson, T. A. (1957). "The chemistry of quinazoline". In Elderfield, R. C. Heterocyclic Compounds. 6. New York: John Wiley ... "An expedient synthesis of oxazepino and oxazocino quinazolines". Tetrahedron Lett. 56 (46): 6478-6483. doi:10.1016/j.tetlet. ...
more infohttps://en.wikipedia.org/wiki/Niementowski_quinazoline_synthesis
Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning  Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning
Various quinazoline inhibitors targeting ErbB1 or ErbB2 - 4 have been developed as anti-cancer agents and might be useful for ... Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal ... These results indicate an antipsychotic potential of quinazoline ErbB1 inhibitors. ErbB receptor tyrosine kinases may be novel ...
more infohttps://www.jstage.jst.go.jp/article/jphs/114/3/114_10099FP/_article
6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxaldehyde- CAS Number 93955-15-8  6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxaldehyde- CAS Number 93955-15-8
... quinazoline-2-carboxaldehyde - CAS Number 93955-15-8 from LGC Standards. Please login or register to view prices, check ... 6-Chloro-4-(2-chlorophenyl)-quinazoline-2-carbaldehyde ; Lorazepam USP RC C ;Lorazepam Imp. E (EP) ;. Read more.. ...
more infohttps://www.lgcstandards.com/DE/en/6-Chloro-4-2-chlorophenyl-quinazoline-2-carboxaldehyde/p/BP%20376
6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxaldehyde- CAS Number 93955-15-8  6-Chloro-4-(2-chlorophenyl)quinazoline-2-carboxaldehyde- CAS Number 93955-15-8
... quinazoline-2-carboxaldehyde - CAS Number 93955-15-8 from LGC Standards. Please login or register to view prices, check ... Lorazepam USP Related Compound C ; 6-Chloro-4-(2-chlorophenyl)-quinazoline-2-carbaldehyde ;Lorazepam Imp. E (EP) ;. Read more.. ...
more infohttps://www.lgcstandards.com/IT/en/6-Chloro-4-2-chlorophenyl-quinazoline-2-carboxaldehyde/p/BP%20376
Synthesis of SF5-containing benzisoxazoles, quinolines, and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl...  Synthesis of SF5-containing benzisoxazoles, quinolines, and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl...
... and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl)benzenes ... Finally, quinazoline 14 was synthesized by the reaction of aminoketone 11a with benzylamine in the presence of t-BuOOH and ... Several reliable synthetic methods giving quinolones [32,33] or quinazolines [34,35] have been reported in the literature. One ... Synthesis of SF5-containing benzisoxazoles, quinolines, and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl) ...
more infohttps://www.beilstein-journals.org/bjoc/articles/9/43
p-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and  | DDDT  p-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and | DDDT
Keywords: thiazolo[3,2-a]pyrimidine and thiazolo[2,3-b]quinazoline, hepatocellular carcinoma, domino reactions, interleukins, ... quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs bearing a bridgehead nitrogen atom. This domino protocol ... quinazoline system showed the optimum effect. The in silico simulations suggested crucial hydrogen bond and π-π stacking ... quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against ...
more infohttps://www.dovepress.com/p-tsa-promoted-syntheses-of-5h-benzohthiazolo23-bquinazoline-and-inden-peer-reviewed-article-DDDT