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*  Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed | PNAS
1995) Quantitative trait locus analysis of a recombinant inbred line population derived from a Lycopersicon esculentum x ... "Golden Rice" and high oleic acid soya are two examples of output traits with the potential to make a difference. In addition to ... Over the last decades, biotechnology has successfully delivered agronomical input traits (14). The consumers demand for ... To achieve this goal the development of output traits represent a major agricultural objective. " ...
https://www.pnas.org/content/early/2017/09/19/1708349114.full
*  Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus | PNAS
Genetic and genomic mapping show that core members of canonical Tgfβ signaling segregate with quantitative trait loci (QTL) for ... Biologists have long been captivated by novel traits because they provide insights into both the origin of and constraints on ... and genetic mapping to implicate the Tgfβ pathway in the development of this unusual trait. Given the functions of Tgfβ ...
http://www.pnas.org/content/115/27/7063.short?rss=1
*  Genetic variation in the SIM1 locus is associated with erectile dysfunction | PNAS
To test SNPs for expression of quantitative trait locus effects, we queried the Genotype-Tissue Expression (GTEx) Portal (53). ... Genetic variation in the SIM1 locus is associated with erectile dysfunction. Eric Jorgenson, Navneet Matharu, Melody R. Palmer ... Genetic variation in the SIM1 locus is associated with erectile dysfunction. Eric Jorgenson, Navneet Matharu, Melody R. Palmer ... Genetic variation in the SIM1 locus is associated with erectile dysfunction Message Subject (Your Name) has sent you a message ...
https://www.pnas.org/content/115/43/11018
*  Common coding variant in SERPINA1 increases the risk for large artery stroke | PNAS
Also, expression quantitative trait locus (eQTL) analysis revealed no association between M1(A213) and AAT levels in ... 2012) Imputation of exome sequence variants into population-based samples and blood-cell-trait-associated loci in African ... 2015) Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study. Lancet Neurol 15(2):174- ... 2012) Novel loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet 8(8): ...
https://www.pnas.org/content/114/14/3613
*  Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light | PNAS
Because PHYB has been proposed as a candidate gene for several quantitative trait loci (QTLs) affecting light response, we have ... Because PHYB has been proposed as a candidate gene for several quantitative trait loci (QTLs) affecting light response, we have ...
https://www.pnas.org/content/105/8/3157.abstract
*  Parallel epigenetic modifications induced by hatchery rearing in a Pacific salmon | PNAS
... and quantitative trait loci for production traits. Evol Appl 10:276-296. ... To detect outlier loci between sexes (Fig. S1) and test for possible selective effect within a single generation between HOR ... traits occurring in hatcheries have focused on finding signatures of selection at the genome level by identifying loci with a ... if such rapid selection on complex phenotypic traits would rather induce subtle changes in allele frequency over multiple loci ...
https://www.pnas.org/content/114/49/12964.full
*  Relationships of cereal crops and other grasses | PNAS
However, a study that mapped quantitative trait loci (QTL) for salt or drought tolerance for any one of the species could ... When descendants have different traits (e.g., different linkages of 7a and 7b), the ability to extrapolate to an ancestor ... Rapid Genome Divergence at Orthologous Low Molecular Weight Glutenin Loci of the A and Am Genomes of Wheat ... Anchored Reference Loci in Loblolly Pine (Pinus taeda L.) for Integrating Pine Genomics ...
https://www.pnas.org/content/95/5/2005?ijkey=da290c036d3166e26e02ed0cdd928b296ad16f59&keytype2=tf_ipsecsha
*  Parkin-deficient mice are not a robust model of parkinsonism | PNAS
For example, genes and quantitative trait loci closely linked to parkin are confounding because they are known to modify body ... For example, Parkin-deficient mice with a targeted deletion of exon 7 (B6;129) have fewer norepinephrine neurons in the locus ... Deletion of exon 2 was confirmed at the parkin genomic locus with Southern analysis and PCR (Fig. 3 B and C). Mutant parkin ... an increase in the number of norepinephrine neurons in the locus coeruleus (28-30). We found that 129S4 mice with a targeted ...
https://www.pnas.org/content/102/6/2174?ijkey=2c06b9095ed77aae8ad6c2af6d4e4b5d8094f1c3&keytype2=tf_ipsecsha
*  Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic...
... such a quantitative trait locus (QTL)-based approach would require years of conventional breeding to achieve significant ... We carried out quantitative profiling of the carotenoid content by HPLC and found that the total carotenoid level in transgenic ... 2006) Use of the affinity/HPLC method for quantitative estimation of folic acid in enriched cereal-grain products. J Nutr 136: ... For example, 4 polymorphisms at the lcye locus in corn were recently shown to alter the flux between the α-carotene and β- ...
http://www.pnas.org/content/106/19/7762?ijkey=8d11ef1f8063f648d6e5c2e7d5e669da96ff22a0&keytype2=tf_ipsecsha
*  Regulation of inflorescence architecture by intertissue layer ligand-receptor communication between endodermis and phloem | PNAS
... to be downstream of ER-signaling based on a bioinformatics study that combined seedling expression quantitative trait loci data ... epfl4 epfl6 has large cortex cells similar to er (asterisks). (Scale bars: 25 μm.) (J) Quantitative analysis of cortex cell ... Scale bar: 25 μm.) (K) Quantitative analysis of cortex cell length (n = 26-30). Bars indicate mean values; error bars indicate ...
http://www.pnas.org/content/109/16/6337
*  Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae | PNAS
... of genes had expression affected by quantitative trait loci (QTL) with evidence of significant interactions with the ... interactions in studies of quantitative traits (8), results from the mutational process generating variation in phenotypic ... The Vm was found to differ among environments (indicating GxE interactions) for some traits (29⇓⇓-32) but not others (33, 34), ... 25⇓⇓-28). By comparing trait variation among lines in which nonlethal mutations have accumulated in the near absence of ...
http://www.pnas.org/content/114/52/E11218.full
*  Molecular distinction in genetic regulation of nonphotochemical quenching in rice | PNAS
By quantitative trait loci (QTL) analysis of these data, we identified two loci on chromosome 1 (Fig. 3B). Fig. 3C shows ... Two loci were identified in QTL analysis between an Indica and a Japonica cultivar. The results suggest one of these loci ... two loci were identified. Of these two loci, qNPQ1-2 seems to regulate NPQ between Indica and Japonica, whereas qNPQ1-1 seems ... The locus qNPQ1-1 showed a LOD score peak at approximately 9.0 to 11.5 Mb, and qNPQ1-2 showed a peak at approximately 37.0 to ...
https://www.pnas.org/content/108/33/13835
*  A single domestication for maize shown by multilocus microsatellite genotyping | PNAS
Exploiting quantitative trait loci in gene discovery. *. Transgenic Maize and the Evolution of Landrace Diversity in Mexico. ... We used 99 microsatellite loci that are evenly distributed throughout the genome. A list of the microsatellite loci with their ... Thirteen novel alleles were found for the 33 loci and confirmed by sequencing. The estimates of μ and σ. were 4.28 × 10−4 and ... We calculated the mean (δμ)2 distance (18) over the 33 loci between Mexican maize and ssp. parviglumis. The number of ...
http://www.pnas.org/content/99/9/6080
*  Clock Mutants of Drosophila melanogaster | PNAS
Footprints in time: comparative quantitative trait loci mapping of the pitcher-plant mosquito, Wyeomyia smithii ...
http://www.pnas.org/content/68/9/2112.short
*  Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis | PNAS
Network Quantitative Trait Loci Mapping of Circadian Clock Outputs Identifies Metabolic Pathway-to-Clock Linkages in ... Detailed methods of quantitative RT-PCR are described in SI Methods . Note scalar differences between regulatory and structural ... www.atted.bio.titech.ac.jp/locus/At4g03050.html) revealed that this gene is expressed specifically in fruit, suggesting AOP3 as ...
http://www.pnas.org/content/104/15/6478.full
*  Sexual selection and speciation in field crickets | PNAS
Quantitative Trait Loci Responsible for Variation in Sexually Dimorphic Traits in Drosophila melanogaster ... Quantitative genetic parameters apply to the population sampled at the time of sampling. As we do not know the population ... The within-locality quantitative genetic estimates for G. texensis were highly variable and had high standard errors, ... a genetic correlation between the male trait and the female preference, and (iii) no character displacement in male song, ...
http://www.pnas.org/content/97/26/14449
*  Ancient polyploidization predating divergence of the cereals, and its consequences for comparative genomics | PNAS
Comparison of Quantitative Trait Loci for Adaptive Traits Between Oak and Chestnut Based on an Expressed Sequence Tag Consensus ... and Relationship to Quantitative Trait Loci, of Sorghum Genes with Rhizome-Enriched Expression ... many loci deviate from these syntenic/colinear relationships (Table 2). Across the entire genome, incongruent loci occurred on ... Pairs of loci with Ks values within 0.1 units of the peak (0.75-0.95: Fig. 1 Lower) show much less "noise" obscuring ...
https://www.pnas.org/content/101/26/9903?ijkey=6f3e8aa6a03abfada6ba6586f8aacb8d2159d6d9&keytype2=tf_ipsecsha
*  Fertilization-independent seed development in Arabidopsis thaliana | PNAS
Mapping Quantitative Trait Loci Affecting Arabidopsis thaliana Seed Morphology Features Extracted Computationally From Images ... the pollen from this plant was used to transfer the mutant fis3 trait to progeny. These results indicate that the fis traits ... One of the 450 plants for the FIS1 locus and 2 of the 1621 plants for FIS2 were homozygous fis1/fis1 and fis2/fis2. No plants ... Plants with the fis phenotype originally were isolated in a male-sterile pi/pi background so that the fis trait could not be ...
https://www.pnas.org/content/94/8/4223?ijkey=3e0696cafb0db829f2886ce7c8ed4d0caa4fe9d3&keytype2=tf_ipsecsha
*  Control of fertilization-independent endosperm development by the MEDEA polycomb gene in Arabidopsis | PNAS
Mapping Quantitative Trait Loci Affecting Arabidopsis thaliana Seed Morphology Features Extracted Computationally From Images ... Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes ... Mutation of the RESURRECTION1 Locus of Arabidopsis Reveals an Association of Cuticular Wax with Embryo Development ...
https://www.pnas.org/content/96/7/4186?ijkey=912a4a46ee2b94acc929d9ae7704de75d8723c6d&keytype2=tf_ipsecsha
*  Polycomb group proteins are required to couple seed coat initiation to fertilization | PNAS
Mapping Quantitative Trait Loci Affecting Arabidopsis thaliana Seed Morphology Features Extracted Computationally From Images ... Independent single transgene locus insertion T2 lines were analyzed. The AGL62:AGL62-GFP-containing vector was generated by ... The construct was transformed into the agl62-2 mutant and independent single transgene locus insertion T2 lines were analyzed. ... 2007) Positive darwinian selection at the imprinted MEDEA locus in plants. Nature 448:349-352. ...
http://www.pnas.org/content/108/51/20826
*  Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant...
Identification of Quantitative Trait Loci Controlling Gene Expression during the Innate Immunity Response of Soybean ... B) Quantitative analysis of DAB on leaves 6 h postinoculation with DC3000(avrRpm1) at 2.5 × 107 cfu/ml, DC3000 (same inoculum ... Pp isolate Emco5 is fully virulent on Col-0 cotyledons, but triggers resistance, conditioned by a single locus, in the emerging ...
http://www.pnas.org/content/99/1/517?ijkey=da174b5928ff1cfa74e5c20c9eae9a15c36b9f0a&keytype2=tf_ipsecsha
*  Statistical significance for genomewide studies | PNAS
Expression Quantitative Trait Loci for Extreme Host Response to Influenza A in Pre-Collaborative Cross Mice ... Linkage was tested between 3,312 markers spanning the genome and each of these 6,215 "quantitative traits." A statistically ... A cutoff of 1.6 × 10-4 yields 205 genes showing linkage to at least one locus, where 1 is expected by chance. The p values are ... This strict criterion is used mainly because one or very few loci are expected to show linkage in any given study (1, 2). ...
https://www.pnas.org/content/100/16/9440.full
*  Artificial selection for a green revolution gene during japonica rice domestication | PNAS
Quantitative Trait Locus and Haplotype Analyses of Wild and Crop-Mimic Traits in U.S. Weedy Rice ... The semidwarf phenotype has been extensively selected during modern crop breeding as an agronomically important trait. ...
https://www.pnas.org/content/early/2011/06/01/1019490108
*  Dual pathways for regulation of root branching by nitrate | PNAS
Quantitative Trait Loci Analysis of Water and Anion Contents in Interaction With Nitrogen Availability in Arabidopsis thaliana ... Quantitative Analysis of Lateral Root Development: Pitfalls and How to Avoid Them ...
http://www.pnas.org/content/96/11/6529?ijkey=9763589cb42d08981b6559b91d1ef259d15b7074&keytype2=tf_ipsecsha