Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus | PNAS
Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus. Juergen Kroymann, Susanne Donnerhacke, ... Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus. Juergen Kroymann, Susanne Donnerhacke, ... Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus Message Subject (Your Name) has sent you a ... Network Quantitative Trait Loci Mapping of Circadian Clock Outputs Identifies Metabolic Pathway-to-Clock Linkages in ...https://www.pnas.org/content/100/suppl_2/14587?ijkey=142b2725b62d11462c28c17c68fcdaffbe2f663f&keytype2=tf_ipsecsha
Comparative genetics in the grasses | PNAS
Comparison of Quantitative Trait Loci for Adaptive Traits Between Oak and Chestnut Based on an Expressed Sequence Tag Consensus ... Haplotype variation in structure and expression of a gene cluster associated with a quantitative trait locus for improved yield ... which have been measured as quantitative trait loci (QTLs) in other genomes. An example is the alignment of the major maize ... Bennetzen's group (21) and Chen et al. (22) have obtained sequence of the region spanning the A1 and Sh2 loci in sorghum and ...https://www.pnas.org/content/95/5/1971?ijkey=4ad52d0237139587f7842c69dcaaba9e6b2164db&keytype2=tf_ipsecsha
The genetic mediation of individual differences in sensitivity to pain and its inhibition | PNAS
... demonstrating linkage of a pain-related trait to chromosomal locations in the mouse. A two-step quantitative trait locus (QTL) ... Heritability of Pain-Related Traits. That individual differences in pain-related traits exist, of course, does not imply that ... to determine whether traits share genetic mediation (see ref. 61). The fact that a given gene can influence more than one trait ... As predicted by the hypothesis of Oprd1 as a male-specific QTL for this trait, we observed a sex- and strain-dependent pattern ...https://www.pnas.org/content/96/14/7744?ijkey=61d06c9aa4c8a6590b8d8fa8d4870c36b2a96ce6&keytype2=tf_ipsecsha
Identifying genes of agronomic importance in maize by screening microsatellites for evidence of selection during domestication ...
quantitative trait locus;. N,. number of alleles;. ΔGD,. relative loss in genetic diversity;. Δ Allele,. relative loss in the ... Knowing the functions and map locations of these genes will be useful for associating them with quantitative trait loci (QTL) ... One is the intended bias to enrich the pool for nonneutral loci. The other bias is to enrich the pool for neutral loci that are ... Are we identifying selected loci or neutral loci that are simply tightly linked to selected ones? Barring a focused ...https://www.pnas.org/content/99/15/9650?ijkey=eca7cb8f3f71ad36917fd4ef03297b322bc0a935&keytype2=tf_ipsecsha
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice | PNAS
quantitative trait locus/loci;. Cdcs,. cytokine deficiency-induced colitis susceptibility;. cM,. centimorgan;. ECM,. ... A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Mark A. Farmer, John P. ... A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice ... A Quantitative Trait Loci Analysis to Map Genes Involved in Lipopolysaccharide-Induced Inflammatory Response: Identification of ...http://www.pnas.org/content/98/24/13820
3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture |...
2006) Quantitative trait loci for root architecture traits correlated with phosphorus acquisition in common bean. Crop Sci 46(1 ... We identified 89 quantitative trait loci (QTLs) at 13 clusters among 25 RSA traits. Several clusters correspond to QTLs ... 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture. ... 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture ...https://www.pnas.org/content/110/18/E1695?ijkey=e2dc4d5740481c941778d810689075b1ab41ec67&keytype2=tf_ipsecsha
Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo | PNAS
2014) SplicePlot: A utility for visualizing splicing quantitative trait loci. Bioinformatics 30(7):1025-1026. ... 2009) A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis ... Linkage and Sequencing Analysis Identifies Cflar as One of the Loci Conferring the Trait.. As was shown earlier (Fig. 1 B-D), ... Using lethality as a readout, we identified several loci linked to resistance, with a Chr1 locus showing the highest linkage. ...http://www.pnas.org/content/113/6/1606.long
Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type...
2000) Quantitative trait loci affecting prion incubation time in mice. Genomics 69:47-53. ... 2001) Identification of multiple quantitative trait loci linked to prion disease incubation period in mice. Proc Natl Acad Sci ... Although the genes responsible for mouse incubation time quantitative trait loci have not yet been identified, orthologous ... quantitative, and biochemical study. Am J Pathol 164:143-153. ...http://www.pnas.org/content/105/10/3885.long
A genetic basis of variation in eccrine sweat gland and hair follicle density | PNAS
Whole genome quantitative trait locus (QTL) mapping in the F2 population using ninety individuals selected from the tails of ... Quantitative trait locus mapping identified a large region on mouse Chromosome 1 that controls both hair and eccrine gland ... 2009) Quantitative trait locus analysis using J/qtl. Methods Mol Biol 573:175-188. ... 2013) Dissecting quantitative traits in mice. Annu Rev Genomics Hum Genet 14:421-439. ...https://www.pnas.org/content/112/32/9932?ijkey=4f215e5c2d17b14549f62be935c8a7ba906c5a0e&keytype2=tf_ipsecsha
Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize | PNAS
quantitative trait loci mapping. Resistance to diseases in many plant and animal systems is based on complex inheritance. ... 2008) Quantitative trait loci for slow-rusting resistance in wheat to leaf rust and stripe rust identified with multi- ... Twenty-nine quantitative trait loci were identified, and most had multiple alleles. The large variation in resistance ... 2005) Maize association population: A high-resolution platform for quantitative trait locus dissection. Plant J 44:1054-1064. ...https://www.pnas.org/content/108/17/6893
Identification of genetic variants influencing the human plasma proteome | PNAS
2008) A genome-wide association study identifies protein quantitative trait loci (pQTLs) PLoS Genet 4(5):e1000072. ... These studies have identified a series of metabolic quantitative trait loci (mQTL) affecting the level of these biomolecules (7 ... 2010) Identification of quantitative trait loci underlying proteome variation in human lymphoblastoid cells. Mol Cell ... have demonstrated the presence of protein quantitative trait loci (pQTL) (10⇓-12), i.e., genetic variants impacting protein ...http://www.pnas.org/content/110/12/4673
MOTHER-OF-FT-AND-TFL1 represses seed germination under far-red light by modulating phytohormone responses in Arabidopsis...
2006) Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis. Proc Natl Acad Sci USA 103:17042- ... In Arabidopsis there are six PEBP proteins and extensive analyses of two of them, FLOWERING-LOCUS-T (FT) and TERMINAL-FLOWER1 ( ... 1998) The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell 10:1043-1054. ... followed by quantitative PCR (qPCR) whether PIF1 binds the MFT promoter in FR-treated seeds but we found no evidence of such an ...http://www.pnas.org/content/115/33/8442
Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture |...
2C), partially overlapping regions with previously identified root morphology quantitative trait loci (QTL) (4⇓-6, 15⇓⇓-18). We ... 2002) Quantitative trait loci analysis of growth response to varying nitrogen sources in Arabidopsis thaliana. Theor Appl Genet ... 2006) Identification of quantitative trait loci that regulate Arabidopsis root system size and plasticity. Genetics 172(1):485- ... 2010) A hyperactive quantitative trait locus allele of Arabidopsis BRX contributes to natural variation in root growth vigor. ...http://www.pnas.org/content/110/37/15133?ijkey=f99cbd6332ac1a14ac270b10574de050443644b2&keytype2=tf_ipsecsha
Natural diversity in daily rhythms of gene expression contributes to phenotypic variation | PNAS
2006) Analysis of phase of LUCIFERASE expression reveals novel circadian quantitative trait loci in Arabidopsis. Plant Physiol ... a complex quantitative trait known to be under the control of many small effect loci (50, 51). Theoretical models predict that ... quantitative trait loci (QTL) of moderate effect that precisely regulated the timing of GI expression during the LD 16-h cycle ... A) Hypocotyl length and (B) PIF4 mRNA levels at zeitgeber time (ZT) 20 h, quantified by quantitative RT-PCR (qRT-PCR) in LDs of ...http://www.pnas.org/content/112/3/905.full
DELAY OF GERMINATION 1 mediates a conserved coat-dormancy mechanism for the temperature- and gibberellin-dependent control of...
2006) Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis. Proc Natl Acad Sci USA 103(45): ... 2011) Variation in seed dormancy quantitative trait loci in Arabidopsis thaliana originating from one site. PLoS ONE 6(6): ... Quantitative trait genes (QTGs), including DELAY OF GERMINATION1 (DOG1) (3, 10⇓-12), provide the genetic basis for the observed ... Seed dormancy is an important adaptive early-life history trait because it controls the distribution of germination in space (e ...http://www.pnas.org/content/111/34/E3571
Genetic structure and domestication history of the grape | PNAS
sativa) berry: A quantitative trait locus to quantitative trait nucleotide integrated study. Genetics 183:1127-1139. ... We demonstrate this by mapping the locus responsible for lighter berry pigmentation, a trait that experienced strong artificial ... the locus underlying a particular phenotypic difference between clones may be the same locus involved in segregating variation ... 2008) Genome-wide association studies for complex traits: Consensus, uncertainty and challenges. Nat Rev Genet 9:356-369. ...http://www.pnas.org/content/108/9/3530.full
Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector...
... the map positions determined for quantitative trait loci (QTLs) are also approximate. Because QTLs control such important ... A TAC contig was constructed in the region of the SGR1 locus, and individual clones with ca. 80-kb inserts were tested for ... The Arabidopsis mutant sgr1 is deficient in the gravitropic response of its hypocotyl and stem (17). The SGR1 locus has been ... The results also demonstrate a single locus insertion of the transgene in all but one (line G) of the T2 families (Table 2) ...http://www.pnas.org/content/96/11/6535
Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape...
2003) Quantitative trait locus analysis of leaf dissection in tomato using Lycopersicon pennellii segmental introgression lines ... 2013) A quantitative genetic basis for leaf morphology in a set of precisely defined tomato introgression lines. Plant Cell 25( ... 4A and SI Appendix, Table S7) as well as defects in reproductive traits including bracteate inflorescences (SI Appendix, Fig. ... 2013) A cytochrome P450 regulates a domestication trait in cultivated tomato. Proc Natl Acad Sci USA 110(42):17125-17130. ...https://www.pnas.org/content/111/25/E2616?ijkey=2d2d40c2794a5c929ea28848750e430faa037637&keytype2=tf_ipsecsha
Table of Contents - November 20, 2001, 98 (24) | PNAS
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice Mark A. Farmer, John P. ...http://www.pnas.org/content/98/24/
Measuring missing heritability: Inferring the contribution of common variants | PNAS
1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2(1):3-19. ... General Model of Quantitative Traits.. In the general case, a quantitative phenotype p depends on genotype g and environment e ... in which the first step entails applying a simple recipe appropriate for quantitative traits to a disease trait coded as 0/1 ... the phenotype is an additive polygenic quantitative trait, in which case we have f. (. h. 2. ,. G. i. j. ). =. h. 2. G. i. j. ...http://www.pnas.org/content/111/49/E5272.full
The origin and evolution of fragrance in rice (Oryza sativa L.) | Proceedings of the National Academy of Sciences
2008) Mapping of quantitative trait loci for basmati quality traits in rice (Oryza sativa L.) Mol Breed 21:49-65. ... 1996) Aroma in rice: Genetic analysis of a quantitative trait. Theor Appl Genet 93:1145-1151. ... Fragrance in the grain is one of the most highly valued grain quality traits in rice, yet the origin and evolution of the ... Fragrance is considered one of the most important grain quality traits in rice, as it is a key factor in determining market ...http://www.pnas.org/content/106/34/14444.full
Continuous immunotypes describe human immune variation and predict diverse responses | PNAS
2004) A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11. Genes Immun 5:548-552. ... 2016) Differential effects of environmental and genetic factors on T and B cell immune traits. Cell Reports 17:2474-2487. ... rather than separate clusters of individuals sharing immunological traits, there is a continuum of human immune variation. This ... we asked whether a healthy population formed well-separated clusters of individuals with similar immune cell composition traits ...http://www.pnas.org/content/early/2017/07/06/1705065114.full
Evidence for widespread adaptive evolution of gene expression in budding yeast | PNAS
genetic drift in phenotypic evolution using quantitative trait locus data. Genetics 149:2099-2104. ... Gene expression levels can be treated as quantitative traits (12), but, unfortunately, too few gene expression quantitative ... in an elegant test of selection on quantitative traits: if alleles increasing the value of a trait are preferentially found in ... Trait ascertainment bias is an issue addressed by Orr (11), but not usually applicable to gene expression traits (SI Text). ...http://www.pnas.org/content/107/7/2977
Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed | PNAS
1995) Quantitative trait locus analysis of a recombinant inbred line population derived from a Lycopersicon esculentum x ... "Golden Rice" and high oleic acid soya are two examples of output traits with the potential to make a difference. In addition to ... Over the last decades, biotechnology has successfully delivered agronomical input traits (14). The consumers demand for ... To achieve this goal the development of output traits represent a major agricultural objective. " ...https://www.pnas.org/content/early/2017/09/19/1708349114.full
Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus | PNAS
Genetic and genomic mapping show that core members of canonical Tgfβ signaling segregate with quantitative trait loci (QTL) for ... Biologists have long been captivated by novel traits because they provide insights into both the origin of and constraints on ... and genetic mapping to implicate the Tgfβ pathway in the development of this unusual trait. Given the functions of Tgfβ ...http://www.pnas.org/content/115/27/7063.short?rss=1