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*  Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis.
PTEN Phosphohydrolase. Phosphoric Monoester Hydrolases / genetics. Retrospective Studies. Tomography, X-Ray Computed. Tumor ... 0/Tumor Suppressor Proteins; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN ... That patient was observed to have a deletion in the critical portion of Exon 5 of the PTEN gene, the gene associated with ...
http://www.biomedsearch.com/nih/Cowden-disease-Lhermitte-Duclos-characterization/10690726.html
*  A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces...
Because inactivation of PTEN is a somatic event, PTEN mutations represent an important genetic difference between cancer cells ... The PTEN tumor suppressor gene is one of the most commonly mutated genes in human cancer. ... EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase ... PTEN Phosphohydrolase / genetics*. Phosphatidylinositol 3-Kinases / genetics*. Proto-Oncogene Proteins c-akt / metabolism. ...
http://www.biomedsearch.com/nih/High-Throughput-Screen-with-Isogenic/21335596.html
*  Expression of CDC47/MCM7 (A), Akt (B) and Phospho-Akt ( | Open-i
PTEN Phosphohydrolase. *Phosphorylation. *Protein Tyrosine Phosphatases/analysis. *Proto-Oncogene Proteins c-akt ... PTEN protein, a phosphatase involved in the regulation of Akt phosphorylation, was present at all days of estrous cycle and ... PTEN protein, a phosphatase involved in the regulation of Akt phosphorylation, was present at all days of estrous cycle and ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC161822_1477-7827-1-47-6&req=4
*  A Schematic Representation of the Potential for Novel M | Open-i
PTEN Phosphohydrolase/deficiency/physiology. *Protein Kinases/physiology. *Proto-Oncogene Proteins c-akt/physiology ... loss of PTEN function is a common feature in both types of GBMs. Response to chemotherapy may be modified by the level of ... loss of PTEN function is a common feature in both types of GBMs. Response to chemotherapy may be modified by the level of ... and PTEN, or activate oncogenes such as MDM2 and CDKs 4 and 6; alterations in EGFR are less common or absent... Frequently, ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211557_pmed.0050021.g003&req=4
*  "PTEN is a tumor suppressor in CML stem cells and BCR-ABL induced leuke" by Cong Peng, Yaoyu Chen et al.
PTEN suppresses LSCs and induces cell cycle arrest of leukemia cells. Moreover, PTEN suppresses B-ALL development through ... and that PTEN deletion causes acceleration of CML development. In addition, overexpression of PTEN delays the development of ... Using our mouse model of BCR-ABL induced leukemias, we show that PTEN is down-regulated by BCR-ABL in leukemia stem cells (LSCs ... These results demonstrate a critical role of PTEN in BCR-ABL induced leukemias and suggest a potential strategy for the ...
https://escholarship.umassmed.edu/gsbs_sp/1632/
*  Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth.
The inhibition of PTEN, a negative regulator of AKT, or the expression of a constitutively active form of AKT restores myelin ... PTEN Phosphohydrolase. Proto-Oncogene Proteins c-akt. Metadata. Show full item record ...
https://pearl.plymouth.ac.uk/handle/10026.1/6645
*  Phase II study of copanlisib, a PI3K inhibitor, in relapsed or refractory, indolent or aggressive lymphoma.
PTEN Phosphohydrolase. Phosphatidylinositol 3-Kinases. Pyrimidines. Quinazolines. Recurrence. Survival Analysis. Research team ...
https://repository.icr.ac.uk/handle/internal/695
*  Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis. - Schmitz Martine
PTEN Phosphohydrolase/analysis ; Phosphatidylinositol 3-Kinases/analysis ; Prognosis ; Prostate/chemistry/pathology ; Prostatic ... PTEN and p-Akt protein expression. We provide evidence that loss of PTEN expression rather than upregulated EGF/IGF1 receptor ... exhibited already loss of PTEN expression at first diagnosis. These findings demonstrate that loss of PTEN expression is an ... We therefore compared PTEN expression in patient biopsies at first time diagnosis recruited prospectively (Study I, 112 ...
http://orbilu.uni.lu/handle/10993/23945
*  Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53...
PTEN Phosphohydrolase (MeSH) * Tumor Suppressor Protein p53 (MeSH) published in * British Journal of Cancer Journal ... Overall, PIK3CA mutations are most commonly seen, with fewer TP53 and PTEN mutations, similar to the profile seen in luminal A ... Differences in mutation profiles and patterns of gene gains/losses are seen between BRCA2 (associated with TP53/PTEN mutations ... and one PTEN mutation. Common gains were seen in GNAS (34.1%) and losses were seen in GNAQ (36.4%), ABL1 (47.7%) and ATM (34.1 ...
https://scholars.latrobe.edu.au/display/publication45717
*  List of MeSH codes (D08) - Wikipedia
... pten phosphohydrolase MeSH D08.811.277.352.660 --- phosphoric triester hydrolases MeSH D08.811.277.352.660.500 --- ... gtp phosphohydrolases MeSH D08.811.277.040.330.200 --- dynamins MeSH D08.811.277.040.330.200.100 --- dynamin i MeSH D08.811. ... gtp phosphohydrolase-linked elongation factors MeSH D08.811.277.040.330.300.100.200 --- peptide elongation factor g MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL. - Radcliffe Department of...
They exhibit recurrent secondary genomic rearrangements that lead to Myc overexpression and loss of Pten activity. Because β- ... deficient for Pten, our results suggest that activation of the canonical Wnt pathway is associated with a subtype of Notch- ... independent T-ALLs that bear Myc gene rearrangements and Pten mutations. ... PTEN Phosphohydrolase, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Receptors, Notch, T-Lymphocytes, Up-Regulation, Wnt ...
https://www.rdm.ox.ac.uk/publications/407782
*  Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage...
PTEN Phosphohydrolase/chemistry. *PTEN Phosphohydrolase/metabolism. *Phosphatidylinositol Phosphates/chemistry. * ... Voltage-sensing phosphatases (VSPs) are homologs of phosphatase and tensin homolog (PTEN), a phosphatidylinositol 3,4- ...
https://www.ncbi.nlm.nih.gov/pubmed/27222577
*  Ercument Dirice, PH.D. | Harvard Catalyst Profiles | Harvard Catalyst
PTEN Phosphohydrolase. *Pyridines. *Pyrimidines. *Rats. *Rats, Wistar. *Receptor, Insulin. *Receptors, TNF-Related Apoptosis- ...
https://connects.catalyst.harvard.edu/Profiles/display/Person/1253/Network/ResearchAreas
*  "A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BA" by Naomi Elster, Mattia Cremona et al.
P53 or PTEN status. The combination of HER2-targeted therapies and BAY 80-6946 inhibited growth more effectively than either ... A panel of HER2-positive breast cancer cells were profiled for their mutational status using Sequenom MassARRAY, PTEN status by ... PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Pyrimidines, Quinazolines, Receptor, ErbB-2, ... A panel of HER2-positive breast cancer cells were profiled for their mutational status using Sequenom MassARRAY, PTEN status by ...
https://epubs.rcsi.ie/molmedart/28/
*  NAVER Academic | p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
PTEN Phosphohydrolase, Proto-Oncogene Proteins c-myc, Tumor Suppressor Protein p53. ... p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.. Author. Hongwu Zheng, Haoqiang Ying, ...
http://academic.naver.com/article.naver?doc_id=146501449
*  Tumor Suppressor Proteins - Proteins, Tumor Suppressor Summary Report | CureHunter
PTEN Phosphohydrolase: 565. *Tumor Suppressor Protein p53: 537. *Neurofibromin 2: 497. *Neurofibromin 1: 338 ... PTEN and p53) intricately linked to tumor growth and survival.". 10/02/2015 - "The loss of RASSF1A (an upstream regulator of ... PTEN and p53) in breast cancer cell lines. ". 01/01/2008 - "GADD45A is an evolutionary conserved gene whose expression is ...
http://www.curehunter.com/public/keywordSummaryD025521-Tumor-Suppressor-Proteins-Proteins--Tumor-Suppressor.do
*  Vivian Budnik's research topics | Profiles RNS
PTEN Phosphohydrolase. *Pyridinium Compounds. *Quaternary Ammonium Compounds. *rab GTP-Binding Proteins. *Radiotherapy, ...
https://profiles.umassmed.edu/display/133179/Network/ResearchAreas
*  Faculty Collaboration Database - Mesh term Phosphoric Monoester Hydrolases
PTEN Phosphohydrolase. Phosphatidate Phosphatase. Phosphofructokinase-2. Phosphoinositide Phosphatases. Phosphoprotein ...
https://fcd.mcw.edu/?module=search&func=showTerm&id=68010744
*  Welcome to LibAge, the ageing reference resource
PTEN Phosphohydrolase *Phosphatidylinositol 3-Kinases/antagonists & inhibitors/metabolism *Phosphoric Monoester Hydrolases/ ... 1999) "Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3- ... 1998) "Pten is essential for embryonic development and tumour suppression." Nat. Genet. 19(4):348-355 (PubMed) ...
http://libage.ageing-map.org/entries/tags/154/
*  Welcome to LibAge, the ageing reference resource
PTEN Phosphohydrolase *Phosphoric Monoester Hydrolases *Protein Tyrosine Phosphatases/genetics/physiology *RNA, Messenger/ ... 1998) "Pten is essential for embryonic development and tumour suppression." Nat. Genet. 19(4):348-355 (PubMed) ...
http://la.ageing-map.org/entries/tags/411/
*  Welcome to LibAge, the ageing reference resource
PTEN Phosphohydrolase *Phosphoric Monoester Hydrolases/metabolism *Plasmids/metabolism *Precipitin Tests *Protein Binding ...
http://libage.ageing-map.org/entries/tags/101/