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*  HGF | Cancer Genetics Web
Proto-Oncogene Proteins c-myc. *Cell Movement. *Lung Cancer. *Proto-Oncogene Proteins pp60(c-src) ... BACKGROUND: c-Met is the receptor tyrosine kinase for hepatocyte growth factor (HGF) encoded by the MET proto-oncogene. ... To identify proteins modulated by a low concentration of SF, we treated HT29 colon cancer cells with 2.5 μM SF. Protein ... PURPOSE: Rearrangement of the proto-oncogene rearranged during transfection (RET) has been newly identified potential driver ...
http://www.cancerindex.org/geneweb/HGF.htm
*  Cloning of a novel inhibitory adaptor, SLAP-2. (A) Huma | Open-i
Proto-Oncogene Proteins pp60(c-src)/genetics*/immunology*. *Receptors, Antigen, B-Cell/immunology* ... The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a ... The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a ... Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195979_010067f2b&req=4
*  Confocal images of COS-7 cells expressing mutant Tiam1 | Open-i
Confocal images of COS-7 cells expressing mutant Tiam1 proteins. Confocal laser scanning microscopic images of COS-7 cells ... JNK Mitogen-Activated Protein Kinases. *Mice. *Proto-Oncogene Proteins pp60(c-src)/genetics ... 6 E, inset). A fusion protein containing the NH2-terminal Src domain in front of the C1199-ΔPHn Tiam1 protein was also able to ... 6 E, inset). A fusion protein containing the NH2-terminal Src domain in front of the C1199-ΔPHn Tiam1 protein was also able to ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2139766_JCB.michiels6m&req=4
*  Restricted expression of Slap-1 in the rodent cerebral cortex. - Oxford Neuroscience
One of the genes we isolated was the rat homologue of the mouse Slap-1. SLAP-1 is an adaptor protein containing SH2-SH3 domains ... Proto-Oncogene Proteins pp60(c-src), RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptor Protein-Tyrosine Kinases, src ... One of the genes we isolated was the rat homologue of the mouse Slap-1. SLAP-1 is an adaptor protein containing SH2-SH3 domains ... Adaptor Proteins, Signal Transducing, Animals, Animals, Newborn, Cell Differentiation, Cerebral Cortex, DNA, Complementary, ...
https://www.neuroscience.ox.ac.uk/publications/114575
*  NAVER Academic | Malignant Osteopetrosis: c-src kinase is not reduced in fibroblasts
... congenital osteopetrosis for the expression of c-src at the protein level. No differences could be detected in c-src protein ... Thus, impairment of c-src function as an etiological factor in human osteopetrosis appears unlikely in the individuals ... As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with ... and c-src kinase activity levels between fbroblasts from healthy controls and affected individuals. ...
https://academic.naver.com/article.naver?doc_id=139579223
*  Phospho-SRC (Tyr527) Antibody
Phospho-SRC (Tyr527) Polyclonal Antibody from Invitrogen for Western Blot and Immunohistochemistry (Paraffin) applications. ... p60-Src; pp60c-src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; Rous ... tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; v- ... Protein Aliases: c-Src; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; OTTHUMP00000174476; ...
https://www.thermofisher.com/antibody/product/Phospho-Src-pTyr527-Antibody-Polyclonal/PA5-17781
*  Localization of the Normal Cellular SRC Protein to the Growth Cone of Differentiating Neurons in Brain and Retina | SpringerLink
... src is implicated in the development of the vertebrate nervous system. Its product pp60c-srcis a tyrosine-specific protein ... The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine- ... Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene, Nature, 316, 557-559.CrossRefGoogle Scholar ... specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly ...
https://link.springer.com/chapter/10.1007/978-1-4757-5876-4_10
*  List of MeSH codes (D08) - Wikipedia
... proto-oncogene proteins c-yes MeSH D08.811.913.696.620.682.725.800.630 --- proto-oncogene proteins pp60(c-src) MeSH D08.811. ... oncogene protein pp60(v-src) MeSH D08.811.913.696.620.682.725.800.551 --- proto-oncogene proteins c-fyn MeSH D08.811.913.696. ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Erwin Gelfand's research topics | Colorado PROFILES
Proto-Oncogene Proteins. *Proto-Oncogene Proteins c-pim-1. *Proto-Oncogene Proteins pp60(c-src) ...
https://profiles.ucdenver.edu/display/225744/Network/ResearchAreas
*  Proteogenomic characterization of human colon and rectal cancer. | Broad Institute
Neoplasm Proteins, Point Mutation, Proteome, Proteomics, Proto-Oncogene Proteins pp60(c-src), Rectal Neoplasms, RNA, Messenger ... and SRC (SRC proto-oncogene, non-receptor tyrosine kinase). Integrated proteogenomic analysis provides functional context to ... The chromosome 20q amplicon was associated with the largest global changes at both mRNA and protein levels; proteomics data ... Somatic variants displayed reduced protein abundance compared to germline variants. Messenger RNA transcript abundance did not ...
https://www.broadinstitute.org/publications/broad5917
*  Christopher E. Rudd - Wikipedia
... and CD8 on T-cells with protein-tyrosine kinase p56lck. His discovery provided a role for members of the proto-oncogene pp60src ... a function was provided for the p60 src family of proto-oncogenes in normal cell growth. Rudd CE, Trevillyan JM, Wong LL, ... His research has also shown that a mutant form of an immune adapter protein termed ADAP can block the infection of T-cells by ... In particular he made the seminal discovery that that CD4 and CD8 co-receptor molecules are linked to the p56 lck src family ...
https://en.wikipedia.org/wiki/Christopher_E._Rudd
*  Angiotensin II Signal Transduction in Vascular Smooth Muscle | Circulation Research
15 induction of proto-oncogenes,7 protein tyrosine phosphorylation,16 17 18 and activation of the 42- and 44-kD MAP kinases.19 ... c-Src, v-Src. =. pp60c-src kinase, pp60v-src kinase. ... proto-oncogene expression, and protein synthesis, on the basis ... This protein was originally isolated from v-Src-transformed chicken embryo fibroblasts by Kanner et al.62 FAK exhibits protein ... Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβy subunit-mediated activation of mitogen-activated protein ...
http://circres.ahajournals.org/content/80/5/607
*  Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal | 04-857
... clone 2N8 is an antibody against phospho-Src family (Tyr416) for use in WB. Find MSDS or SDS, a COA, data sheets and more ... Src and Src-family protein kinases are proto-oncogenes that play key roles in cell morphology, motility, proliferation, and ... Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and ... Gene Symbol: pp60c-src, ASV, c-SRC, SRC1, p60-Src, c-src, SRC UniProt Number: P12931 Research Sub-Category: Cytoskeletal ...
http://www.merckmillipore.com/INTL/en/product/Anti-phospho-Src-family-Tyr416-Antibody-clone-2N8-rabbit-monoclonal,MM_NF-04-857
*  Sequence Similarity - 1O4L: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. Sequence Similarity Report Page
Src are identical to those for high affinity binding of full length inhibitors. ... V-SRC SH2 DOMAIN 11886 2.7.10.2 , Details 5 1O48 1 A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC SH2 DOMAIN 9606 2.7.10.2 , ... C-SRC TYROSINE KINASE SH2 DOMAIN 9606 2.7.10.2 , Details 38 1SKJ 1 A PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN SH2 DOMAIN ... V-SRC SH2 DOMAIN 11886 2.7.10.2 , Details 33 1O46 1 A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC SH2 DOMAIN 9606 2.7.10.2 , ...
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1O4L&entity=1&seqid=95
*  Tyrosine Kinase Phosphorylation in Human Neutrophil Activation by PAF and other Agonists | Springer for Research & Development
... src) and in some growth factor receptors (1). Until recently, protein phosphorylation... ... Protein kinases specific for tyrosine (PTK) were initially detected in oncogenic products of viral tumors (pp60v- ... such as the products of the proto-oncogenes c-src, chck, c fes/fps and c-fgr, are known to be present in white blood cells, ... Protein kinases specific for tyrosine (PTK) were initially detected in oncogenic products of viral tumors (pp60v-src ) and in ...
https://rd.springer.com/chapter/10.1007/978-1-4899-0727-1_28
*  Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... motif for a phosphorylation site of a protein kinase. In the method of the invention, a protein kinase is contacted with an ... the Raf-Mos proto-oncogene family of kinases, including Raf, A-Raf, PKS and Mos; and 7) the STE7 family of kinases (e.g. STE7 ... wherein the member of the src family of protein kinases is selected from the group consisting of pp60.sup.c-src, pp60.sup.v-src ...
http://www.patentgenius.com/patent/5532167.html
*  Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung...
Proto-Oncogene Proteins pp60(c-src), Superoxides. Abstract. ,p,The molecular mechanisms by which the endothelial barrier ... Finally, we found that the pp60-Src-mediated decrease in DDAH activity was mediated by the phosphorylation of DDAH II at Y207 ... mutant and attenuated by over-expression of dominant negative pp60Src mutant or reducing pp60Src expression. LPS induces both ... We conclude that pp60Src can directly inhibit DDAH II and this is involved in the increased ADMA levels that enhance eNOS ...
http://garcialab.uahs.arizona.edu/hyper-activation-pp60src-limits-nitric-oxide-signaling-increasing-asymmetric-dimethylarginine-levels
*  Structure Cluster - 1IJR: Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic 3D...
... exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. ... Description: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK protein , Length: 104 No structure alignment results are available for ... Pre-calculated protein structure alignments at the RCSB PDB website. Bioinformatics 26: 2983-2985 ...
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1IJR
*  Browse our NCOA1 ELISA Kits
... tyrosine protein kinase pp60-c-src , tyrosine-protein kinase Src-2 , v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog ... Src proto oncogene sequence , Src64B-PB , Src64B-PC , Src64B-PD , Src64B-PE , Src64B-PF , Src64B-PG , Src64B-PH , Src64B-PI , ... pp60c-src, pp60v-src, RIP160, si:dkey-5g7.6, si:dkey-34f16.6, SRA1, src, src-1, src1, src2, src64, SRC 64B, src64b, xsrc, zgc: ... v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (src-b) Elisa Kit ...
http://www.antibodies-online.com/intracellular-steroid-hormone-receptor-signaling-pathway-pathway-34/ncoa1-elisa-kit-1430/
*  CiNii 論文 - Genistein, a Soybean Isoflavone, Inhibits Inward Rectifier K^+ Channels in Rat...
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice SORIANO P. ... Requirement of pp60^,c-src, expression for osteoclasts to form ruffled borders and resorb bone in mice BOYCE B. F. ... Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women ALEKEL DL. ... Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat ...
http://ci.nii.ac.jp/naid/10008294516
*  Milli-Mark™Anti-Src-FITC Antibody, clone GD11 | FCMAB253F
... clone GD11 detects level of Src & has been published & validated for use in FC. Find MSDS or SDS, a COA, data sheets and more ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... Recombinant chicken pp60src purified from extracts of E. coli containing the plasmid plac-Src (Kuo, 2006). ... Gene Symbol: SRC, c-src, p60-Src, SRC1, c-SRC, ASV, pp60c-src Research Category: Signaling Research Sub-Category: Cytoskeletal ...
http://www.merckmillipore.com/INTL/en/product/Milli-MarkAnti-Src-FITC-Antibody-clone-GD11,MM_NF-FCMAB253F
*  Anti-Src antibody [EPR5496] (ab109381) | Abcam
Rabbit recombinant monoclonal Src antibody [EPR5496] validated for WB, IHC, Flow Cyt and tested in Human, Mouse and Rat. ... Proto oncogene tyrosine protein kinase Src antibody. *Proto-oncogene c-Src antibody ... c SRC antibody. *CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src ... v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog antibody. *V src sarcoma (Schmidt Ruppin A 2) viral oncogene ...
http://www.abcam.com/src-antibody-epr5496-ab109381.html
*  PUBLICATIONS
Soriano, P., Montgomery, C., Geske, R., and Bradley, A. (1991).Targeted disruption of the c-src proto-oncogene leads to ... Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P., and Mundy, G. R. (1992). Requirement of pp60c-src expression for osteoclasts ... Thomas, J., Soriano, P., and Brugge, J. S. (1991). Phosphorylation of c-src on tyrosine 527 by another protein tyrosine kinase ... Induction of tumor formation and cell transformation by Polyoma middle T antigen in the absence of src. Oncogene, 8, 2521-29. ...
http://labs.icahn.mssm.edu/sorianolab/publications/
*  Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ... Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 244:707-712. [PubMed] ... Oncogene. 1995;11:933-939. [PubMed]. *Bose S, Weikl T, Bügl H, Buchner J. Chaperone function of Hsp90-associated proteins. ... The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 1986;319:226-230. [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC434387/?lang=en-ca
*  Mouse disabled (mDab1): a Src binding protein implicated in neuronal development | The EMBO Journal
Soriano P, Montgomery C, Geske R and Bradley A (1991) Targeted disruption of the c‐src protooncogene leads to osteopetrosis in ... Stable association of pp60src and pp59fyn with the focal adhesion‐associated protein tyrosine kinase, pp125fak. Mol Cell Biol, ... LexA-Src(wt), LexA-Src(FF), LexA-Src(ΔSH3), LexA-Src(SH2′) and LexA-Src(295R) (Table I). Total DNA was purified from selected ... Several labeled proteins including Src and proteins of ∼60 and 80 kDa were observed (Figure 6). To test whether mDab1 proteins ...
http://emboj.embopress.org/content/16/1/121