SMART: Secondary literature for RAS domain
The protein R-Ras p21 is about 50% identical to the Ras p21 protooncogene product. This protein is incapable of transforming ... Ras genes are among the most frequently activated oncogenes in cancer. The corresponding protooncogenes are proteins expressed ... The ras p21 protooncogene products, H-ras, K-ras, and N-ras, transmit signals from growth factor receptors to a cascade of ... ras p21/ras p21-like small G proteins and their regulatory proteins] ...http://smart.embl.de/smart/show_secondary.cgi?domain=RAS
HRAS Exon 4 Primer Set (B) - FemtoPath | HongJing弘晉
... p19 H-RasIDX protein; c-has/bas p21 protein; transforming protein p21; Ha-Ras1 proto-oncoprotein; c-ras-Ki-2 activated oncogene ... Ras family small GTP binding protein H-Ras; CTLO; HAMSV; K-RAS; N-RAS; RASH1; C-HRAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; ... HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; HRAS1; GTPase HRas; p21ras; H-Ras- 1; ... GTP- and GDP-binding peptide B; transformation gene: oncogene HAMSV; ...http://femtopath.com/product/hras-exon-4-primer-set-b/
EREG | Cancer Genetics Web
Proto-Oncogene Proteins p21(ras). *Intercellular Signaling Peptides and Proteins. *Amphiregulin. *Antineoplastic Agents ... Proteins downregulated in tumors were studied by GO and KEGG pathways enrichment analyses. Six proteins were found both ... Juergens RA, Bratman SV, Tsao MS, et al.. Biology and patterns of response to EGFR-inhibition in squamous cell cancers of the ... protein binding - response to peptide hormone stimulus - wound healing Data from Gene Ontology via CGAP [Hide] ...http://www.cancerindex.org/geneweb/EREG.htm
CD74 | Cancer Genetics Web
Proto-Oncogene Proteins p21(ras). *Immunophenotyping. *Immunohistochemistry. Tag cloud generated 16 March, 2017 using data from ... MHC class II protein binding - MHC class II protein complex - multivesicular body - negative regulation of apoptotic process - ... This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). ... Kirsten rat sarcoma viral oncogene homolog (KRAS), fusions of anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and ...http://www.cancerindex.org/geneweb/CD74.htm
A) Structure of ATPD-1 and scheme of the transfection | Open-i
Proto-Oncogene Proteins p21(ras)/genetics*. *Transcription Factors/metabolism*. Minor. *Cell Line, Tumor ... an oncogene playing a key role in the pathogenesis of urinary bladder cancer (5,6,33,34). These molecules should bind ... an oncogene playing a key role in the pathogenesis of urinary bladder cancer (5,6,33,34). These molecules should bind ... Our study provides relevant information for the rationale design of targeted therapy drugs specific for the HRAS oncogene. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4117790_gku574fig8&req=4
acinar carcinoma 2005:2010 - BioMedLib™ search engine
Kras2 protein, mouse; EC 22.214.171.124 / Proto-Oncogene Proteins p21(ras) ... Proto-Oncogene Proteins p21(ras) / genetics. *[MeSH-minor] Acinar Cells / enzymology. Animals. Carcinogenesis / metabolism. ... Proto-Oncogene Proteins p21(ras) / metabolism. *[MeSH-minor] Animals. Animals, Genetically Modified. Cell Proliferation. ... Nerve Tissue Proteins; 0 / Neurog3 protein, mouse; 0 / Tumor Suppressor Proteins; 0 / tuberous sclerosis complex 1 protein; EC ...http://bmlsearch.com/?kwr=acinar%20carcinoma%202005:2010
"Divergent mechanisms for homologous desensitization of p21ras by insul" by Jes K. Klarlund, Andrew D. Cherniack et al.
... and PDGF all cause disassembly of Sos proteins from signaling complexes during p21ras desensitization, but at least two ... Here we show that p21ras is desensitized by insulin in 3T3-L1 adipocytes in the continued presence of activated insulin ... Nonetheless, the desensitization of p21ras in response to these stimuli was homologous, in that each peptide could reactivate [ ... PDGF action triggers both mechanisms of Grb2 disassembly, which probably operate in concert with GAP to attenuate p21ras ...https://escholarship.umassmed.edu/oapubs/807/
ras Proteins Summary Report | CureHunter
... monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21 ... The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell ... RAS), plays a role in normal cellular growth, differentiation and development. ... GTP-Binding Proteins: 5070*Monomeric GTP-Binding Proteins: 286*ras Proteins: 224*Proto-Oncogene Proteins p21(ras): 108 ...http://www.curehunter.com/public/keywordSummaryD018631-ras-Proteins.do
"Histone demethylase KDM2B regulates lineage commitment in normal and m" by Jaclyn Andricovich, Yan Kai et al.
Proto-Oncogene Proteins p21(ras) ... F-Box Proteins; Gene Expression Regulation, Leukemic; ...https://hsrc.himmelfarb.gwu.edu/smhs_anatregbio_facpubs/119/
"Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desen" by Andrew D. Cherniack, Jes K. Klarlund et al.
The disassembly of Grb2 from Sos proteins slightly precedes the time course of p21ras deactivation in response to insulin. ... Here we show that in 32P-labeled 3T3-L1 adipocytes the elevated cellular concentrations of [32P]GTP-bound p21ras in response to ... These data are consistent with the hypothesis that the dissociation of Grb2 from Sos proteins caused by insulin in 3T3-L1 cells ... Similarly, anti-Grb2 immunoprecipitates of such lysates revealed the presence of decreased Sos1 protein due to insulin action. ...https://escholarship.umassmed.edu/oapubs/813/
Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are...
Proto-Oncogene Proteins p21(ras). -. dc.title. Host determinants of DNA alkylation and DNA repair activity in human colorectal ... AT transition in the K-ras oncogene.Authors: Jackson PE, Hall CN, O'Connor PJ, Cooper DP, Margison GP, Povey AC. Issue date: ... 23 had K-ras mutations, whereas none of the 7 individuals with cd genotype had a K-ras mutation (P=0.04). No other associations ... 23 had K-ras mutations, whereas none of the 7 individuals with cd genotype had a K-ras mutation (P=0.04). No other associations ...http://christie.openrepository.com/christie/handle/10541/85754
Find NIH Grants - Indiana University School of Medicine
Proto-Oncogene Proteins p21(ras) TISSUE SPECIFIC GENE THERAPY FOR HUMAN PROSTATE CANCER. Kao, C. ...https://indiana.pure.elsevier.com/en/projects/?format=&page=28
BsmI polymorphism in N-ras intron I (RASN). - The Christie Research Publications Repository
Proto-Oncogene Proteins p21(ras). -. dc.title. BsmI polymorphism in N-ras intron I (RASN).. en. ... PCR primers to convert c-Ki-ras to a four allele RsaI system (KRAS2).Authors: Heighway J. Issue date: 1991 Dec 25 ... BsmI polymorphism in N-ras intron I (RASN). 1991, 19 (3):682 Nucleic Acids Res.. Journal:. Nucleic Acids Research. Issue Date: ... BsmI polymorphism in N-ras intron I (RASN).. Authors:. Heighway, Jim. Affiliation:. Department of Cancer Genetics, Christie ...http://christie.openrepository.com/christie/handle/10541/104753
Denigma: Jazwinski SM et al., 2010
Membrane Proteins/*genetics; Middle Aged; Proto-Oncogene Proteins p21(ras)/*genetics; Sphingosine N-Acyltransferase. Journal: ...http://denigma.de/datasets/reference/2199
Hypoxia-induced autophagy via the RAGE-KRAS-HIF1α path | Open-i
Proto-Oncogene Proteins/metabolism*. *Proto-Oncogene Proteins p21(ras)/metabolism*. *Receptors, Immunologic/metabolism* ... Protein levels were assayed by western blot Mentions: Although HIF1α has a major role in the cell survival response to hypoxia, ... The adaptor protein p62/SQSTM1 is decreased when autophagy is induced, whereas it accumulates when autophagy is impaired.36 ... The adaptor protein p62/SQSTM1 is decreased when autophagy is induced, whereas it accumulates when autophagy is impaired.36 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4237264_cddis2014445f4&req=4
Inhibition of PI-3K restores nuclear p27(Kip1) expression in a mouse model of Kras-driven lung cancer. - authors@Fred Hutch
Proto-Oncogene Proteins p21(ras)/genetics/*metabolism; RNA, Messenger/genetics/metabolism; Urethane/pharmacology ... The Ras effector Akt is known to regulate p27 mRNA abundance by phosphorylating and inactivating the FOXO transcription factors ... Urethane-induced lung tumors in mice frequently harbor mutations in the Kras oncogene, and in this study, we use this model to ... Tumors showed a reduced nuclear/cytoplasmic ratio of p27 protein, together with an increase in phosphorylated Thr197 p27 in the ...http://authors.fhcrc.org/332/
adenocarcinoma in situ of thyroid 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins c-ret / genetics. Proto-Oncogene Proteins p21(ras) / genetics ... Proto-Oncogene Proteins B-raf; EC 126.96.36.199 / HRAS protein, human; EC 188.8.131.52 / Proto-Oncogene Proteins p21(ras); EC 184.108.40.206 / ... RET protein, human; EC 220.127.116.11 / BRAF protein, human; EC 18.104.22.168 / Proto-Oncogene Proteins B-raf; EC 22.214.171.124 / ras Proteins ... Proto-Oncogene Proteins; 0 / Receptors, Cell Surface; EC 126.96.36.199 / Proto-Oncogene Proteins c-ret; EC 188.8.131.52 / RET protein, ...http://www.bmlsearch.com/?kwr=adenocarcinoma+in+situ+of+thyroid+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
HRAS - HRas proto-oncogene, GTPase - Bos taurus (Bovine) - HRAS gene & protein
HRas proto-oncogene, GTPase. BOVIN. 189. p21 ras protein (Fragment). BOVIN. 96. ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 9913.ENSBTAP00000055845 ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 9913.ENSBTAP00000055845 ... Protein predictedi ,p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein ...https://www.uniprot.org/uniprot/G3N1U2
List of MeSH codes (D12.776.157) - Wikipedia
... oncogene protein p21(ras) MeSH D12.776.157.325.515.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.157.325.515.700 -- ... rap gtp-binding proteins MeSH D12.776.157.325.515.475.100 -- rap1 gtp-binding proteins MeSH D12.776.157.325.515.500 -- ras ... smad1 protein MeSH D12.776.157.057.170.500.200 -- smad2 protein MeSH D12.776.157.057.170.500.300 -- smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 -- smad6 protein MeSH D12.776.157.057.170.249.700 -- smad7 protein ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction...
... the expression of miR-let7-a was specifically induced in cancer cells but not in normal cells and it was associated with K-ras ... quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras. ... Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), Quercetin, ras Proteins ... Hyde Group - Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories ...https://www.rdm.ox.ac.uk/publications/658746
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline. -...
The RAS proto-oncogene Harvey rat sarcoma viral oncogene homolog (HRAS) encodes a small GTPase that transduces signals from ... Proto-Oncogene Proteins p21(ras), Selection, Genetic ... The RAS proto-oncogene Harvey rat sarcoma viral oncogene ...https://www.rdm.ox.ac.uk/publications/440163
List of MeSH codes (D12.776.476) - Wikipedia
... oncogene protein p21(ras) MeSH D12.776.476.525.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 -- ... oncogene proteins v-raf MeSH D12.776.476.400.842.374 -- proto-oncogene proteins a-raf MeSH D12.776.476.400.842.437 -- proto- ... oncogene proteins b-raf MeSH D12.776.476.400.842.500 -- proto-oncogene proteins c-raf MeSH D12.776.476.450.169.500 -- mitogen- ... proto-oncogene proteins c-vav MeSH D12.776.476.325.300.600 -- ral guanine nucleotide exchange factor MeSH D12.776.476.325. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. - PubMed - NCBI
Proto-Oncogene Proteins p21(ras)/genetics. *Proto-Oncogene Proteins p21(ras)/metabolism ... These p53 mutations frequently result in expression of a stable protein, p53(R175H), rather than complete loss of protein ... Morton JP1, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR ... A-C) β-Galactosidase staining at pH 6, (D-F) p53 immunohistochemical staining, (G-I) p21 immunohistochemical staining, and (J-L ...https://www.ncbi.nlm.nih.gov/pubmed/20018721
A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in...
Proto-Oncogene Proteins/antagonists & inhibitors. *Proto-Oncogene Proteins p21(ras)/genetics. *Sulfones/adverse effects ... Rigosertib (ON 01910.Na), a first-in-class Ras mimetic and small-molecule inhibitor of multiple signaling pathways including ... PI3K inhibitor; PLK1 inhibitor; Ras mimetic; pancreatic cancer; phase II/III; rigosertib ...https://www.ncbi.nlm.nih.gov/pubmed/26091808
"Mutations in BRAF and KRAS converge on activation of the mitogen-activ" by H Ji, Z Wang et al.
... suggesting that the mitogen-activated protein kinase (MAPK) pathway is preferentially activated in lung cancers. Here, we show ... Mitogen-Activated-Protein-Kinases, Mutation, Proto-Oncogene-Proteins-B-raf, Proto-Oncogene-Proteins-p21(ras) ... Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. ... Adenocarcinoma-Bronchiolo-Alveolar, Animals, Benzamides, Disease-Models-Animal, Doxycycline, Genes-ras, Lung-Neoplasms, MAP- ...https://mouseion.jax.org/stfb2000_2009/1574/