Patent US6015892 - Oligonucleotide modulation of protein kinase C - Google PatentsPatent US6015892 - Oligonucleotide modulation of protein kinase C - Google Patents

Compositions and methods are provided for the treatment, detection and diagnosis of diseases associated with protein kinase C ... New nucleic acid sequences are provided which encode 3 untranslated regions of human protein kinase C alpha polynucleotide ... Methods of treating conditions amenable to therapeutic intervention by modulating protein kinase C expression with an ... Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. ...
more infohttp://www.google.com.au/patents/US6015892

Identification and Regulation of c-Myb Target Genes in MCF-7 Cells | BMC Cancer | Full TextIdentification and Regulation of c-Myb Target Genes in MCF-7 Cells | BMC Cancer | Full Text

By using different antibodies and different growth conditions, the c-Myb protein was found associated with over 10,000 ... Although oncogenic versions of c-Myb were first associated with leukemias, over expression or rearrangement of the c-myb gene ... but little is known about the activities of the c-Myb protein or what genes it regulates in estrogen-stimulated cells. We used ... We studied one target gene, CXCR4, in detail, showing that c-Myb associated with the CXCR4 gene promoter and activated a CXCR4 ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-30

Towards functional characterisation of the members of the R2R3-MYB gene family from Arabidopsis thalianaTowards functional characterisation of the members of the R2R3-MYB gene family from Arabidopsis thaliana

The regulatory c1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural ... Transcription factors containing a conserved DNA-binding domain similar to that of the proto-oncogene c-myb have been ... Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain.. Peters CW ... MYB-related proteins from plants generally contain two related helix-turn-helix motifs, the R2 and R3 repeats. It was estimated ...
more infohttps://pub.uni-bielefeld.de/publication/1867763

AtMYB4: a transcription factor general in the battle against UV.AtMYB4: a transcription factor general in the battle against UV.

Recently, the Arabidopsis thaliana MYB, AtMYB4, was shown to regul ... Mounting evidence indicates that members of the large family of plant MYB proteins are involved in the transcriptional ... 0/DNA-Binding Proteins; 0/Malates; 0/Phenylpropionates; 0/Plant Proteins; 0/Proto-Oncogene Proteins c-myb; 0/Transcription ... Plant Proteins / genetics*, metabolism. Proto-Oncogene Proteins c-myb*. Trans-Cinnamate 4-Monooxygenase. Transcription Factors ...
more infohttp://www.biomedsearch.com/nih/AtMYB4-transcription-factor-general-in/11286899.html

Linking Myb to the cell cycle: cyclin-dependent phosphorylation and regulation of A-Myb activity.Linking Myb to the cell cycle: cyclin-dependent phosphorylation and regulation of A-Myb activity.

... a conserved member of the Myb proto-oncogene family, encodes a sequence-specific DNA binding protein (A-Myb) that binds to and ... transactivates promoters containing myb-binding sites. Previous work has suggested that the C-terminus of A-Myb func ... 0/MYBL1 protein, human; 0/Mybl1 protein, mouse; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-myb; 0/Trans-Activators ... Proto-Oncogene Proteins / antagonists & inhibitors, biosynthesis, metabolism*, physiology*. Proto-Oncogene Proteins c-myb. ...
more infohttp://www.biomedsearch.com/nih/Linking-Myb-to-cell-cycle/9285555.html

ZFIN  Publication: Bertrand et al., 2008ZFIN Publication: Bertrand et al., 2008

Proto-Oncogene Proteins c-myb/metabolism*. *Zebrafish/embryology*. *Zebrafish/genetics. *Zebrafish/metabolism ...
more infohttps://zfin.org/ZDB-PUB-080422-4

MYB (gene) - WikipediaMYB (gene) - Wikipedia

Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.[ ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor. ... MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein ...
more infohttps://en.wikipedia.org/wiki/MYB_

P. Antal-Szalmás - Research Output
     - Hungarian ConsortiumP. Antal-Szalmás - Research Output - Hungarian Consortium

Proto-Oncogene Proteins c-myb Proteins HL-60 Cells 8 Citations (Scopus) ... A DNA uptake-stimulating protein increases the antiproliferative effect of c-myb antisense oligonucleotide on leukemic cells. ... Serum human epididymis protein 4 (HE4) as a tumor marker in men with lung cancer. Nagy, B., Bhattoa, H., Steiber, Z., Csobán, M ... Human epididymis protein 4 (HE4) in laboratory medicine and an algorithm in renal disorders. Kappelmayer, J., Antal-Szalmás, P. ...
more infohttps://hungary.pure.elsevier.com/hu/persons/p-antal-szalm%C3%A1s/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

G 4460 - AdisInsightG 4460 - AdisInsight

G 4460 is a phosphorothioate-modified antisense oligonucleotide directed against c-myb. Genta Incorporated in-licensed the ... Mechanism of Action Proto oncogene proteins c myb inhibitors * Orphan Drug Status Orphan designation is assigned by a ... Alternative Names: c-myb antisense oligonucleotide G4460; G4460; INX 3001; INXC 3001; LR3001 Latest Information Update: 09 Mar ...
more infohttps://adisinsight.springer.com/drugs/800007895?error=cookies_not_supported&code=d15fd318-ec66-4520-9be8-b3618eee378a

RPS19 | Cancer Genetics WebRPS19 | Cancer Genetics Web

These include myc proto-oncogene, 40S ribosomal protein S19, heat shock proteins, leukosialin S (CD43), integrin alphaL (CD11A ... including the erythropoietic transcription factor MYB (encoding c-myb), and translational genes were greatly dysregulated, ... The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause ... What does this gene/protein do?. Show (26). RPS19 is implicated in:. - anatomical structure development - cellular protein ...
more infohttp://cancer-genetics.org/RPS19.htm

Expression profiling analysis of Myb regulated genes. ( | Open-iExpression profiling analysis of Myb regulated genes. ( | Open-i

B) The ER-Myb fusion transcript is expressed at an almo ... Expression profiling analysis of Myb regulated genes. (A) ... Proto-Oncogene Proteins c-myb/metabolism*. *Repressor Proteins/metabolism*. *Transcription Factors/genetics* ... Myb) or deprived of β-E2 for 6 h (−β-E2 or inactivated-Myb). The employment of the ER antibody rather than Myb antibody ... Myb) or deprived of β-E2 for 6 h (−β-E2 or inactivated-Myb). The employment of the ER antibody rather than Myb antibody ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3113568_gkr024f1&req=4

MYB (gene) - WikipediaMYB (gene) - Wikipedia

Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene. ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein ... MYB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Myb oncogene-like - The ...
more infohttps://en.wikipedia.org/wiki/MYB_(gene)

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal...Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal...

Proto-Oncogene Proteins c-myb, Quantitative Trait Loci, Twin Studies as Topic, Journal Article, Research Support, Non-U.S. ... Proto-Oncogene Proteins c-myb,Quantitative Trait Loci,Twin Studies as Topic,Journal Article,Research Support, Non-U.S. Govt}, ... The QTL encompasses several genes including HBS1L, a member of the GTP-binding protein family that is expressed in erythroid ... The QTL encompasses several genes including HBS1L, a member of the GTP-binding protein family that is expressed in erythroid ...
more infohttps://lup.lub.lu.se/search/publication/0f0e59a5-9353-48d2-9ec9-10d7f5c78593

Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replicationInvestigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication

... that the C-terminal DNA binding domain of mTTF-I is highly homologous with the c-Myb proto-oncogene protein and c-Myb protein ... A previous study demonstrated that the murine TTF-I Myb-like domain is highly homologous to c-Myb protein (15). In addition, it ... 3), as hTTF-I 521-732 has striking homology with the DNA-binding domain of c-Myb protein. It was previously reported that c-Myb ... who studied the effect of original c-Myb protein on the LTR promoter, while hTTF-I 521-732 showed homology with only the DNA- ...
more infohttp://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.7.032

WO1990005445A1 - Antisense oligonucleotides to c-myb proto-oncogene and uses thereof 
        - Google PatentsWO1990005445A1 - Antisense oligonucleotides to c-myb proto-oncogene and uses thereof - Google Patents

These antisense oligonucleotides are hybridizable to the c-myb mRNA transcript. Such oligonucleotides are useful in treating ... are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-myb gene. ... The c-myb gene codes for a nuclear protein expressed primarily in hematopoietic cells. It is a proto-oncogene, that is, it ... Antisense oligonucleotides to c-myb proto-oncogene and uses thereof - Google Patents. Antisense oligonucleotides to c-myb proto ...
more infohttps://patents.google.com/patent/WO1990005445A1

Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells | BMC Cancer | Full...Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells | BMC Cancer | Full...

We confirmed significantly reduced MYBBP1A protein levels on tissue sections of recurrent mouse tumors compared to primary ... One differentially expressed gene codes for Myb-binding protein 1a (MYBBP1A), which is known as a transcriptional co-regulator ... tumors by immunohistochemistry, and found aberrant MYBBP1A protein levels also in tumor samples of HNSCC patients. ... Originally, MYBBP1A was identified as a c-Myb proto-oncogene product interacting protein [9, 10]. Several findings support the ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-72

Critical functions for c-Myb at three checkpoints during thymocyte development.  - PubMed - NCBICritical functions for c-Myb at three checkpoints during thymocyte development. - PubMed - NCBI

Proto-Oncogene Proteins c-myb/deficiency. *Proto-Oncogene Proteins c-myb/genetics ... However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using ... Critical functions for c-Myb at three checkpoints during thymocyte development.. Bender TP1, Kremer CS, Kraus M, Buch T, ... Thus, c-Myb is essential at several stages during T cell development in the thymus. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/15195090?dopt=Abstract

BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2  - CSHL Scientific Digital RepositoryBAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2 - CSHL Scientific Digital Repository

Fungal Molecular Sequence Data Proto-Oncogene Proteins/*genetics Proto-Oncogene Proteins c-myb Research Support, Non-U.S. Govt ... BAS1 has an NH2-terminal region similar to those of the myb proto-oncogene family. BAS1 and BAS2, which contains a homeo box, ... Tice-Baldwin, K., Fink, G. R., Arndt, K. T. (November 1989) BAS1 has a Myb motif and activates HIS4 transcription only in ... BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2 ...
more infohttp://repository.cshl.edu/34913/

Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are...Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are...

Proto-Oncogene Proteins. *Proto-Oncogene Proteins c-myb. *SYCP1 protein, human. *Sycp1 protein, mouse ... Transcription of the Sycp1 gene (synaptonemal complex protein 1) starts as early as the leptotene and zygotene stages. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10096061?dopt=Abstract

Experts and Doctors on arabidopsis proteins in GermanyExperts and Doctors on arabidopsis proteins in Germany

Scientific Experts about Experts and Doctors on arabidopsis proteins in Germany ... proto oncogene proteins c myb*arabidopsis agamous protein*cotyledon*gibberellins*light harvesting protein complexes*botrytis* ... mads domain proteins*phytochrome b*galactolipids*peroxisomes*pattern recognition receptors*nucleobase transport proteins* ... Balsera M, Stengel A, Soll J, Bölter B. Tic62: a protein family from metabolism to protein translocation. BMC Evol Biol. 2007;7 ...
more infohttp://www.labome.org/locale/experts-and-doctors-on-arabidopsis-proteins-in-germany-53270.html

Myb proto-oncogene like 1 - WikipediaMyb proto-oncogene like 1 - Wikipedia

MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. GRCh38: Ensembl release 89: ENSG00000185697 ... MYB proto-oncogene like 1". Retrieved 2016-11-15. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, ...
more infohttps://en.wikipedia.org/wiki/Myb_proto-oncogene_like_1

Maize R2R3 Myb Genes: Sequence Analysis Reveals Amplification in the Higher Plants | GeneticsMaize R2R3 Myb Genes: Sequence Analysis Reveals Amplification in the Higher Plants | Genetics

1987 The regulatory c1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural ... 10 Myb-domain proteins have been identified to date in vertebrates, including c-Myb, A-Myb, and B-Myb (e.g., Lipsick 1996). c- ... The MybBRH region as a probe to assess R2R3 Myb gene evolution: The ability to easily amplify and clone the MybBRH region by RT ... Analysis of the MybBRH region encoded by maize R2R3 Myb genes: The MybBRH region is formed by the last five residues (residues ...
more infohttps://www.genetics.org/content/153/1/427?ijkey=cfbf6d698ddf98a34de14a2c4234a063b09fc30b&keytype2=tf_ipsecsha

CiNii 論文 - 
 		
 		
 			
 		 	
 		 		
 		 			Self-interaction of DcMYB1 proteins involved in stress-inducible DcPAL1 expression...CiNii 論文 - Self-interaction of DcMYB1 proteins involved in stress-inducible DcPAL1 expression...

the regulatory C1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural ... B-myb protooncogene products interact in vivo with each other via the carboxy-terminal conserved region KIM T ... DcMYB1 is a member of the R2R3-type MYB protein family in carrot and can activate expression of the ,i,DcPAL1,/i, gene induced ... Characterization of MYB proteins acting as transcriptional regulatory factors for carrot phenylalanine ammonia-lyase gene ( ...
more infohttps://ci.nii.ac.jp/naid/10021908545

Development and characterization of xenograft model systems for adenoid cystic carcinoma - Semantic ScholarDevelopment and characterization of xenograft model systems for adenoid cystic carcinoma - Semantic Scholar

Of 12 xenograft models, 11 (92%) revealed MYB locus rearrangement and 10 (83%) showed evidence of fusion of the MYB and NFIB ... of 12 ACC xenograft models was performed that assayed MYB locus break-apart and MYB-NFIB locus fusion. ... suggesting MYB translocation to a novel fusion partner gene. Overall, our results indicate that ACC is amenable to xenografting ... As ACC is known to frequently contain a t(6;9) translocation that fuses the MYB and NFIB genes, fluorescence in situ ...
more infohttps://www.semanticscholar.org/paper/Development-and-characterization-of-xenograft-model-Moskaluk-Baras/2e36ac6296d0a3f6d5a6d85b1756404169ac81a8

Transcription Factors
      - Transcription Factor
     Summary Report | CureHunterTranscription Factors - Transcription Factor Summary Report | CureHunter

... usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. ... Proto-Oncogene Proteins c-myb: 13. *transcription factor MTF-1: 12. *APECED protein: 11 ... Amino Acids, Peptides, and Proteins*Proteins: 90489*Transcription Factors: 20597*NF-kappa B: 11194 ... Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic ...
more infohttp://www.curehunter.com/public/keywordSummaryD014157.do