Proto-Oncogene Proteins c-mdm2 | Profiles RNS
"Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or ... Proto-Oncogene Proteins c-mdm2*Proto-Oncogene Proteins c-mdm2. *Proto Oncogene Proteins c mdm2 ... "Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. ...
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
... that forms a complex with both mutant and wild-type p53 protein has been characterized, purified, and identified. The protein ... Tumor Suppressor Protein p53 * Mdm2 protein, mouse * Mdm2 protein, rat * Proto-Oncogene Proteins c-mdm2 ... Thus, a product of the mdm-2 oncogene forms a tight complex with the p53 protein, and the mdm-2 oncogene can inhibit p53- ... The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell. 1992 Jun 26;69( ...
Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms
MDM2 is overexpressed in many human cancers, including breast, colon, and prostate cancer; 2) high MDM2 levels are associated ... The MDM2 oncogene has been suggested as a novel target for cancer therapy, based on the following observations: 1) ... with poor prognosis in patients with cancer; 3) MDM2 overex … ... Proto-Oncogene Proteins / genetics* * Proto-Oncogene Proteins c ... The MDM2 oncogene has been suggested as a novel target for cancer therapy, based on the following observations: 1) MDM2 is ...
Glutamate-rich protein 3 - Wikipedia
NCBI (April 2015). "MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]". {{cite journal}}: Cite ... Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173, is a protein encoded by the ERICH3 gene. ERICH3 was ... The C1orf173 protein has been predicted or experimentally observed to interact with the following proteins: CRISPLD2 GIMAP4 ... C1orf173 is predicted to be a nuclear protein based on PSORT II analysis and the suggested protein interactions found between ...
Predictive value of p53, mdm-2, p21, and mib-1 for chemotherapy response in advanced breast cancer | Lund University...
Proto-Oncogene Proteins/biosynthesis, Proto-Oncogene Proteins c-mdm2, Randomized Controlled Trials as Topic, Taxoids, Tumor ... Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins c-mdm2; Randomized Controlled Trials as Topic; Taxoids; Tumor ... The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. In response to ... The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. In response to ...
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2-Potential interplay with the PKB/Akt pathway and p14(ARF)<...
Proto-Oncogene Proteins c-akt Medicine & Life Sciences 64% * Mouse Mdm2 protein Medicine & Life Sciences 53% ... Mdm2), but not protein kinase B (PKB)/Akt-phosphorylated Ser166 and Ser188. Pim-mediated phosphorylation of Ser186 blocks ... Mdm2), but not protein kinase B (PKB)/Akt-phosphorylated Ser166 and Ser188. Pim-mediated phosphorylation of Ser186 blocks ... Mdm2), but not protein kinase B (PKB)/Akt-phosphorylated Ser166 and Ser188. Pim-mediated phosphorylation of Ser186 blocks ...
beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as...
Receptors, G-Protein-Coupled. *Receptor, IGF Type 1. *RNA, Small Interfering. *Proto-Oncogene Proteins c-mdm2 ... Both MDM2 and beta-arrestin co-immunoprecipitated with the IGF-1R. The beta-arrestin isoform 1 appeared to be more strongly ... Here we provide evidence that beta-arrestin, otherwise known to be involved in the regulation of G protein-coupled receptors, ... serves as an adaptor to bring the oncoprotein E3 ubiquitin ligase MDM2 to the IGF-1R. In this way, beta-arrestin acts as a ...
Promoter hypermethylation influences the suppressive role of long non‑coding RNA MEG3 in the development of multiple myeloma
The p53 protein is regulated by MDM2 proto-oncogene (MDM2), which is an E3 ubiquitin ligase that inhibits the function of p53 ... Total protein was quantified using the Bicinchoninic Acid Protein Assay kit (Beyotime Institute of Biotechnology), according to ... which exerts its effect by downregulating MDM2 expression, as well as activating p53(38). Furthermore, MDM2 suppression ... Subsequently, 50 µg protein/lane was separated on 10% SDS-PAGE gels by electrophoresis and then transferred to PVDF membranes. ...
DeCS
Proto-Oncogene Protein, c-mdm2 c mdm2 Proto Oncogene Protein c-mdm2 Proto-Oncogene Protein c-mdm2, Proto-Oncogene Proteins ... Proto-Oncogene Protein, c-mdm2. c mdm2 Proto Oncogene Protein. c-mdm2 Proto-Oncogene Protein. c-mdm2, Proto-Oncogene Proteins. ... Proto-Oncogene Proteins c-mdm2 Entry term(s). Double Minute 2 Protein MDMX Protein Mdm 2 Protein Mdm-2 Protein Mdm2 Protein ... MDMX Protein. Mdm 2 Protein. Mdm-2 Protein. Mdm2 Protein. Murine Double Minute 2 Protein. Proto Oncogene Proteins c mdm2. ...
Related GMR Articles | Page 5 | GMR | Genetics and Molecular Research | The Original by FUNPEC-RP
Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction; Young Adult ... Proto-Oncogene Proteins c-akt AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation ... MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and ... Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell ...
Search Results (51) | Profiles RNS
Arrestins. Medical search
Proto-oncogene protein c-mdm2 is a cellular protein that regulates the activity of the tumor suppressor protein p53, and its ... GTP-Binding ProteinsAntigensPhosphoproteinsRecombinant Fusion ProteinsProto-Oncogene Proteins c-mdm2Green Fluorescent Proteins ... FluorescencePhotoreceptor CellsPhosphoproteinsRecombinant Fusion ProteinsProto-Oncogene Proteins c-mdm2Protein Structure, ... Proto-oncogene proteins c-mdm2 are a family of proteins that play a role in regulating the activity of the tumor suppressor ...
MDM2 and ADRB2 Interaction - Wiki-Pi
... a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein ... MDM2. ADRB2. Gene Name. MDM2 proto-oncogene, E3 ubiquitin protein ligase. adrenoceptor beta 2, surface. ... Protein-Protein Interactions. 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA ... Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process. *Negative Regulation Of Cysteine-type ...
MDM2 and PKM Interaction - Wiki-Pi
... a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein ... MDM2. PKM. Gene Name. MDM2 proto-oncogene, E3 ubiquitin protein ligase. pyruvate kinase, muscle. ... Protein-Protein Interactions. 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA ... Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process. *Negative Regulation Of Cysteine-type ...
MDM2 and PTK2 Interaction - Wiki-Pi
... a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein ... MDM2. PTK2. Gene Name. MDM2 proto-oncogene, E3 ubiquitin protein ligase. protein tyrosine kinase 2. ... Protein-Protein Interactions. 185 interactors: ABL1 ADRB2 ADRBK1 AKT1 ANKRD17 APEX1 APP AR ARRB2 ATF3 ATF4 ATM ATP2A2 AURKA ... Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process. *Negative Regulation Of Cysteine-type ...
Pim-1 protein kinase is nuclear in Burkitt's lymphoma: Nuclear localization is necessary for its biologic effects<...
Protein Kinases Medicine & Life Sciences 50% * Proto-Oncogene Proteins c-mdm2 Medicine & Life Sciences 44% ... Background: The Pim-1 33-kDa protein is a serine/threonine protein kinase that is capable of enhancing the rate of occurrence ... abstract = "Background: The Pim-1 33-kDa protein is a serine/threonine protein kinase that is capable of enhancing the rate of ... N2 - Background: The Pim-1 33-kDa protein is a serine/threonine protein kinase that is capable of enhancing the rate of ...
Nicole Prutsch, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
USP7/HAUSP stimulates repair of oxidative DNA lesions. - Department of Oncology
USP7 is involved in the cellular stress response by regulating Mdm2 and p53 protein levels following severe DNA damage. In ... Proto-Oncogene Proteins c-mdm2, RNA Interference, Ubiquitin Thiolesterase, Ubiquitin-Specific Peptidase 7 ... USP7 is involved in the cellular stress response by regulating Mdm2 and p53 protein levels following severe DNA damage. In ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
CNVs also increased with GBC development and affected cyclin-dependent kinase inhibitor 2A, MDM2 proto-oncogene, tumor protein ... Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype ... We conduct comprehensive simulations and analyze real protein, metabolite, mRNA expression and genotype data to compare the ... Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and ...
![anti-MDM2 antibody [SQab22259] (ARG66931) - arigo Biolaboratories](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAMAAAAoLQ9TAAAAUVBMVEVHcEz5gYz3R1T3Q0//9vj2NUL3YGr2MT/3PUr1rLb3cHv2MD73QU74Ym73Pkz3VmL3WGP2SVf4YWz2N0b7nqb4mJ72MD/2Lj32KTn2JTX2ITF6QFzdAAAAFnRSTlMAI92iCNdU97sWN+iASs27q2uLlTJdQQgiuwAAAH5JREFUGJWFj0kWwzAIQ+2knp2xrQDf/6D1kGYbbRAfvQco9ahXEmeHizZHpfbFUgmdbMLim3E8j4hA5lHRep3AR594aZFsTk5f3cmxMtFpGCXsY5UWeAPwlK/dS6Gp9ttkLxAFRKCV7/McqmrqBrpQBfDu8yfB15B5h+df1Q+0aQcdMx7t2QAAAABJRU5ErkJggg==)
anti-MDM2 antibody [SQab22259] (ARG66931) - arigo Biolaboratories
... recognizes MDM2, which can be used for IHC-Formalin-fixed paraffin-embed ... anti-MDM2 antibody [SQab22259] is a Recombinant Rabbit Monoclonal antibody [SQab22259] ... MDM2 proto-oncogene, E3 ubiquitin protein ligase. Background. This gene is a target gene of the transcription factor tumor ... Protein Full Name. E3 ubiquitin-protein ligase Mdm2. Alternate Names. EC 6.3.2.-; Double minute 2 protein; p53-binding protein ...
mdm2 Expression as a Prognostic Indicator in Clear Cell Renal Cell Carcinoma: Comparison with p53 Overexpression and...
The transcription of the mdm2 gene is regulated by wild-type p53 protein (2, 3). In addition, the mdm2 proto-oncogene product ... p53 protein is involved in cell cycle control but can be inactivated by binding to mdm2 or viral proteins. mdm2 is a cellular ... For detection of mdm2 protein, a monoclonal antibody against MDM2 (Ab-1; clone IF2;Oncogene Science, Uniondale, NY; dilution, 1 ... Expression of mdm2 and p53 Protein. Positive staining for mdm2 was detected in 5 of 44 grade 2 clear cell RCCs (11.36%), 9 of ...
MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation. - Nuffield Department of Medicine
The G-allele of a single nucleotide polymorphism in the promoter of the MDM2 gene (MDM2 SNP309, T/G) associates with the ... RESULTS: Interestingly, the G-allele of MDM2 SNP309 is shown to associate with a 9-year earlier age of PDAC onset (P = 0.021). ... In this report, the possible role of the MDM2 SNP309 locus with regard to sex, age, and p53 mutational status in the ... These observations suggest a novel role of the MDM2 SNP309 locus in regulating PDAC tumor formation in a male-specific manner. ...
Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. -...
There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in ... Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. ... Proto-Oncogene Proteins c-mdm2, Seasons, Selection, Genetic, Stress, Physiological, Temperature, Transcriptional Activation, ... There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in ...
Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation. - Ludwig...
By comparing the p53 protein level and its ability to transactivate target genes Waf1/Cip1 and mdm2 in both T22 and NIH3T3 ... When the cells were irradiated with 10 J/m2 of u.v., there was a substantial increase in expression of Waf1/ Cip1 and mdm2. ... However, little increase in Waf1/Cip1 and mdm2 expression was observed in T22 and NIH3T3 cells 8 or 9 h after exposure to 50 J/ ... Discordance between the transcriptional activity of p53 and its protein level was further studied using a cell line expressing ...
Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence | PLOS ONE
Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting ... Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic ... Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb ... Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication ...
Kevetrin - p53 Inducer by Cellceutix | Cancer Biology
... which also induces the regulatory protein Mdm2. Mdm2 is a proto-oncogene that is amplified in approximately 7% of cancers and ... A proto-oncogene is a gene that becomes an oncogene, a gene that has the potential to cause cancer, through mutations or an ... Mdm2 protein has the activity of an ubiquitin ligase, which allows for the targeted degradation of its substrates, including ... Researchers have recently discovered Mdm2 in human tumors and these scientists hypothesize that Mdm2 plays a role in ...
Melanotic Neuroectodermal Tumor of Infancy Workup: Laboratory Studies, Imaging Studies, Procedures
A study analyzing cell-cycle regulatory proteins in MNTI found that MDM-2 protein, the product of a proto-oncogene that ... Cell cycle-associated proteins in melanotic neuroectodermal tumor of infancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod ... The same researchers have also found greater expression of cyclin D1 and other cell-cycle regulatory proteins, such as cyclin A ... The larger polygonal cells express cytokeratins 8 and 18, protein gene product (PGP) 9.5, neuron-specific enolase, and melanoma ...