ETS2 | Cancer Genetics Web
Proto-Oncogene Protein c-ets-1. *Transcriptional Regulator ERG. *Signal Transduction. *Leukaemia ... ETS-1, ETS-2 and ETS variant gene‑4 (ETV‑4), in PCa as a proof of principle. Using western blot analysis, we show that ERG, ETS ... and ETS-1/ETS-2 and C/EBPα could interact with corresponding binding sites. In addition, overexpression of ETS-1/2 or C/EBPα ... The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is ...http://www.cancerindex.org/geneweb/ETS2.htm
lambda Spi-1 Summary Report | CureHunter
DNA-Activated Protein Kinase 7. Proto-Oncogene Proteins c-ets 8. MicroRNAs (MicroRNA) ... and investigated the expression of the tagged proteins both in vitro and in vivo during murine salmonellosis. ". 01/01/2014 - " ... is correlated with Spi-1 oncogene activation by insertional mutagenesis. ". ...http://www.curehunter.com/public/keywordSummaryC086597-lambda-Spi-1.do
Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro. - Sheridan P. L.
Proto-Oncogene Protein c-ets-1 ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-ets ; Recombinant Proteins/ ... Individually or collectively, none of the three enhancer-binding proteins (LEF-1, Ets-1, and TFE-3) could activate ... or LEF-1 and Ets-1) supplemented with fractions containing the promoter-binding protein, Sp1. Addition of TFE-3, which binds to ... en] Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell ...http://orbi.ulg.ac.be/handle/2268/135381
ZFIN Publication: Zhu et al., 2005
Proto-Oncogene Protein c-ets-1/biosynthesis. *Transcription Factors. *Zebrafish/embryology*. *Zebrafish/genetics ... This element contains critical ETS-binding sites conserved between zebrafish and pufferfish. Furthermore, we show that ets1 is ... we generated stable transgenic zebrafish that express green fluorescent protein (EGFP) or DsRed under the control of an lmo2 ...https://zfin.org/ZDB-PUB-050518-14
"Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal ce" by Ying Zhang, Mohammad Q. Hassan et al.
Taken together, our data suggest that basal Runx2 gene transcription is regulated by dynamic interactions between SP1 and ETS- ... both proteins are transiently co-expressed when Runx2 expression is enhanced. ... and ETS-like factors (e.g. ETS1 and ELK1). Forced expression of SP1 increases Runx2 P1 promoter activity through the Y-repeats ... reveal that Y-repeat binds at least two different classes of transcription factors related to GC box binding proteins (e.g. SP1 ...https://escholarship.umassmed.edu/oapubs/2147/
Gene Module Based Regulator Inference Identifying miR-139 as a Tumor Suppressor in Colorectal Cancer
Proto-Oncogene Protein c-ets-1. Cancer cells--Proliferation. Abstract. : Colorectal cancer is one of the most commonly ... By integrating gene differential expression and co-expression information with a protein-protein interaction network, the ... A known oncogene ETS1, a key transcription factor in the gene module, was experimentally verified as a novel target of miR-139 ...http://libtreasures.utdallas.edu/xmlui/handle/10735.1/4229
The transcription factor ETS-1: its role in tumour development and strategies for its inhibition. - Nuffield Department of...
In this review we focus on Ets-1, the prototype of the ETS family of transcription factors. ETS family members play important ... With regard to the involvement of some ETS transcription factors, especially Ets-1, in malignant transformation and tumour ... Several ets genes are rearranged in human leukaemia, Ewing tumours and prostate cancer to produce chimeric oncoproteins. ... Most of them are downstream nuclear targets of Ras-MAP kinase signalling and the deregulation of ets genes results in malignant ...https://www.ndorms.ox.ac.uk/publications/272425
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. - The Christie Research Publications...
Proto-Oncogene Proteins. -. dc.subject.mesh. Proto-Oncogene Proteins c-ets. -. dc.subject.mesh. Proto-Oncogene Proteins c-raf. ... Proto-Oncogene Protein c-ets-2. -. dc.subject.mesh. ... Proto-Oncogene Protein c-ets-1. -. dc.subject.mesh. ... Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.. Authors:. Ohtani, Naoko; Zebedee, ... Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. 2001, 409 (6823):1067-70 Nature. en ...http://christie.openrepository.com/christie/handle/10541/85725
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell...
Gata2 is initially activated by Fli1 but later maintained by another ETS factor, Etv2. We also establish that Flk1 and Etv2 act ... Thus, the two ETS factors Fli1 and Etv6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the ... Proto-Oncogene Protein c-fli-1, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, Repressor Proteins, Signal Transduction ... Thus, the two ETS factors Fli1 and Etv6, which drives the VEGFA expression in both somites and the DLP, sit at the top of the ...https://www.rdm.ox.ac.uk/publications/401426
Expression and function of transcription factor cMyb during cranial neural crest development. - Radcliffe Department of Medicine
Proto-Oncogene Protein c-ets-1, Transcription Factors, Twist-Related Protein 1 ... Gene regulatory network, Neural crest, Neural plate border, Transcription factor, cMyb, Animals, Avian Proteins, Chick Embryo, ...https://www.rdm.ox.ac.uk/publications/449222
Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. - Physiology, Anatomy and...
We demonstrate that coexpression of the Forkhead protein FoxC2 and the Ets protein Etv2 induces ectopic expression of vascular ... Finally, we show that FOX:ETS motifs are present in many known endothelial-specific enhancers and that this motif is an ... This enhancer is regulated by a composite cis-acting element, the FOX:ETS motif, which is bound and synergistically activated ... Proto-Oncogene Proteins c-ets, Xenopus, Zebrafish ... coexpression of the Forkhead protein FoxC2 and the Ets protein ...https://www.dpag.ox.ac.uk/publications/68051
The role of SPINK1 in ETS rearrangement-negative prostate cancers. - Nuffield Department of Surgical Sciences
Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS ... We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can ... the key molecular alterations in ETS-negative cancers are unclear. ... suggesting a functional role in ETS rearrangement-negative prostate cancers. ...https://www.nds.ox.ac.uk/publications/365927
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. - PubMed - NCBI
Proto-Oncogene Proteins c-ets/genetics*. *Proto-Oncogene Proteins c-ets/metabolism* ... The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.. Kanaya T1, Hase K, ... Here we show the Ets transcription factor Spi-B was induced early during M-cell differentiation. Absence of Spi-B silenced the ... The Ets Transcription Factor Spi-B Is Essential for the Differentiation of Intestinal Microfold (M) Cells ...https://www.ncbi.nlm.nih.gov/pubmed/22706340/
ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer. - PubMed - NCBI
ETS translocation variant 6 protein. *Iodine Radioisotopes. *Proto-Oncogene Proteins c-ets ... The ETS variant gene 6 (ETV6)-neurotrophin receptor 3 (NTRK3) rearrangement (ETV6-NTRK3) was identified by RNA-Seq in a tumor ...https://www.ncbi.nlm.nih.gov/pubmed/24327398
The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E...
Proto-Oncogene Proteins c-ets/genetics. *Proto-Oncogene Proteins c-ets/metabolism* ... The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E ... The transcription factor sterile alpha motif (SAM) pointed domain-containing ETS transcription factor (SPDEF) is required for E ... Our previous studies demonstrate that SAM pointed domain-containing ETS transcription factor (SPDEF) inhibited prostate cancer ...https://www.ncbi.nlm.nih.gov/pubmed/23449978
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. -...
Protein Binding. *Protein Kinase Inhibitors/therapeutic use*. *Proto-Oncogene Proteins c-ets/metabolism ... Chaperone-Renilla luciferase fusion protein is stably expressed in 293T cells. 3xFLAG-tagged bait proteins are transfected into ... b) Protein kinases are in equilibrium between the fully folded conformation and a partially unfolded conformation that is ... 293T cells stably expressing CDC37-Renilla luciferase fusion protein and transfected with 3xFLAG tagged kinases were treated ...https://www.ncbi.nlm.nih.gov/pubmed/?term=Chaperones+as+thermodynamic+sensors+of+drug-target+interactions+reveal+kinase+inhibitor+specificities+in+living+cells
Yin yang 1 regulates the expression of snail through a distal enhancer. - PubMed - NCBI
ETS1 protein, human. *Proto-Oncogene Protein c-ets-1. *SOX Transcription Factors ... Proteins specifically binding these sequences were detected by electrophoretic mobility shift assay. The Ets/YY1 binding ... Sequence-specific binding of proteins to the Ets/YY1 site in vitro ... at the Ets (mut-1), YY1 (mut-2), combined Ets/YY1 (mut-3) site, or irrelevant site (mut-4) used as a negative control. ...https://www.ncbi.nlm.nih.gov/pubmed/19208738
Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements. -...
We conclude that ETS transcription factors regulate specific and shared target genes and that TDRD1, FKBP10, and GRPR are ... We performed differential expression analysis on nine normal prostate tissues and 50 PCa enriched for different ETS ... was significantly affected by specific ETS silencing in VCaP and LNCaP cell line models, respectively, whereas the expression ... was significantly affected by silencing of either ETS. Interestingly, we demonstrate that the expression of TDRD1, the topmost ...https://www.nds.ox.ac.uk/publications/817559
Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer...
... enhancer contains four perfect consensus Ets transcription factor binding sites that are efficiently bound by Ets-1 protein in ... Thus, these studies identify mef2c as a direct transcriptional target of Ets factors via an evolutionarily conserved ... Proto-Oncogene Protein c-ets-1, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, Sequence Alignment, Sequence Analysis, ... enhancer contains four perfect consensus Ets transcription factor binding sites that are efficiently bound by Ets-1 protein in ...https://www.dpag.ox.ac.uk/publications/68224
Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay. -...
The isoflavones also inhibited Ets 1 expression, providing some insight into the molecular mechanisms of their action. ... their capacity to inhibit vascular endothelial growth factor-induced endothelial cell proliferation and expression of the Ets 1 ... Proto-Oncogene Proteins c-ets, Proto-Oncogene Protein c-ets-1 ... New role for Wiskott-Aldrich Syndrome protein * NDORMS ... Proto-Oncogene Proteins, Transcription Factors, Cell Proliferation, Structure-Activity Relationship, Soy Foods, ...https://www.ndorms.ox.ac.uk/publications/271204
ETS1 Gene - GeneCards | ETS1 Protein | ETS1 Antibody
Protein Coding), ETS Proto-Oncogene 1, Transcription Factor, including: function, proteins, disorders, pathways, orthologs, and ... ETS1 (ETS Proto-Oncogene 1, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS1 include Jacobsen ... Protein Symbol:. P14921-ETS1_HUMAN. Recommended name:. Protein C-ets-1 Protein Accession:. P14921. Secondary Accessions: * ... Avian Erythroblastosis Virus E26 (V-Ets) Oncogene Homolog-1 2 3 * V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 2 3 ...http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=2113
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. - Semantic Scholar
... that fuses EWS to the human homologue of the murine ETS gene ER81. This gene, designated ETV1 (for ETS Translocation Variant), ... These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI1 or ERG genes, both members of the ETS family of ... These findings confirm that the fusion of EWS to different ETS family members can result in a similar tumor phenotype. ... sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS ...https://www.semanticscholar.org/paper/A-variant-Ewing%27s-sarcoma-translocation-%287%3B22%29-the-Jeon-Davis/d0359c37ed8af63b2be140c0c8b0b00494dec5da
Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma -...
The EWS/ets chimeric proteins act as aberrant transcription factors leading to tumorigenic processes. We searched for genes ... The EWS/ets chimeric proteins activated the Id2 gene via the 5′-upstream promoter sequence. Chromatin-immunoprecipitation ... chimeric proteins and that the c-myc/Id2 pathway plays a pivotal role in the tumorigenic processes provoked by EWS/ets proteins ... Since EWS/Fli-1 transactivates c-myc, a cooperative action of the chimeric protein and c-myc leads to overexpression of Id2. In ...https://www.semanticscholar.org/paper/Upregulation-of-Id2%2C-an-oncogenic-helix-loop-helix-Fukuma-Okita/b3411539221260744c14051b167edf52db2b57fc
Efficacy of ETS-1 transcriptional silencing. Expression | Open-i
Expression level of ETS-1 in the Panc-1 cells was decreased after ETS-1 shRNA transfection. (A) Brightfield and flu ... Proto-Oncogene Protein c-ets-1/genetics*/metabolism. Minor. *Cadherins/genetics. *Cell Adhesion ... v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained ... v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4306275_OR-33-02-0559-g01&req=4
Ets1 - Protein C-ets-1 - Mus musculus (Mouse) - Ets1 gene & protein
Proto-oncogene. ,p>This section describes post-translational modifications (PTMs) and/or processing events.,p>,a href='/help/ ... View protein in PROSITE. PS00345 ETS_DOMAIN_1, 1 hit. PS00346 ETS_DOMAIN_2, 1 hit. PS50061 ETS_DOMAIN_3, 1 hit. PS51433 PNT ... View protein in PROSITE. PS00345 ETS_DOMAIN_1, 1 hit. PS00346 ETS_DOMAIN_2, 1 hit. PS50061 ETS_DOMAIN_3, 1 hit. PS51433 PNT ... View protein in InterPro. IPR000418 Ets_dom. IPR003118 Pointed_dom. IPR013761 SAM/pointed_sf. IPR016311 Transform_prot_C-ets. ...https://www.uniprot.org/uniprot/P27577