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*  WikiGenes - MYC - v-myc avian myelocytomatosis viral...
Synonyms: BHLHE39, Class E basic helix-loop-helix protein 39, MRTL, MYCC, Myc proto-oncogene protein, ... ... Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene [1]. ... NF-kappaB/rel proteins, tumor suppressor p53, and oncogene c-Myc are critical transcription factors involved in coordinating ... The MYC proto-oncogene encodes a ubiquitous transcription factor (c-MYC) involved in the control of cell proliferation and ...
https://www.wikigenes.org/e/gene/e/4609.html
*  WikiGenes - JUND - jun D proto-oncogene
Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1. Hennige, A.M., Lammers, R., Höppner, W., Arlt, D ... Altered genes in high-grade tumours were related to cell cycle (cyclin-dependent kinase 4) and transcription (jun d proto- ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... oncogene) [6].. *PDE4C-containing cosmids also contained the genes for the growth regulatory transcription factor, JUND, and ...
http://www.wikigenes.org/e/gene/e/3727.html
*  WikiGenes - HCK - HCK proto-oncogene, Src family tyrosine...
The 57-kilodalton protein encoded by HCK resembles the product of the proto-oncogene c-src and is therefore likely to be a ... The human proto-oncogene HCK encodes two versions of a protein-tyrosine kinase, with molecular weights of 59,000 (p59hck) and ... Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Quintrell, N ... Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region. Lichtenberg, U., Quintrell, ...
https://www.wikigenes.org/e/gene/e/3055.html
*  WikiGenes - MAS1 - MAS1 proto-oncogene, G protein-coupled...
Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by ... The MAS proto-oncogene is not imprinted in humans. Riesewijk, A.M., Schepens, M.T., Mariman, E.M., Ropers, H.H., Kalscheuer, V. ... Cell type-specific expression of the Mas proto-oncogene in testis. Alenina, N., Baranova, T., Smirnow, E., Bader, M., Lippoldt ... The mammalian proto-oncogene MAS has been identified as a novel neuronal angiotensin receptor, which responds preferentially to ...
https://www.wikigenes.org/e/gene/e/4142.html
*  WikiGenes - Met - met proto-oncogene
Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis. Pollack, A.L., Barth, A.I., ... Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Rong, S., ... Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung ... Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Rong, S., Bodescot, M., Blair, D., Dunn, J ...
https://www.wikigenes.org/e/gene/e/17295.html
*  WikiGenes - Intercellular Junctions
The Met proto-oncogene mesenchymal to epithelial cell conversion. Tsarfaty, I., Rong, S., Resau, J.H., Rulong, S., da Silva, P. ... E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and ... The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Hoskins, R., Hajnal ... The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske, J.S., Köppen, M., Sims, P., ...
https://www.wikigenes.org/e/mesh/e/2903.html
*  WikiGenes - SH3KBP1 - SH3-domain kinase binding protein 1
... a recently identified protein that interacts with the Cbl proto-oncogene [4]. ... Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. Hutchings, N.J., Clarkson, N., ... Synonyms: CD2-binding protein 3, CD2BP3, CIN85, Cbl-interacting protein of 85 kDa, GIG10, ... ... Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor ...
http://www.wikigenes.org/e/gene/e/30011.html
*  WikiGenes - Phenotype
Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Korsmeyer, S.J. Annu. Rev. Immunol. (1992) [ ... The product of gene secC is involved in the synthesis of exported proteins in E. coli. Ferro-Novick, S., Honma, M., Beckwith, J ... Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Li, W., Ohlmeyer, J.T., ... Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cooke, M.P., Abraham, K.M., Forbush, ...
http://www.wikigenes.org/e/mesh/e/253.html
*  WikiGenes - MST1 - macrophage stimulating 1 (hepatocyte...
Macrophage-stimulating protein (MSP) is an 80-kD serum protein with homology to hepatocyte growth factor (HGF) [17]. ... Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Ghigna, C., Giordano, S., Shen, H ... Oncogene (2006) [Pubmed] ... Macrophage-stimulating protein and its receptor in non-small- ... The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis. ...
https://www.wikigenes.org/e/gene/e/4485.html
*  WikiGenes - NIH 3T3 Cells
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its ... NIH 3T3 cells transfected with the cDNA of this protein expressed the exogenous 150 kd protein on their surface [7]. ... Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Buss, J.E., Solski, P.A., ... Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Velu, T.J., Beguinot, L., Vass, W.C., ...
https://www.wikigenes.org/e/mesh/e/22574.html
*  WikiGenes - Oncogenes
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian ... PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary ... Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Anand, N., Murthy, S., Amann, G., Wernick, M., ... Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase ...
http://www.wikigenes.org/e/mesh/e/129.html
*  WikiGenes - AmbotzHAA1166 - (2S,3R)-2-amino-3-hydroxy-butanamide
A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid ... Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. ... Ca2+/calmodulin-dependent protein kinase IV (Camk4; also known as CaMKIV), a multifunctional serine/threonine protein kinase ... The protein serine/threonine phosphatase protein phosphatase-1 (PP1) is a ubiquitous eukaryotic enzyme that regulates a variety ...
https://www.wikigenes.org/e/chem/e/444078.html
*  WikiGenes - Leukemia, Myeloid, Chronic
Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Korsmeyer, S.J. Annu. Rev. Immunol. (1992) [ ... protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase [11]. ... A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo. Okuda, K., D'Andrea, A., Etten, R.A., ... The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have ...
https://www.wikigenes.org/e/mesh/e/76.html
*  WikiGenes - FGF3 - fibroblast growth factor 3
Her-2/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to ... Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. Antoine, M ... In the present study, amplification of the proto-oncogenes Her-2/neu (also known as ERBB2) and INT2 was studied in primary ... int-2 proto-oncogene) is located on chromosome 11q13.3, a region already identified as being susceptible to rearrangement/ ...
https://www.wikigenes.org/e/gene/e/2248.html
*  WikiGenes - Pdgfb - platelet derived growth factor, B polypeptide
Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15. Kozak, C.A., Sears, J.F., Hoggan, M.D. Science (1983) [ ... Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s). Howe, ... The results show that Mlvi -2 is present on mouse chromosome 15 but is unrelated to the c-myc and c-sis proto-oncogenes, which ... The oncogene PDGF-B provides a key switch from cell death to survival induced by TNF. Au, P.Y., Martin, N., Chau, H., Moemeni, ...
http://www.wikigenes.org/e/gene/e/18591.html
*  WikiGenes - TWIST1 - twist family bHLH transcription factor 1
Mechanism of transcriptional activation by the proto-oncogene Twist1. Laursen, K.B., Mielke, E., Iannaccone, P., Füchtbauer, E. ... Searching for potential protein interacting partners we found that HOXA5 binds to an anti-apoptotic protein, Twist [19]. ... Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Hamamori, Y., ... Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome. ...
https://www.wikigenes.org/e/gene/e/7291.html
*  WikiGenes - Kit - kit oncogene
In the mouse, mutations in the c-Kit proto-oncogene, a member of the receptor tyrosine kinase (RTK) gene family, have ... to 165-Kd protein, the product of c-kit, in +/+-CMC, whereas tyrosine phosphorylation of the protein was barely detectable in ... Effects of G-protein mutations on skin color. Van Raamsdonk, C.D., Fitch, K.R., Fuchs, H., de Angelis, M.H., Barsh, G.S. Nat. ... Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. ...
https://www.wikigenes.org/e/gene/e/16590.html
*  WikiGenes - leucine - (2R)-2-amino-4-methyl-pentanoic acid
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its ... Continuous protein synthesis is required to maintain the probability of entry into S phase. Brooks, R.F. Cell (1977) [Pubmed] ... Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax. Perini, G., Wagner, S., Green, M.R. Nature ... The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats. ...
http://www.wikigenes.org/e/chem/e/439524.html
*  WikiGenes
The Mdm2 proto-oncogene was originally identified as one of several genes contained on a mouse double minute chromosome present ... The Mdm2 oncoprotein forms a complex with the p53 tumour-suppressor protein and inhibits p53-mediated transregulation of gene ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound ...
http://www.wikigenes.org/e/ref/e/7477327.html
*  WikiGenes - Sarcoma, Synovial
The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co ... SYT sequences constitute the N-terminal segment of a fusion oncogene product, SYT-SSX, routinely detected in synovial sarcoma, ... Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial ... p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Eid, J.E., Kung, A.L., ...
https://www.wikigenes.org/e/mesh/e/6768.html
*  WikiGenes - MCTS1 - malignant T cell amplified sequence 1
Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H [4]. ... "proto-oncogenic" transcription factor MYCN [2]. ... A novel candidate oncogene, MCT-1, is involved in cell cycle ... Expression and stabilization of the MCT-1 protein by DNA damaging agents. Herbert, G.B., Shi, B., Gartenhaus, R.B. Oncogene ( ... The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Hsu, H.L., Shi ...
https://www.wikigenes.org/e/gene/e/28985.html
*  WikiGenes - Leukemia, Myelocytic, Acute
In the present study, we addressed the role of the c-jun proto-oncogene in the mitogenic response of human fibroblasts and ... Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML. Cuenco, G.M., ... Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia. Pelicci, P.G., Lanfrancone, L., Brathwaite, ... Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML [26]. ...
http://www.wikigenes.org/e/mesh/e/268.html
*  WikiGenes - Blast Crisis
High expression of the sister-chromatid separation regulator and proto-oncogene hSecurin occurs in a subset of myeloid ... Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes ... BRCA1 protein is nearly undetectable in leukemia cells from patients with CML, both during the chronic phase and in blast ... These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of ...
https://www.wikigenes.org/e/mesh/e/739.html
*  WikiGenes - Genetic Screening
Cancers connected with mutations in RET proto-oncogene. Altanerová, V. Neoplasma (2001) [Pubmed] ... One of these protein factors, hPMC2 (human homolog of Xenopus gene which prevents mitotic catastrophe), directly binds to the ... Our genetic screening identified the MCK1 gene, which encodes a glycogen synthetase kinase-3 family protein kinase, as a ... Germline mutations in the RET protooncogene have been identified in families manifesting these syndromes and genetic screening ...
https://www.wikigenes.org/e/mesh/e/5454.html
*  WikiGenes
... has recently been identified as the 190-kDa heterodimeric tyrosine kinase encoded by the MET proto-oncogene (p190MET). The ... In these cells activation of protein kinase C or the increase of intracellular [Ca2+] inhibits tyrosine phosphorylation of the ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound ...
https://www.wikigenes.org/e/ref/e/1718989.html