The ER membrane protein complex is a transmembrane domain insertase | Science
Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature 475, 394-397 (2011). doi:10.1038 ... 1 Detection of a non-TRC insertion pathway for TA proteins.. (A) Diagram of the TA protein reporter cassette used for most of ... To determine whether the EMC is sufficient for TA protein insertion, we purified the intact 10-protein complex (Fig. 4A and fig ... close to the C terminus mediates post-translational TA protein targeting and membrane insertion. Many TA proteins destined for ...
NetWatch | Science
But the charged particles can enter and exit cells through protein tunnels known as ion channels that are embedded in the ...