Signals through Kit receptor tyrosine kinase are essential for development of erythrocytes, melanocytes, germ cells, mast cells ... Signals through Kit receptor tyrosine kinase are essential for development of erythrocytes, melanocytes, germ cells, mast cells ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Protein family membership. *Tyrosine-protein kinase, non-receptor Jak/Tyk2 (IPR016251)*Tyrosine-protein kinase, non-receptor ... 0004672 protein kinase activity GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Protein tyrosine kinases Src and Csk: a tails tale.. Curr Opin Chem Biol 7 580-5 2003 ... CSK is a kinase that catalyzes phosphorylation of the tail tyrosine site in Src kinase. Similar to Src, it contains an SH2 ...
... and methods of using them to treat tyrosine kinase-dependent diseases and conditions in mammals: wherein n is an integer, ... regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, ... Protein tyrosine kinase inhibitors. US20090298855 *. Jul 28, 2009. Dec 3, 2009. Critical Outcome Technologies Inc.. Protein ... Tyrosine kinases can be categorized as receptor type or non-receptor type. Receptor type tyrosine kinases have an extracellular ...
... induces protein tyrosine phosphorylation, implicating one or more B-cell protein-tyrosine kinases (PTKs) in sIg signal ... Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.. A L Burkhardt, M Brunswick, J ... Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. ... Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. ...
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.. Silvennoinen O1, Ihle JN, Schlessinger J, Levy DE. ... Genetic complementation studies implicated the tyrosine kinase Tyk2 in IFN-alpha signalling and, more recently, the related ... Overexpression also activated endogenous Jak kinases, suggesting that interactions between Jak kinases are required during ... We now present biochemical evidence for Jak-family kinase involvement in IFN signal transduction. Jak1 was activated in ...
View protein in PROSITE. PS00107 PROTEIN_KINASE_ATP, 1 hit. PS50011 PROTEIN_KINASE_DOM, 1 hit. PS00109 PROTEIN_KINASE_TYR, 1 ... View protein in PROSITE. PS00107 PROTEIN_KINASE_ATP, 1 hit. PS50011 PROTEIN_KINASE_DOM, 1 hit. PS00109 PROTEIN_KINASE_TYR, 1 ... IPR011009 Kinase-like_dom_sf. IPR000719 Prot_kinase_dom. IPR017441 Protein_kinase_ATP_BS. IPR001245 Ser-Thr/Tyr_kinase_cat_dom ... IPR011009 Kinase-like_dom_sf. IPR000719 Prot_kinase_dom. IPR017441 Protein_kinase_ATP_BS. IPR001245 Ser-Thr/Tyr_kinase_cat_dom ...
... is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion protein of the Abelson murine ... Abl Protein Tyrosine Kinase (AbI) is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion ... 1X NEBuffer™ for Protein Kinases (PK) Incubate at 30°C 1X NEBuffer™ for Protein Kinases (PK) 50 mM Tris-HCl 10 mM MgCl2 0.1 mM ... The recognition motif for phosphorylation by Abl is I/V/LYXXP/F. Abl, like many cytosolic protein tyrosine kinases, ...
Met receptor tyrosine kinase: enhanced signaling through adapter proteins.. Furge KA1, Zhang YW, Vande Woude GF. ... The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth factor receptors that when activated ... and the large adapter protein Gab1. These adapter proteins in turn recruit several signal transducing proteins to form an ... Analysis of how these adapter proteins bind to the Met receptor and what signal transducers they recruit have led to more ...
Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene. The ... BLK B lymphoid tyrosine kinase". Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): ... 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector ...
Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This ... Universal protein resource accession number P41240 for "Tyrosine-protein kinase CSK" at UniProt. Bräuninger A, Holtrich U, ... This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell growth, differentiation, migration ... CSK tyrosine-protein kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ...
... triggering factor via tyrosine protein kinases - Volume 120 Issue 3 - M. HAMADIEN, M. BAKHIET, R. A. HARRIS ... Lapatinib-Binding Protein Kinases in the African Trypanosome: Identification of Cellular Targets for Kinase-Directed Chemical ... Interferon-γ induces secretion of trypanosome lymphocyte triggering factor via tyrosine protein kinases. * M. HAMADIEN (a1), M ... Furthermore, IFN-γ-induced secretion was dependent on tyrosine protein kinase activity. Specific blockers of this signalling ...
... peptidyl-tyrosine autophosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine ... non-membrane spanning protein tyrosine kinase activity, signaling receptor binding, cell differentiation, cell migration, ... Kinase, Transferase, Tyrosine-protein kinaseUniRule annotation. Automatic assertion according to rulesi ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS50011 PROTEIN_KINASE_DOM, 1 hit. ...
The protein tyrosine kinases are a large multigene family with particular relevance to many human diseases, including ca … ... Of the 90 tyrosine kinases, 58 are receptor type, distributed into 20 subfamilies. The 32 nonreceptor tyrosine kinases can be ... The protein tyrosine kinase family of the human genome Oncogene. 2000 Nov 20;19(49):5548-57. doi: 10.1038/sj.onc.1203957. ... mouse orthologs can be identified for nearly all the human tyrosine kinases. The completion of the human tyrosine kinase family ...
ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor. ... High Purity Kinase Inhibitors on Signaling Pathways. Trusted by ...
SH2/SH3 Adaptor Proteins Can Link Tyrosine Kinases to a Ste20-related Protein Kinase, HPK1 ... Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.. J McGlade, A Cheng, G Pelicci, ... The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell ... Calcium- and Protein Kinase C Dependent Activation of the Tyrosine Kinase PYK2 by Angiotensin II in Vascular Smooth Muscle ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner ... ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein] UniProt ... This protein in other organisms (by gene name): P23458 - Homo sapiens 38 * Q62126 - Mus musculus no matching PDB entries ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. UniProt ... Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and ... This protein in other organisms (by gene name): P06241 - Homo sapiens 27 * Q3TAT3 - Mus musculus no matching PDB entries ...
Tyrosine-protein kinase Fgr. Details. Name. Tyrosine-protein kinase Fgr. Kind. protein. Organism. Human. Polypeptides. Name. ... Tyrosine-protein kinase Fgr. P09769. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ...
Tyrosine-protein kinase ABL1. Details. Name. Tyrosine-protein kinase ABL1. Kind. protein. Organism. Human. Polypeptides. Name. ... Tyrosine-protein kinase ABL1. P00519. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ...
... Summary According to the recently published report Tyrosine Protein ... Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 2.7.10.2) - Tyrosine-protein kinase CSK ... Tyrosine Protein Kinase CSK - Pipeline Review, H1 2020; Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase ... The report reviews Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 2.7.10.2) targeted ...
A number of tyrosine kinase inhibitors that target c-Src tyrosine kinase (as well as related tyrosine kinases) have been ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by CSK. ... c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ...
A. A. Akhand, M. Kato, H. Suzuki et al., "Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase ... P. Chiarugi and P. Cirri, "Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal ... H. P. Monteiro, R. J. Arai, and L. R. Travassos, "Protein tyrosine phosphorylation and protein tyrosine nitration in redox ... phosphorylation and dephosphorylation of specific tyrosine residues on the kinase protein by other PTKs or protein tyrosine ...
... Izumi Nakashima, ... Izumi Nakashima, Yoshiyuki Kawamoto, Kozue Takeda, and Masashi Kato, "Control of Genetically Prescribed Protein Tyrosine Kinase ...
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.