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*  MAPPING THE TRANSCRIPTIONAL REGULATORY NETWORK OF THE AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN (AICD) | ScholarBank@NUS
AICD, the C-terminal tail generated from the proteolytic cleavage of the Amyloid Precursor Protein (APP), has been generating ... WONG WAN QING (2013-01-02). MAPPING THE TRANSCRIPTIONAL REGULATORY NETWORK OF THE AMYLOID PRECURSOR PROTEIN INTRACELLULAR ... MAPPING THE TRANSCRIPTIONAL REGULATORY NETWORK OF THE AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN (AICD). ...
http://scholarbank.nus.edu.sg/handle/10635/37860
*  Alzheimer's Disease Research Center at UCLA, Los Angeles, California - Ming Guo, M.D., Ph.D. - Associate Professor and Clinical...
Guo M, Hong E, Fernandes J, Zipursky SL, and Hay B. A reporter for amyloid precursor protein gamma-secretase activity in ... Role of X11 and ubiquilin as in vivo Regulators of Amyloid Precursor Protein in Drosophila. PLoS ONE 2008;3(6):e2495. ... The protein degradation in Parkinson disease revisited: It's complex. J Clinical Invest 2009;119(3):442-445. ... Echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with ...
http://www.eastonad.ucla.edu/research/research-programs/item/ming-guo-md-phd
*  Alzheimer's Disease Research Center at UCLA, Los Angeles, California - David B. Teplow, Ph.D. - Interim Director of the UCLA...
Fradinger EA, Maji S, Lazo ND, Teplow DB. (2005) Studying amyloid β-protein assembly. In: Xia W, Xu H, eds. Amyloid Precursor ... 1993) Normal cellular processing of the β-amyloid precursor protein results in the secretion of the amyloid " peptide and ... Lazo ND, Maji, SK, Fradinger EA, Bitan G, and Teplow DB. (2005) The amyloid β-protein. In Sipe J (Ed.), Amyloid Proteins: The ... Protein structure and function of amyloid proteins, structural biology of neurodegenerative diseases, folding and dynamics, ...
http://www.eastonad.ucla.edu/research/research-programs/item/david-teplow-phd?category_id=60
*  C756 | Prosaposin (PSAP)- Cloud-Clone Corp.
The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. ... Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine ... Prosaposin also known as PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C ... The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. ...
http://www.cloud-clone.com/items/C756.html
*  APBA2 (amyloid beta precursor protein binding family A member 2)
... amyloid beta precursor protein binding family A member 2), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol ... amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like). ... Protein : pattern, domain, 3D structure. UniProt/SwissProt. Q99767 [function] [subcellular_location] [family_and_domains] [ ... Human Protein Atlas. ENSG00000034053-APBA2 [pathology] [cell] [tissue]. ...
http://atlasgeneticsoncology.org/Genes/GC_APBA2.html
*  Bone: Dedifferentiated chondrosarcoma
Genes involved and Proteins. Note. Tumor suppressor gene mutations may play a major role in the development, progression, and / ... Controversy remains as to whether the anaplastic and cartilaginous components are derived from a common precursor cell, or ... two clones derive from a single precursor but a substantial number of genetic alterations occur after the diversion of the two ... which exhibits a longer half-life than the wild-type protein. Recent genetic analyses revealed that p53 mutations were detected ...
http://atlasgeneticsoncology.org/Tumors/DediffChondrosarcID5337.html
*  Three-Dimensional Structure Of The Amyloid Precursor Protein Intracellular Domain (AICD) In Complex With Human FE65-PTB2 -...
1. A protein-complex comprising the intracellular domain (AICD) of human amyloid precursor protein (APP695) and human Fe65-PTB2 ... 0008] Since the interaction of the human adaptor protein Fe65 with the amyloid precursor protein intracellular domain (AICD) ... of human amyloid precursor protein (APP695) in complex with human Fe65-PTB2 (i.e. a protein-complex comprising the ... a protein-complex comprising the intracellular domain (AICD) of human amyloid precursor protein (APP695) and the human Fe65- ...
http://www.patentsencyclopedia.com/app/20110118439
*  Cell signaling, post-translational protein modifications and NMR spectroscopy | SpringerLink
Post-translationally modified proteins make up the majority of the proteome and establish, to a large part, the impressive ... Ramelot TA, Nicholson LK (2001) Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail ... Roth J (2002) Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein ... Cohen P (2002a) Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1(4):309-315Google ...
https://link.springer.com/article/10.1007%2Fs10858-012-9674-x
*  Welcome to CDC stacks | Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant...
Lysosomal-Associated Membrane Protein 2 Mass Spectrometry Mice Mutant Proteins Nervous System Diseases Phenotype Psychosine ... Saposins A, B, C and D are derived from a common precursor, prosaposin (psap). The few patients with saposin C deficiency ... Saposin C is a lysosomal protein needed for optimal GCase activity. To test the in vivo effects of saposin C on GCase, saposin ... Relative to V394L/V394L mice, 4L;C* mice had diminished GCase protein and activity. Marked increases (20- to 30-fold) of ...
https://stacks.cdc.gov/view/cdc/22927
*  Saposin protein domain - Wikipedia
All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, ... In molecular biology a saposin protein domain is a region of the saposin protein that has a certain conserved sequence or ... Ponting CP (1994). "Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D". Protein ... The Saposin-B domains also occur in other proteins, many of them active in the lysis of membranes. Below is a schematic diagram ...
https://en.wikipedia.org/wiki/Saposin_protein_domain
*  Protein precursor - Wikipedia
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an ... Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available ... Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that ... Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre- ...
https://en.wikipedia.org/wiki/Protein_precursor
*  Protein precursors - definition of Protein precursors by The Free Dictionary
Protein precursors synonyms, Protein precursors pronunciation, Protein precursors translation, English dictionary definition of ... Protein precursors. n. See proenzyme. n biochem any of a group of compounds that are inactive precursors of enzymes and are ... Protein precursors - definition of Protein precursors by The Free Dictionary https://www.thefreedictionary.com/Protein+ ... redirected from Protein precursors). Also found in: Thesaurus, Medical, Encyclopedia. zy·mo·gen. (zī′mə-jən). n.. See proenzyme ...
https://www.thefreedictionary.com/Protein+precursors
*  colH - ColH protein precursor - Hathewaya histolytica - colH gene & protein
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF01752. Peptidase_M9. 1 hit. PF08453. Peptidase_M9_N. 1 hit ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF01752. Peptidase_M9. 1 hit. PF08453. Peptidase_M9_N. 1 hit ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR013320. ...
http://www.uniprot.org/uniprot/Q46085
*  Cysteine-rich venom protein precursor - Protobothrops jerdonii (Jerdon's pitviper)
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS01009 CRISP_1, 1 hit. PS01010 CRISP ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS01009 CRISP_1, 1 hit. PS01010 CRISP ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR001283 ...
https://www.uniprot.org/uniprot/Q7ZZN9
*  Amyloid precursor protein - Wikipedia
Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of ... "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proceedings ... a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". The Journal of Biological ... enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological ...
https://en.wikipedia.org/wiki/Amyloid_precursor_protein
*  CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene & protein
Protein-protein interaction databases. Protein interaction database and analysis system. More...IntActi. Q6VE48, 1 interactor ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR017341 ...
https://www.uniprot.org/uniprot/Q6VE48
*  CRP - C-reactive protein precursor - Homo sapiens (Human) - CRP gene & protein
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS00289 PTX_1, 1 hit. PS51828 PTX_2 ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR013320 ...
https://www.uniprot.org/uniprot/P02741
*  PLTP - Phospholipid transfer protein precursor - Homo sapiens (Human) - PLTP gene & protein
Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P55058. B3KUE5. P55058-4. Homo sapiens (Human). ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P55058. B3KUE5. P55058-4. H2QKH6. UPI0000E256DF. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. P55058. B3KUE5. P55058-4. H2QKH6. UPI0000E256DF. ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ...
http://www.uniprot.org/uniprot/P55058
*  LBP - Lipopolysaccharide-binding protein precursor - Homo sapiens (Human) - LBP gene & protein
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF01273 LBP_BPI_CETP, 1 hit. PF02886 LBP_BPI_CETP_C, 1 hit ... section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR017943 ...
https://www.uniprot.org/uniprot/P18428
*  VCAN - Versican core protein precursor - Homo sapiens (Human) - VCAN gene & protein
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Species. Score. Length. Source. P13611. Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_b ... Protein. Similar proteins. Species. Score. Length. Source. P13611. Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_b ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF00008 EGF, 2 hits. PF00059 Lectin_C, 1 hit. PF00084 ...
https://www.uniprot.org/uniprot/P13611
*  Lman2l - VIP36-like protein precursor - Mus musculus (Mouse) - Lman2l gene & protein
Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 10090. ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR013320 ... p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.,p>,a ...
https://www.uniprot.org/uniprot/P59481
*  Aspartic and glutamic acid-rich protein precursor - Acropora millepora (Staghorn coral)
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.,p>,a ... for any given protein.,p>,a href='/help/annotation_score' target='_top'>More...,/a>,/p>-Experimental evidence at protein leveli ... p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence ...
https://www.uniprot.org/uniprot/B7W112
*  Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene | SpringerLink
... ß protein in Alzheimer's brain is a cleavage product of the precursor protein (BPP). The sequence analysis of its BPP cDNA ... Amyloid ß protein in Alzheimer's brain is a cleavage product of the precursor protein (BPP). The sequence analysis of its BPP ... Alternative Splice Splice Acceptor Site Amyloid Protein Precursor mRNA Protease Inhibitor Domain Human Genomic Library These ... Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene. ...
https://link.springer.com/chapter/10.1007/978-1-4684-5844-2_10
*  Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis | SpringerLink
Golde, T.E., Estus, St., Usiak, M., Younkin, L.H., Younkin, G.St.: Expression of ß amyloid protein precursor mRNA: Recognition ... K: Localization of Alzheimer 1.3A4 precursor protein at central and peripheral synaptic sites. Brain Res. 563. 184-194 (1991). ... Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis. ... ß precursor protein by stimulated human peripheral blood leukocytes. FEBS Lett. 277, 261-266 (1990).PubMedCrossRefGoogle ...
https://link.springer.com/chapter/10.1007/978-1-4757-9613-1_36
*  Amyloid precursor protein secretase - Wikipedia
Among other roles in the cell, secretases act on the amyloid precursor protein (APP) to cleave the protein into three fragments ... BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex ... If α-secretase acts on APP first instead of BACE, no amyloid-β is formed because α-secretase recognizes a target protein ... Besides their involvement in the pathogenesis of Alzheimer's, these proteins also have other functional roles in the cell. γ- ...
https://en.wikipedia.org/wiki/Amyloid_precursor_protein_secretase