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*  JCI - SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth
... a type II protein arginine methyltransferase, and increased its multiprotein complex and methyltransferase activity. Activated ...
https://www.jci.org/articles/view/95410/pdf
*  sGC - Inhibitors of Protein Methyltransferases as Chemical Tools
2018 Inhibitors of Protein Methyltransferases as Chemical Tools Entries (RSS) and Comments (RSS) Child theme Enough Child of ... Inhibitors of Protein Methyltransferases as Chemical Tools This content shows Simple View ... First these cells have enhanced levels of DNA repair proteins including those involved in repair of DSBs and they demonstrate ... iPSC unlike the parent cells they are derived from mimic hESC in their ROS levels cell cycle profiles restoration protein ...
http://bio-naturlan.com/category/sgc/
*  A role for protein arginine methyltransferase 5 (PRMT5) in the mechanism of novel anticancer agent, AS1411. | Cancer Research
Several nucleolin-interacting proteins, including protein arginine methyltransferase 5 (PRMT5), were identified by MALDI-TOF- ... A role for protein arginine methyltransferase 5 (PRMT5) in the mechanism of novel anticancer agent, AS1411.. Yun Teng and Paula ... A role for protein arginine methyltransferase 5 (PRMT5) in the mechanism of novel anticancer agent, AS1411. ... A role for protein arginine methyltransferase 5 (PRMT5) in the mechanism of novel anticancer agent, AS1411. ...
http://cancerres.aacrjournals.org/content/66/8_Supplement/1295.1
*  Vemurafenib - Small Molecule Inhibitors of Protein Arginine Methyltransferases
Background During mammalian protein will not have ENGase activity and phrase. *Compelled expression of lineage-specific ... Background It is reported the iron-responsive element-binding protein 2 (IREB2) gene. by Ross Marshall ... 21] also found increased IREB2 protein in human being lung cells via assessment of COPD individuals with controls. Therefore ... Background It is reported the iron-responsive element-binding protein 2 (IREB2) gene rs2568494 polymorphism might be associated ...
http://welbourneprimary.com/tag/vemurafenib/
*  Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-Histone Protein Lysine Methyltransferase...
Here we obtain new insights into non-histone lysine methylation and protein lysine methyltransferase (PKMT) activity by ... Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-Histone Protein Lysine Methyltransferase ... Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-Histone Protein Lysine Methyltransferase ... Elongation Factor Methyltransferase 3 - A Novel Eukaryotic Lysine Methyltransferase. *De novo Identification and Quantification ...
https://www.jpt.com/literature/Stoichiometry-of-Saccharomyces-cerevisiae-Lysine-Methylation-Insights-into-Non-Histone-Protein-Lysine-Methyltransferase-Activity/
*  Frontiers | Synthesis of lysine methyltransferase inhibitors | Chemistry
However, inhibiting Lysine methyltransferases selectively has presented many challenges to medicinal chemists. During the past ... However, inhibiting Lysine methyltransferases selectively has presented many challenges to medicinal chemists. During the past ... In this review, we describe the development of selective, small-molecule inhibitors of lysine methyltransferases with an ... In this review, we describe the development of selective, small-molecule inhibitors of lysine methyltransferases with an ...
https://www.frontiersin.org/articles/10.3389/fchem.2015.00044/full
*  Vassiliki Saloura, M.D. Ph. D. | Center for Cancer Research
Protein methyltransferases (PMTs) and demethylases (PDMTs) are a class of approximately 100 enzymes that modify histone and non ... Our goal is to develop a translational research program focusing on histone and non-histone protein methylation, and to ... 1) histone epigenetics 2) non-histone protein methylation 3) tumor immunology 4) squamous cell carcinoma of the head and neck ... Saloura's laboratory aims to elucidate the role of protein methylation mediated by PMTs and PDMTs in oncogenesis, therapy ...
https://ccr.cancer.gov/Thoracic-and-Gastrointestinal-Oncology-Branch/vassiliki-saloura?qt-staff_profile_tabs=3
*  Systems Biology and Biological Regulation | UCLA Chemistry and Biochemistry
The group is presently determining the biological role of protein methyltransferases that can initiate the conversion of D- ... The composition and structure of noncovalently-bound protein-protein and protein-ligand interactions are studied by ... This interest has led them into three main areas: (1) learning how membrane proteins fold and how they can be stabilized; (2) ... The group is currently focused on Spire (Spir) and Cappuccino (Capu), two proteins that collaborate to build an actin network ...
https://www.chemistry.ucla.edu/systems-biology-and-biological-regulation
*  A high throughput scintillation proximity imaging assay for protein methyltransferases. - PubMed - NCBI
A high throughput scintillation proximity imaging assay for protein methyltransferases.. Ibanez G1, Shum D, Blum G, Bhinder B, ... Protein methyltransferases (PMTs) orchestrate epigenetic modifications through post-translational methylation of various ... A High Throughput Scintillation Proximity Imaging Assay for Protein Methyltransferases. Comb Chem High Throughput Screen. ;15(5 ... A High Throughput Scintillation Proximity Imaging Assay for Protein Methyltransferases. Comb Chem High Throughput Screen. ;15(5 ...
https://www.ncbi.nlm.nih.gov/pubmed/22256970
*  Molecular pathways: protein methyltransferases in cancer. - Semantic Scholar
Oncogenic alterations (e.g., mutations, chromosomal translocations, and others) of PMTs, or of associated proteins, have been ... The protein methyltransferases (PMT) constitute a large and important class of enzymes that catalyze site-specific methylation ... of lysine or arginine residues on histones and other proteins. Site-specific histone methylation is a critical component of ... protein methyltransferases in cancer.. @article{Copeland2013MolecularPP, title={Molecular pathways: protein methyltransferases ...
https://www.semanticscholar.org/paper/Molecular-pathways%3A-protein-methyltransferases-in-Copeland/5ff22768c5d40df0a0d10ab1b03613bfcce29853
*  cheR - Chemotaxis protein methyltransferase - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - cheR gene & protein
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in ... Protein. Similar proteins. Species. Score. Length. Source. P07801. Chemotaxis protein methyltransferase. Salmonella enterica ... Protein. Similar proteins. Species. Score. Length. Source. P07801. Chemotaxis protein methyltransferase. Salmonella enterica ... Chemotaxis protein methyltransferaseAdd BLAST. 288. Proteomic databases. PaxDb, a database of protein abundance averages across ...
https://www.uniprot.org/uniprot/P07801
*  RCSB PDB - 1MLV: Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase Macromolecule...
Structure and catalytic mechanism of a SET domain protein methyltransferase. ... set domain protein methyltransferase, domain 1 A2. 1mlvA02. Alpha Beta Alpha-Beta Complex set domain protein methyltransferase ... set domain protein methyltransferase, domain 1 B2. 1mlvB02. Alpha Beta Alpha-Beta Complex set domain protein methyltransferase ... set domain protein methyltransferase, domain 1 C2. 1mlvC02. Alpha Beta Alpha-Beta Complex set domain protein methyltransferase ...
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1MLV
*  Protein Lysine Methyltransferases (PKMTs)
... recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, ... BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and ...
https://www.biovision.com/products/cancer-research/epigenetic-regulation/writer-enzymes/protein-lysine-methyltransferases-pkmts.html
*  Protein arginine methyltransferase 5 - Wikipedia
"The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase ... "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase ... "Entrez Gene: PRMT5 protein arginine methyltransferase 5". Kim S, Gunesdogan, U, Zylicz JJ, Hackett, JA, Cougot, D, Bao, S, Lee ... Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. PRMT5 symmetrically ...
https://en.wikipedia.org/wiki/Protein_arginine_methyltransferase_5
*  Dimethylamine-corrinoid protein Co-methyltransferase - Wikipedia
Dimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.249, mtbB (gene), dimethylamine methyltransferase) is an enzyme ... Dimethylamine---corrinoid protein Co-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) ... coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". ... This enzyme catalyses the following chemical reaction dimethylamine + [Co(I) dimethylamine-specific corrinoid protein] ⇌ {\ ...
https://en.wikipedia.org/wiki/Dimethylamine-corrinoid_protein_Co-methyltransferase
*  Vilazodone | Selective Inhibitors of Protein Methyltransferases
... and forms quinone-haptens to the tyrosinase protein [31]. Quinone metabolites of catechols or phenols possess been demonstrated ...
http://onetownmanyvoices.com/tag/vilazodone/
*  Fasiglifam | Selective Inhibitors of Protein Methyltransferases
Mouse monoclonal to Neuropilin and tolloid-like protein 1 Several different methods available for isolation of are offered in ...
http://onetownmanyvoices.com/tag/fasiglifam/
*  Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8 | PNAS
Protein lysine methyltransferases (PKMTs) catalyze the methylation of protein substrates, and their dysregulation has been ... 2005) The SET-domain protein superfamily: Protein lysine methyltransferases. Genome Biol 6(8):227. ... Product specificity and mechanism of protein lysine methyltransferases: Insights from the histone lysine methyltransferase SET8 ... phenylethanolamine N-methyltransferase (PNMT), histamine N-methyltransferase (HMT), and hydroxyindole o-methyltransferase ( ...
http://www.pnas.org/content/113/52/E8369
*  RCSB PDB - Protein Feature View - Protein-lysine methyltransferase METTL21D - Q9H867 (MT21D HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ... This protein in other organisms (by gene name): Q9H867 - Homo sapiens 1 * Q3UML0 - Mus musculus no matching PDB entries ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ...
http://www.rcsb.org/pdb/protein/Q9H867
*  VDR - Inhibitors of Protein Methyltransferases as Chemical Tools
2018 Inhibitors of Protein Methyltransferases as Chemical Tools Entries (RSS) and Comments (RSS) Child theme Enough Child of ... Inhibitors of Protein Methyltransferases as Chemical Tools This content shows Simple View ...
http://bio-naturlan.com/category/vdr/
*  Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. - PubMed - NCBI
Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.. Zheng W1, Ibáñez G, Wu H ... Among the key regulators that orchestrate epigenetic signaling are over 50 human protein lysine methyltransferases (PKMTs). ... Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2 ... Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2 ...
https://www.ncbi.nlm.nih.gov/pubmed/23043551
*  SCOPe 2.06: Protein: Monomethylamine methyltransferase MtmB
Timeline for Protein Monomethylamine methyltransferase MtmB from c.1.25.1: Monomethylamine methyltransferase MtmB: *Protein ... Family c.1.25.1: Monomethylamine methyltransferase MtmB [75099] (1 protein). *. Protein Monomethylamine methyltransferase MtmB ... Lineage for Protein: Monomethylamine methyltransferase MtmB. *Root: SCOPe 2.06 *. Class c: Alpha and beta proteins (a/b) [51349 ... Protein Monomethylamine methyltransferase MtmB from c.1.25.1: Monomethylamine methyltransferase MtmB appears in SCOPe 2.05. ...
http://scop.berkeley.edu/sunid=75100
*  Exercise-induced Protein Arginine Methyltransferase Expression in Skeletal Muscle
This study aimed to determine protein arginine methyltransferase 1 (PRMT1), -4 (also known as coactivator-associated arginine ... Acute physical activity also augmented (P < 0.05) the targeted methyltransferase activities of the PRMT in the myonuclear ... Despite the significant activation of canonical exercise-induced signaling involving AMP-activated protein kinase and ... methyltransferase 1 [CARM1]), and -5 expression and function during acute, exercise-induced skeletal muscle remodeling in vivo. ...
https://insights.ovid.com/pubmed?PMID=29112628
*  The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling | Science Signaling
Protein arginine methylation is catalyzed by a family of enzymes termed protein arginine methyltransferases (PRMTs) (21). The ... The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Message Subject. (Your Name) has ... The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. By Neah Likhite, Christopher A. ... The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. By Neah Likhite, Christopher A. ...
http://stke.sciencemag.org/content/8/402/ra115
*  Modification of Isoaspartyl Peptides and Proteins by Protein Carboxyl Methyltransferase from Bovine Brain | SpringerLink
... from mammalian brain and erythrocytes selectively and stoichiometrically methylate peptides and proteins which contain... ... Recent findings indicate that protein carboxyl methyltransfer-ases (PCMTs) ... Modification of Isoaspartyl Peptides and Proteins by Protein Carboxyl Methyltransferase from Bovine Brain. ... Modification of Isoaspartyl Peptides and Proteins by Protein Carboxyl Methyltransferase from Bovine Brain. In: Zappia V., ...
https://link.springer.com/chapter/10.1007/978-1-4684-9042-8_19