Molecular Modulation of HBV Capsid Assembly - Adam Zlotnick
We have found that HBV assembly is allosterically regulated: capsid protein has assembly-active and -inactive conformations. ... Assembly is critical to HBV replication and is unique to the virus (there are no cellular homologs to capsid protein). The HBV ... 2015) Core protein: A pleiotropic keystone in the HBV lifecycle. Antiviral Res 121:82-93 ... 2018) Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids. Elife 7: ...
Structural biology of biotin-dependent carboxylases - Vivien Yee
Yu, Lu; Lee, Seung-Joo; Yee, Vivien C (2015) Crystal Structures of Polymorphic Prion Protein ?1 Peptides Reveal Variable Steric ... Zipper Conformations. Biochemistry 54:3640-8 Souri, Masayoshi; Yee, Vivien C; Fujii, Noriko et al. (2012) Molecular modeling ... 2010) Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J 29:251-62 ... 2012) Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics. J ...
Cardiac Exosomes in myocardial Ischemic injury - Jochen Muehlschlegel
Peptide and Protein Conformations. *Halocarbon Toxicity: Free Radicals and Liver Injury. *REU Site: Research and education in ... including proteins, lipids, and ncRNAs. The ncRNAs contained in EV, namely extracellular RNAs (exRNA), include microRNAs and ...
The Brain Health Registry for facilitating interdisciplinary aging research - Michael Weiner
Electrostatics: protein conformation and metal binding. *Family Processes and Rural African-American Children ... Enrichment of the State-1 Conformation of the HIV-1 Envelope Glycoprotein ...
Binding-Site Modeling with Multiple-Instance Machine-Learning - Ajay Jain
2014) Protein function annotation by local binding site surface similarity. Proteins 82:679-94 ... The pocketmol configuration is chosen such that the optimal conformation and alignment of a ligand (based on the docking ... Cleves, Ann E; Jain, Ajay N (2015) Chemical and protein structural basis for biological crosstalk between PPAR? and COX enzymes ... 2013) A structure-guided approach for protein pocket modeling and affinity prediction. J Comput Aided Mol Des 27:917-34 ...
Deep learning frameworks for regulatory genomics. - Anshul Kundaje
Greenside, Peyton; Hillenmeyer, Maureen; Kundaje, Anshul (2018) Prediction of protein-ligand interactions from paired protein ... 2018) GenomeDISCO: a concordance score for chromosome conformation capture experiments using random walks on contact map graphs ...
Molecular Dissection of the Coronavirus Spike - Thomas Gallagher
... he will attempt to trigger conversion of the spikes into a fusion-active conformation. Fusion conformations will be identified ... 2001) Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion. J Virol ... The investigator will investigate how naturally occurring variation in the coronavirus spike protein impacts the efficiency of ... the long-term objective is to describe the molecular mechanisms by which spike proteins carry out the functions required for ...
Bilirubin and Photobilirubin - Metabolism and Excretion - Antony McDonagh
McDonagh, Antony F; Lightner, David A (2007) Influence of conformation and intramolecular hydrogen bonding on the acyl ... Slipping past UGT1A1 and multidrug resistance-associated protein 2 in the liver: effects of steric compression and hydrogen ...
Mechanism of Outer Hair Cell Motility - Richard Hallworth
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension. *Harnessing multiplexed ... One study will look for evidence of motor conformation changes in the noise statistics of the cells average length. Another ... 2009) Fluorescence microscopy methods in the study of protein structure and function. Methods Mol Biol 493:369-79 ... Sushi domain proteins as synapse protective factors in brain development and aging ...
Molecular Biophysics Training Program - Susan Taylor
Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions. Methods 144:43-52 ... Novel Tools to Investigate Local and Global RNA Conformations in the Spliceosome ... 2018) Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly. Nat Chem 10:732-739 ... The trainees complete a rigorous core curriculum designed to expose them to biophysical treatment of protein structure and ...
Centrosome Maturation and Duplication in the C. elegans - Kevin O'Connell
We have cloned szy-5 and find it encodes a protein with four zinc fingers and a coiled-coil domain. Thus, SZY-5 might spatially ... Recombinant antibodies to differentiate among the many conformations of glaucoma-associated myocilin ... This might be due to the high concentrations of centriolar proteins that are produced in the female germ line and stored in the ... One of these suppressors is a mutation in the sun-1 gene, which encodes an inner nuclear envelope protein. Together with ZYG-12 ...
Functional genomic resource and integrative model of dopaminergic circuitry associated with psychiatric disease - Schahram...
3D genome/chromosomal conformation) maps for midbrain dopaminergic neurons and for their surrounding non- neuronal cells, and ... Structure/Function of Protein Tyrosine Phosphatases. *NeoProteoglycans as synthetic materials for regenerative medicine and ...
Neuroantomy of the Aged Hippocampal Formation - Peter Rapp
Recombinant antibodies to differentiate among the many conformations of glaucoma-associated myocilin ... Structure-Based Design of Protein Function. *Design/Synthesis/Evaluation of Inhibitors of Gamma Glutamyl Hydrolase ...