Proscillaridin - Wikipedia
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In rodents, AQP7 is Proscillaridin A certainly up-regulated by fasting, low insulin, peroxisome Proscillaridin A proliferators- ... Individual cultured differentiated Proscillaridin A adipocytes demonstrated an aquaporin-7 and -10 labelling generally in the ... Nucleus was counterstained with Proscillaridin A DAPI (blue). (discover also Body 4D).(AVI) pone.0054474.s002.avi (1.0M) GUID:? ... AQPs are essential membrane protein that operate Proscillaridin A as drinking water channels. Up to now 13 AQP homologues have ...
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Using this assay, they found that Proscillaridin A induced apoptosis at earlier time points and higher rates in 3D spheroids ... The compound is called Proscillaridin A, a cardiac glycoside that is known for treating congestive heart failure and cardiac ... Next, the authors wanted to determine how Proscillaridin A impacts tumor cell viability. Could it induce apoptosis in tumor ... This means that Proscillaridin A would not have been identified as a candidate if the screen was done using only 2D cultures. ...
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Proscillaridin A induced a significant loss of lysine acetylation in histone H3 (at lysine 9, 14, 18 and 27) and in non-histone ... METHODS: Proscillaridin A anticancer activity was investigated against a panel of human leukemia and solid tumor cell lines ... Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. ... Importantly, proscillaridin A demonstrated anticancer activity against lymphoid and myeloid stem cell populations characterized ...
A New Purpose: Heart Failure Drug Shows Promise in Treating Leukemia
... known as proscillaridin A, has been found to show potential in fighting the MYC gene mutation in patients with leukemia. ... Using proscillaridin A to treat leukemia is a major advancement in drug repositioning, or using drugs designed for certain ... Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. BMC website ... A repurposed drug, known as proscillaridin A, has been found to show potential in fighting the MYC gene mutation in patients ...
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June 2022 - Functional selection of protease inhibitory antibodies
Wells of 96-well microtiter Proscillaridin A plates were coated with the supernatant from a healthy wheat flower (bad control) ... was added into each Proscillaridin A well and the plates were incubated at 37?C for 1?h. After three rinses with PBST, a ... Proscillaridin A /th /thead 18G10IgG1 10?77.439G4IgG1 10?65.8723F4IgG1 10?710.1422A10IgG1 10?78.58 Open in a separate window ...
Meta-Data Analysis to Explore the Hub of the Hub-Genes That Influence SARS-CoV-2 Infections Highlighting Their Pathogenetic...
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Hydralazine And Hydrochlorothiazide (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
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Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2...
Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial...
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Nevan Krogan, PhD · School of Pharmacy · UCSF
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MeSH Browser
Proscillaridin Preferred Term Term UI T033765. Date01/01/1999. LexicalTag NON. ThesaurusID ... Proscillaridin Preferred Concept UI. M0017785. Registry Number. KC6BL281EN. Related Numbers. 466-06-8. Scope Note. A ... Proscillaridin. Tree Number(s). D04.210.500.155.580.064.580. D09.408.180.660. Unique ID. D011442. RDF Unique Identifier. http ... Proscillaridin A Term UI T033766. Date11/11/1974. LexicalTag NON. ThesaurusID ...
MeSH Browser
Proscillaridin Preferred Term Term UI T033765. Date01/01/1999. LexicalTag NON. ThesaurusID ... Proscillaridin Preferred Concept UI. M0017785. Registry Number. KC6BL281EN. Related Numbers. 466-06-8. Scope Note. A ... Proscillaridin. Tree Number(s). D04.210.500.155.580.064.580. D09.408.180.660. Unique ID. D011442. RDF Unique Identifier. http ... Proscillaridin A Term UI T033766. Date11/11/1974. LexicalTag NON. ThesaurusID ...
E0000163|Adriamycin|doxorubicin
DeCS
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth<...
Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1α protein ... Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1α protein ... Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1α protein ... Eleven of these drugs were cardiac glycosides, including digoxin, ouabain, and proscillaridin A, which inhibited HIF-1α protein ...
FDA UNII Code (use for SPL) FDA Preferred Term NCI Concept Code
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科研成果-论文
Ouabain - the optimal prevention of myocardial infarction
Some other endogenous cardiac glycosides were identified: digoxin (146-147), dihydro-ouabain (148) proscillaridin (133), 19- ... Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities. Life Sci 62:1023-33, ...
Microbial metabolites such as short chain fatty acids (SCFAs) are highly - PARP Inhibitors in Ovarian and Other Cancers
C4 mostly remains in and is utilized by the epithelial cells whereas C2 and C3 are readily Proscillaridin A transported to ... Th1 or Th17 effector T cells depending on cytokine milieu It is a question of interest if SCFAs can regulate Proscillaridin A ... tasks of SCFAs in rules of T cell differentiation into effector and IL-10+ regulatory T cells with the research Proscillaridin ... indicate that SCFAs promote T cell differentiation into both effector and regulatory T cells to promote either Proscillaridin A ...