It is a parent hydrocarbon for two series of steroids stemming from 5α-pregnane (originally allopregnane) and 5β-pregnane (17β- ... Pregnanes are steroid derivatives with carbons present at positions 1 through 21. Most biologically significant pregnane ... ISBN 978-0-85404-182-4. Media related to Pregnane at Wikimedia Commons Pregnanes at the U.S. National Library of Medicine ... Pregnane, also known as 17β-ethylandrostane or as 10β,13β-dimethyl-17β-ethylgonane, is a C21 steroid and, indirectly, a parent ...
... *Formula: C19H30O5 ... 3α,17α,20α,21-tetrahydroxy-5β-Pregnane-11-one ...
Runyon, S., Rogawski, MA., Cook, E., Kepler, J., Navarro, H., Kaminski, R., & Orr, M. (2013). Androstane and pregnane steroids ... Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties ... Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties. ...
The pregnane x receptor (PXR, NR1I2) was first identified in 1998 as a member of the NR superfamily. Over the past decade, it ...
Check Pregnane X Receptors pathway , inhibitors reviews and assay information. ... Pregnane X Receptors Inhibitors on signaling pathway are available at Adooq Bioscience. ... Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and ...
pregnane X receptor. Oatp2. organic anion transporting polypeptide. PCN. pregnenolone-16α-carbonitrile. PXR-KO. PXR-knockout ... Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor. Jeff Staudinger, Yaping Liu, Ajay Madan, ... Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor. Jeff Staudinger, Yaping Liu, Ajay Madan, ... Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor. Jeff Staudinger, Yaping Liu, Ajay Madan, ...
Treatment of rats with pregnenolone-16α-carbonitrile (PCN), a ligand for the rodent pregnane X receptor (PXR), significantly ... Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16α-carbonitrile Is via Interaction with Pregnane X ... Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16α-carbonitrile Is via Interaction with Pregnane X ... Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16α-carbonitrile Is via Interaction with Pregnane X ...
"Pregnanes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Pregnanes" by people in this website by year, and whether " ... Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series ... Below are the most recent publications written about "Pregnanes" by people in Profiles. ...
... Auteurs. Planque C, Rajabi F, Grillet F, Finetti P, ... we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), behaves as a key driver of CSC-mediated tumor recurrence. ...
Analytical and development services in chemical and environmental science
Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. Qinghao Jin, Xiang Hua Han, Cheong Yong Yun, Chul Lee, Jin ... Dive into the research topics of Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. Together they form a ...
Scheer, N., Ross, J., Kapelyukh, Y., Rode, A., & Wolf, C. R. (2010). In Vivo Responses of the Human and Murine Pregnane X ... Scheer, N, Ross, J, Kapelyukh, Y, Rode, A & Wolf, CR 2010, In Vivo Responses of the Human and Murine Pregnane X Receptor to ... In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice. In: Drug Metabolism and Disposition. ... In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice. Drug Metabolism and Disposition. 2010 ...
Purpose: Pregnane x receptor (PXR) - activated overexpression of the multidrug resistance 1 (MDR1) gene is an important way for ... Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 ... Keywords: multidrug resistance, p-glycoprotein, protein arginine methyl transferase 1, pregnane X receptor ...
PREGNANE 3,2O DIOL MONO- AND DI-SULPHATES - [origin: WO9850415A1] This invention provides a compound having formula (I) wherein ... EP 0980384 A1 20000223 - PREGNANE 3,2O DIOL MONO- AND DI-SULPHATES. Title (en). PREGNANE 3,2O DIOL MONO- AND DI-SULPHATES ...
... pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the ... Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) ... PARylation, SUMOylation, acetylation, cell signaling, nuclear receptor, phosphorylation, pregnane X receptor, ubiquitination, ... The Interface between Cell Signaling Pathways and Pregnane X Receptor. Cells. 2021; 10(11). doi: 10.3390/cells10113262. ...
17-ALPHA-PREGNANE-3-BETA,20-BETA,21-TRIYL TRIACETATE AldrichCPR; Linear Formula: C27H42O7; find -R215449 MSDS, related peer- ... 17-BETA-HYDROXY-5-ALPHA,17-ALPHA-PREGNANE-3-BETA,20-BETA,21-TRIYL TRIACETATE. ...
Fecal 20-oxo-pregnane concentrations in free-ranging African elephants (Loxodonta africana) treated with porcine zona pellucida ... Fecal 20-oxo-pregnane concentrations in free-ranging African elephants (Loxodonta africana) treated with porcine zona pellucida ...
When compared with other functionally related receptors such as the pregnane X receptor (PXR), the majority of the FXR-active ... Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos 39, 151-159, 10.1124/dmd. ... Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clin ...
... pregnane X receptor; CAR, constitutive androstane receptor. ...
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures. ...
Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives Vojtech Vyklicky, Tereza ...
2003) Expression and potential roles of pregnane X receptor in endometrial cancer. J Clin Endocrinol Metab 88:4446-4454. ... In contrast, progesterone has been shown to enhance activities of pregnane X receptor (PXR)-driven promoters in various ... 2005) Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X ... in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated ...
Bacteriocides and Organochlorine Compounds Activate the Human Pregnane X Receptor (PXR). Toxicology and Applied Pharmacology, ...
Spectroscopic Data of Steroid Glycosides Volume 5: Pregnanes, Androstanes, and Miscellaneous (Ahmad). 348.00. ... Spectroscopic Data of Steroid Glycosides Volume 4: Cardenolides and Pregnanes (Ahmad). 384.00. ...
The human nuclear pregnane X receptor has a hydrophobic ligand-binding cavity with a small number of polar residues that are ... The human nuclear pregnane X receptor has a hydrophobic ligand-binding cavity with a small number of polar residues that are ... In the human liver, nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A in response to a wide variety of drugs and ...
Pregnanes [D04.210.500.745]. *Pregnadienes [D04.210.500.745.432]. *Pregnadienetriols [D04.210.500.745.432.769]. *Dexamethasone ...
Pregnanes [D04.210.500.745]. *Pregnadienes [D04.210.500.745.432]. *Pregnadienetriols [D04.210.500.745.432.769]. *Paramethasone ...
Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Authors. ...