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*  Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists
They function as agonists for peroxisome proliferator-activated receptor alpha (PPARα). PPARα is a transcriptional nuclear ... PPARα agonist administration to primary hepatocytes to assess PPARα activity. In order to estimate whether PPARα activity was ... Activation of PPARα by three PPARα agonists. Primary hepatocytes were co-transfected with a luciferase reporter construct ... Examination of PPARα-deficient mice demonstrated that the activation of PPARα is required exclusively for mediating both ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1683558/?lang=en-ca
*  Frontiers | Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines? | Frontiers in...
In early clinical research, one PPARα agonist, palmitoylethanolamide, shows promise in relieving chronic pain. If this link can ... In early clinical research, one PPARα agonist, palmitoylethanolamide, shows promise in relieving chronic pain. If this link can ... Experimental evidence suggests a connection between PPAR agonists' pain ameliorating effects and suppression of inflammatory ... Experimental evidence suggests a connection between PPAR agonists' pain ameliorating effects and suppression of inflammatory ...
https://www.frontiersin.org/articles/10.3389/fncel.2014.00238/full
*  Peroxisome Proliferator-Activated Receptor Alpha (PPAR-Alpha) | SpringerLink
NR1C1 (nuclear receptor subfamily 1, group C, member 1) The first peroxisome proliferator-activated receptor or PPAR was ... Popeijus H.E. (2018) Peroxisome Proliferator-Activated Receptor Alpha (PPAR-Alpha). In: Choi S. (eds) Encyclopedia of Signaling ... Huang D, Zhao Q, Liu H, Guo Y, Xu H. PPAR-alpha agonist WY-14643 inhibits LPS-induced inflammation in synovial fibroblasts via ... The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates ...
https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101552
*  PPAR-alpha antibody | acris-antibodies.com
PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR- ... Anti-PPAR alpha (N -terminal specific) (Rabbit) to detect a 52 kDa band corresponding to PPAR alpha present in a 3T3 whole cell ... IHC showing PPAR alpha antibody staining of PPAR alpha protein in mouse liver tissue section (Formalin/PFA-fixed paraffin- ... Alternative names for PPAR-alpha antibody. NR1C1, PPAR, PPARA, Peroxisome proliferator-activated receptor alpha, Nuclear ...
https://www.acris-antibodies.com/target/ppar-alpha-antibody.htm
*  PPAR alpha/NR1C1 Antibody (3B6/PPAR) (NB300-537): Novus Biologicals
3B6/PPAR). Validated: WB, ChIP, Flow, GS, ICC/IF, IHC, IHC-P, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... Home » PPAR alpha/NR1C1 » PPAR alpha/NR1C1 Antibodies » PPAR alpha/NR1C1 Antibody (3B6/PPAR) ... Additional PPAR alpha/NR1C1 Products. PPAR alpha/NR1C1 NB300-537 * PPAR alpha/NR1C1 Antibodies ... PPAR alpha/NR1C1 Antibody (3B6/PPAR) Summary. Immunogen. Purified recombinant PPAR alpha protein. ...
https://www.novusbio.com/products/ppar-alpha-nr1c1-antibody-3b6-ppar_nb300-537
*  GeneBLAzer PPAR alpha UAS-bla HEK 293T Cellular Assay Kit - Thermo Fisher Scientific
... monitoring the cellular response of PPAR alpha to drug candidates or other stimuli.Features of the The GeneBLAzer PPAR alpha- ... The GeneBLAzer PPAR alpha-UAS-bla HEK 293T Cellular Assay provides an accurate, sensitive, and easy-to-use method for ... Features of the The GeneBLAzer® PPAR alpha-UAS-bla HEK 293T Cellular Assay:. • Convenience-plate cells and perform assay ... of the human peroxisome proliferator-activated receptor alpha (PPAR alpha) fused to the DNA-binding domain of GAL4 transiently ...
https://www.thermofisher.com/order/catalog/product/K1875
*  Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-alpha -gamma activator properties.
PPAR-alpha is involved in the regulation of fatty acid (FA) uptake and oxidation, inflam.. ... Synthetic PPAR-alpha or PPAR-gamma agonists have been widely used in the treatment of dyslipidaemia, hyperglycaemia and their ... Given the favourable metabolic effects of both PPAR-alpha and PPAR-gamma activators, as well as their potential to modulate ... To date, a medication that may combine the beneficial metabolic effects of PPAR-alpha and PPAR-gamma activation with fewer ...
https://www.omicsonline.org/references/pomegranate-flower-a-unique-traditional-antidiabetic-medicine-with-dual-pparalpha-gamma-activator-properties-1157400.html
*  Regulation of Lipid Metabolism by PPARalpha | www.antikoerper-online.de
ELISA kits and proteins related to the Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha ( ... ADD1 - alpha Adducin: ADD1 Antikörper ADD1 ELISA Kits ADD1 Proteine ALAS1 (Aminolevulinate, delta-, Synthase 1): ALAS1 ... PEX11A (Peroxisomal Biogenesis Factor 11 alpha): PEX11A Antikörper PEX11A Proteine PPARA - Peroxisome Proliferator-Activated ... NFYA (Nuclear Transcription Factor Y, alpha): NFYA Antikörper NFYA ELISA Kits NFYA Proteine ...
https://www.antikoerper-online.de/regulation-of-lipid-metabolism-by-pparalpha-pathway-66/
*  RCSB PDB - 1I7G: CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ...
... ligand selectivity and agonist activation in the PPAR family. ... Structure of the PPARalpha and -gamma ligand binding domain in ... Peroxisome proliferator activated receptor alpha, PPAR- alpha Human (Homo sapiens) [TaxId: 9606] ... CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242. ... All alpha proteins Nuclear receptor ligand-binding domain Nuclear receptor ligand-binding domain Nuclear receptor ligand- ...
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1I7G
*  A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma:...
PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.. ... PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. ... PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. ... PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. ...
http://diabetes.diabetesjournals.org/content/47/12/1841
*  30 GREEN COFFEE EXTRACT INCREASED PPAR ALPHA AND PPAR GAMMA GENE EXPRESSION IN METABOLIC SYNDROME RAT MODEL
... ... PPARα and PPARγ are the molecular targets of a number of marketed drugs for the treatment of metabolic syndrome. Green coffee ... Administration of green coffe extract for 9 weeks have beneficial effect in improvement of PPARα and PPARγ gene expression in ... This study aimed to investigate the effect of green coffee extract administration on PPARα and PPARγ gene expression in ...
https://insights.ovid.com/jhype/201807002/00004872-201807002-00030
*  GENFIT: Risk of confusion between PPAR alpha/delta Phase 3 drug candidate elafibranor and PPAR a/d/gamma Phase 2 compound...
GENFIT: Risk of confusion between PPAR alpha/delta Phase 3 drug candidate elafibranor and PPAR a/d/gamma Phase 2 compound ... Elafibranor is a specific dual agonist of the PPAR alpha and PPAR delta isoforms, but is pharmacologically inactive on PPAR ... Elafibranor (INN granted in 2015), first-in-class PPAR alpha/delta dual agonist, has shown no PPAR gamma activity nor side ... GENFIT: Risk of confusion between PPAR alpha/delta Phase 3 drug candidate elafibranor and PPAR a/d/gamma Phase 2 compound ...
https://www.pharmiweb.com/PressReleases/pressrel.asp?ROW_ID=243543
*  PPAR\(\alpha\) Deficiency in Inflammatory Cells Suppresses Tumor Growth
... alpha\)-deficient mice. These findings suggest that the absence of PPAR\(\alpha\) activity renders inflammatory infiltrates ... PPAR\(\alpha\) deficiency in inflammatory cells suppresses tumor growth. PLoS ONE 2(2): e260. ... Here we show that PPAR\(\alpha\) deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess ... Bone marrow transplantation and granulocyte depletion show that PPAR\(\alpha\) expressing granulocytes are necessary for tumor ...
https://dash.harvard.edu/handle/1/10196734
*  A role for PPAR-alpha in the Central Nervous System in pain and inflammation control - fedOA
... a synthetic PPAR-alpha agonist (and a pain-reducing compound), increases this complex formation. We conclude that i) PPAR-alpha ... Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a ligand activated transcription factor belonging to the ... PPAR-alpha, CNS, palmitoylethanolamide, pain, inflammation. Settori scientifico-disciplinari del MIUR:. Area 05 - Scienze ... D'Agostino, Giuseppe (2010) A role for PPAR-alpha in the Central Nervous System in pain and inflammation control. [Tesi di ...
http://www.fedoa.unina.it/8294/
*  Papers with the keyword PPAR alpha AND Astaxanthine | Read by QxMD
... directly interacts with peroxisome proliferator-activated receptors PPARα and PPARγ, activating PPARα while inhibiting PPARγ, ... high-fat-fed-c57bl-6j-mice-via-activation-of-peroxisome-proliferator-activated-receptor-ppar-alpha-and-inhibition-of-ppar-gamma ... PPAR) alpha and inhibition of PPAR gamma and Akt. ... AX binding activated PPAR-α, but inhibited PPAR-γ ... The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the ...
https://www.readbyqxmd.com/keyword/94996
*  Human PPAR alpha (LBD)-GAL4 (DBD) Stable Cell Line-HEK 293T(UAS-bla) - Creative Biogene
Three distinct subtypes of PPARs are known as PPAR alpha, PPAR beta/delta, and PPAR gamma respectively. All of PPAR subfamily ... Activation of PPAR alpha by fibrates lowers triglycerides, raises HDL, and has insulin sensitizing effects. PPAR alpha also ... alpha , PPAR; hPPAR; NR1C1; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated ... receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; PPAR; PPARalpha; MGC2237; MGC2452; ...
https://www.creative-biogene.com/Human-PPAR-alpha-LBD-GAL4-DBD-Stable-Cell-Line-HEK-293TUAS-bla-CSC-RN0014-196823-11.html
*  Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent...
3-dihydrobenzofuran-2-carboxylic acids as highly potent and subtype-selective PPARalpha agonists are reported. Systematic study ... PPAR alpha / agonists*, genetics. Radioligand Assay. Stereoisomerism. Structure-Activity Relationship. Transcriptional ... Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent ... and triglyceride-lowering activity at dose levels that were much lower than the marketed weak PPARalpha agonist fenofibrate.. ...
http://www.biomedsearch.com/nih/Novel-23-dihydrobenzofuran-2-carboxylic/16107159.html
*  Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.
PPAR alpha / metabolism*. Plant Extracts / pharmacology. Rats. Rats, Wistar. Saponins / therapeutic use*. Sea Cucumbers. Signal ... The PPAR? mRNA level was unchanged between C and OA group, however 0.05% SSC could enhance PPAR? mRNA level by 1.37-fold (P , ... 0/PPAR alpha; 0/Plant Extracts; 0/Saponins; 0/Sterol Regulatory Element Binding Protein 1; 0/Triglycerides; 57-88-5/Cholesterol ... modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genesToxicol Appl PharmacolYear: ...
http://www.biomedsearch.com/nih/Dietary-saponins-sea-cucumber-alleviate/20211032.html
*  MicroRNA-21 (miR-21) Induces Down-regulation Of PEDF In Retinal Pigmented Epithelial Cells By Suppression Of PPAR Alpha | IOVS ...
We have identified a PPAR alpha responsive element on the PEDF promoter region. PPAR alpha has shown to be a potential target ... Our results demonstrate a novel role for miR-21 in down-regulating PEDF expression by its ability to block PPAR alpha ... MicroRNA-21 (miR-21) Induces Down-regulation Of PEDF In Retinal Pigmented Epithelial Cells By Suppression Of PPAR Alpha ... MicroRNA-21 (miR-21) Induces Down-regulation Of PEDF In Retinal Pigmented Epithelial Cells By Suppression Of PPAR Alpha ...
https://iovs.arvojournals.org/article.aspx?articleid=2146208
*  PPAR alpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid...
Glucocorticoid receptor alpha (GR alpha) and peroxisome proliferator-activated receptor alpha (PPAR alpha) are transcription ... article{677023, abstract = {Glucocorticoid receptor alpha (GR alpha) and peroxisome proliferator-activated receptor alpha (PPAR ... PPAR alpha agonists inhibit the expression of classical glucocorticoid response element (GRE)-driven genes in a PPAR alpha- ... PPAR alpha agonists inhibit the expression of classical glucocorticoid response element (GRE)-driven genes in a PPAR alpha- ...
https://biblio.ugent.be/publication/677023
*  HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of...
... signaling via the Akt/mTOR pathway in a selective peroxisome proliferator-activated receptor alpha (PPAR-α)-dependent manner. ... PPARα, but not PPARγ antagonist, significantly inhibited PEA effects, with this being further confirmed in a transgenic PPARα ... In PPARα−/− mice, PEA displayed no effects. In wildtype rats, PEA, via PPARα-dependent mechanism, resulted in a significant ... Additional file 2: PEA failed to improve diarrhea course in PPARα−/− mice. HIV-1 Tat (130 ng/Kg)-induced diarrhea in PPARα−/− ...
https://rd.springer.com/article/10.1186/s12974-018-1126-4
*  Anti Human PPAR Alpha (N-Terminal) Antibody | Bio-Rad
... alpha (PPARA), a member of the nuclear hormone rec… ... strong,Rabbit anti PPAR alpha antibody,/strong, detects an ... Lefebvre, P. et al. (2006) Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest. ... Rabbit anti PPAR alpha antibody detects an epitope within the N-terminal region of human peroxisome proliferator-activated ... Antisera to human PPAR alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG ...
https://www.bio-rad-antibodies.com/polyclonal/human-ppar-alpha-antibody-ahp1271.html
*  MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities. - Semantic...
PPAR)alpha and PPARgamma. In cell-based assays, MK-0767 produced potent activation of human PPARgamma and PPARalpha with a ... gamma:alpha potency ratio of approximately 2. The dual agonist induced high affinity interactions of PPARalpha and PPARgamma ... We conclude that MK-0767 is a potent dual PPARalpha/gamma agonist with robust insulin sensitizing and hypolipidemic activities. ... PPAR)alpha and PPARgamma. In cell-based assays, MK-0767 produced potent activation of human PPARgamma and PPARalpha with a ...
https://www.semanticscholar.org/paper/MK-0767%2C-a-novel-dual-PPARalpha%2Fgamma-agonist%2C-and-Doebber-Kelly/3d19d0fa0460a528ce473d43d9a5fb1525651740
*  PPAR alpha Blocking Peptide (Mouse) | WB IHC
A synthetic PPAR alpha peptide for use as a blocking control in assays to test for specificity of PPARalpha antibody, catalog ... PPAR alpha Blocking Peptide (Mouse) (30R-AP012) A synthetic PPAR alpha peptide for use as a blocking control in assays to test ... See all options for PPAR alpha Blocking Peptide (Mouse) Specifications. Residues. Region of PPAR Alpha protein corresponding to ...
https://www.fitzgerald-fii.com/ppar-alpha-blocking-peptide-mouse-30r-ap012.html
*  Anticonvulsant - Wikipedia
"PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings". PLoS ONE. 8 (5): e64541. doi:10.1371/journal.pone. ... Rogawski MA, Bazil CW (July 2008). "New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M ... Another potential target of antiepileptic drugs is the peroxisome proliferator-activated receptor alpha. The drug class was the ... 2013). "Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of ...
https://en.wikipedia.org/wiki/Anticonvulsant