The lollipop plot above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on Show Cancer Mutations). The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. ...
View our 6 PPAR alpha Receptor Agonists Small Molecules for your research. ...
3B6/PPAR] (GTX12412). Validated in WB, ICC/IF, FACS, IP, ChIP assay, Gel supershift assays. Tested in Human, Mouse, Rat, Rabbit ... There are currently no reviews for PPAR alpha antibody [3B6/PPAR] (GTX12412). Be the first to share your experience with this ... ICC/IF analysis of HCT116 cells using GTX12412 PPAR alpha antibody [3B6/PPAR]. Panel e is a no primary antibody control.. Green ... There are currently no references for PPAR alpha antibody [3B6/PPAR] (GTX12412). Be the first to share your publications with ...
3KDT: Crystal Structure Of Peroxisome Proliferator-Activatedecepto (Pparalpha) Complex With N-3-((2-(4-Chlorophenyl)-5-Methyl- ...
Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms. Download Prime ... Cardiovascular DiseasesClofibric AcidDyslipidemiasHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPPAR alphaSignal ... whereas fibrates are activators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). The ... whereas fibrates are activators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). The ...
endothelin-1, cyclosporin A, PPAR-alpha activators, ciprofibric acid, HMG-CoA inhibitors, compactin ... HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured ... Furthermore, we suggest that the mevalonate metabolism would interfere with PPAR-alpha activity. ... PPAR)-alpha activator, inhibit the CsA-induced ET secretion to the level below the basal ET secretion, by -32% and -26% ...
Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by PPARα. In the first study, we ... In silico analysis of the MRP3 promoter identified multiple PPARα response elements. Electrophoretic mobility shift (EMSA) ... Recently, fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARa) agonist has become an off-label therapeutic ... Gallucci, Gina, "MECHANISMS OF PPAR-ALPHA TARGETED THERAPY IN CHOLESTASIS: TRANSLATIONAL STUDIES" (2023). Open Access ...
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... gamma coactivator 1 alpha (PGC-1 alpha) in human adipocytes and the involvement of PPARalpha and PPARgamma in PGC-1 alpha ... Primary cultures of human adipocytes were transduced with a PGC-1 alpha adenovirus and treated with PPARgamma and PPARalpha ... To investigate glycerol kinase (GyK), a target of PGC-1 alpha, we measured enzymatic activity and glycerol incorporation into ... RESULTS: Among the large number of genes regulated by PGC-1 alpha independently of PPARgamma, new targets involved in ...
The activation or antagonism of PPAR-gamma did not affect the expression of PPAR-alpha or -beta, indicating that the three ... a selective PPAR- gamma agonist, was injected intraperitoneally at 1 h before GCIRI. The expression changes of PPAR-alpha ... no significant change in PPAR-alpha or -beta expression was detected. Rosiglitazone, a PPAR-gamma agonist, plays a protective ... The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the ...
Peroxisome proliferator-activated receptor alpha (PPARα) is a transcription factor that belongs to the nuclear receptor family ... In this study, we examined the role of PPARα in sleep/wake regulation using PPARα knockout (KO) mice. Sleep, body temperature ( ... PPARα promotes hepatic fatty acid oxidation and ketogenesis in response to fasting. Because energy metabolism is known to ... These results suggest that PPARα and/or lipid metabolism is involved in the maintenance of wakefulness and locomotor activity ...
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993. 259:87-91. ... The proximal PPARγ binding site in the OLR1 promoter is the predominant PPRE. (A) Identification of putative PPARγ binding ... Although results from tissue-specific knockout models suggest direct roles of PPARγ in liver and muscle (72-74), PPARγ is ... Differential gene regulation by PPARγ agonist and constitutively active PPARγ. Mol. Endocrinol. 2002. 16:1040-1048. View this ...
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. Kenji Saito ... Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. The Journal ... CtBP2 interacts with PPARα to repress its activity, and the interaction is enhanced upon binding to malonyl-CoA, a metabolic ... These findings support our model where CtBP2 exists primarily as a monomer in the metabolic milieu of obesity to repress PPARα ...
Invitrogen Anti-PPAR gamma-2 Polyclonal, Catalog # PA1-824. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) ... This antibody does not detect PPAR alpha or PPAR delta. PA1-824 has been successfully used in Western blot and ... Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR gamma 2, like several other nuclear ... PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in ...
The aim of this study was to investigate the role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in ... Although PPAR-alpha-null mice also had elevated plasma free fatty acids, they had neither decreased cardiac GLUT-4 levels nor ... Wild-type and PPAR-alpha-null mouse hearts were isolated and perfused 6 wk after streptozotocin administration or after 14 mo ... The aim of this study was to investigate the role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in ...
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... which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various ... PPAR alpha / antagonists & inhibitors * Pandemics* * Pneumonia, Viral / drug therapy* * SARS-CoV-2 ... Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background ...
PPAR-alpha (G17) Polyclonal Antibody , MBS3001522 , Mybiosource Product Short Name: [PPAR-alpha] Product Name Synonyme: [PPARA ... PPAR-alpha; Nuclear receptor subfamily 1 group C member 1; PPARA;... ...
PPAR-alpha and PPAR-gamma are the molecular targets of a number of marketed drugs. The main classes of PPAR agonists are: An ... The 7(S) enantiomer bound with micromolar affity to PPAR alpha with 10 fold higher affinity compared to the (R) enantiomer and ... PPARδ (delta) is the main target of a research chemical named GW501516. It has been shown that agonism of PPARδ changes the ... A fourth class of dual PPAR agonists, so-called glitazars, which bind to both the α and γ PPAR isoforms, are currently under ...
Phospho-I-kappa-B-alpha Conjugated Antibody. Cat# MBS9456307. Supplier: MyBiosource. Europe Distribution. ... PPAR-alpha (G17) Polyclonal Antibody , MBS3001522 , Mybiosource Product Short Name: [PPAR-alpha] Product Name Synonyme: [PPARA ... Other Names: [NF-kappa-B inhibitor alpha; NF-kappa-B inhibitor alpha; NF-kappa-B inhibitor alpha; ikB-alpha; IkappaBalpha; I- ... Product Short Name: [Phospho-I-kappa-B-alpha]. Product Name Synonyme: [I kappa B alpha antibody; I-kappa-B-alpha antibody; ...
PPARαTooltip Peroxisome proliferator-activated receptor alpha. *Agonists: 15-HETE. *15-HpETE ... membrane-bound PPARγ-binding assay showed that genistein can directly interact with the PPARγ ligand binding domain and has a ... PPARγTooltip Peroxisome proliferator-activated receptor gamma. *Agonists: 5-Oxo-ETE ... Isoflavones genistein and daidzein bind to and transactivate all three PPAR isoforms, α, δ, and γ.[20] For example, ...
Seabuckthorn Leaves Increase PPAR-Alpha & PPAR-Gamma Expression, Keep the Liver Fat Free and Fatty Oxidation Up. Plus: PPARs - ... Suppversity Excerpt Seabuckthorn Leaves Increase PPAR-Alpha & PPAR-Gamma Expression, Keep the Liver Fat Free and Fatty ... And on the endocrine side of things you want to keep an eye on optimal DHEA levels (read more about its effects on PPAR-gamma ... This in turn reminds me of the effects of fish oil and TTA (a pan PPAR-activator), which - despite their questionable use as a ...
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Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in ... The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known about the effect of PPARα ... Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. A ... Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα ...
PPARα and PGC1α in liver were lower than in CR rats. From these results, we make the hypothesis that in CS rats, CCK increased ... PPARα, and PGC1α in liver were lower than in CR rats. From these results, we make the hypothesis that in CS rats, CCK increased ... peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARα, peroxisome proliferator-activated receptor alpha; ... Peroxisome proliferator-activated receptor alpha (PPARα); branched-chain amino acid metabolism [branched chain amino-acid ...
MDM2 and MDMX promote ferroptosis by PPAR alpha-mediated lipid remodeling. Genes Dev. 2020;34:526-43. ... One study has shown that MDM2 and its homolog MDMX amplify ferroptosis through peroxisome proliferator-activated receptor alpha ...
... and peroxisome proliferator-activated receptor alpha, PPAR,i,α,/i,). The results from this study suggest that ACE has the ... ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPAR,i,γ,/i ... Furthermore, PPARγ, FAS, and SREBP-1c are proteins involved in the production of lipids in hepatic tissues [24, 25] and PPARα ... The high-fat diet markedly upregulated the hepatic gene expressions of PPAR-γ, FAS, and SREBP-1c, while PPAR-α was ...
Rakhshandehroo, M.; Knoch, B.; Müller, M.; Kersten, S. Peroxisome Proliferator-Activated Receptor Alpha Target Genes. PPAR Res. ... N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: Anti-inflammatory implications in liver ... Nevertheless, its overexpression in transgenic mice did not alter amino acid homeostasis [68]. Oat is a PPARα-regulated gene [ ...
PPAR-alpha receptors are proteins on the surface of cells. They control how much sugar enters the cells. Activating PPAR-alpha ... However, it appears to be related to its ability to activate PPAR-alpha receptors. ...
Nuclei and alpha-tubulin were counterstained with DAPI (blue) and ...read more ... element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha ...