Unreeling the chromatin thread: a genomic perspective on organization around the periphery of the Arabidopsis nucleus | Genome...
... chromatin landscape at the periphery of the plant cell nucleus reveals substantial enrichment of heterochromatin and Polycomb- ... whereas genes marked by H3K27me3 and silenced by the Polycomb Repressive Complex 2 (PRC2) are frequently involved in long-range ... heterochromatinized TEs and Polycomb-repressed genes (Fig. 1b). Determining whether repressive chromatin domains are in direct ... The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol. 2010;11:490-501. ...
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 | Genome...
Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, ... Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in ... Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells. Exp Cell Res. 2015; ... After nuclear lysis, the chromatin complex was subjected to sonication for 180 s (10 s on and 10 s off) on ice with a Branson ...
Getting the genome in shape: the formation of loops, domains and compartments | Genome Biology | Full Text
Three hypotheses for the strategy by which the cohesin complex is involved in the formation of chromatin loops. a After initial ... A polycomb group protein is retained at specific sites on chromatin in mitosis. PLoS Genet. 2012;8:e1003135. ... To exert stimulatory or repressive effects on transcription, accessible regulatory DNA elements must be in close spatial ... b The cohesin ring remains open when the complex is attached to one roadblock. Only when a second cognate anchor sequence comes ...
A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types | Genome...
... is regulated by the Polycomb complex, and is thought to carry out cell type-specific repression [27, 28]. Facultative ... These regions are characterized by both the activating marks H3K4me3 and H3K27ac as well as the repressive marks H3K27me3 and ... Bivalent regions are regulatory elements with both activating and repressive marks and are believed to be "poised" for ... Morey L, Helin K. Polycomb group protein-mediated repression of transcription. Trends Biochem Sci. 2010; 35(6):323-32. ...
Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated...
Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for ... H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and ... esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat ... An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional ...
Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia | Genome Biology | Full Text
In stem cells, the repressive PcG complex cooperates with OCT4, SOX2 and NANOG to silence lineage-specific genes and to ... Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad ... This observation suggests a complex relationship between methylation in gene bodies in the regulation of gene expression, which ... Figure 1. Unsupervised analysis of DNA methylation in acute lymphoblastic leukemia (ALL) samples and non-leukemic reference ...
The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility | Genome Biology | Full...
Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. ... 3f). On the other hand, BAF60 binding co-localizes, but to a much lower extent, with the repressive marks H3K27me3 and H3K9me2 ... The BAF60 subunit of the SWI/SNF chromatin-remodeling complex directly controls the formation of a gene loop at FLOWERING LOCUS ... Aichinger E, Villar CBR, Di Mambro R, Sabatini S, Köhler C. The CHD3 chromatin remodeler PICKLE and polycomb group proteins ...