JCI - The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid...
... is a widespread physiological phenomenon observed particularly in plants, fish, and amphibians (1). Although it is less common ... To our knowledge, these results are the first demonstration in a physiological context that insulin signaling through Akt ... Some mammalian tissues and organs have significant numbers of tetraploid cells that arise during either physiological or ... Furthermore, daily rhythms progressively emerge during this physiological transition. In the liver, DNA synthesis and mitotic ...https://www.jci.org/articles/view/38677
However, the mechanism of this phenomenon remains unclear. Here, we tested in mice several cancer vaccines and an adoptive T ... Here, we present a comparative study of a panel of mutations that were identified in the noncanonical plant homeodomain (PHD) ... "physiological" fertilization. This Review focuses on the advantages of studying fertilization using gene-manipulated animals ...https://www.jci.org/120/4
JCI - Mitochondrial dysfunction in pathophysiology of heart failure
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol. ... However, the role of mitochondria in heart failure is now increasingly recognized to be beyond that of a failed power plant. In ... Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability ... "power plant" failure. Here we will review some of the development in this area with an emphasis on the crosstalk between ...https://tgnanke.com.www.mobile.jci.org/articles/view/120849
JCI - Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab ... a phenomenon seen in animals (54) and individuals with neurodevelopmental disorders (55). However, it is conceivable that, once ... Genome-wide investigation and expression analyses of WD40 protein family in the model plant foxtail millet (Setaria italica L ... physiological) or 50 pM free 125I-T4 produced approximately 30% less T3 over 24 hours when compared with Thr92-D2HY cells. At ...https://chenghongda.net.insight.mobile.jci.org/articles/view/123176