The protein-tyrosine-pbosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C Isoforms alpha, beta...
The protein-tyrosine-pbosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C Isoforms alpha, beta ... indicating phosphorylation on serine/threonine residues. This phosphorylation was not dependent on insulin receptor or insulin ... Using point mutants of SHP2, we identified serine residues 576 and 591 as phosphorylation sites for PKC. However, no change of ... The protein-tyrosine-pbosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C Isoforms alpha, beta ...http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1582201
In vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C : Effects on the classical and...
Both protein kinases phosphorylated the same serine residue(s) located in the C3a portion of the alpha-chain. In addition, ... In vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C: Effects on the classical and ... It was also found that phosphorylation of C3 in the C3a portion of the alpha-chain inhibited both the classical and alternative ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:515546
Epithelial polarity control by Lkb1 | Philosophical Transactions of the Royal Society B: Biological Sciences
... or equivalent residue) that resides in the activation loop to become active. The AMPK and ARK serine-threonine kinases belong ... 2010 Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr. Biol. 20, 1809-1818. ( ... 1998 A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391, 184-187. (doi:10.1038/34432). ... 2011 Type II transmembrane serine protease (TTSP) deregulation in cancer. Front. Biosci. 16, 539-552. (doi:10.2741/3704). ...http://rstb.royalsocietypublishing.org/content/368/1629/20130111
The increase in phosphorylation levels of serine residues of protein HSP70 during holding at 17ºC is concomitant with a higher...
The increase in phosphorylation levels of serine residues of protein HSP70 during holding at 17ºC is concomitant with a higher ... Home , Articles , Published articles , The increase in phosphorylation levels of serine residues of protein HSP70 during ...https://ddd.uab.cat/record/123289/comments?ln=en
Biochemistry of Type 2 Diabetes Flashcards by Srishti D | Brainscape
Phosphorylation of serine residues on IRS1 > inhibition of signalling cascade activated by insulin binding. Increased SOCS ...https://www.brainscape.com/flashcards/biochemistry-of-type-2-diabetes-5347632/packs/7999805
PHKA1 Gene - GeneCards | KPB1 Protein | KPB1 Antibody
By phosphorylation of various serine residues. Allosteric regulation by calcium. *KPB1_HUMAN,P46020 ... Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may ... Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may ... whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=PHKA1&pubmed=27&rf=/home/genecards/current/website/carddisp.pl
Anti-Cytokeratin 8 antibody [KS8.7] (ab182875) | Abcam
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important ...https://www.abcam.com/cytokeratin-8-antibody-ks87-ab182875.html
PLA2G4A - Cytosolic phospholipase A2 - Gallus gallus (Chicken) - PLA2G4A gene & protein
Activated by phosphorylation on a serine residue.By similarity. Keywords - PTMi. Phosphoprotein. Proteomic databases. PaxDb, a ... p>This subsection of the 'Function' section is used for enzymes and indicates the residues directly involved in catalysis.,p>,a ... p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding ,a href ... Modified residuei. 505. Phosphoserine; by MAPKBy similarity. 1. ...https://www.uniprot.org/uniprot/P49147
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. -...
PKC (protein kinase C); P stands for phosphorylation of serine/threonine residues; Pn S (pregnenolone sulfate, σ1R agonist); Pt ... The activated NMDAR cannot bind to the MOR-HINT1 complex because of σ1R bound to the NR1 and the phosphorylation of the NR1 C1 ... acting on NR1 C1 serines 890 and 896, releases the NMDAR from the MOR-HINT1 inhibitory association, and PKC-recruited Src acts ... on tyrosine residues of the NMDAR NR2 subunits. The activated NMDAR greatly increases calcium levels in its environment, which ...https://www.ncbi.nlm.nih.gov/pubmed/26461475
Frontiers | Overexpression of a Barley Aquaporin Gene, HvPIP2;5 Confers Salt and Osmotic Stress Tolerance in Yeast and Plants |...
The conserved phosphorylation-target serine residues in the C-termini were shown in bold. (B) Six predicted transmembrane ... Conserved phosphorylation-target serine residues were also found in the C-termini of both PIP2;5 orthologs (Supplementary ... Predicted phosphorylation sites in (A) HvPIP2;5 and (B) AtPIP2;5 (At3554820). Phosphorylation site prediction was carried out ... Daniels, M. J., and Yeager, M. (2005). Phosphorylation of aquaporin PvTIP3;1 defined by mass spectrometry and molecular ...https://www.frontiersin.org/articles/10.3389/fpls.2016.01566/full
C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
Phosphorylation of serine 1138 (S1138) residue within the CaMKII target sequence defined in Figure 1A. (A) WT ATP8A2 containing ... Φ is a hydrophobic residue, n is a nonbasic residue and x is any residue (Figure 1A). The serine residue in this motif was ... Phosphorylation of a serine residue within the calcium/calmodulin-dependent protein kinase II binding motif on ATP8A2. Sequence ... Instead, ATP8A2 harbors a serine residue (S1138) within a CaMKII target motif not found in Drs2. This serine undergoes CaMKII- ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5341728/
Furin Antibody (NB100-1903): Novus Biologicals
Phosphorylation of serine residues within this region modulates intracellular routing of Furin protein. An additional signaling ... Synthetic peptide corresponding to residues R(780) G E R T A F I K D Q S A L(793) of human Furin. ... Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase ( ...https://www.novusbio.com/products/furin-antibody_nb100-1903
Caillaud A[au] - PubMed - NCBI
Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Caillaud+A&link_type=AUTHORSEARCH&cmd=search&term=Caillaud+A%5Bau%5D&dispmax=50
Molecules | Free Full-Text | The Rosiglitazone-Like Effects of Vitexilactone, a Constituent from Vitex trifolia L. in 3T3-L1...
... the expression of adiponectin and GLUT4 in the cell membrane and decreased both the size of adipocytes and the phosphorylation ... It has been reported that the phosphorylation of serine residues of IRS up-regulates insulin resistance . The effect of ... Insulin resistance is induced by phosphorylation of serine residues (Ser 307/612/632) of IRS-1 by diabetes-inducing factors ... As vitexilactone suppressed the phosphorylation of serine residues of IRS-1 such as rosiglitagone (Figure 5), vitexilactone may ...https://www.mdpi.com/1420-3049/22/11/2030/htm
Mecanismos de regulação da localização subcelular de maspina em linhagem de células...
Phosphorylation occurs on serine residues and dephosphorylation, on tyrosine residues. Looking for signaling pathways ... EGF also alters the phosphorylation of the protein as observed by 2D-SDSPAGE and gel containing Phos-tag. ... Maspin, a 42 kDa tumor suppressor protein, belongs to the serpin (serine protease inhibitors) superfamily, however, its ...http://www.teses.usp.br/teses/disponiveis/42/42134/tde-08102018-095239/es.php
Frontiers | Functions of GSK-3 Signaling in Development of the Nervous System | Frontiers in Molecular Neuroscience
... mediated GSK-3β phosphorylation at Serine 9 residue. The phosphorylation induced high levels of APC and Glu-tubulin (stabilized ... Additionally, GSK-3 knock-in mice, in which inhibitory serine 9 (β) and 21 (α) residues are substituted by alanine (McManus et ... However, inhibition of the Serine 9 phosphorylation by overexpressing active GSK-3β (S9A) resulted in very low levels of APC ... These results suggest that GSK-3 inactivation via Serine 9 phosphorylation is required for directional migration of cortical ...https://www.frontiersin.org/articles/10.3389/fnmol.2011.00044/full
The Akt-Endothelial Nitric Oxide Synthase Pathway in Lipopolysaccharide Preconditioning-Induced Hypoxic-Ischemic Tolerance in...
eNOS phosphorylation at serine residue 1177 upregulates eNOS enzymatic activity and NO production.19 eNOS-deficient mice are ... Although eNOS phosphorylation was observed as early as 1 hour after LPS, transcriptional regulation of eNOS may be more related ... VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the ... 9 PI3K/Akt-dependent eNOS phosphorylation is important in the antiapoptotic effect of insulin, estrogen, and statins in stroke. ...http://stroke.ahajournals.org/content/41/7/1543
Session Listing | 2017 Drosophila Research Conference
Phosphorylation of serine residues of mutant huntingtin contributes to metabolic function in Huntington's disease in Drosophila ... PINK1-dependent Phosphorylation of PINK1 and Parkin Is Essential for Mitochondrial Quality Control Na Zhuang. 451A Determining ... The PP2A serine/threonine phosphatase complex functions in regulating dendritic diversification Shatabdi Bhattacharjee. 380B ... Odorant sensitivity is regulated by Orco phosphorylation in Drosophila Hao Guo. 416B A broad-spectrum olfactory neuron for ...http://www.genetics-gsa.org/drosophila/2017/pages/sessionlisting/Posters.shtml
Final Report Summary - BASEFOOD (Sustainable exploitation of bioactive components from the Black Sea Area traditional foods) |...
Akt itself becomes activated (p-Akt) through phosphorylation of a serine residue, Ser473. There are already numerous studies ... 10). In addition, the pomegranate and persimmon extract increased AKT and eNOS phosphorylation. The pomegranate extract also ...https://cordis.europa.eu/result/rcn/143081_en.html
In addition, they are regulated by phosphorylation on serine residues by p38MAPK family members. iPLA2s are also found in the ... Fang X., Yu S., Eder A., Mao M., Bast R. C., Jr., Boyd D., Mills G. B. Regulation of BAD phosphorylation at serine 112 by the ... These effects are associated with increased phosphorylation of focal adhesion kinase, increased tyrosine phosphorylation of ... Ohguchi K., Kasai T., Nozawa Y. Tyrosine phosphorylation of 100-115 kDa proteins by phosphatidic acid generated via ...http://clincancerres.aacrjournals.org/content/6/6/2482
KEGG ENZYME: 184.108.40.206
Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) ...https://www.genome.jp/dbget-bin/www_bget?enzyme+220.127.116.11
NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes | Journal...
To ensure the phosphorylation of p47phox at serine residues mediated through PKC-α, as shown in Figure 4d, LTA-stimulated ... we first determined whether LTA stimulates p47phox phosphorylation at serine residues; as shown in Figure 3a, LTA stimulated ... phosphorylation of serine residues on p47phox was attenuated by pretreatment with Gö6976 (1 μM). To confirm the role of PKCα in ... The phosphorylation of serine, ATF2, and p300 or total Nox, p47phox, PKCα, ATF2 and p300 were identified and quantified by ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-110
Role of STAT3 in Cancer Metastasis and Translational Advances
Conserved serine phosphorylation site is present in many transactivation domains. Phosphorylation of this serine residue is ... "Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on ... "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation," ... inhibits STAT3 and STAT1 tyrosine phosphorylation and STAT3 serine phosphorylation in HepG2 cells . ...https://www.hindawi.com/journals/bmri/2013/421821/
JCI - Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology
Tau phosphorylation at serine 396 residue is required for hippocampal LTD. J Neurosci. 2015;35(12):4804-4812.. View this ... between the H82 residue of the CD loop and the H4 residue of the mTIDM peptide (Supplemental Figure 5C; right). Moreover, ... between the NE1 atom of the conserved histidine residue (H82) of the CD loop and the ND atom of the histidine (H4) residue of ... Residue-level interaction was evaluated by the Cβ atom potential, and long-range interactions were validated by the all-atom ...https://www.jci.org/articles/view/96209
Patent US7393925 - Leucine-based motif and Clostridial neurotoxins - Google Patents
Italicized serine residues are potential sites of phosphorylation. The modified neurotoxin may be formed from any neurotoxin. ... More preferably, the hydroxyl containing amino acid is a serine which can be phosphorylated to allow for the binding of adaptor ... In another embodiment, the quintet of amino acids comprises at least one hydroxyl containing amino acid, for example a serine, ... Sometimes, the process of nicking involves the removal of approximately 10 amino acid residues from the single-chain to create ...http://www.google.com/patents/US7393925?dq=7,321,221