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*  CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase - CDP Diacylglycerol Inositol 3 Phosphatidyltransferase ...
An enzyme that catalyzes the formation of PHOSPHATIDYLINOSITOL and CMP from CDP-DIACYLGLYCEROL and MYOINOSITOL. ... Diphosphate 1,2-Diacyl-sn-Glycerol - Inositol Transferase; Inositol Phosphatidyltransferase; Phosphatidylinositol Synthase; 3- ... An enzyme that catalyzes the formation of PHOSPHATIDYLINOSITOL and CMP from CDP-DIACYLGLYCEROL and MYOINOSITOL. ... diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small ...
http://www.curehunter.com/public/keywordSummaryD051607-CDP-Diacylglycerol-Inositol-3-Phosphatidyltransferase-CDP-Diacylglycerol-Inositol-3-Phosphatidyltransferase.do
*  Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate - Semantic Scholar
We show that Cx43-based cell-cell communication is inhibited by depletion of phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5] ... When PtdIns(4,5)P(2) is overproduced by PtdIns(4)P 5-kinase, Cx43 channel closure is impaired. We find that the Cx43 binding ... Using a translocatable 5-phosphatase, we show that PtdIns(4,5)P(2) depletion is sufficient to close Cx43 channels. ... Our results show that PtdIns(4,5)P(2) is a key regulator of Cx43 channel function, with no role for other second messengers, ...
https://www.semanticscholar.org/paper/Regulation-of-connexin43-gap-junctional-by-Zeijl-Ponsioen/8b93ad1e13d05971600f941ccfaa69825821494b
*  KEGG T00245: DDB G0275011
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase. DDB_G0275011 (pikC). Membrane trafficking [BR:ddi04131]. Endocytosis ... 04070 Phosphatidylinositol signaling system. DDB_G0275011 (pikC). Human Diseases. Endocrine and metabolic diseases. 04933 AGE- ... phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] ... Ontology (3) KEGG BRITE (3) Pathway (3) KEGG PATHWAY (3) Chemical substance (4) KEGG COMPOUND (4) Chemical reaction (2) KEGG ...
http://www.genome.jp/dbget-bin/www_bget?ddi:DDB_G0275011
*  INP54 - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
... diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize ... nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). ... nor phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P).2 Publications. ,p>Manually ... phosphatidylinositol dephosphorylation Source: SGD ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the ...
http://www.uniprot.org/uniprot/Q08227
*  Effects of different phospholipids on the proteolysis o | Open-i
In the current study, we investigate the binding of Boi1's PH domain to the acidic phospholipids PIP2 (phosphatidylinositol-4,5 ... In the current study, we investigate the binding of Boi1's PH domain to the acidic phospholipids PIP2 (phosphatidylinositol-4,5 ... getmorefigures.php?uid=PMC117597&req=5. .flowplayer { width: px; height: px; } Figure 2: Effects of different phospholipids on ... lanes 4), or PIP2 (lanes 5). Mentions: Fortuitously, we discovered that Boi1-PH can be proteolyzed in yeast extracts in a ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC117597_1471-2121-3-16-2&req=4
*  Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control of plant growth and development...
Rac Homologues and Compartmentalized Phosphatidylinositol 4,5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen ... Role of 1,4,5-Inositol Triphosphate-Induced Ca2+ Release in Pollen Tube Orientation ...
https://www.deepdyve.com/lp/springer_journal/superfamily-of-monomeric-gtp-binding-proteins-in-plants-1-role-of-rop-bJUCGEA0QQ
*  Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and...
Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and ... Cortactin/EMS1 is the first identified molecule that is dissociated in a Rac-phosphatidylinositol 4,5-biphosphate (PIP2)- ...
https://scholars.latrobe.edu.au/display/publication23524
*  A model depicting gating of GIRK channels by the combin | Open-i
The presence of phosphatidylinositol-bis-phosphate (PIP(2)) is required for G protein activation. Formation (via hydrolysis of ... The presence of phosphatidylinositol-bis-phosphate (PIP(2)) is required for G protein activation. Formation (via hydrolysis of ... getmorefigures.php?uid=PMC2230539&req=5. .flowplayer { width: px; height: px; } Figure 8: A model depicting gating of GIRK ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2230539_JGP8035.f8&req=4
*  WenTong HuoXue Cream Can Inhibit the Reduction of the Pain-Related Molecule PLC-β3 in the Dorsal Root Ganglion of a Rat Model...
PLC-β3 activation causes hydrolysis of phosphatidylinositol-4,5-diphosphate (PIP2), resulting in inositol triphosphate (IP3) ... PLC-β includes PLC-β1, PLC-β2, PLC-β3, and PLC-β4. PLC-β1, PLC-β3, and PLC-β4 are distributed in the dorsal root ganglion (DRG ... 4, pp. 663-665, 2017. View at Google Scholar. *S.-K. Han, V. Mancino, and M. I. Simon, "Phospholipase Cβ 3 mediates the ... 2354-2356, 5 edition, 2013. View at Google Scholar. *T.-J. S. Shi, M.-D. Zhang, H. Zeberg et al., "Coenzyme Q10 prevents ...
https://www.hindawi.com/journals/ecam/2018/3416936/
*  PTPRN2 - Wikipedia
Specifically, phogrin was shown to act upon phosphatidylinositol 3-phosphate and Phosphatidylinositol 4,5-diphosphate, whereas ... Phosphorylated forms of phosphatidylinositol (PI) are called phosphoinositides and play important roles in lipid signaling, ... "The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion". J. ... 151 (5): 985-1002. doi:10.1083/jcb.151.5.985. PMC 2174349 . PMID 11086001. Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, ...
https://en.wikipedia.org/wiki/PTPRN2
*  DI-fusion In Chinese hamster ovary K1 cells dog and human thyrotropin...
In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol ... In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol ... The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells. par Van Sande, ... Thyrotropin stimulates the generation of inositol 1,4,5-trisphosphate in human thyroid cells. par Van Sande, Jacqueline , ...
http://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57697/Details
*  List of MeSH codes (D10) - Wikipedia
... phosphatidylinositol phosphates MeSH D10.570.755.375.760.400.942.625.900 --- phosphatidylinositol 4,5-diphosphate MeSH D10.570. ... phosphatidylinositols MeSH D10.570.755.375.760.400.942.250 --- glycosylphosphatidylinositols MeSH D10.570.755.375.760.400. ... prosta-5,13-dienoic acid MeSH D10.251.355.255.550.100 --- prostaglandins a MeSH D10.251.355.255.550.150 --- prostaglandins b ... 12-hydroxy-5,8,10,14-eicosatetraenoic acid MeSH D10.251.355.255 --- eicosanoids MeSH D10.251.355.255.049 --- 5,8,11,14- ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D10)
*  Purinergic stimulation of rat cardiomyocytes induces tyrosine phosphorylation and membrane association of phospholipase Cγ: a...
There, PLCγ becomes activated leading to the hydrolysis of phosphatidylinositol diphosphate and in turn Ins(1,4,5)P3 formation ... Extracellular ATP also increases intracellular Ins(1,4,5)P3 content. All these events (translocation and phosphorylation of PLC ...
http://www.biochemj.org/content/318/2/723
*  US Patent # 9,656,984. PI3K/AKT/mTOR inhibitors and pharmaceutical uses thereof - Patents.com
Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases. Breast cancer research: BCR 13, R125, (2011 ... Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway. ... Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway. ... Phosphoinositide 3-kinases (also called Phosphatidylinositol 3-kinases or PI3Ks) constitute a family of lipid kinase enzymes ...
http://patents.com/us-9656984.html
*  Polymorphisms of SHIP2, a phosphatase involved in the modulation of downstream signals in insulin pathway, in ageing and age...
To regulate the cellular levels of lipid secondary messengers such as PtdIns(3,4,5)P3, cells use two major types of ... phosphoinositide phosphatases: the inositol polyphosphate 3-phosphatase PTEN and SH2 domain-containing inositol 5-phosphatases ... to produce phosphatidylinositol 3,4-diphosphate (PIP2). Thus SHIP2 is an antagonist phosphatidylinositol 3-kinase (PI3K) that ... SHIP2 is a protein that catalyzes the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate (PIP3) ...
https://sens.org/outreach/conferences/polymorphisms-ship2-phosphatase-involved-modulation-downstream-signals-insulin
*  Cutting Edge: Gab2 Mediates an Inhibitory Phosphatidylinositol 3′-Kinase Pathway in T Cell Antigen Receptor Signaling | The...
Phosphatidylinositol 3′-kinase (PI3K) is a key component of multiple signaling pathways, where it typically promotes survival, ... Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, ... Cutting Edge: Gab2 Mediates an Inhibitory Phosphatidylinositol 3′-Kinase Pathway in T Cell Antigen Receptor Signaling. Joanne C ... Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in ...
http://www.jimmunol.org/content/165/8/4158.full
*  APS -APS March Meeting 2012 - Event - High-resolution Structures of Protein-Membrane Complexes by Neutron Reflection and MD...
... and phosphatidylinositol diphosphate (PI(4,5)P$_{2})$ act synergetically in attracting the enzyme to the membrane surface. ... The lipid matrix of biomembranes is an in-plane fluid, thermally and compositionally disordered leaflet of 5 nm thickness and ... Membrane affinities depend strongly on membrane fluidity, which suggests multiple binding sites on the protein for PI(4,5)P$_{2 ... Despite its importance in regulating the levels of the phosphoinositoltriphosphate PI(3,4,5)P$_{3}$, there is little ...
http://meetings.aps.org/Meeting/MAR12/Session/A41.5
*  Plus it
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates ... Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose ... Li JP, Defea K, Roth RA: Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3- ... Downstream molecules such as phosphatidylinositol-dependent kinase (PDK) and protein kinase B (PKB [AKT]) have a pleckstrin ...
http://diabetes.diabetesjournals.org/content/55/Supplement_2/S9
*  NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K...
The phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors. Cancer Res 2001; 61: 7426-9. ... The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7: 606-19. ... Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. ... Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the ...
http://cancerres.aacrjournals.org/content/68/19/8022?ijkey=64e4f4b0583b3da4e3c5fa9eeef12756d8e27400&keytype2=tf_ipsecsha
*  PTPRN2 gene - Genetics Home Reference - NIH
... phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol ... Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol ... Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. ... 5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in ...
https://ghr.nlm.nih.gov/gene/PTPRN2
*  Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels. - Department of...
Gq PCR activation initiates depletion of plasmalemmal phosphatidylinositol 4,5-bisphosphate (PIP2 ). Here, we determined ... were abolished by an inactivating mutation in DrVSP and antagonized by simultaneous co-expression of a phosphatidylinositol-4- ... phosphate 5-kinase that catalyses PIP2 formation. CONCLUSIONS AND IMPLICATIONS: PIP2 acts as a modifier of TMEM16A and TMEM16B ... Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels. ...
https://pharm.ox.ac.uk/publications/702853
*  Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of...
Phosphatidylinositol-dependent activation of DNA polymerase α. Biochem Biophys Res Commun. 1986; 135: 880-885. ... Yu H, Fukami K, Watanabe Y, Ozaki C, Takenawa T. Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA ... and phosphatidylinositol 4,5-diphosphate.9,10 Moreover, nuclear inositol phospholipids have been consistently shown to serve as ... Opioid peptides govern important physiological responses, including pain,1 behavior,2 and learning and memory,3,4 and have also ...
http://circres.ahajournals.org/content/92/6/623
*  Probes for Neurotransmitter Receptors-Section 16.2 | Thermo Fisher Scientific - JP
RPLC = Receptors promoting the hydrolysis of phosphatidylinositol 4,5-diphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3), ... Figure 16.2.4 Detection of L-glutamic acid using the Amplex Red Glutamic Acid/Glutamate Oxidase Assay Kit (A12221). Each ... Figure 16.2.5 Detection of L-glutamate oxidase using the Amplex Red Glutamic Acid/Glutamate Oxidase Assay Kit (A12221). Each ... 4, 6. *All photoactivatable probes are sensitive to light. They should be protected from illumination except when photolysis is ...
https://www.thermofisher.com/jp/en/home/references/molecular-probes-the-handbook/probes-for-endocytosis-receptors-and-ion-channels/probes-for-neurotransmitter-receptors.html
*  Human/Mouse/Rat PTEN Alexa Fluor® 488-conjugated Antibody IC847G-100UG: R&D Systems
... diphosphate by PI 3-kinase upon activation by a variety of stimuli. Therefore, PTEN antagonizes PI 3-kinase-induced downstream ... phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN; PTEN; PTEN1; TEP1MHAM ... This activity reduces the levels of phosphatidylinositol (3,4,5)-triphosphate which is specifically produced from ... evidence has shown that the tumor suppressor activity of PTEN relies on its ability to dephosphorylate phosphatidylinositol (3, ...
https://www.rndsystems.com/products/human-mouse-rat-pten-alexa-fluor-488-conjugated-antibody-217702_ic847g
*  Aperçu des produits pour anti-MARCKS anticorps
These findings demonstrate a critical role for MARCKS-phosphatidylinositol-4,5-diphosphate signaling in regulating dendrite ... lipid kinase activity by binding MARCKS and displacing it from phosphatidylinositol 4,5-bisphosphate (PIP2) headgroups, thereby ... free PIP2 that recruits active PI3K to the membrane and serves as the substrate for the generation of phosphatidylinositol 3,4, ...
https://www.anticorps-enligne.fr/abstract/Myristoylated+Alanine-Rich+Protein+Kinase+C+Substrate+