Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase ... Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase ... Correlation between beta-amyloid peptide production and human APP-induced neuronal death.. In: Peptides, Vol. 23, no. 7, p. ... Correlation between beta-amyloid peptide production and human APP-induced neuronal death.. In: Peptides, Vol. 23, no. 7, p. ...
6.3.2 Acid-D-amino-acid ligases (peptide synthases). 6.3.2.2 glutamate---cysteine ligase. 2729 (GCLC). ...
... Validated for ELISA, WB, IHC. Tested in Human, Mouse, Rat. Order online. ... Synthesized peptide derived from human GSK3alpha/beta around the phosphorylation site of Y279/216. Isotype IgG ... Target See all Glycogen Synthase Kinase 3 (GSK3) Antibodies Glycogen Synthase Kinase 3 (GSK3) Binding Specificity All epitopes ... anti-Glycogen Synthase Kinase 3 (GSK3) (pTyr216), (pTyr279) antibody GSK3 Reactivity: Human ELISA, WB, IHC, IF Host: Rabbit ...
Ribosome-Independent Biosynthesis of Peptide Natural Products: Nonribosomal Peptide Synthetases and Cyclodipeptide Synthases by ...
Enhancement of Inducible Nitric Oxide Synthase Activity by Low Molecular Weight Peptides Derived from Protamine: A Potential ... In lab tests, the peptides increased nitric oxide production in mouse immune cells and cells that line airways, making them a ... The researchers developed a simple method to make molecules called low-molecular-weight, arginine-rich peptides from an already ...
Lumazine synthase enzyme is a decameric protein carrier that displays foreign antigens effectively in a polyvalent manner. The ... as a foreign peptide. The primary studies were based on bioinformatics tools and the fusion was expressed and purified in the ... Lumazine Synthase Decameric Carrier in Fusion to Extracellular Domain of Influenza M2E Protein ... In the current study, Brucella lumazine synthase (BLS) was applied for fusion with influenza matrix protein 2 ectodomain (M2E) ...
Piel, J.: A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. ... Piel, J.; Hui, D. Q.; Fusetani, N.; Matsunaga, S.: Targeting modular polyketide synthases with iteratively acting ... Moore, B. S.; Piel, J.: Engineering biodiversity with type II polyketide synthase genes. Antonie van Leeuwenhoek International ... Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase. Chembiochem ...
At the LES, the loss of inhibitory nerves is demonstrated by loss of nitric oxide synthase and vasoactive intestinal peptide ( ...
... g lycogen synthase kinase 3 and C K2-related kinases) or tyrosine kinase; (ii) classification into a Kinase Sequence Database ( ... peptide specificity is the major factor that determines substrate specificity. The prediction of peptide specificity is ... Previously, Predikin used a set of conditional rules of the form "if SDR = X then peptide residue = Y" to make substrate ... The binding mode of substrate peptides to tyrosine kinases is also known to differ somewhat from that of serine-threonine ...
Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin. ... Meki AR, Nassar AY, Rochat H. A bradykinin-potentiating peptide (peptide K12) isolated from the venom of Egyptian scorpion ... and other factors such as vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP) mediate smooth muscle ... Many of these peptides selectively inhibit voltage-activated Ca2+ and Na+ channels, acid-sensitive ion channels (ASIC) or ...
Improving the thermostability of trehalose synthase from Thermomonospora curvata by covalent cyclization using peptide tags and ... Fierer, J.O.; Veggiani, G.; Howarth, M. SpyLigase peptide-peptide ligation polymerizes affibodies to enhance magnetic cancer ... The indexes of "peptide tags", "linkers" and "AGL" were generated by the command "gmx make_ndx" (Gromacs). The stability of the ... The cyclic peptide is a type of naturally occurring polypeptide molecule with a circular structure [34]. Due to its good ...
The uptake of small peptides by rat AM was evaluated using fluorescein isothiocyanate (FITC)-labeled (*) peptides (Arg-Lys*, ... The substrate specificity of Arg-Gly and Arg-Gly-Asp was determined using purified inducible NO synthase (iNOS). The ... This study shows that AM exhibit PepT1-like transporter for small peptide uptake. Arginine-containing peptides, through the ... containing small peptides and utilized these peptides as direct substrates for nitric oxide (NO) production. NO is an important ...
Fabclavines are hexapeptide/polyketide hybrids derived from nonribosomal peptide synthetases (NRPS) and a polyketide synthase ( ... These are generated when the peptide biosynthesis starts directly with the second NRPS enzyme FclJ, which results in the ... Fabclavines are hybrid SMs derived from nonribosomal peptide synthetases (NRPS), polyunsaturated fatty acid (PUFA), and ... PAX peptides, or rhabdopeptides [26,44-46], which will be studied in the future. Furthermore, the identification of fabclavine ...
Furthermore, an obesity-related nonribosomal peptide synthetase (NRPS) was negatively associated with Bacteroidetes,i,, ,/i, ... C. Prieto, C. García-estrada, D. Lorenzana, and J. F. Martín, "NRPSSP: Non-ribosomal peptide synthase substrate predictor," ... NRPS is a class of peptide SMs produced by bacteria and fungi and has been successfully used as antibiotics [18]. AntiSMASH 4.0 ... M. Winn, J. K. Fyans, Y. Zhuo, and J. Micklefield, "Recent advances in engineering nonribosomal peptide assembly lines," ...
... non-ribosomal peptide synthases, a hybrid polyketide synthase-non-ribosomal peptide synthase as well as genes for the ... revealed that only the genes potentially coding for a non-ribosomal peptide synthase (BN1708_006789 and BN1708_014277) were up- ... 2019). Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to ... 2010). Silencing of Vlaro2 for chorismate synthase revealed that the phytopathogen Verticillium longisporum induces the cross- ...
Colocalization of vasoactive intestinal peptide and nitric oxide synthase in neurons of the ferret trachea. Neuroscience 1993; ... VIP and NO synthase (NOS) have been co-localised in neurons innervating ferret and human airways 4, 5. Beyond their presence ... Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways. Science 1980;210:1252- ... Fischer A, Hoffmann B. Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. ...
Biomimetic N-acetylcysteamine thioesters are essential for the study of polyketide synthases, non-ribosomal peptide synthetases ... Subject: Medicine And Pharmacology, Other Keywords: Enzymes, Peptide Hydrolases, Metalloproteases, Biomarkers, Gingival ... Jinqiao 2(JQ2). XMQ showed significantly lower values of net photosynthetic rate, ADPGase activity and starch synthase ... Cyclooxygenases (COX), or prostaglandin endoperoxide synthases (PTGS), are key enzimes in the synthesis of prostaglandins, ...
... highlighting the conveyor-belt assembly line of this non-ribosomal peptide synthase producing the important antibiotic ... "Dissecting modular synthases through inhibition: A complementary chemical and genetic approach". Beld J, Vickery CR, McCulloch ... Bacterial colonies on an agar surface expressing a synthase that produces a deep blue dye. The filter disk (white circle) is ...
One stains for NO synthase and vasoactive intestinal peptide, and the other for choline acetyl transferase and substance P. ... nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, the B wave is abolished, and an A wave (i.e., ... Nitric oxide synthase inhibition appeared to decrease swallow-induced esophageal shortening in the cat, but evidence for a NO- ... Subsequent administration of L-arginine (a substrate of NO synthase that reverses the effect of L-NAME), the B-wave returns. b ...
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. ... Docking of endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane a pentabasic amino acid sequence in the ... An analytical method capable of identifying and quantifying diverse chemical species, including proteins and peptides, by ... Swaney, D. L. & Villén, J. Enrichment of modified peptides via immunoaffinity precipitation with modification-specific ...
The cDNA encodes a 608 amino acid protein of which 78 amino acids form a chloroplast/amyloplast transit peptide of 8.37 kDa. ... Isolation of Genomic Clones Encoding Granule-bound Starch Synthase (GBSS I) in Cassava (Manihot esculenta Crantz). Journal of ... Isolation of Genomic Clones Encoding Granule-bound Starch Synthase (GBSS I) in Cassava (Manihot esculenta Crantz) table, th, td ... Primer design: A cassava granule-bound starch synthase I gene-specific primer pair was designed from cDNA sequences (accession ...
... with polyketide synthases (PKSs), terpene synthases and non‐ribosomal peptide synthetases (NRPSs) ranking as the most frequent ... A Combined Transmembrane Topology and Signal Peptide Prediction Method journal, May 2004 * Käll, Lukas; Krogh, Anders; ... SignalP 4.0: discriminating signal peptides from transmembrane regions journal, September 2011 * Petersen, Thomas Nordahl; ... Although peptides related to housekeeping proteins from nitrite-oxidizing microorganisms were detected, their abundance was not ...
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides ... CavNOxin, a cell-permeable, Cav-1-derived peptide with T90,91,F92 substituted to alanines, has been shown to increase eNOS ... A commentary has been published: Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes- ... Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase ...
... required for post-translational activation of polyketide synthases and non-ribosomal peptide synthases is a virulence factor of ...
Another part of the frozen muscle tissue will be utilized to determine the enzyme activity of citrate synthase [59]. ... Alghannam, A.F., Tsintzas, K., Thompson, D. et al. Post-Exercise Protein Trial: Interactions between Diet and Exercise (PEPTIDE ... Post-Exercise Protein Trial: Interactions between Diet and Exercise (PEPTIDE): study protocol for randomized controlled trial. ... Post-Exercise Protein Trial: Interactions between Diet and Exercise (PEPTIDE): study protocol for randomized controlled trial ...
2001) Nitric oxide synthase mRNA levels correlate with gene expression of angiotensin II type-1 but not type-2 receptors, renin ... The disruption of peptide function could extend to other peptides that neprilysin degrades, such as dynorphin (Hiranuma et al ... Second, we studied peptidase regulation of exogenous peptide which was not influenced by any changes to endogenous peptide ... suggesting that peptidase inhibitors are able to mitigate the reduced peptide function and rescue the impaired peptide ...
... lysyl-tRNA synthase, and β actin, but the results did not reveal new potential candidates that could be the specific target of ... The peptide-MHC class I complexes that are produced by 12-, 13-, or even 14-mer peptides (14) are structurally unique with a ... In this issue of the JCI, two separate studies on MHC-bound peptides reopen the debate on the utility of peptides for the ... Moving peptides into the therapeutic arena. At first sight, peptides are seductive - they are exquisitely specific for MHC ...