Inactivation of the Major Hemolysin Gene Influences Expression of the Nonribosomal Peptide Synthetase Gene swrA in the Insect ... Characterization of the Saframycin A Gene Cluster from Streptomyces lavendulae NRRL 11002 Revealing a Nonribosomal Peptide ... Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down ...
Here we wondered if the ATP synthase similarly is needed for tolerance towards various human AMPs, including human β-defensins ... Previously, we showed that inactivation of the ATP synthase sensitizes S. aureus towards the AMP antibiotic class of polymyxins ... Administration of the ATP synthase inhibitor, resveratrol, sensitizes S. aureus towards hBD4-mediated killing. Neutrophils rely ... hBD1-4), LL-37 and histatin 5. Importantly, we find that the ATP synthase mutant (atpA) is more susceptible to killing by hBD4 ...
Calmodulin bound to peptide from neuronal nitric oxide synthase. *DOI: 10.2210/pdb2O60/pdb ... Peptide corresponding to calmodulin binding domain of neuronal nitric oxide synthase. B ... Crystal structure of calmodulin-neuronal nitric oxide synthase complex. Valentine, K.G., Ng, H.L., Schneeweis, L., Kranz, J.K. ...
Browse our Fatty Acid Synthase/FASN Peptides and Proteins all backed by our Guarantee+. ... Fatty Acid Synthase/FASN Peptides and Proteins available through Novus Biologicals. ... Fatty Acid Synthase/FASN Proteins. We offer Fatty Acid Synthase/FASN Peptides and Fatty Acid Synthase/FASN Proteins for use in ... Our Fatty Acid Synthase/FASN Peptides and Fatty Acid Synthase/FASN Proteins can be used in a variety of model species: Human. ...
... and nonribosomal peptide synthetase (NRPSs) are large multimodular enzymes involved in biosynthesis of polyketide and peptide ... In this study, we considered the most important polyketide and peptide mycotoxins and, for the first time, a phylogenetic ... are also responsible of the synthesis of peptide-polyketide metabolites in fungi. The genes encoding for PKSs and NRPSs have ... Polyketide synthase (PKSs) and non-ribosomal peptide synthetase (NRPSs) are large multimodular enzymes involved in biosynthesis ...
1H-15N HSQC-TROSY spectra of [15N]-labelled IdmH alone (purple) and in the presence of a stoichiometric amount of the ligand indanomycin (orange). Upon the addition of the ligand indanomycin, significant changes in the chemical shifts of some peaks were observed. ...
Non-ribosomal peptide synthetase/polyketide synthaseImported. ,p>Information which has been imported from another database ... tr,L8EU53,L8EU53_STRRM Non-ribosomal peptide synthetase/polyketide synthase OS=Streptomyces rimosus subsp. rimosus ATCC 10970 ... IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020806. PKS_PP-bd. IPR009081. PP-bd_ACP. IPR016039. Thiolase-like. ... IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020806. PKS_PP-bd. IPR009081. PP-bd_ACP. IPR016039. Thiolase-like. ...
Synthetic peptide containing residues surrounding Ser641 and Ser657 of human Muscle Glycogen Synthase. This peptide is pre- ... Glycogen synthase peptide (Sequence: PASVPPSPSLSRHSSPHQ(pS)ED) labeled with ULight™ dye. ... This peptide substrate can be phosphorylated by a variety of kinases including GSK3α and GSK3β. ... Assay options: Multiple substrates are tested so you can select the best peptide sequence and S:B for your kinase ...
Peptides, Antibodies, and Reagents. C5aAP was synthesized by a standard solid-phase method, purified, and characterized ... Aminoguanidine, an inducible nitric oxide synthase (NOS) inhibitor, given before C5aAP returned VP to control levels. Nω-nitro- ... A panel of C5a agonist peptides was developed to address some of these deficiencies. Based on the structure-activity study of ... In conclusion, the C5aAP-induced VP increases appear to originate from the binding of this peptide to C5aR, activation of PMNs ...
... like-pteridine synthase biosynthetic pathway has been illuminated via genome mining. ... A new type of hybrid nonribosomal peptide synthetase (NRPS)- ... peptide synthetase and pteridine synthase - to create a hybrid ... Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster. ... Here, we discovered an unprecedented nonribosomal peptide synthetase-like-pteridine synthase hybrid biosynthetic gene cluster ...
Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat Prod Rep 24:1073. doi ... Mining for Nonribosomal Peptide Synthetase and Polyketide Synthase Genes Revealed a High Level of Diversity in the Sphagnum Bog ... Mining for Nonribosomal Peptide Synthetase and Polyketide Synthase Genes Revealed a High Level of Diversity in the Sphagnum Bog ... Mining for Nonribosomal Peptide Synthetase and Polyketide Synthase Genes Revealed a High Level of Diversity in the Sphagnum Bog ...
Influence of acylation of the peptide corresponding to the amino-terminal region of endothelial Nitric Oxide Synthase on the ... Influence of acylation of the peptide corresponding to the amino-terminal region of endothelial Nitric Oxide Synthase on the ... Endothelial Nitric Oxide Synthase (eNOS) is unique among the NOS isoforms in its being dually acylated by the fatty acids ... The acylated peptides were able to insert deeply into the hydrophobic core of both neutral and acidic phospholipids. Finally, ...
We predicted the chemical backbone structures of non-ribosomal peptides and polyketides synthesized by these gene clusters, ... we sequenced the whole genomes of the five type strains and searched for the presence of their non-ribosomal peptide synthetase ... NRPS) and type-I polyketide synthase (PKS) gene clusters. These clusters are involved in the major secondary metabolite- ... and half to three quarters are associated with non-ribosomal peptide synthase (NRPS) and polyketide synthase (PKS) pathways [8 ...
10). Since MGDG synthase is present in envelope membranes from all chloroplasts and nongreen plastids (4), the leader peptide ... Assay for MGDG Synthase Activity.. MGDG synthase activity was assayed by the method of Teucher and Heinz (7) with 400 μM UDP- ... Nucleotide and deduced amino acid sequences of the cucumber MGDG synthase. Amino acid sequences of peptides obtained from the ... Stable Expression of MGDG Synthase in E. coli.. The PCR primers for the amplification of the mature form of MGDG synthase were ...
... and polyketide synthases (PKSs) are necessary for the production of a variety of secondary metabolites, such as siderophores ... SummaryNon-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are necessary for the production of a variety ... A large gene cluster encoding peptide synthetases and polyketide synthases is involved in production of siderophores and ...
... preventing conditions that result from the abnormally low expression and/or activity of endothelial cell Nitric Oxide Synthase ... In the instant invention, HMG-CoA reductase inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity ... ACE inhibitors include amino acids and derivatives thereof, peptides, including di and tri peptides and antibodies to ACE which ... Nitric Oxide Synthase is the enzyme that catalyzes the reaction that produces nitric oxide from the substrate L-arginine. As ...
... preventing conditions that result from the abnormally low expression and/or activity of endothelial cell Nitric Oxide Synthase ... In the instant invention, rho GTPase function inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase ... ACE inhibitors include amino acids and derivatives thereof, peptides, including di and tri peptides and antibodies to ACE which ... NO is produced from the guanidino nitrogen of L-arginine by NO Synthase (Moncada, S and Higgs, E A, Eur J Clin Invest, 1991, 21 ...
Jenkins, R. J. & Dotson, G. D. Dual targeting antibacterial peptide inhibitor of early lipid A biosynthesis. Acs. Chem. Biol. 7 ... Bohl, T.E., Shi, K., Lee, J.K. et al. Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli. Nat Commun ... Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli. *Thomas E. Bohl ORCID: orcid.org/0000-0003-0910- ... Antisense inhibition of lpxB gene expression in Acinetobacter baumannii by peptide-PNA conjugates and synergy with colistin * ...
Insect-Specific Polyketide Synthases (PKSs), Potential PKS-Nonribosomal Peptide Synthetase Hybrids, and Novel PKS Clades in ... A Putative Polyketide Synthase/Peptide Synthetase from Magnaporthe grisea Signals Pathogen Attack to Resistant Rice ... Abbreviations: PK, polyketide; PKS, PK synthase; KS, ketoacyl synthase; AT, acyl transferase; DH, dehydratase; NPS, ... the first of which comprised the 6-methylsalicylic acid synthases, and the second of which was a nonribosomal peptide ...
New ACC synthase genes from pineapple are disclosed which have utility as targets for the generation of transgenic plants in ... which the expression of ACC synthase is substantially controlled to effect the regulation of plant development, and, in ... mat_peptide. 103..194. CDS. 195..961. 3 ACC CGA AAC CAG CCT GGC TCT ACT TCC GCA AAT GAG ATT CTC ATT TTC 48 Thr Arg Asn Gln Pro ... Design of Primers for Amplification of ACC Synthases From Higher Plants. Homology studies of several ACC synthase proteins ...
unidentified peptide. C [auth D]. 9. Rhodobacter sphaeroides 2.4.1. Mutation(s): 0 ... Cellulose Synthase subunit A. A. 803. Rhodobacter sphaeroides 2.4.1. Mutation(s): 0 Gene Names: RSP_0333. EC: 2.4.1.12. ... Cellulose Synthase subunit B. B. 724. Rhodobacter sphaeroides 2.4.1. Mutation(s): 0 Gene Names: RSP_0332. ... Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP.. Morgan, J.L., McNamara, J.T., Zimmer, J.. (2014) Nat ...
Prostaglandin I Synthase (mouse) Blocking Peptide. Cat No: 10005257 Size: 200 µg ... Cross selling for this product : Prostaglandin I Synthase (mouse) Blocking Peptide There are 4 products. ...
... peptide library, procedures, protein engineering, site directed mutagenesis", ... Abdallah, I. I., van Merkerk, R., Klumpenaar, E., & Quax, W. J. (2018). Catalysis of amorpha-4,11-diene synthase unraveled and ... Abdallah, II, van Merkerk, R, Klumpenaar, E & Quax, WJ 2018, Catalysis of amorpha-4,11-diene synthase unraveled and improved ... N2 - Amorpha-4,11-diene synthase (ADS) cyclizes the substrate farnesyl pyrophosphate to produce amorpha-4,11-diene as a major ...
... increasing mRNA levels for type A natriuretic peptide (type A-NP), type B natriuretic peptide (type B-NP), β-myosin heavy chain ... nitric oxide synthase; NP, natriuretic peptide; NT, nitrotyrosine; p-, phosphorylated; PLB, phospholamban; PV, pressure-volume ... Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. Circ. Res. 2004. 94:657-663. View this ... Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation. 2001. ...
Peptide Synthesis-. A 19-amino acid peptide (CMASAVSPANLPAVLLQPR) containing the N-terminal 18-amino acid peptide of HCF-1 (as ... In the case of only two peptides matched, one of the peptides was required to have a Mascot score of at least 40. All spectra ... It was observed that the presence of naked peptides suppressed the ionization of O-GlcNAc peptides by at least 10-fold in the ... Then the MS spectrum containing each selected peptide was then inspected for a companion peptide 10 Da apart (Fig. 2C, middle ...
Homocitrate synthase LYS20/LYS21 subfamily.Curated. Keywords - Domaini. Transit peptide. Phylogenomic databases. evolutionary ... Homocitrate synthase, cytosolic isozyme (LYS20), Homocitrate synthase, mitochondrial (LYS21). *Homocitrate dehydratase, ... Belongs to the alpha-IPM synthase/homocitrate synthase family. ... homocitrate synthase activity Source: SGD ,p>Inferred from ... "Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae.". Chen S., Brockenbrough J.S., Dove J.E. ...
Nonribosomal peptide synthase 1 - Also known as NPS1_AJECA, NPS1. Nonribosomal peptide synthase; part of the gene cluster that ... Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores ... Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores ...
Polymorphisms within the atrial natriuretic peptide gene in essential hypertension. J Hypertens. 1995;13:953-955. ... Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension. Yoshihiro Miyamoto, Yoshihiko ... Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension. Yoshihiro Miyamoto, Yoshihiko ... Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension. Yoshihiro Miyamoto, Yoshihiko ...
14 genes encoding bacterial elongation factors EF-Tu and 7 genes encoding the beta-subunit of bacterial F1F0 type ATP-synthases ... Peptide Elongation Factor Tu / genetics* * Phylogeny* * Polymerase Chain Reaction * Proton-Translocating ATPases / genetics* ... Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta- ... 14 genes encoding bacterial elongation factors EF-Tu and 7 genes encoding the beta-subunit of bacterial F1F0 type ATP-synthases ...
Lau KF, Miller CC, Anderton BH, Shaw PC: Expression analysis of glycogen synthase kinase-3 in human tissues. J Peptide Res54 : ... GS, glycogen synthase; GSK-3, glycogen synthase kinase 3; GTT, glucose tolerance test; ipGTT, intraperitoneal glucose tolerance ... Wang Y, Roach PJ: Inactivation of rabbit muscle glycogen synthase by glycogen synthase kinase-3. Dominant role of the ... Orena SJ, Torchia AJ, Garofalo RS: Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport ...