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*  Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection - Organic &...
... we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows ... Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection ... Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection D. Gahtory ... In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids ...
http://pubs.rsc.org/en/content/articlelanding/2017/ob/c7ob01592e
*  Frontiers | Exploration of Using Antisense Peptide Nucleic Acid (PNA)-cell Penetrating Peptide (CPP) as a Novel Bactericide...
We determined that a 10-nucleotide oligomer of peptide nucleic acid (PNA) targeting the start codon region of an essential gene ... We determined that a 10-nucleotide oligomer of peptide nucleic acid (PNA) targeting the start codon region of an essential gene ... Antisense antimicrobials are oligomers of nucleic acid homologs with antisense sequence of essential genes in bacteria. The ... We found that conjugation of cell penetrating peptide (CPP) to PNA is essential for the antimicrobial effect, with CPP1 [(KFF) ...
https://www.frontiersin.org/articles/10.3389/fmicb.2017.00687/full
*  Can pseudocomplementary peptide nucleic acid nucleases (pcPNANs) be a new tool for genetic engineering? [PeerJ Preprints]
In this paper, we propose a new tool for genetic engineering, the pseudocomplementary peptide nucleic acid nucleases (pcPNANs ... Can pseudocomplementary peptide nucleic acid nucleases (pcPNANs) be a new tool for genetic engineering?. Penghui Shi ​ ... Shi P. (2014) Can pseudocomplementary peptide nucleic acid nucleases (pcPNANs) be a new tool for genetic engineering? PeerJ ... In this paper, we propose a new tool for genetic engineering, the pseudocomplementary peptide nucleic acid nucleases (pcPNANs ...
https://peerj.com/preprints/229/
*  Peptide Nucleic Acids (PNA)
PNAs are nucleic acid analogues in which the phospho-sugar backbone is replaced by : a peptide linkage maintaining the correct ... Peptide Nucleic Acids (PNA). martin LEACH leach at bu.edu Mon Apr 1 16:58:32 EST 1996 *Previous message: oligo annealing/ ... peptide or protein nucleic acids). These analogues : (apparently) bind more tightly to DNA strands than a complemantary : ...
http://www.bio.net/bionet/mm/methods/1996-April/042516.html
*  Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs) | IntechOpen
Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs). By Rosangela Marchelli, Roberto Corradini, Alex ... Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs), Targets in Gene Therapy Yongping You, IntechOpen, ... Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs), Targets in Gene Therapy Yongping You, IntechOpen, ... www.intechopen.com/embed/targets-in-gene-therapy/gene-modulation-by-peptide-nucleic-acids-pnas-targeting-micrornas-mirs-' /,. ...
https://www.intechopen.com/books/targets-in-gene-therapy/gene-modulation-by-peptide-nucleic-acids-pnas-targeting-micrornas-mirs-/
*  Synthesis and Purification of Peptide Nucleic Acids - Current Protocols
Peptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine ... Automated synthesis of peptide nucleic acids (PNAs) and peptide nucleic acidpeptide conjugates. Anal. Biochem. 268:401‐404. ... Peptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine ... Targeting peptide nucleic acid protein conjugates to structural features within duplex DNA. Bioorg. Med. Chem. 3:437‐445. ...
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-nc0411.html
*  Converging peptide- and DNA-nanotechnology: molecular self-assembly of peptide nucleic acids
Peptide nucleic acids containing a peptide-like backbone and nucleic acid side-chains has been found to efficiently form ... This material, termed PNA (peptide nucleic acid) has the backbone of a peptide, but the residues of the DNA. This family of ... Converging peptide- and DNA-nanotechnology: molecular self-assembly of peptide nucleic acids. ... Converging peptide- and DNA-nanotechnology: molecular self-assembly of peptide nucleic acids ...
http://www.esrf.eu/home/UsersAndScience/Publications/Highlights/highlights-2015/structural-biology/sb03.html
*  Peptide nucleic acid | definition of peptide nucleic acid by Medical dictionary
What is peptide nucleic acid? Meaning of peptide nucleic acid medical term. What does peptide nucleic acid mean? ... Looking for online definition of peptide nucleic acid in the Medical Dictionary? peptide nucleic acid explanation free. ... peptide nucleic acid. Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia. peptide nucleic acid. ... Peptide nucleic acid characterization by MALDI-TOF mass spectrometry.. Design and use of a peptide nucleic acid for detection ...
https://medical-dictionary.thefreedictionary.com/Peptide+nucleic+acid
*  Biotage - Microwave Assisted Synthesis of Peptide Nucleic Acid Oligomers
Microwave Assisted Synthesis of Peptide Nucleic Acid Oligomers. 07 March 2016 Peptide nucleic acid (PNA) oligomers were ... Peptide nucleic acids (PNAs) are DNA mimics where the sugar phosphate backbone of DNA is replaced by a peptide backbone ... Microwave Assisted Synthesis of Peptide Nucleic Acid (PNA) Oligomers Using Biotage® Initiator+ Alstra™ Part No: AN110 Published ... Biotage® Initiator+ Alstra™ microwave peptide synthesizer is the ideal tool for the synthesis of PNAs and conjugates. With the ...
https://www.biotage.com/news/microwave-assisted-synthesis-of-peptide-nucleic-acid-oligomers
*  Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell-specific Fluorescence Imaging
Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone. J Am Chem Soc. 1992;114:1895-7 ... Peptide nucleic acids rather than RNA may have been the first genetic molecule. Proc Natl Acad Sci U S A. 2000;97:3868-71 ... A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells. J Mol ... Nielsen PE, Haaima G. Peptide Nucleic-Acid (PNA) - A DNA Mimic with a Pseudopeptide Backbone. CHEM SOC REV. 1997;26:73-8 ...
http://www.medsci.org/v09p0001.htm
*  Peptide nucleic acid - Wikipedia
Peptide synthesis Oligonucleotide synthesis Glycol nucleic acid Threose nucleic acid Clicked peptide polymer Nielsen PE, Egholm ... Peptide nucleic acid (PNA) is an artificially synthesized polymer similar to DNA or RNA. It was invented by Peter E. Nielsen ( ... June 2006). "Peptide Nucleic Acid (PNA): A Review". Journal of Chemical Technology and Biotechnology. An overview of the PNA ... Synthetic peptide nucleic acid oligomers have been used in recent years in molecular biology procedures, diagnostic assays, and ...
https://en.wikipedia.org/wiki/Peptide_nucleic_acid
*  Molecules | Free Full-Text | Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases −...
... peptide nucleic acids Modified nucleoside analogues; microwave irradiation; peptide nucleic acids This is an open access ... Building Blocks for Peptide Nucleic Acids. Molecules 2007, 12, 543-551. AMA Style. Qu G, Zhang Z, Guo H, Geng M, Xia R. ... Building Blocks for Peptide Nucleic Acids. Guirong Qu * , Zhiguang Zhang. ... Building Blocks for Peptide Nucleic Acids." Molecules 12, no. 3: 543-551. ...
https://www.mdpi.com/1420-3049/12/3/543
*  Synthesis and Characterization of an Electrochemical Peptide Nucleic Acid Probe | Research Project Database | Grantee...
peptide nucleic acid probe, electrochemical hybridization assay, ribosomal RNA, ferrocene nucleic acid probe, electrochemical ... Synthesis and Characterization of an Electrochemical Peptide Nucleic Acid Probe. EPA Grant Number: R827072C015. Subproject: ... Title: Synthesis and Characterization of an Electrochemical Peptide Nucleic Acid Probe. Investigators: Campbell, Naomi F. ... R827072C015 Synthesis and Characterization of an Electrochemical Peptide Nucleic Acid Probe. R827072C016 Determinants of Small- ...
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/6035
*  A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS [Abstract]
A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS Ruediger Pipkorn1✉ ... Pipkorn R, Braun K, Wiessler M, Waldeck W, Schrenk HH, Koch M, Semmler W, Komljenovic D. A Peptide & Peptide Nucleic Acid ... Keywords: Functional peptides, Ligation chemistry, Linker systems, Solid Phase Peptide Synthesis, Therapy, Diagnostics, ... The role of peptides in the interrelations between the structure and function of proteins is widely investigated, especially by ...
http://www.medsci.org/v11p0697
*  Exploitation of a Very Small Peptide Nucleic Acid as a New Inhibitor of miR-509-3p Involved in the Regulation of Cystic...
"Efficient inhibition of miR-155 function in vivo by peptide nucleic acids," Nucleic Acids Research, vol. 38, no. 13, pp. 4466- ... "Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs," Nucleic Acids ... P. E. Nielsen, "Peptide Nucleic Acids (PNA) in chemical biology and drug discovery," Chemistry and Biodiversity, vol. 7, no. 4 ... X. Zhang, T. Ishihara, and D. R. Corey, "Strand invasion by mixed base PNAs and a PNA-peptide chimera," Nucleic Acids Research ...
https://www.hindawi.com/journals/bmri/2014/610718/
*  Frontiers | Peptide Nucleic Acid Knockdown and Intra-host Cell Complementation of Ehrlichia Type IV Secretion System Effector |...
This study examined the use of Peptide Nucleic Acids (PNAs) technology to interrupt type IV secretion system (T4SS) effector ... This study examined the use of Peptide Nucleic Acids (PNAs) technology to interrupt type IV secretion system (T4SS) effector ... Peptide Nucleic Acids (PNAs) are single-stranded synthetic nucleic acids with a pseudopeptide backbone in place of the ... Peptide Nucleic Acid Knockdown and Intra-host Cell Complementation of Ehrlichia Type IV Secretion System Effector. Pratibha ...
https://www.frontiersin.org/articles/10.3389/fcimb.2017.00228/full
*  Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide...
We report the protocols for the synthesis and purification of Peptide Nucleic Acid (PNA) oligomers incorporating modified ... Fabani, M. M., et al. Efficient inhibition of miR-155 function in vivo by peptide nucleic acids. Nucleic Acids Res. 38, (13), ... Rozners, E. Recent Advances in Chemical Modification of Peptide Nucleic Acids. J Nucleic Acids. 2012, 8 (2012). ... Nucleic Acid Ther. 26, (5), 277-285 (2016).. *Avitabile, C., et al. Targeting pre-miRNA by peptide nucleic acids: a new ...
https://www.jove.com/video/56221/sequence-specific-selective-recognition-double-stranded-rnas-over
*  Double-duplex Invasion of Pseudocomplementary Peptide Nucleic Acids into Duplex DNA at Elevated Salt Concentration
In this connection, peptide nucleic acids (PNA) represent one of the most promising oligonucleotide mimics with unique ... Double-duplex Invasion of Pseudocomplementary Peptide Nucleic Acids into Duplex DNA at Elevated Salt Concentration. Synthetic ...
http://www.jbsdonline.com/double-duplex-invasion-pseudocomplementary-peptide-nucleic-acids-into-duplex-dna-elevated-salt-concentration-p11530.html
*  Abstract A31: Comparison of direct sequencing and peptide nucleic acid clamping of EGFR gene in patients with non-small cell...
The aim of this study is to prove higher detection rate of EGFR mutation with peptide nucleic acid (PNA) clamping compared to ... Abstract A31: Comparison of direct sequencing and peptide nucleic acid clamping of EGFR gene in patients with non-small cell ... Comparison of direct sequencing and peptide nucleic acid clamping of EGFR gene in patients with non-small cell lung cancer. [ ... Abstract A31: Comparison of direct sequencing and peptide nucleic acid clamping of EGFR gene in patients with non-small cell ...
http://clincancerres.aacrjournals.org/content/20/2_Supplement/A31
*  Global Peptide Nucleic Acids Industry Market Analysis & Forecast 2018-2023
... Published by spinvestconsulting at researchbeam.com ... Chapter 1 Peptide Nucleic Acids Market Overview. 1.1 Product Overview and Scope of Peptide Nucleic Acids. 1.2 Peptide Nucleic ... Global Peptide Nucleic Acids Market: Product Segment Analysis. Double Chain. Single Chain. Type 3 Global Peptide Nucleic Acids ... 6.2 Global Peptide Nucleic Acids Revenue and Market Share by Type (2013-2018). 6.3 Global Peptide Nucleic Acids Price by Type ( ...
https://www.researchbeam.com/global-peptide-nucleic-acids-industry-analysis-and-forecast-2018-2023-market
*  Peptide Nucleic Acid Fluorescent In Situ Hybridization for Hospital-Acquired Enterococcal Bacteremia: Delivering Earlier...
The peptide nucleic acid fluorescent in situ hybridization (PNA FISH) test for Enterococcus faecalis and other enterococci ( ... Peptide Nucleic Acid Fluorescent In Situ Hybridization for Hospital-Acquired Enterococcal Bacteremia: Delivering Earlier ... Peptide Nucleic Acid Fluorescent In Situ Hybridization for Hospital-Acquired Enterococcal Bacteremia: Delivering Earlier ... Peptide Nucleic Acid Fluorescent In Situ Hybridization for Hospital-Acquired Enterococcal Bacteremia: Delivering Earlier ...
https://aac.asm.org/content/52/10/3558.abstract
*  Biological activity of anti-miR-221 Peptide Nucleic Acids and relative building blocks - EprintsUnife
2012) Biological activity of anti-miR-221 Peptide Nucleic Acids and relative building blocks. PhD Thesis , Università degli ... Biological activity of anti-miR-221 Peptide Nucleic Acids and relative building blocks ... 221 and able to be internalized in target tumor cells thanking to a linked Arg-8 peptide), the results here presented allows to ...
http://eprints.unife.it/633/
*  Immunological Response to Peptide Nucleic Acid and its Peptide Conjugate Targeted to Transactivation Response (TAR) Region of...
Anti-HIV-1 activity of anti-TAR polyamide nucleic acid conjugated with various membrane transducing peptides. Nucleic Acids Res ... Immunological Response to Peptide Nucleic Acid and its Peptide Conjugate Targeted to Transactivation Response (TAR) Region of ... Anti-human immunodeficiency virus-1 (HIV-1) polyamide (peptide) nucleic acids (PNAs) conjugated with cell-penetrating peptides ... Nucleic Acids Res. 2001;29:5099-5106. [PMC free article] [PubMed]. *KOPPELHUS U. NIELSEN P.E. Cellular delivery of peptide ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2948452/
*  Potential of Peptide Nucleic Acids in Future Therapeutic Applications
... glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker. Considering the unique properties of PNA ... Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)- ... Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to ... Potential of Peptide Nucleic Acids in Future Therapeutic Applications. Soheila Montazersaheb 1,2,3 * , Mohammad Saeid Hejazi 2, ...
https://apb.tbzmed.ac.ir/Abstract/apb-20642
*  Peptide Nucleic Acids - CHEMICAL BIOLOGY
... - reflects the multidimensional character of chemical biology, focusing in particular ... Thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution. Anal. Biochem. ... J. Peptide Sci. 1995; 3:175-183.. 36. Beck F, Nielsen PE. Peptide Nucleic Acid (PNA): A DNA mimic with a pseudopeptide backbone ... Peptide nucleic acids (PNAs) containing thymine monomers derived from chiral amino acids: Hybridization and solubility ...
http://schoolbag.info/chemistry/chemical_biology/128.html