... as opposed to singly phosphorylated peptides. This study suggests a role for nuclear RSK and MAP kinase in modulating newly ... The phosphorylation sites identified for RSK (Ser-362) and MAP kinase (Ser-374) are in the transrepression domain. Cooperative ... MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. The major phosphopeptides derived from biosynthetically ... phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the peptide ...
... one for the carboxyl side of asparaginyl peptide bonds and another for the amino side of seryl/threonyl peptide bonds have been ... one for the carboxyl side of aspartyl peptide bonds, ... reactions on these modifications change the peptide mapping ... one for the carboxyl side of asparaginyl peptide bonds and another for the amino side of seryl/threonyl peptide bonds have been ... Additionally, these reactions simultaneously react on several post-translationally modified groups in peptides or proteins. The ...
Peptide Mapping * Proteome / analysis* * Proteomics / methods* * Pseudogenes * Reverse Transcriptase Polymerase Chain Reaction ... In addition, the sequence of the peptides determined by LCMSMS and experiments of in vitro translation allows us to identify a ...
Peptide Mapping * Phenylalanine * Protein Conformation* * Recombinant Proteins / chemistry * Recombinant Proteins / isolation ...
Understanding the pathway and kinetics of aspartic acid isomerization in peptide mapping methods for monoclonal antibodies. ... of a Quantitative Method for Monitoring Aspartate Isomerization of a Monoclonal Antibody by Focused Peptide Mapping. Cao M, Mo ...
... is an important basis for the development of a hypoallergenic peptide vaccine for mugwort allergy. ... which can be blocked with IgG raised against non-IgE reactive Art v 1 peptides, ... For indirect mapping, peptide-specific rabbit antibodies were raised to block IgE against surface-exposed epitopes on folded ... sequential peptide epitopes. Blocking of allergic patients IgE with peptide-specific rabbit antisera identified a hitherto ...
The feeble phenotype was mapped to a mutation in Slc15a4, which encodes the peptide/histidine transporter 1 (PHT1) and has not ...
Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein ... Intracellular Signaling Peptides and Proteins * MAP Kinase Signaling System * Mitogen-Activated Protein Kinase 3 / metabolism ... Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein ...
A cyclic peptide (RO 25-1553) and a secretion analogue ([R16 … ... Their messenger RNAs have been mapped in rat brain by in situ ... The iodinated peptides retained the high affinity and selectivity of the unlabelled peptides and were used for the mapping of ... Their messenger RNAs have been mapped in rat brain by in situ hybridization. A cyclic peptide (RO 25-1553) and a secretion ... analogue ([R16]chicken secretin) were identified as selective agonist peptides for the VIP2- and VIP1 receptors, respectively. ...
Peptides. 2006 Jun;27(6):1520-6. doi: 10.1016/j.peptides.2005.10.012. Epub 2005 Nov 15. ... The heart rate responses paralleled the MAP responses. CTAP, the mu antagonist, paradoxically increased the MAP in both control ... DOI: 10.1016/j.peptides.2005.10.012 Abstract Beta-endorphin decreases blood pressure in normal rats but increases blood ... Rats were also implanted with telemetry transmitters and intracerebroventricular (ICV) cannulas for recording and peptide ...
Extracellular Signal-Regulated MAP Kinases / metabolism * Humans * Intercellular Signaling Peptides and Proteins / chemistry ...
Epitope mapping revealed that a majority of the polyclonal antibodies recognized multiple linear epitopes, and based on these ... of more than 40 protein targets showed that approximately half of the antibodies enriched at least one functional peptide ... antibodies generated via immunization of recombinant protein fragments could be used for the enrichment of target peptides to ... results, a semi-automated method was developed for peptide enrichment using polyclonal antibodies immobilized on protein A- ...
MAP Kinase Signaling System* * Mating Factor * Mitogen-Activated Protein Kinases / metabolism * Multigene Family ... Peptides / pharmacology * Peptides / physiology * Pheromones * Protein Kinase C / metabolism * Repressor Proteins* * ...
... from 76.0 to 81.5 minutes on the genetic map. This brings the total of contiguous sequence from the E.coli genome project to ... Seven new genes--arsE, arsF, arsG, treF, xylR, xylG, and xylH--were identified as well as the previously mapped pit and dctA ... Thirty-one putative signal peptides were found, including those of thirteen known membrane or periplasmic proteins. One tRNA ... from 76.0 to 81.5 minutes on the genetic map. This brings the total of contiguous sequence from the E.coli genome project to ...
Peptide library scanning showed consistent binding in this region but to only a single peptide. Lack of overlapping peptide ... When we mapped these amino acids on the trimerized structure, they spanned across oligomers, supporting the notion that the ... in the overlapping region of the previously identified peptide. Additional amino acids at sites 524 and 579 were also ...
The S. tropica genome features polyketide synthase systems of every known formally classified family, nonribosomal peptide ...
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly. Chouraki V, et al. Mol Psychiatry ... Genes and mapped phenotypes. Search database. All Databases. Assembly. Biocollections. BioProject. BioSample. Books. ClinVar. ... A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.. EBI GWAS ...
... including the secretion signal peptide coding region under control of the polyhedrin promoter, was introduced into Bombyx mori ... The structures of the PA-sugar chains were identified by a combination of two-dimensional PA-sugar chain mapping, MS analysis, ... The full-length mouse interferon-beta (mIFN-beta) cDNA, including the secretion signal peptide coding region under control of ...
More specifically, we present recent work on the molecular bases of transient peptide-mediated interactions and the role that ... Protein Interaction Mapping * Protein Processing, Post-Translational * Protein Structure, Tertiary * Signal Transduction ...
In vitro proteome-wide detection of CN-binding peptides, in vivo SLiM-dependent proximity labeling, and in silico modeling of ... Protein Interaction Maps * Proteome / metabolism * Receptor, Notch1 / metabolism * Saccharomyces cerevisiae * Saccharomyces ... proteomic peptide phage display; proximity-dependent biotinylation. ...
... recognition of a short peptide motif in target partners by a groove on the catalytic domain that is separate from the active ... MAP Kinase Signaling System * Models, Biological * Models, Molecular * Multiprotein Complexes * Phosphoprotein Phosphatases / ...
4. Genome-wide PSR1 binding profiling was performed with polyclonal antibody against PSR1 peptide A region and PSR1 peptide B ... The comprehensive maps of functional chromatin signatures in a major clade of eukaryotic life and the discovery of a central ...
The backbone of all 42 residues and nearly all side chains are well resolved in the EM density map, including the entire N ... Amyloid beta-Peptides * Peptide Fragments * amyloid beta-protein (1-42) Grants and funding * European Research Council/ ...
The c.462delA deletion led to a complete lack of NDUFS4 peptide in isolated mitochondria, and this deficiency caused an ... An identity-by-descent mapping and candidate gene approach was used to identify a novel homozygous c.393dupA frameshift ...
Title: Role of vasoactive peptides in high glucose-induced increased expression of Gαq/11 proteins and associated signaling in ... Title: Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα( ... Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/ ...
The present study is the first report of a Y-sutural congenital cataract mapping to 19q13.3. The mutation observed in FTL in ... Conclusions: The present study is the first report of a Y-sutural congenital cataract mapping to 19q13.3. The mutation observed ...
By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations. ... Intracellular Signaling Peptides and Proteins * Membrane Proteins / genetics * Membrane Proteins / metabolism * Oligonucleotide ...
Genes and mapped phenotypes. Search database. All Databases. Assembly. Biocollections. BioProject. BioSample. Books. ClinVar. ...
Genes and mapped phenotypes. Search database. All Databases. Assembly. Biocollections. BioProject. BioSample. Books. ClinVar. ... Find Recombinant Proteins and Peptides *NITE Biological Resource Center. * Human cDNA clones used in NEDO Project / AK023560 ...
Genes and mapped phenotypes. Search database. All Databases. Assembly. Biocollections. BioProject. BioSample. Books. ClinVar. ... Peptides and Proteins * Primary Antibodies Molecular Biology Databases *Bgee database. * KIFC1 gene expression ...