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*  Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms. - Nuffield Department of...
... that form the major contacts with the PDZ domain's 'binding groove'. We solved crystal structures of seven human PDZ domains, ... of the PDZ domains from PDLIM1 and PDLIM4 also presented here allow comparison with canonical binding for the PDLIM PDZ domain ... These interactions may be indicative of intermediate states between unbound and fully bound PDZ domain and target protein. The ... Comparison with canonical binding suggests that the rearrangement during binding involves both the PDZ domain and its ligand. ...
https://www.ndorms.ox.ac.uk/publications/258116
*  Gene Report for G00000032 - Genes2Cognition Neuroscience Research Programme
PDZ domains typically interact with the very carboxyl terminus of their binding partners. Type 1 PDZ domains usually require ... The PDZ domain is highly conserved among the family members, significantly different from other known PDZ domains, and ... Experiments with single PDZ domains indicated that the strongest contribution was by the second PDZ domain. Unexpectedly, ... Using a pilot set of 22 PDZ domains, 4 PDZ domain clusters, and 20 peptides, we define a gold standard dataset by determining ...
http://www.genes2cognition.org/db/Gene/G00000032
*  The Multiple Languages of Endothelial Cell-to-Cell Communication | Arteriosclerosis, Thrombosis, and Vascular Biology
... which exhibit a PDZ-binding domain in the C-terminus and a src homology region 3 (SH3). PDZ domains are known to mediate the ... JAM-A (but also JAM-B and JAM-C) presents at its C-terminus a consensus binding sequence for type II PDZ domains. It was ... Kausalya PJ, Phua DC, Hunziker W. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins ... Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions ...
http://atvb.ahajournals.org/content/26/7/1431
*  MPP1 Full-Length MS Protein Standard - Creative Proteomics
... and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in ... The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) ... The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) ... motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional ...
https://www.creative-proteomics.com/product/detail-cpfl301754_904.htm
*  Carom, a novel gene, is up-regulated by homocysteine through DNA hypomethylation to inhibit endothelial cell migration and...
WW and PDZ domain containing 1 (MAGI1). In this thesis, we describe this gene as Carom. Carom belongs to the Fes/CIP4 homology ... We identified FCH and double SH3 domains 2 (FCHSD2), a novel gene, as an Hcy-responsive gene through Differential Display in ...
http://digital.library.temple.edu/cdm/ref/collection/p245801coll10/id/276456/
*  PDZ domain (IPR001478) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Domain relationships *PDZ domain (IPR001478) *GRASP55/65 PDZ-like domain (IPR024958). *Tricorn protease, PDZ domain (IPR029414) ... PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (beta-A to beta-F) and two alpha-helices, A and B, ... The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding ...
https://www.ebi.ac.uk/interpro/entry/IPR001478
*  PDZBase: a protein-protein interaction database for PDZ-domains. - PubMed - NCBI
PDZBase: a protein-protein interaction database for PDZ-domains.. Beuming T1, Skrabanek L, Niv MY, Mukherjee P, Weinstein H. ... PDZBase is a database that aims to contain all known PDZ-domain-mediated protein-protein interactions. Currently, PDZBase ...
https://www.ncbi.nlm.nih.gov/pubmed/15513994
*  SMART: PDZ domain annotation
3rd PDZ domain of Multiple PDZ Domain Protein MPDZ (CASP Target). 2iwo. 12th PDZ domain of Multiple PDZ Domain Protein MPDZ ( ... Solution Structure of PDZ domain of PDZ and LIM domain protein. 2eeh. Solution Structure of First PDZ domain of PDZ Domain ... Other PDZ domains form homotypic dimers: the PDZ domain of the neuronal enzyme nitric oxide synthase binds to the PDZ domain of ... CRYSTAL STRUCTURE OF THE HUMAN BETA-2-SYNTROPHIN PDZ DOMAIN. 2vsp. Crystal structure of the fourth PDZ domain of PDZ domain- ...
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=PDZ&
*  Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (IPR030035) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... WW and PDZ domain-containing protein 3 (MAGI3) is a scaffold protein that recruits various proteins via its PDZ domains at cell ... Roles of the PDZ domain-binding motif of the human papillomavirus type 16 E6 on the immortalization and differentiation of ... Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3.. Virology 320 ...
http://www.ebi.ac.uk/interpro/entry/IPR030035?q=GO:0007165
*  Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. - PubMed - NCBI
Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity.. Bhat MA1, Izaddoost S, Lu Y, Cho ... and maintain cell polarity and participates in different molecular complexes that define apical and lateral membrane domains. ... depends on a hierarchical process whereby specific membrane-associated proteins become targeted to specialized membrane domains ...
https://www.ncbi.nlm.nih.gov/pubmed/10102271?dopt=Abstract
*  Frmpd4 MGI Mouse Gene Detail - MGI:3042378 - FERM and PDZ domain containing 4
View mouse Frmpd4 ChrX:167471309-168577231 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
http://www.informatics.jax.org/marker/MGI:3042378
*  RCSB PDB - 1N7E: Crystal structure of the sixth PDZ domain of GRIP1 Methods Report Page
Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain ...
http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1N7E
*  Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF | PNAS
Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF. Heath G. Pascoe, Stephen Gutowski, ... We report a crystal structure of the complex between the cytoplasmic region of PlexinB2 and the PDZ domain of PDZ-RhoGEF. The ... Here, we present the crystal structure of the full-length cytoplasmic region of PlexinB2 in complex with the PDZ domain of PDZ- ... Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF ...
http://www.pnas.org/content/112/48/14852.short
*  PDZ domain - Wikipedia
A PDZ interaction between PSD-95, nNOS and syntrophin is mediated by the second PDZ domain. The third and final PDZ domain ... There are roughly 260 PDZ domains in humans. Several proteins contain multiple PDZ domains, so the number of unique PDZ- ... the new title of the domain would be changed. Thus, the name "PDZ domain" was introduced to the world. PDZ domain structure is ... Most PDZ domains have such a binding site located between one of the β-strands and the long α-helix. PDZ domains have two main ...
https://en.wikipedia.org/wiki/PDZ_domain
*  pdzd3, PDZ domain containing 3 - Creative Biogene
PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; PDZK2; Protein ... PDZD3; PDZ domain containing 3; PDZ domain containing 2 , PDZK2; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; FLJ22756; ... IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na/Pi cotransporter C-terminal- ... DLNB27; Sodium-hydrogen exchanger regulatory factor 4; PDZ domain containing 2; NHERF4 ...
https://www.creative-biogene.com/symbolsearch_pdzd3.html
*  RCSB PDB - 2EGN: Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide
Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide ... Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide. *DOI: 10.2210/pdb2EGN/pdb ... Our study suggests a novel regulatory mechanism of the PDZ domain, by which Tamalin switches between the trafficking-inhibited ... In the absence of mGluR, Tamalin self-assembles into autoinhibited conformations, through its PDZ domain and C-terminal ...
https://www.rcsb.org/structure/2EGN
*  Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 | 322337
Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease ... The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is ... More,, The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor ... Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other ...
http://www.emdmillipore.com/PR/en/product/Dvl-PDZ-Domain-Inhibitor-Peptide-Pen-N3,EMD_BIO-322337
*  Folding and misfolding in a naturally occurring circularly permuted PDZ domain
... Ivarsson, Ylva University of Rome, La Sapienza. ... Although circular permutation of PDZ domains may be necessary for a correct orientation of their functional sites in multi- ... This finding contrasts with what was previously observed for canonical PDZ domains that, although displaying a similar primary ... a PDZ domain from the green alga Scenedesmus obliquus. Data reveal that the folding of the permuted protein is characterized by ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:636249
*  Deciphering the unconventional peptide binding to the PDZ domain of MAST2 | Biochemical Journal
The two proteins interact via the PDZ (PSD-95, Dlg1, Zo-1) domain of MAST2 (MAST2-PDZ). During infection by rabies virus, the ... PDZ-binding motif; PDZ, PSD-95, Dlg1, Zo-1; PSD-95, post synaptic density 95; PTEN, phosphatase and tensin homologue; Zo-1, ... Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Florent Delhommel, Alain Chaffotte, Elouan Terrien, ... Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Florent Delhommel, Alain Chaffotte, Elouan Terrien, ...
http://www.biochemj.org/content/469/1/159
*  PDZ domain-containing protein 5C | definition of PDZ domain-containing protein 5C by Medical dictionary
What is PDZ domain-containing protein 5C? Meaning of PDZ domain-containing protein 5C medical term. What does PDZ domain- ... Looking for online definition of PDZ domain-containing protein 5C in the Medical Dictionary? PDZ domain-containing protein 5C ... PDZ domain-containing protein 5C , definition of PDZ domain-containing protein 5C by Medical dictionary https://medical- ... redirected from PDZ domain-containing protein 5C) FRMPD2. A gene on chromosome 10q11 that encodes a protein which may play a ...
https://medical-dictionary.thefreedictionary.com/PDZ+domain-containing+protein+5C
*  Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction | Science
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction ... Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction ... Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction ... Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction ...
http://science.sciencemag.org/content/287/5461/2262?ijkey=1ad4ecf575d1e9821a2aaa992d889ccafe9a3bf6&keytype2=tf_ipsecsha
*  DSpace@MIT: Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains ... Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions. Research and Teaching ... "Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions." Journal of the American ... Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions. Download ...
https://dspace.mit.edu/handle/1721.1/86182
*  Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
We solved the crystal structure and investigated the folding pathway of a circularly permuted variant of a PDZ domain, SAP97 ... This observation contrasts with previous data on the circularly permuted PDZ2 domain from PTP-BL, for which the folding pathway ... The circular permutant retains the overall structure and function of the native protein domain. Further, unlike most examples ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050055
*  PSD 95
PDZ domain - 124 014. A component of postsynaptic densities in central synapses. Polyclonal Guinea pig antiserum ...
https://www.sysy.com/products/psd95/facts-124014.php
*  Magi3 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 - Rattus norvegicus (Rat) - Magi3 gene &...
... help/domain' target='_top'>More...,/a>,/p>Domaini. 18 - 108. PDZ 1PROSITE-ProRule annotation. ,p>Manual validated information ... help/domain' target='_top'>More...,/a>,/p>Domaini. 413 - 495. PDZ 2PROSITE-ProRule annotation. ,p>Manual validated information ... help/domain' target='_top'>More...,/a>,/p>Domaini. 581 - 657. PDZ 3PROSITE-ProRule annotation. ,p>Manual validated information ... help/domain' target='_top'>More...,/a>,/p>Domaini. 729 - 811. PDZ 4PROSITE-ProRule annotation. ,p>Manual validated information ...
https://www.uniprot.org/uniprot/Q9JK71