Loading...
*  ZFIN Publication: Burgess et al., 2002
Octamer Transcription Factor-3; PAX2 Transcription Factor; Rhombencephalon/embryology*; Transcription Factors/classification; ... Transcription Factors/genetics*; Transcription Factors/metabolism*; Transcription Factors/physiology*; Zebrafish/classification ... a gene encoding the Pou2 transcription factor. Based on chromosomal synteny, phylogenetic sequence comparison, and expression ...
http://zfin.org/ZDB-PUB-020306-4
*  ZFIN Publication: Gou et al., 2018
PAX2 Transcription Factor/genetics. *PAX2 Transcription Factor/metabolism. *Receptors, Notch/genetics. *Receptors, Notch/ ... Disruption of medial factor pax2a eliminated the ability of sox2/3 misexpression to expand sensory but not neurogenic domains. ... neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a ...
http://zfin.org/ZDB-PUB-180123-5
*  Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of...
... which upregulate the transcription factor Pax2 during their last mitosis (Weisheit et al., 2006; Leto et al., 2009). These ... Q-T) Ectopic interneurons in the P30 Pax2/GFP/Ccnd2-/- cerebellum: Pax2-positive Golgi cells in the ML (arrows in Q,R), PV- ... 5B,C). The same procedure was applied to assess the distribution of cells double-labelled for BrdU and GFP in Pax2/GFP and Pax2 ... of Pax2/GFP and Pax2/GFP/Ccnd2-/- mice. The animals were killed at P30. The laminar distribution of BrdU-labelled cells was ...
http://dev.biologists.org/content/138/16/3463
*  Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome...
2000). Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. Development 127, 3703-3713. ... Within the PAX2/5/8 gene subfamily, PAX2 is associated with the highest number of CNEs. An additional WGD experienced in the ... They demonstrated that the insertion of Pax5 cDNA into the Pax2 locus is able to rescue Pax2-mutant phenotypes in mouse, even ... 2004). Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 38, 195-199. ...
http://dev.biologists.org/content/138/5/879
*  Plus it
Pax2 is a member of the pax protein transcription factor family that is characterized by a DNA-binding element called the ... The present studies show that in the developing optic nerve, the paired-box transcription factor Pax2 is a specific marker of ... We found that the Pax2 transcription factor is expressed specifically by all astrocyte lineage cells in the optic nerve ... First, the astrocyte precursors and astrocytes share several antigens including the Pax2 transcription factor. Second, ...
http://www.jneurosci.org/content/19/3/1049
*  PAX2 - Wikipedia
Pax 2 is a transcription factor controlled by the signaling molecules Wnt1 and Fgf8. Pax2 along with other transcription ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • transcription factor activity, sequence- ... The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed ... transcription factor binding. • core promoter proximal region sequence-specific DNA binding. • protein binding. • transcription ...
https://en.wikipedia.org/wiki/PAX2
*  Zebrafish Pronephros Development | SpringerLink
Bouchard M, Pfeffer P, Busslinger M (2000) Functional equivalence of the transcription factors Pax2 and Pax5 in mouse ... Marra AN, Wingert RA (2016) Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and ... Reggiani L, Raciti D, Airik R, Kispert A, Brandli AW (2007) The prepattern transcription factor Irx3 directs nephron segment ... Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and ...
https://link.springer.com/chapter/10.1007/978-3-319-51436-9_2
*  JCI - Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1
We stained postnatal cerebella with 2 different neuronal GABAergic precursor markers: Pax2, a transcription factor that defines ... Scale bars: 50 μm (Pax2); 100 μm (glial markers GFAP). SCA1 stem cells yield a greater number of both Pax2 and GFAP cells than ... Scale bars: 50 μm (Pax2); 100 μm (glial markers GFAP). Atxn1-/- stem cells and WT stem cells resulted in a similar number of ... There were approximately 1.6 times more Pax2-expressing cells in the Sca1154Q/2Q cerebella than in WT cerebella (Supplemental ...
https://www.jci.org/articles/view/96765
*  Paired domain (IPR001523) | InterPro | EMBL-EBI
Mammalian protein Pax2, a probable transcription factor that may have a role in kidney cell differentiation. ... Mammalian protein Pax5, also known as B-cell specific transcription factor (BSAP). Pax5 is involved in the regulation of the ... Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor with important functions in eye and nasal development. In ... The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory ...
http://www.ebi.ac.uk/interpro/entry/IPR001523
*  Plus it
... all dorsal horn spinal cord inhibitory interneurons express the transcription factor Pax2, which is completely absent from ... 2A-C); however, none of the MGE cells coexpressed Pax2 (Figs. 2D-F). We conclude that post-SNI MGE cells retain neurochemical ... Here, we performed double immunostaining for MGE-derived GFP and for SST or Pax2 (Fig. 2) in spinal cord cryosections collected ... Post-SNI transplants express SST but not Pax2. Confocal micrographs of coronal sections prepared from lumbar segments of post- ...
http://www.jneurosci.org/content/36/46/11634
*  Cell Recognition Molecule L1 Regulates Cell Surface Glycosylation to Modulate Cell Survival and Migration
Doberstein K, Pfeilschifter J, Gutwein P. The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. ... L1cam promotes tumor progression and metastasis and is an independent unfavorable prognostic factor in gastric cancer. J ... L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic ...
http://www.medsci.org/v14p1276.htm
*  Potter Syndrome: Background, Pathophysiology, Epidemiology
For example, the Lim1 and Pax2 transcription factors are essential for the formation of the mesonephric duct, from which the ... Transcription factors such as EMX-2, BF-2, fibroblast growth factor 7 (FGF 7), epithelial growth factor receptor (EGF-R), GDNF ... During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ... Similarly, transcription factor EYA1 from the metanephric mesenchyme is required for ureteric bud outgrowth, and deficiency of ...
https://emedicine.medscape.com/article/983477-overview
*  Chaperone-mediated autophagy - Wikipedia
For example, known CMA substrates include, MEF2D, a neuronal factor important for survival; Pax2, a transcription factor, ... Yang, Q.; She, H.; Gearing, M.; Colla, E.; Lee, M.; Shacka, J. J.; Mao, Z. (2009). "Regulation of Neuronal Survival Factor ...
https://en.wikipedia.org/wiki/Chaperone-mediated_autophagy
*  Plus it
PPs coexpress WT1 and PAX-2, two transcription factors with important roles in nephrogenesis. The PAX-2 gene, a mammalian ... It is a zinc finger protein that regulates the transcription of PDX (64), nephrin (80), and paired box gene 2 (PAX-2) (70). WT1 ... Therefore, PAX-2 could be used as a marker of dedifferentiation. However, one study observed PAX-2 expression in normal PECs as ... Importantly, there were no cells coexpressing synaptopodin and PAX-2, vascular endothelial growth factor (as a podocyte marker ...
http://ajprenal.physiology.org/content/296/2/F230
*  Subfractionation of Differentiating Human Embryonic Stem Cell Populations Allows the Isolation of a Mesodermal Population...
Gene-targeting studies have identified the transcription factors Pax2, Lim1 (LHX1), and Wt1 as critically important for kidney ... These cells up-regulated the expression of the renal transcription factors PAX2, LHX1, and WT1 when compared with ... A subset of GCTM2−/PAX2+/WT1+ cells was detectable (Fig. 5). In addition, GCTM2− cells that labeled positive for either PAX2 or ... There are many known transcription factors that differentiate between the MM fated to become nephron versus interstitium and ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3143417/?lang=en-ca
*  SMART: Schnipsel domain PAX
Mammalian protein Pax2, a probable transcription factor that may have a role in kidney cell differentiation. ... Mammalian protein Pax5, also known as B-cell specific transcription factor (BSAP). Pax5 is involved in the regulation of the ... Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor with important functions in eye and nasal development. In ... PAX genes are developmental control genes that encode transcription factors containing a DNA-binding paired domain. Mutations ...
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=Blast:PAX&START=121&END=169&E_VALUE=6e-24&TYPE=BLAST&BLAST=LTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYD
*  Grafts of ShhC25II-soaked beads reproduce the stage-dep | Open-i
PAX2 Transcription Factor/biosynthesis/genetics. *Purines/pharmacology. *Recombinant Proteins/pharmacology. *Retina/embryology ... Pax2, score 2 to 3, 70%; Vax1b, score 2, 25%). Compared to PMP, ShhC25II beads resulted in some embryos expressing Pax2 within ... Pax2, score 2 to 3, 70%; Vax1b, score 2, 25%). Compared to PMP, ShhC25II beads resulted in some embryos expressing Pax2 within ... Triangles point to ectopic Pax2 expression in the dorsal marginal zone and arrows to expanded ventral expression domains of ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4373414_13064_2015_35_Fig3_HTML&req=4
*  Genome-wide analysis of Pax8 binding provides new insights into thyroid functions | BMC Genomics | Full Text
Moreover, both factors modulate Pax8-dependent transcriptional activation of the sodium iodide symporter (Nis) gene promoter. ... which functionally cooperate with Pax8 in the regulation of thyroid gene transcription. Besides, our data demonstrate ... The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes ... Recent reports have associated the transcription factors Pax2 and Pax5 with increased capabilities for cell motility and ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-147
*  SFRP2 - Wikipedia
... gene is a target of the Pax2 transcription factor". J. Biol. Chem. 278 (52): 52401-5. doi:10.1074/jbc.M305614200. PMID 14561758 ...
https://en.wikipedia.org/wiki/SFRP2
*  Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?
Recent studies demonstrate that Pax2, a transcription factor critical for normal kidney development, is an important ... a developmentally regulated transcription factor, to regulate expression of UMOD or aggravate the phenotype of ADPKD [87, 88]. ... stimulate its transcription by making it accessible to the transcription machinery, or silence it by packing into ... T. Hiesberger, X. Shao, E. Gourley, A. Reimann, M. Pontoglio, and P. Igarashi, "Role of the hepatocyte nuclear factor-1β (HNF-1 ...
https://www.hindawi.com/journals/ijn/2012/909083/
*  Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression
WNT4 and WNT11, transcription factors that are regulated by Pax2, were decreased in mRNA; 0.2 fold, p=0.04 and 0.5 fold, p=0.01 ... WT1 inhibits and Pax2 upregulates transcription of WNT4,47 and the observed dysregulation of these factors is associated with ... At this time point, mRNA and protein expression of transcription and growth factors WT1, Pax2, FGF2 (mesenchyme condensation ... suggesting that the Pax2 cascade is suppressed by maternal FR. WT1 inhibits transcription of Pax2,43;44 and may be, in part, ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2932650/?lang=en-ca
*  Phenotype of autosomal recessive congenital microphthalmia mapping to chromosome 14q32 | British Journal of Ophthalmology
Four transcription factors (PAX2, PAX3,PAX6, and CRX) have been associated with ocular disease in humans, but none has been ... 1996) Transcription factor genes and the developing eye: a genetic perspective. Hum Mol Genet 5:1471-1488. ... At least 14 transcription factors that are essential for normal mammalian eye development have been described, along with 32 ... is syntenic with a region of mouse chromosome 12 which contains a number of transcription factors, some of which are important ...
http://bjo.bmj.com/content/83/8/919
*  OSR1 - Wikipedia
Osr1 acts upstream of and causes expression of the transcription factors Lhx1, Pax2 and Wt1 which are involved in early ... OSR1, ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ... OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd,[5] bowl, sob[9] and ...
https://en.wikipedia.org/wiki/OSR1
*  Stefan Heller | Stanford Medicine Profiles
In vertebrates, the paired-box transcription factor Pax-2 is one of the earliest markers of the developing inner ear and is ... LIM-homeodomain transcription factors (LIM-HDs) are essential in tissue patterning and differentiation. But their expression ... Diverse Expression Patterns of LIM-Homeodomain Transcription Factors (LIM-HDs) in Mammalian Inner Ear Development DEVELOPMENTAL ... This implicates Pax-2 as a marker for proliferating hair and supporting cell progenitors. Furthermore, the likelihood that Pax- ...
https://med.stanford.edu/profiles/stefan-heller