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*  Advanced paternal age: How old is too old? | Journal of Epidemiology & Community Health
Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or ...
http://jech.bmj.com/content/60/10/851
*  British Library EThOS: Paternal age effect mutations in germ cell development : pathological correlates in normal testis and...
... paternal age effect mutations ; normal testis ; testicular tumours ... Paternal age effect mutations in germ cell development : pathological correlates in normal testis and testicular tumours ... Evidence from previous studies indicates that these so-called paternal age-effect mutations confer a proliferative advantage to ... Pathogenic gain-of-function mutations associated with increased paternal age, albeit harmful to embryonic development, are ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556213
*  News on Genetics: Paternal Age and Autism Risk
... wouldn't an epigenetic basis be more suggested by a correlation with maternal age after correcting for paternal age? ... If paternal age itself somehow leads to autism, then the cause is less likely to be genetic (a father's genes don't change as ... I never meant to dispute the idea that mutations accumulate with paternal age. However, the cases that Crow points to in the ... The Washington Post describes a new study by Abraham Reichenberg and colleagues showing a significant effect of paternal age on ...
http://newsongenetics.blogspot.com/2006/09/paternal-age-and-autism-risk.html
*  What is Advanced Paternal Age (APA)? - Definition from FertilitySmarts
Advanced paternal age (APA) most commonly refers to a man who is 40 years or older at the time of conception. As a.... ... Advanced Paternal Age (APA) Definition - What does Advanced Paternal Age (APA) mean? Advanced paternal age (APA) most commonly ... FertilitySmarts explains Advanced Paternal Age (APA). There is no universally accepted definition for an age at which a man ... Studies have found that there may be a linear correlation between advanced paternal age and the risk of autism and psychiatric ...
https://www.fertilitysmarts.com/definition/1169/advanced-paternal-age-apa-fertility
*  Mutation risk associated with paternal and maternal age in a cohort of retinoblastoma survivors | SpringerLink
... also exhibits a paternal age effect due to the paternal origin o ... are known to be associated with advanced paternal age, and it ... The modeling strategy evaluated effects of continuous increasing maternal and paternal age and 5-year age increases adjusted ... also exhibits a paternal age effect due to the paternal origin of most new germline RB1 mutations. To further our understanding ... Our study suggests a weak paternal age effect for Rb resulting from de novo germline mutations consistent with the paternal ...
https://link.springer.com/article/10.1007%2Fs00439-011-1126-2
*  The years of our fathers: paternal age and the rate of de novo mutations | Beyond the Ion Channel
Paternal age impacts on the de novo rate. The correlation between paternal age and the frequency of de novo mutations is as ... The rate of de novo mutations per genome virtually doubles when the paternal age increases from 20 to 40. With an age of 80, ... And most of these mutations are transmitted from the paternal germline.. The correlation between paternal age and rate of de ... is well established with maternal age. Whether the paternal age also increases the risk for disorders in the offspring had long ...
http://epilepsygenetics.net/2012/08/28/the-years-of-our-fathers-paternal-age-and-the-rate-of-de-novo-mutations/
*  Journal of Public Health and Epidemiology - impact of environmental factors on the prevalence of autistic disorder after 1979
Increased paternal age and DSM revisions were not related to rising autistic disorder prevalence. Key words: Autism disorder, ... while no relationship was found between paternal age or Diagnostic and Statistical Manual (DSM) revisions and autistic disorder ... The children vaccinated with MMRII, Varicella and Hepatitis A vaccines varied from 19 to 35 months of age at the time of ... The live births, grouped by father's age, were from the US and Australia. ...
http://academicjournals.org/journal/JPHE/article-abstract/C98151247042
*  Achondroplasia | Colleton Medical Center
Advanced paternal age causing spontaneous mutations. Symptoms. Symptoms of achondroplasia include:. *Short stature, a normal ...
https://colletonmedical.com/hl/?/23862/
*  Fighting the male biological clock by banking sperm - CNN
Though studies do suggest that there is an increased risk with advanced paternal age, he said, the risk of any man having a ... Writing in the journal Nature, Alexey Kondrashov, a biologist at the University of Michigan, said that if advanced paternal age ... Some young men pay to store their sperm out of fear of advanced paternal age ... 450 a year to store their sperm at California Cryobank out of fear of advanced paternal age, according to Scott Brown, the ...
http://edition.cnn.com/2016/08/12/health/men-banking-sperm/index.html
*  Achondroplasia - SNPedia
It occurs as a sporadic mutation in approximately 80% of cases (associated with advanced paternal age) or it may be inherited ...
https://www.snpedia.com/index.php/Achondroplasia
*  Apert syndrome | Connective Tissue Gene Tests
Many FGFR mutations are associated with advanced paternal age.. Apert syndrome (MIM 101200) is a relatively severe form of ...
http://ctgt.net/disorder/apert-syndrome
*  DorfWiki: MerWan
Is Dwarfism Achondroplasia effects roughly two out of every 100,000 reside births and is related with advancing paternal age ( ...
http://www.dorfwiki.org/wiki.cgi?MerWan
*  Psychology of Medicine: Achondroplasia
It occurs as a sporadic mutation in approximately 80% of cases (associated with advanced paternal age) or may be inherited as ... New gene mutations leading to achondroplasia are associated with increasing paternal age (over 35 years old). Studies have ... diagnosis can be made by fetal ultrasound by progressive discordance between the femur length and biparietal diameter by age. ...
http://monsterologist.blogspot.com/2014/12/achondroplasia.html
*  Vampire bats of Argentina | Open Science
1976 Age composition of vampire bats (Desmodus rotundus) in northern Argentina and southern Brazil. J. Mammal. 57, 573-576. ( ... 2014 Forgotten fathers: paternal influences on mammalian sex allocation. Trends Ecol. Evol. 29, 158-164. (doi:10.1016/j.tree. ... Age and reproduction. Relatively old bats were still reproductive. Two pregnant females were banded as adults more than 10 and ... Fixed factors were age category (young or old), roost type (tree, building, cave), sex (male, female), the interaction between ...
http://rsos.royalsocietypublishing.org/content/4/4/160959
*  Paternal age effect - Wikipedia
The paternal age effect is the statistical relationship between paternal age at conception and biological effects on the child. ... Some classify the paternal age effect as one of two different types. One effect is directly related to advanced paternal age ... Scientific interest in paternal age effects is relevant because the average paternal age increased in countries such as the ... 375 The paternal age effect for achondroplasia was described by Lionel Penrose in 1955. At a DNA level, the paternal age effect ...
https://en.wikipedia.org/wiki/Paternal_age_effect
*  Paternal age and mortality in children | SpringerLink
... a paternal age effect on offspring's survival is expected but unsettled. We examined the association... ... BackgroundSince paternal age correlates with some diseases that have a high case-fatality, ... Background Since paternal age correlates with some diseases that have a high case-fatality, a paternal age effect on ... De La RE, Thonneau P. Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. ...
https://link.springer.com/article/10.1007%2Fs10654-008-9253-3
*  Older Paternal Age Linked to Adverse Perinatal Outcomes | Physician's Weekly
After adjustment for maternal age, infants born to fathers aged 45 years and older versus those born to fathers aged 25 to 34 ... Older Paternal Age Linked to Adverse Perinatal Outcomes. Nov 5, 2018 , HealthDay , 0 , ... "Given that many couples might not be aware of the potential impact of paternal age on perinatal health, the current findings ... The researchers found associations between older paternal age and increased risk for premature birth, low birth weight, and low ...
https://www.physiciansweekly.com/older-paternal-age-linked-to-adverse-perinatal-outcomes/
*  UTHealth research: Both maternal and paternal age linked to autism - Healthcanal.com : Healthcanal.com
"This should put to rest discrepancies in previous studies showing that just maternal age or just paternal age are linked to ... Home Pregnancy and Childbirth UTHealth research: Both maternal and paternal age linked to autism ... Geriatrics and Aging*Hematology*Immune System*Vaccines & Immunizations. *Kidneys and Urinary System*Male Reproductive*Low ... The corresponding age difference for fathers was 5.9 years.. In previous studies, Rahbar said that because of the statistical ...
https://www.healthcanal.com/pregnancy-childbirth/26472-uthealth-research-both-maternal-and-paternal-age-linked-to-autism.html
*  Genetic Mutations Linked to Paternal Age | babyMed.com
There is no known cause of autism and no definitive link between paternal age and genetic diseases, but as the average paternal ... There are other studies on autism that link paternal age to autism risk. Some studies have even gone so far as to list the ... The study did not definitely connect paternal age to disease-causing genetic mutations, but the implication is there. ... It is the latter mutations that occur with age that sparked the interest of researchers. In a study of nearly 80 trios (mother ...
https://www.babymed.com/pregnancy-news/genetic-mutations-linked-paternal-age
*  Advanced paternal age and risk of fetal death: a cohort study. - Semantic Scholar
... age effect on offspring health due to mutations of paternal origin should be reflected in an association between paternal age ... The paternal age-related risk of late fetal death was higher than the risk of early fetal death and started to increase from ... The paternal age-related risks of fetal death and its components, early and late fetal loss, were estimated using survival ... Pregnancies fathered by a man aged 50 or more years (n = 124) had almost twice the risk of ending in a fetal loss compared with ...
https://www.semanticscholar.org/paper/Advanced-paternal-age-and-risk-of-fetal-death%3A-a-Andersen-Hansen/ac00e82349f4adb40b7885298404797737ecc7c5
*  Frontiers | Impact of Paternal Age on Seminal Parameters and Reproductive Outcome of Intracytoplasmatic Sperm Injection in...
Objective: To evaluate whether the advancing of the paternal age may have effect on the seminal parameters, thus negatively ... Male age groups did not reveal any statistical significant differences in any age-related semen parameters. We also confirmed a ... Male age groups did not reveal any statistical significant differences in any age-related semen parameters. We also confirmed a ... We found that the advanced male age increases the probability of obtaining one or no type A embryo (NA ≤1), which was almost ...
https://www.frontiersin.org/articles/10.3389/fendo.2019.00035/full
*  Browsing Titles index "Paternal age explains a major portion of de novo germline mutation rate variability in healthy...
Paternal age explains a major portion of de novo germline mutation rate variability in healthy individuals  Girard, Simon L.; ... Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation ... ... Browsing Titles index "Paternal age explains a major portion of de novo germline mutation rate variability in healthy ...
https://papyrus.bib.umontreal.ca/xmlui/handle/1866/19699/browse?type=titleindex&value=Paternal+age+explains+a+major+portion+of+de+novo+germline+mutation+rate+variability+in%0D%0Ahealthy+individuals
*  Paternal Age and Epigenetics
Increasing paternal age has various effects on molecular mechanisms such as DNA mutations, chromosomal aberrations and ... Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsImprinting and Inheritance. Paternal Age and Epigenetics. Rakesh ... Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance. Advanced Paternal Age at ... Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring ...
https://www.epibeat.com/developmental-biology-stem-cells/paternal-age-epignetics/2567/
*  Advancing paternal age and the risk of schizophrenia. - Semantic Scholar
Categories of mother's age showed no significant effects, after adjusting for paternal age. CONCLUSIONS These findings support ... METHOD We investigated whether the risk of schizophrenia was associated with advancing paternal age in a population-based birth ... we found that paternal age was a strong and significant predictor of the schizophrenia diagnoses, but not of other psychiatric ... After controlling for maternal age and other confounding factors (sex, ethnicity, education [to reflect socioeconomic status], ...
https://www.semanticscholar.org/paper/Advancing-paternal-age-and-the-risk-of-Malaspina-Harlap/491a5802d3879810796659f7653c5e6ba6830088
*  Aberrant Epigenetic Regulation Could Explain the Relationship of Paternal Age to Schizophrenia : Schizophrenia Bulletin - oi
Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat ... Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat ... Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and ... Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and ...
http://oxfordindex.oup.com/view/10.1093/schbul/sbm093?rskey=A4s5Qf&result=8